bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: egene_temp_file_orthology_annotation_similarity_blast_database_966
164,496 sequences; 82,071,388 total letters
Query= Eace_0098_orf6
Length=580
Score E
Sequences producing significant alignments: (Bits) Value
tgo:TGME49_030420 calcium-transporting ATPase, putative (EC:3.... 742 0.0
ath:AT4G00900 ECA2; ECA2 (ER-TYPE CA2+-ATPASE 2); calcium-tran... 562 2e-159
bbo:BBOV_II005700 18.m06474; calcium ATPase SERCA-like (EC:3.6... 540 5e-153
ath:AT1G07670 calcium-transporting ATPase; K01537 Ca2+-transpo... 509 1e-143
ath:AT1G07810 ECA1; ECA1 (ER-TYPE CA2+-ATPASE 1); calcium-tran... 506 1e-142
cel:K11D9.2 sca-1; SERCA (Sarco-Endoplasmic Reticulum Calcium ... 498 2e-140
mmu:11937 Atp2a1, SERCA1; ATPase, Ca++ transporting, cardiac m... 497 5e-140
dre:393940 atp2a2a, MGC55380, atp2a2, zgc:55380; ATPase, Ca++ ... 496 9e-140
dre:568265 atp2a2b, SERCA2, fb51e04, fb80c02, si:dkey-83d9.6, ... 494 3e-139
dre:494489 atp2a1l, zgc:154094; ATPase, Ca++ transporting, car... 494 5e-139
xla:380096 atp2a2, MGC52615, atp2b, ca-p60a, dar, serca2; ATPa... 493 8e-139
hsa:487 ATP2A1, ATP2A, SERCA1; ATPase, Ca++ transporting, card... 492 2e-138
hsa:488 ATP2A2, ATP2B, DAR, DD, DKFZp686P0211, FLJ20293, FLJ38... 491 3e-138
dre:562640 si:dkey-28b4.8; K05853 Ca2+ transporting ATPase, sa... 491 4e-138
mmu:11938 Atp2a2, 9530097L16Rik, D5Wsu150e, KIAA4195, SERCA2, ... 491 5e-138
dre:568671 atp2a3, si:dkey-205l20.1; ATPase, Ca++ transporting... 489 1e-137
xla:495046 hypothetical LOC495046; K05853 Ca2+ transporting AT... 488 2e-137
ath:AT1G10130 ECA3; ECA3 (ENDOPLASMIC RETICULUM-TYPE CALCIUM-T... 485 2e-136
xla:446229 atp2a1, atp2a, atp2a2, serca1; ATPase, Ca++ transpo... 485 2e-136
dre:260440 atp2a1, MGC92110, cb279, serca, serca1, wu:cegs655,... 484 4e-136
xla:495440 atp2a3, serca3; ATPase, Ca++ transporting, ubiquito... 482 1e-135
mmu:53313 Atp2a3, SERCA3b, Serca3; ATPase, Ca++ transporting, ... 473 1e-132
hsa:489 ATP2A3, SERCA3; ATPase, Ca++ transporting, ubiquitous ... 472 2e-132
cpv:cgd7_4190 cation-transporting P-type ATpase with 11 or mor... 411 3e-114
pfa:PFA_0310c calcium-transporting ATPase, putative (EC:3.6.3.... 315 3e-85
tpv:TP02_0524 calcium-transporting ATPase; K01537 Ca2+-transpo... 309 2e-83
hsa:27032 ATP2C1, ATP2C1A, BCPM, HHD, KIAA1347, PMR1, SPCA1, h... 297 7e-80
mmu:235574 Atp2c1, 1700121J11Rik, ATP2C1A, AW061228, BCPM, D93... 292 3e-78
cel:ZK256.1 pmr-1; PMR-type Golgi ATPase family member (pmr-1)... 291 3e-78
sce:YGL167C PMR1, BSD1, LDB1, SSC1; High affinity Ca2+/Mn2+ P-... 288 3e-77
dre:566794 atp2c1; ATPase, Ca++ transporting, type 2C, member ... 283 2e-75
xla:735042 atp2c2; ATPase, Ca++ transporting, type 2C, member ... 276 2e-73
hsa:479 ATP12A, ATP1AL1; ATPase, H+/K+ transporting, nongastri... 268 7e-71
hsa:9914 ATP2C2, DKFZp686H22230, KIAA0703, SPCA2; ATPase, Ca++... 266 2e-70
dre:64613 atp1a1a.2, atp1a1l2, atp[a]1A2b, cb703, zgc:110523; ... 265 3e-70
hsa:495 ATP4A, ATP6A; ATPase, H+/K+ exchanging, alpha polypept... 264 7e-70
dre:64614 atp1a1a.3, atp1a1l3, atp[a]1A2a; ATPase, Na+/K+ tran... 263 1e-69
mmu:69047 Atp2c2, 1810010G06Rik, KIAA0703, Spca2, mKIAA0703; A... 261 7e-69
xla:399450 atp4a; ATPase, H+/K+ exchanging, alpha polypeptide ... 260 1e-68
xla:733327 hypothetical protein LOC733327 259 1e-68
mmu:192113 Atp12a, Atp1al1, HKalpha2, MGC124416, cHKA; ATPase,... 257 9e-68
bbo:BBOV_IV010020 23.m06075; P-type ATPase4 (EC:3.6.3.8) 256 1e-67
dre:64611 atp1a3b, MGC109873, atp[a]3A, cb706, fj35g11, wu:fj3... 256 2e-67
dre:245703 atp1a1a.5, cb709; ATPase, Na+/K+ transporting, alph... 256 2e-67
mmu:27222 Atp1a4; ATPase, Na+/K+ transporting, alpha 4 polypep... 255 3e-67
xla:379283 atp12a-b, atp12ab, atp1al1; ATPase, H+/K+ transport... 255 3e-67
mmu:11944 Atp4a; ATPase, H+/K+ exchanging, gastric, alpha poly... 255 4e-67
dre:64610 atp1a3a, atp[a]3B, cb705, wu:fj56a06; ATPase, Na+/K+... 254 5e-67
xla:398752 atp1a2, MGC68460; ATPase, Na+/K+ transporting, alph... 253 1e-66
cel:B0365.3 eat-6; EATing: abnormal pharyngeal pumping family ... 253 2e-66
> tgo:TGME49_030420 calcium-transporting ATPase, putative (EC:3.6.3.8);
K01537 Ca2+-transporting ATPase [EC:3.6.3.8]
Length=1093
Score = 742 bits (1916), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 394/590 (66%), Positives = 451/590 (76%), Gaps = 18/590 (3%)
Query 2 TGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDA 61
TGM T+IG IQ+AV EAG D+ Q+PLQQKLDEFGE LSKVI +C+VVW+INI HFSD
Sbjct 268 TGMRTEIGKIQSAVQEAGADDEDQTPLQQKLDEFGEILSKVIFVICIVVWVINIKHFSDP 327
Query 62 VHGSALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETLG 121
VHG LRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVR+L SVETLG
Sbjct 328 VHGGFLRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRKLASVETLG 387
Query 122 CTTVICSDKTGTLTTNEMTCVRFCVVGQSSTEVDVFTVDGTGFCATGSVSREMRGGAKGS 181
CTTVICSDKTGTLTTNEMTCVRFCV D +T +G+ + G+V+ G+ S
Sbjct 388 CTTVICSDKTGTLTTNEMTCVRFCVPNMRHG-TDEYTCEGSCYSPIGAVN---YAGSSHS 443
Query 182 QSLTGHQ-----AVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKL 236
Q H L WL RCAT+CNEA L +APG S+G + R+GEPTEAALLVLVEKL
Sbjct 444 QRRKFHHIEETDQNLQWLARCATLCNEARLEIAPG-SQGMKFTRLGEPTEAALLVLVEKL 502
Query 237 GLFSDEQISRR--ANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVLSRNSKTKR 294
G +D ++ R R P PFCDYW + LATLEF+R+RKSMSVL R + +
Sbjct 503 GC-TDSTLNARFLQCEGRKEQAPMPFCDYWASSWNSLATLEFTRERKSMSVLCRERNSSQ 561
Query 295 NELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDVAGMARGALRTLALAVRLDA 354
N LFVKGAPE++L RC +++LPNG V ++E RK + DV MA ALRTLALA++ D
Sbjct 562 NTLFVKGAPESVLERCTSVLLPNGTVTALTEGIRKKIQNDVDTMAADALRTLALAMKRDC 621
Query 355 GPLADYG----GETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRD 410
G LADY E+ +R LLED A +A +ES L F+G+VGL DPPRPEV +AI CR
Sbjct 622 GELADYDSASPSESRHPARKLLEDAANFAKIESDLIFLGLVGLMDPPRPEVSAAIDACRG 681
Query 411 AGIRVVMITGDNKDTAEAVADLVHIREGFDKTFPSYTGKEFEALSASEKMRVLSSPGGAI 470
AGI+VVMITGDNK TAEAVA ++HI + S+TGKEFE LS EK VLS G +
Sbjct 682 AGIKVVMITGDNKLTAEAVASMIHIVDDGCVGNCSFTGKEFEGLSLEEKKEVLSQ-DGVV 740
Query 471 FSRTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMV 530
FSRTEPKHKQ+I++LL+ELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEA+DMV
Sbjct 741 FSRTEPKHKQMIIRLLRELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEAADMV 800
Query 531 LADDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
LADDNFSTIV+AVEEGRSIYNNMKAFIRYLISSNIGEVASIF TAALGVP
Sbjct 801 LADDNFSTIVAAVEEGRSIYNNMKAFIRYLISSNIGEVASIFFTAALGVP 850
> ath:AT4G00900 ECA2; ECA2 (ER-TYPE CA2+-ATPASE 2); calcium-transporting
ATPase; K01537 Ca2+-transporting ATPase [EC:3.6.3.8]
Length=1054
Score = 562 bits (1448), Expect = 2e-159, Method: Compositional matrix adjust.
Identities = 319/592 (53%), Positives = 399/592 (67%), Gaps = 30/592 (5%)
Query 3 GMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHF--SD 60
GM T+IG IQ +HEA +++++PL++KLDEFG L+ IC VCV+VW+IN +F D
Sbjct 234 GMDTEIGKIQRQIHEAS-LEESETPLKKKLDEFGSRLTTAICIVCVLVWMINYKNFVSWD 292
Query 61 AVHGS-------ALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRR 113
V G + C YYFKIAVALAVAAIPEGLPAVITTCLALGTRKMA+KNAIVR+
Sbjct 293 VVDGYKPVNIKFSFEKCTYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAQKNAIVRK 352
Query 114 LQSVETLGCTTVICSDKTGTLTTNEMTCVRFCVVGQSSTEVDVFTVDGTGFCATGSVSRE 173
L SVETLGCTTVICSDKTGTLTTN+M+ F +G +T VF+V GT + +
Sbjct 353 LPSVETLGCTTVICSDKTGTLTTNQMSATEFFTLGGKTTTTRVFSVSGTTY--------D 404
Query 174 MRGGAKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLV 233
+ G A L + +ICN+A + EG + G PTEAAL VLV
Sbjct 405 PKDGGIVDWGCNNMDANLQAVAEICSICNDAGV-----FYEGKLFRATGLPTEAALKVLV 459
Query 234 EKLGL---FSDEQISRRANTKRTAAN-PTPFCDYWKGEYKDLATLEFSRDRKSMSVLSRN 289
EK+G+ + E I N ++ CD+W K +ATLEF R RKSMSV+ +
Sbjct 460 EKMGIPEKKNSENIEEVTNFSDNGSSVKLACCDWWNKRSKKVATLEFDRVRKSMSVIV-S 518
Query 290 SKTKRNELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDVAGMARGALRTLALA 349
+N L VKGA E++L R L +G +V + E++R+V+L + M LR L LA
Sbjct 519 EPNGQNRLLVKGAAESILERSSFAQLADGSLVALDESSREVILKKHSEMTSKGLRCLGLA 578
Query 350 VRLDAGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCR 409
+ + G +DY E + + LL D + Y+ +E++L F+GVVGL DPPR EVG AI CR
Sbjct 579 YKDELGEFSDYSSEEHPSHKKLL-DPSSYSNIETNLIFVGVVGLRDPPREEVGRAIEDCR 637
Query 410 DAGIRVVMITGDNKDTAEAVA-DLVHIREGFDKTFPSYTGKEFEALSASEKMRVLSSPGG 468
DAGIRV++ITGDNK TAEA+ ++ E D + S+TGKEF +L AS + +LS GG
Sbjct 638 DAGIRVMVITGDNKSTAEAICCEIRLFSENEDLSQSSFTGKEFMSLPASRRSEILSKSGG 697
Query 469 AIFSRTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASD 528
+FSR EP+HKQ IV++LKE+GE AMTGDGVNDAPALK ADIG+AMGI GTEVAKEASD
Sbjct 698 KVFSRAEPRHKQEIVRMLKEMGEIVAMTGDGVNDAPALKLADIGIAMGITGTEVAKEASD 757
Query 529 MVLADDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
MVLADDNFSTIVSAV EGRSIYNNMKAFIRY+ISSN+GEV SIF+TAALG+P
Sbjct 758 MVLADDNFSTIVSAVAEGRSIYNNMKAFIRYMISSNVGEVISIFLTAALGIP 809
> bbo:BBOV_II005700 18.m06474; calcium ATPase SERCA-like (EC:3.6.3.8);
K01537 Ca2+-transporting ATPase [EC:3.6.3.8]
Length=1028
Score = 540 bits (1392), Expect = 5e-153, Method: Compositional matrix adjust.
Identities = 323/589 (54%), Positives = 391/589 (66%), Gaps = 49/589 (8%)
Query 2 TGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDA 61
TGM+T+IG IQAAV EA ++ D +PLQ+ LD+FG LSK I +C+ VW IN HFSD
Sbjct 242 TGMSTEIGAIQAAVLEA-DNQDRSTPLQRMLDDFGTTLSKFITLICIAVWAINFRHFSDP 300
Query 62 VHGSALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETLG 121
VH + +GCIYYFKIA+ALAVAAIPEGLPAVITT LALGTR MAK+NAIVR+L SVETLG
Sbjct 301 VHSNVFKGCIYYFKIAIALAVAAIPEGLPAVITTSLALGTRNMAKRNAIVRKLPSVETLG 360
Query 122 CTTVICSDKTGTLTTNEMTCVRFCVVGQSSTEVD--VFTVDGTGFCATGSVSREMRGGAK 179
CTTVICSDKTGT+TTN+M V+ + Q +VD FT DG +GS AK
Sbjct 361 CTTVICSDKTGTITTNKMR-VQLLKLFQDDHKVDQICFTPDGEVDAKSGSAKDY---AAK 416
Query 180 GSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLGLF 239
G S A+ L +C ++C+EA + H E GEPTE A+L +V+ L F
Sbjct 417 GKLS-----ALAETLFKCGSVCSEASVE---------HDE--GEPTEVAILHMVDNLHAF 460
Query 240 SDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVLSRNSKTKRNELFV 299
+ A+ Y K KD ATLEF RDRK MSV++ + +++
Sbjct 461 VTGVKGQPASV-----------GYQKSIQKD-ATLEFCRDRKMMSVIANENGVY--QVYT 506
Query 300 KGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDVAGMARGALRTLALAVRLDAGPLAD 359
KGAPE++L RC M P+G VVP++ + +VL +V MAR ALRT+A A DA +
Sbjct 507 KGAPESVLERCTHYMKPDGSVVPITAELKGLVLKEVELMAREALRTIAFACHSDAKDCLE 566
Query 360 YGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAGIRVVMIT 419
+ + A A +A +E L ++GV G+ DPPRP V AI R AGIRV MIT
Sbjct 567 LYKQKSSAGAVSEGSPAFFADIERDLVYLGVTGILDPPRPHVQHAISVARRAGIRVFMIT 626
Query 420 GDNKDTAEAVADLVHIREGFDKTFP--------SYTGKEFEALSASEKMRVLSSPGGAIF 471
GDNK TAEA+A V I +P S+TGKEFE LS E+ RV+S+ G +F
Sbjct 627 GDNKLTAEAIAKKVGI---IPHEYPNVGTHLYYSFTGKEFETLSLEERRRVVSAEG-VVF 682
Query 472 SRTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVL 531
SRTEPKHKQ IV LLKE+GET AMTGDGVNDAPALK ADIGVAMGIAGTEVAKEASDMVL
Sbjct 683 SRTEPKHKQEIVSLLKEMGETVAMTGDGVNDAPALKMADIGVAMGIAGTEVAKEASDMVL 742
Query 532 ADDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
DDNF +IV+A+EEGR IY+NMKAFIRYLISSNIGEVASIF+TAALG+P
Sbjct 743 VDDNFQSIVAAIEEGRCIYSNMKAFIRYLISSNIGEVASIFLTAALGIP 791
> ath:AT1G07670 calcium-transporting ATPase; K01537 Ca2+-transporting
ATPase [EC:3.6.3.8]
Length=1061
Score = 509 bits (1311), Expect = 1e-143, Method: Compositional matrix adjust.
Identities = 299/588 (50%), Positives = 376/588 (63%), Gaps = 32/588 (5%)
Query 2 TGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHF--S 59
TGM T+IG + + + EA + ++ +PL++KL+EFGE L+ +I +C +VWLIN+ +F
Sbjct 249 TGMNTEIGRVHSQIQEAAQHEE-DTPLKKKLNEFGEVLTMIIGLICALVWLINVKYFLSW 307
Query 60 DAVHGS------ALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRR 113
+ V G + C YYF+IAVALAVAAIPEGLPAVITTCLALGTRKMA+KNA+VR+
Sbjct 308 EYVDGWPRNFKFSFEKCTYYFEIAVALAVAAIPEGLPAVITTCLALGTRKMAQKNALVRK 367
Query 114 LQSVETLGCTTVICSDKTGTLTTNEMTCVRFCVVGQSSTEVDVFTVDGTGFCATGSVSRE 173
L SVETLGCTTVICSDKTGTLTTN+M + +G + F V+GT F +
Sbjct 368 LPSVETLGCTTVICSDKTGTLTTNQMAVSKLVAMGSRIGTLRSFNVEGTSF--------D 419
Query 174 MRGGAKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLV 233
R G A L + + A ICN+A++ + G PTEAAL VLV
Sbjct 420 PRDGKIEDWPTGRMDANLQMIAKIAAICNDANVE-----KSDQQFVSRGMPTEAALKVLV 474
Query 234 EKLGLFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVLSRNSKTK 293
EK+G N + N C W + +ATLEF RDRKSM V+ +S K
Sbjct 475 EKMGF------PEGLNEASSDGNVLRCCRLWSELEQRIATLEFDRDRKSMGVMVDSSSGK 528
Query 294 RNELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDVAGMARGALRTLALAVRLD 353
+ L VKGA E +L R + L +G + + +R ++L + M+ ALR L A
Sbjct 529 K-LLLVKGAVENVLERSTHIQLLDGSTRELDQYSRDLILQSLHDMSLSALRCLGFAYSDV 587
Query 354 AGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAGI 413
A Y G + L + + Y+++ES+L F+G VGL DPPR EV AI CR AGI
Sbjct 588 PSDFATYDGSEDHPAHQQLLNPSNYSSIESNLVFVGFVGLRDPPRKEVRQAIADCRTAGI 647
Query 414 RVVMITGDNKDTAEAVADLVHIREG-FDKTFPSYTGKEFEALSASEKMRVLSSPGGAIFS 472
RV++ITGDNK TAEA+ + + E D + S TGKEF + ++ L GG +FS
Sbjct 648 RVMVITGDNKSTAEAICREIGVFEADEDISSRSLTGKEF--MDVKDQKNHLRQTGGLLFS 705
Query 473 RTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLA 532
R EPKHKQ IV+LLKE GE AMTGDGVNDAPALK ADIGVAMGI+GTEVAKEASD+VLA
Sbjct 706 RAEPKHKQEIVRLLKEDGEVVAMTGDGVNDAPALKLADIGVAMGISGTEVAKEASDLVLA 765
Query 533 DDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
DDNFSTIV+AV EGRSIYNNMKAFIRY+ISSNIGEVASIF+TAALG+P
Sbjct 766 DDNFSTIVAAVGEGRSIYNNMKAFIRYMISSNIGEVASIFLTAALGIP 813
> ath:AT1G07810 ECA1; ECA1 (ER-TYPE CA2+-ATPASE 1); calcium-transporting
ATPase; K01537 Ca2+-transporting ATPase [EC:3.6.3.8]
Length=1061
Score = 506 bits (1302), Expect = 1e-142, Method: Compositional matrix adjust.
Identities = 297/588 (50%), Positives = 375/588 (63%), Gaps = 32/588 (5%)
Query 2 TGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHF--S 59
TGM T+IG + + + EA + ++ +PL++KL+EFGE L+ +I +C +VWLIN+ +F
Sbjct 249 TGMNTEIGRVHSQIQEAAQHEE-DTPLKKKLNEFGEVLTMIIGLICALVWLINVKYFLSW 307
Query 60 DAVHGS------ALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRR 113
+ V G + C YYF+IAVALAVAAIPEGLPAVITTCLALGTRKMA+KNA+VR+
Sbjct 308 EYVDGWPRNFKFSFEKCTYYFEIAVALAVAAIPEGLPAVITTCLALGTRKMAQKNALVRK 367
Query 114 LQSVETLGCTTVICSDKTGTLTTNEMTCVRFCVVGQSSTEVDVFTVDGTGFCATGSVSRE 173
L SVETLGCTTVICSDKTGTLTTN+M + +G + F V+GT F +
Sbjct 368 LPSVETLGCTTVICSDKTGTLTTNQMAVSKLVAMGSRIGTLRSFNVEGTSF--------D 419
Query 174 MRGGAKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLV 233
R G + A L + + A ICN+A++ + G PTEAAL VLV
Sbjct 420 PRDGKIEDWPMGRMDANLQMIAKIAAICNDANVE-----QSDQQFVSRGMPTEAALKVLV 474
Query 234 EKLGLFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVLSRNSKTK 293
EK+G N + + C W + +ATLEF RDRKSM V+ +S +
Sbjct 475 EKMGF------PEGLNEASSDGDVLRCCRLWSELEQRIATLEFDRDRKSMGVMV-DSSSG 527
Query 294 RNELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDVAGMARGALRTLALAVRLD 353
L VKGA E +L R + L +G + + +R ++L + M+ ALR L A
Sbjct 528 NKLLLVKGAVENVLERSTHIQLLDGSKRELDQYSRDLILQSLRDMSLSALRCLGFAYSDV 587
Query 354 AGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAGI 413
A Y G + L + + Y+++ES+L F+G VGL DPPR EV AI CR AGI
Sbjct 588 PSDFATYDGSEDHPAHQQLLNPSNYSSIESNLIFVGFVGLRDPPRKEVRQAIADCRTAGI 647
Query 414 RVVMITGDNKDTAEAVADLVHIREG-FDKTFPSYTGKEFEALSASEKMRVLSSPGGAIFS 472
RV++ITGDNK TAEA+ + + E D + S TG EF + ++ L GG +FS
Sbjct 648 RVMVITGDNKSTAEAICREIGVFEADEDISSRSLTGIEF--MDVQDQKNHLRQTGGLLFS 705
Query 473 RTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLA 532
R EPKHKQ IV+LLKE GE AMTGDGVNDAPALK ADIGVAMGI+GTEVAKEASDMVLA
Sbjct 706 RAEPKHKQEIVRLLKEDGEVVAMTGDGVNDAPALKLADIGVAMGISGTEVAKEASDMVLA 765
Query 533 DDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
DDNFSTIV+AV EGRSIYNNMKAFIRY+ISSNIGEVASIF+TAALG+P
Sbjct 766 DDNFSTIVAAVGEGRSIYNNMKAFIRYMISSNIGEVASIFLTAALGIP 813
> cel:K11D9.2 sca-1; SERCA (Sarco-Endoplasmic Reticulum Calcium
ATPase) family member (sca-1); K05853 Ca2+ transporting ATPase,
sarcoplasmic/endoplasmic reticulum [EC:3.6.3.8]
Length=1004
Score = 498 bits (1282), Expect = 2e-140, Method: Compositional matrix adjust.
Identities = 306/601 (50%), Positives = 389/601 (64%), Gaps = 65/601 (10%)
Query 2 TGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDA 61
TG+ T+IG I+ E E+++ ++PLQQKLDEFGE LSKVI +CV VW INIGHF+D
Sbjct 228 TGLTTEIGKIRT---EMAETENEKTPLQQKLDEFGEQLSKVISVICVAVWAINIGHFNDP 284
Query 62 VHG-SALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETL 120
HG S ++G IYYFKIAVALAVAAIPEGLPAVITTCLALGTR+MAKKNAIVR L SVETL
Sbjct 285 AHGGSWVKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETL 344
Query 121 GCTTVICSDKTGTLTTNEMTCVRFCVVGQSSTEVDVFT---VDGTGFCATGSVS---REM 174
GCT+VICSDKTGTLTTN+M+ + + GQ+S + FT + G+ + G VS RE+
Sbjct 345 GCTSVICSDKTGTLTTNQMSVSKMFIAGQASGDNINFTEFAISGSTYEPVGKVSTNGREI 404
Query 175 RGGAKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVE 234
A +SLT L+ +C +CN++ ++ + YE++GE TE AL+VL E
Sbjct 405 NPAAGEFESLTE----LAMIC---AMCNDSSVDY---NETKKIYEKVGEATETALIVLAE 454
Query 235 KLGLFSDEQISRRANTKRTAANPTPF---CD-----YWKGEYKDLATLEFSRDRKSMSVL 286
K+ +F T + +P C+ WK E+ TLEFSRDRKSMS
Sbjct 455 KMNVFG---------TSKAGLSPKELGGVCNRVIQQKWKKEF----TLEFSRDRKSMSAY 501
Query 287 ----SRNSKTKRNELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDVA--GMAR 340
S S K +FVKGAPE +L RC T + NG VP++ A + ++ G R
Sbjct 502 CFPASGGSGAK---MFVKGAPEGVLGRC-THVRVNGQKVPLTSAMTQKIVDQCVQYGTGR 557
Query 341 GALRTLALAVRLDAGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPE 400
LR LAL +D P++ S LED + E + F+GVVG+ DPPR E
Sbjct 558 DTLRCLALGT-IDT-PVS--------VSNMNLEDSTQFVKYEQDITFVGVVGMLDPPRTE 607
Query 401 VGSAILQCRDAGIRVVMITGDNKDTAEAVADLVHIR-EGFDKTFPSYTGKEFEALSASEK 459
V +I C AGIRV+MITGDNK+TAEA+ + + E D T +YTG+EF+ L ++
Sbjct 608 VSDSIKACNHAGIRVIMITGDNKNTAEAIGRRIGLFGENEDTTGKAYTGREFDDLPPEQQ 667
Query 460 MRVLSSPGGAIFSRTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAG 519
+F+R EP HK IV +L+ GE TAMTGDGVNDAPALK+A+IG++MG +G
Sbjct 668 SEACRR--AKLFARVEPSHKSKIVDILQSQGEITAMTGDGVNDAPALKKAEIGISMG-SG 724
Query 520 TEVAKEASDMVLADDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGV 579
T VAK AS+MVLADDNF++IVSAVEEGR+IYNNMK FIRYLISSN+GEV SIFM AALG+
Sbjct 725 TAVAKSASEMVLADDNFASIVSAVEEGRAIYNNMKQFIRYLISSNVGEVVSIFMVAALGI 784
Query 580 P 580
P
Sbjct 785 P 785
> mmu:11937 Atp2a1, SERCA1; ATPase, Ca++ transporting, cardiac
muscle, fast twitch 1 (EC:3.6.3.8); K05853 Ca2+ transporting
ATPase, sarcoplasmic/endoplasmic reticulum [EC:3.6.3.8]
Length=994
Score = 497 bits (1280), Expect = 5e-140, Method: Compositional matrix adjust.
Identities = 303/590 (51%), Positives = 390/590 (66%), Gaps = 42/590 (7%)
Query 2 TGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDA 61
TG++T+IG I+ + A E D T PLQQKLDEFGE LSKVI +CV VWLINIGHF+D
Sbjct 226 TGVSTEIGKIRDQMA-ATEQDKT--PLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDP 282
Query 62 VHG-SALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETL 120
VHG S RG IYYFKIAVALAVAAIPEGLPAVITTCLALGTR+MAKKNAIVR L SVETL
Sbjct 283 VHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETL 342
Query 121 GCTTVICSDKTGTLTTNEMTCVRFCVVGQSSTEV---DVFTVDGTGFCATGSVSREMRGG 177
GCT+VICSDKTGTLTTN+M+ + ++ + +V + F++ G+ + G V + +
Sbjct 343 GCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDVCSLNEFSITGSTYAPEGEVLKNDKPV 402
Query 178 AKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLG 237
G + ++ CA +CN++ L+ ++G YE++GE TE AL LVEK+
Sbjct 403 RAGQ-----YDGLVELATICA-LCNDSSLDF--NETKGV-YEKVGEATETALTTLVEKMN 453
Query 238 LFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVLSRNSKTKR--- 294
+F+ E + + +R A + K E+ TLEFSRDRKSMSV +K+ R
Sbjct 454 VFNTE-VRSLSKVERANACNSVIRQLMKKEF----TLEFSRDRKSMSVYCSPAKSSRAAV 508
Query 295 -NELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDVA--GMARGALRTLALAVR 351
N++FVKGAPE ++ RC + + VP++ ++ +++ + G R LR LALA R
Sbjct 509 GNKMFVKGAPEGVIDRCNYVRV-GTTRVPLTGPVKEKIMSVIKEWGTGRDTLRCLALATR 567
Query 352 LDAGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDA 411
D P + +L+D A + E L F+GVVG+ DPPR EV +I CRDA
Sbjct 568 -DTPP---------KREEMVLDDSAKFMEYEMDLTFVGVVGMLDPPRKEVTGSIQLCRDA 617
Query 412 GIRVVMITGDNKDTAEAVADLVHI-REGFDKTFPSYTGKEFEALSASEKMRVLSSPGGAI 470
GIRV+MITGDNK TA A+ + I E + T +YTG+EF+ L +E+
Sbjct 618 GIRVIMITGDNKGTAIAICRRIGIFSENEEVTDRAYTGREFDDLPLAEQREACRR--ACC 675
Query 471 FSRTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMV 530
F+R EP HK IV+ L+ E TAMTGDGVNDAPALK+A+IG+AMG +GT VAK AS+MV
Sbjct 676 FARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKTASEMV 734
Query 531 LADDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
LADDNFSTIV+AVEEGR+IYNNMK FIRYLISSN+GEV IF+TAALG+P
Sbjct 735 LADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLP 784
> dre:393940 atp2a2a, MGC55380, atp2a2, zgc:55380; ATPase, Ca++
transporting, cardiac muscle, slow twitch 2a (EC:3.6.3.8);
K05853 Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum
[EC:3.6.3.8]
Length=996
Score = 496 bits (1278), Expect = 9e-140, Method: Compositional matrix adjust.
Identities = 301/588 (51%), Positives = 388/588 (65%), Gaps = 40/588 (6%)
Query 2 TGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDA 61
TG+ T+IG I+ E ++ ++PLQQKLDEFGE LSKVI +C+ VW+INIGHF+D
Sbjct 226 TGVNTEIGKIR---DEMASTEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDP 282
Query 62 VHG-SALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETL 120
VHG S +RG +YYFKIAVALAVAAIPEGLPAVITTCLALGTR+MAKKNAIVR L SVETL
Sbjct 283 VHGGSWIRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETL 342
Query 121 GCTTVICSDKTGTLTTNEMTCVRFCVVGQSSTE---VDVFTVDGTGFCATGSVSREMRGG 177
GCT+VICSDKTGTLTTN+M+ R ++ ++ E + FT+ G+ + G V + R
Sbjct 343 GCTSVICSDKTGTLTTNQMSVCRMFIIDKAEGENCSLTEFTISGSTYAPEGDVCLDNR-I 401
Query 178 AKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLG 237
K SQ + ++ CA +CN++ L+ S+G YE++GE TE AL LVEK+
Sbjct 402 VKCSQ----YDGLVELATICA-LCNDSSLDF--NESKGV-YEKVGEATETALTCLVEKMN 453
Query 238 LFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVLSRNSKTK--RN 295
+F D + + +R A K E+ TLEFSRDRKSMSV +K K +
Sbjct 454 VF-DTDVRNLSKIERANACNAVIKQLMKKEF----TLEFSRDRKSMSVYCSPNKAKSSSS 508
Query 296 ELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDV--AGMARGALRTLALAVRLD 353
++FVKGAPE ++ RC + + G VP+++ + +++ + G R LR LALA R
Sbjct 509 KMFVKGAPEGVIDRCAYVRV-GGSKVPLTQGIKDKIMSVIREYGTGRDTLRCLALATR-- 565
Query 354 AGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAGI 413
PL + +L D A +A ES L F+G VG+ DPPR EV ++I CR AGI
Sbjct 566 DNPL--------KKEEMVLSDTARFADYESDLTFVGCVGMLDPPRTEVAASIKLCRHAGI 617
Query 414 RVVMITGDNKDTAEAVADLVHIREGFDKTFP-SYTGKEFEALSASEKMRVLSSPGGAIFS 472
RV+MITGDNK TA A+ + I D ++TG+EF+ LS + ++ F+
Sbjct 618 RVIMITGDNKGTAVAICRRIGIFSDDDDVHRMAFTGREFDDLSPHAQREAVTV--ARCFA 675
Query 473 RTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLA 532
R EP HK IV+ L+ E TAMTGDGVNDAPALK+A+IG+AMG +GT VAK AS+MVLA
Sbjct 676 RVEPSHKSKIVEFLQGFDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKTASEMVLA 734
Query 533 DDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
DDNFSTIV+AVEEGR+IYNNMK FIRYLISSN+GEV IF+TAALG P
Sbjct 735 DDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFP 782
> dre:568265 atp2a2b, SERCA2, fb51e04, fb80c02, si:dkey-83d9.6,
wu:fb51e04, wu:fb80c02, zK83D9.6; ATPase, Ca++ transporting,
cardiac muscle, slow twitch 2b; K05853 Ca2+ transporting
ATPase, sarcoplasmic/endoplasmic reticulum [EC:3.6.3.8]
Length=1035
Score = 494 bits (1272), Expect = 3e-139, Method: Compositional matrix adjust.
Identities = 301/585 (51%), Positives = 393/585 (67%), Gaps = 42/585 (7%)
Query 6 TQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDAVHG- 64
T+IG I+ E ++ ++PLQQKLDEFG+ LSKVI +C+ VW+INIGHF+D VHG
Sbjct 224 TEIGKIR---DEMASTEQERTPLQQKLDEFGQQLSKVISLICIAVWIINIGHFNDPVHGG 280
Query 65 SALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETLGCTT 124
S +RG +YYFKIAVALAVAAIPEGLPAVITTCLALGTR+MAKKNAIVR L SVETLGCT+
Sbjct 281 SWVRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTS 340
Query 125 VICSDKTGTLTTNEMTCVRFCVVGQ---SSTEVDVFTVDGTGFCATGSVSREMRGGAKGS 181
VICSDKTGTLTTN+M+ R +V Q ++ + F++ G+ + G V E K
Sbjct 341 VICSDKTGTLTTNQMSVCRMFIVDQANGNTCSLKEFSISGSTYAPDGQVCHE----GKPV 396
Query 182 QSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLGLFSD 241
Q + A++ CA +CN++ L+ ++G YE++GE TE AL LVEK+ +F D
Sbjct 397 QC-SKFDALVEMASICA-LCNDSSLDY--NEAKGV-YEKVGEATETALTCLVEKMNVF-D 450
Query 242 EQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVLSRNSKTKRN--ELFV 299
++ + +R A + K E+ TLEFSRDRKSMSV +K + + ++FV
Sbjct 451 TELKGLSKVERANACNSVIKQLMKKEF----TLEFSRDRKSMSVYCTPNKARSSMGKMFV 506
Query 300 KGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDV--AGMARGALRTLALAVRLDAGPL 357
KGAPE ++ RC T + G+ VPM+ ++ +++ + G R LR LALA R PL
Sbjct 507 KGAPEGVIDRC-THIRVGGNKVPMTPGIKEKIMSVIREYGTGRDTLRCLALATR--DNPL 563
Query 358 ADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAGIRVVM 417
+ +LED + E+ L F+G VG+ DPPR EV ++I CR AGIRV+M
Sbjct 564 SK--------ESLVLEDSTRFVEYETDLTFVGCVGMLDPPRAEVAASIKLCRQAGIRVIM 615
Query 418 ITGDNKDTAEAVADLVHIR-EGFDKTFPSYTGKEFEALS-ASEKMRVLSSPGGAIFSRTE 475
ITGDNK TA A+ + I E D + +YTG+EF+ LS A+++ VL++ F+R E
Sbjct 616 ITGDNKGTAVAICRRIGIFGENDDVSRMAYTGREFDDLSAAAQREAVLTA---RCFARVE 672
Query 476 PKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLADDN 535
P HK IV+ L+ E TAMTGDGVNDAPALK+A+IG+AMG +GT VAK AS+MVLADDN
Sbjct 673 PSHKSKIVEFLQSYDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKTASEMVLADDN 731
Query 536 FSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
FSTIV+AVEEGR+IYNNMK FIRYLISSN+GEV IF+TAALG P
Sbjct 732 FSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFP 776
> dre:494489 atp2a1l, zgc:154094; ATPase, Ca++ transporting, cardiac
muscle, fast twitch 1 like; K05853 Ca2+ transporting
ATPase, sarcoplasmic/endoplasmic reticulum [EC:3.6.3.8]
Length=991
Score = 494 bits (1271), Expect = 5e-139, Method: Compositional matrix adjust.
Identities = 303/587 (51%), Positives = 381/587 (64%), Gaps = 39/587 (6%)
Query 2 TGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDA 61
TG+AT+IG I+ + ++ ++PLQQKLDEFGE LSKVI +CV VW+INIGHF+D
Sbjct 226 TGVATEIGKIR---DQMAATEQEKTPLQQKLDEFGEQLSKVISLICVAVWMINIGHFNDP 282
Query 62 VHG-SALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETL 120
VHG S +RG +YYFKIAVALAVAAIPEGLPAVITTCLALGTR+MAKKNAIVR L SVETL
Sbjct 283 VHGGSWIRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETL 342
Query 121 GCTTVICSDKTGTLTTNEMTCVRFCVVGQ---SSTEVDVFTVDGTGFCATGSVSREMRGG 177
GCT+VICSDKTGTLTTN+M + V+ + E+D F + G+ + G V++ G
Sbjct 343 GCTSVICSDKTGTLTTNQMCVTKMFVIDRIDGDHVELDSFDISGSKYTPEGEVTKL---G 399
Query 178 AKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLG 237
AK S L+ +C +CN++ L+ + YE++GE TE AL LVEK+
Sbjct 400 AKVDCSQYDGLVELATIC---ALCNDSSLDY---NETKKIYEKVGEATETALCCLVEKMN 453
Query 238 LFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVLSRNSKTKR-NE 296
+F + + +R A C K K TLEFSRDRKSMSV K ++
Sbjct 454 VFKS-NVGNLSKVERANA----CCSVVKQLMKKNFTLEFSRDRKSMSVYCTPVKGDAGSK 508
Query 297 LFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDVA--GMARGALRTLALAVRLDA 354
+FVKGAPE ++ RC T + VP++ A + ++ + G R LR LALA R
Sbjct 509 MFVKGAPEGVIDRC-TYVRVGSTRVPLTGAVKDKIMNVIKEWGTGRDTLRCLALATR--D 565
Query 355 GPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAGIR 414
PL + LED +A E+ L F+G VG+ DPPR EV +I CR AGIR
Sbjct 566 SPL--------KVEEMNLEDSTKFADYETDLTFVGCVGMLDPPRKEVTGSIELCRAAGIR 617
Query 415 VVMITGDNKDTAEAVADLVHI-REGFDKTFPSYTGKEFEALSASEKMRVLSSPGGAIFSR 473
V+MITGDNK TA A+ + I E D T +YTG+EF+ L SE+ + F+R
Sbjct 618 VIMITGDNKGTAVAICRRIGIFSEDEDVTGKAYTGREFDDLPHSEQSEAVRR--ACCFAR 675
Query 474 TEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLAD 533
EP HK IV+ L+ E TAMTGDGVNDAPALK+A+IG+AMG +GT VAK AS+MVLAD
Sbjct 676 VEPSHKSKIVEFLQGYDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSASEMVLAD 734
Query 534 DNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
DNFS+IV+AVEEGR+IYNNMK FIRYLISSNIGEV IF+TAALG+P
Sbjct 735 DNFSSIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVCIFLTAALGLP 781
> xla:380096 atp2a2, MGC52615, atp2b, ca-p60a, dar, serca2; ATPase,
Ca++ transporting, cardiac muscle, slow twitch 2; K05853
Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum
[EC:3.6.3.8]
Length=996
Score = 493 bits (1269), Expect = 8e-139, Method: Compositional matrix adjust.
Identities = 296/590 (50%), Positives = 388/590 (65%), Gaps = 42/590 (7%)
Query 2 TGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDA 61
TG T+IG I+ E ++ ++PLQQKLDEFGE LSKVI +CV VWLINIGHF+D
Sbjct 226 TGPNTEIGKIR---DEMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDP 282
Query 62 VHG-SALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETL 120
+HG S ++G +YYFKIAVALAVAAIPEGLPAVITTCLALGTR+MAKKNAIVR L SVETL
Sbjct 283 IHGGSWIKGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETL 342
Query 121 GCTTVICSDKTGTLTTNEMTCVRFCVVGQSSTEV---DVFTVDGTGFCATGSVSREMRGG 177
GCT+VICSDKTGTLTTN+M+ R V+ + ++ + F++ G+ + G V + +
Sbjct 343 GCTSVICSDKTGTLTTNQMSVCRMFVLDKVDGDICSLNEFSITGSTYAPEGEVLKNDKTV 402
Query 178 AKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLG 237
G + ++ CA +CN++ L+ S+G +E++GE TE AL LVEK+
Sbjct 403 KAGQ-----YDGLVELATICA-LCNDSSLDF--NESKGV-FEKVGEATETALTTLVEKMN 453
Query 238 LFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVLSRNSKTKR--- 294
+F+ + + + +R A + K E+ T+EFSRDRKSMSV +K R
Sbjct 454 VFNTD-VRSLSKVERANACNSVIKQLMKKEF----TMEFSRDRKSMSVYCTPAKASRAAV 508
Query 295 -NELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDVA--GMARGALRTLALAVR 351
N++FVKGAPE ++ RC + + VP++ A + +LT + G R LR LALA R
Sbjct 509 GNKMFVKGAPEGVIDRCNYVRVGTTR-VPLTSAIKDTILTVIKEWGTGRDTLRCLALATR 567
Query 352 LDAGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDA 411
D P + +LED + E+ L F+G VG+ DPPR EV +I CR+A
Sbjct 568 -DTPP---------KREDMVLEDSTKFVDYETDLTFVGCVGMLDPPRKEVMGSIKLCREA 617
Query 412 GIRVVMITGDNKDTAEAVADLVHIR-EGFDKTFPSYTGKEFEALSASEKMRVLSSPGGAI 470
GIRV+MITGDNK TA A+ + I E D + ++TG+EF+ L +E+ +
Sbjct 618 GIRVIMITGDNKGTAIAICRRIGIFGENDDVSRLAFTGREFDDLPPAEQREACKR--ASC 675
Query 471 FSRTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMV 530
F+R EP HK IV+ L+ E TAMTGDGVNDAPALK+A+IG+AMG +GT VAK AS+MV
Sbjct 676 FARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKTASEMV 734
Query 531 LADDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
LADDNFSTIV+AVEEGR+IYNNMK FIRYLISSN+GEV IF+TAALG+P
Sbjct 735 LADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLP 784
> hsa:487 ATP2A1, ATP2A, SERCA1; ATPase, Ca++ transporting, cardiac
muscle, fast twitch 1 (EC:3.6.3.8); K05853 Ca2+ transporting
ATPase, sarcoplasmic/endoplasmic reticulum [EC:3.6.3.8]
Length=994
Score = 492 bits (1266), Expect = 2e-138, Method: Compositional matrix adjust.
Identities = 296/590 (50%), Positives = 388/590 (65%), Gaps = 42/590 (7%)
Query 2 TGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDA 61
TG+ T+IG I+ + ++ ++PLQQKLDEFGE LSKVI +CV VWLINIGHF+D
Sbjct 226 TGVGTEIGKIR---DQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDP 282
Query 62 VHG-SALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETL 120
VHG S RG IYYFKIAVALAVAAIPEGLPAVITTCLALGTR+MAKKNAIVR L SVETL
Sbjct 283 VHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETL 342
Query 121 GCTTVICSDKTGTLTTNEMTCVRFCVVGQSSTEV---DVFTVDGTGFCATGSVSREMRGG 177
GCT+VICSDKTGTLTTN+M+ + ++ + ++ + F++ G+ + G V + +
Sbjct 343 GCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDICLLNEFSITGSTYAPEGEVLKNDKPV 402
Query 178 AKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLG 237
G + ++ CA +CN++ L+ ++G YE++GE TE AL LVEK+
Sbjct 403 RPGQ-----YDGLVELATICA-LCNDSSLDF--NEAKGV-YEKVGEATETALTTLVEKMN 453
Query 238 LFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVLSRNSKTKR--- 294
+F+ + + + +R A + K E+ TLEFSRDRKSMSV +K+ R
Sbjct 454 VFNTD-VRSLSKVERANACNSVIRQLMKKEF----TLEFSRDRKSMSVYCSPAKSSRAAV 508
Query 295 -NELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDVA--GMARGALRTLALAVR 351
N++FVKGAPE ++ RC + + VP++ ++ ++ + G R LR LALA R
Sbjct 509 GNKMFVKGAPEGVIDRCNYVRV-GTTRVPLTGPVKEKIMAVIKEWGTGRDTLRCLALATR 567
Query 352 LDAGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDA 411
D P + +L+D A + E+ L F+GVVG+ DPPR EV +I CRDA
Sbjct 568 -DTPP---------KREEMVLDDSARFLEYETDLTFVGVVGMLDPPRKEVTGSIQLCRDA 617
Query 412 GIRVVMITGDNKDTAEAVADLVHIR-EGFDKTFPSYTGKEFEALSASEKMRVLSSPGGAI 470
GIRV+MITGDNK TA A+ + I E + +YTG+EF+ L +E+
Sbjct 618 GIRVIMITGDNKGTAIAICRRIGIFGENEEVADRAYTGREFDDLPLAEQREACRR--ACC 675
Query 471 FSRTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMV 530
F+R EP HK IV+ L+ E TAMTGDGVNDAPALK+A+IG+AMG +GT VAK AS+MV
Sbjct 676 FARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKTASEMV 734
Query 531 LADDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
LADDNFSTIV+AVEEGR+IYNNMK FIRYLISSN+GEV IF+TAALG+P
Sbjct 735 LADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLP 784
> hsa:488 ATP2A2, ATP2B, DAR, DD, DKFZp686P0211, FLJ20293, FLJ38063,
MGC45367, SERCA2; ATPase, Ca++ transporting, cardiac
muscle, slow twitch 2 (EC:3.6.3.8); K05853 Ca2+ transporting
ATPase, sarcoplasmic/endoplasmic reticulum [EC:3.6.3.8]
Length=1015
Score = 491 bits (1265), Expect = 3e-138, Method: Compositional matrix adjust.
Identities = 297/589 (50%), Positives = 385/589 (65%), Gaps = 41/589 (6%)
Query 2 TGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDA 61
TG+ T+IG I+ E ++ ++PLQQKLDEFGE LSKVI +C+ VW+INIGHF+D
Sbjct 199 TGVNTEIGKIR---DEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDP 255
Query 62 VHG-SALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETL 120
VHG S +RG IYYFKIAVALAVAAIPEGLPAVITTCLALGTR+MAKKNAIVR L SVETL
Sbjct 256 VHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETL 315
Query 121 GCTTVICSDKTGTLTTNEMTCVRFCVVGQ---SSTEVDVFTVDGTGFCATGSVSREMRGG 177
GCT+VICSDKTGTLTTN+M+ R ++ + + ++ FT+ G+ + G V
Sbjct 316 GCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVH------ 369
Query 178 AKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLG 237
K + + HQ L ATIC + + + YE++GE TE AL LVEK+
Sbjct 370 -KDDKPVNCHQ--YDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMN 426
Query 238 LFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVL---SRNSKTKR 294
+F D ++ + +R A + K E+ TLEFSRDRKSMSV ++ S+T
Sbjct 427 VF-DTELKGLSKIERANACNSVIKQLMKKEF----TLEFSRDRKSMSVYCTPNKPSRTSM 481
Query 295 NELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDVAGMARGA--LRTLALAVRL 352
+++FVKGAPE ++ RC T + VPM+ ++ +++ + G+ LR LALA
Sbjct 482 SKMFVKGAPEGVIDRC-THIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATH- 539
Query 353 DAGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAG 412
PL + LED A + E++L F+G VG+ DPPR EV S++ CR AG
Sbjct 540 -DNPL--------RREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAG 590
Query 413 IRVVMITGDNKDTAEAVADLVHIR-EGFDKTFPSYTGKEFEALSASEKMRVLSSPGGAIF 471
IRV+MITGDNK TA A+ + I + D T ++TG+EF+ L+ S + + F
Sbjct 591 IRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRD--ACLNARCF 648
Query 472 SRTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVL 531
+R EP HK IV+ L+ E TAMTGDGVNDAPALK+A+IG+AMG +GT VAK AS+MVL
Sbjct 649 ARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKTASEMVL 707
Query 532 ADDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
ADDNFSTIV+AVEEGR+IYNNMK FIRYLISSN+GEV IF+TAALG P
Sbjct 708 ADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFP 756
> dre:562640 si:dkey-28b4.8; K05853 Ca2+ transporting ATPase,
sarcoplasmic/endoplasmic reticulum [EC:3.6.3.8]
Length=1050
Score = 491 bits (1264), Expect = 4e-138, Method: Compositional matrix adjust.
Identities = 303/597 (50%), Positives = 387/597 (64%), Gaps = 49/597 (8%)
Query 2 TGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDA 61
TG+ T+IG I+ E +D ++PLQQKLD+FGE LS VI +CV VW INIGHF+D
Sbjct 220 TGVHTEIGKIR---DEMAATDPERTPLQQKLDQFGEQLSMVITVICVAVWGINIGHFNDP 276
Query 62 VHG-SALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETL 120
VHG S LRG +YYFKIAVALAVAAIPEGLPAVITTCLALGTR+MA+KNAIVR L SVETL
Sbjct 277 VHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETL 336
Query 121 GCTTVICSDKTGTLTTNEMTCVRFCVVGQSSTE---VDVFTVDGTGFCATGSVSREMRGG 177
GCT+VICSDKTGTLTTN+M+ R +V + E ++ FTV G+ + G VS++
Sbjct 337 GCTSVICSDKTGTLTTNQMSVSRLFIVDMVAGERCLLNEFTVTGSTYAPEGEVSKD---- 392
Query 178 AKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLG 237
G Q L + +CN++ L+ S+G +E++GE TE AL LVEK+
Sbjct 393 --GVQVRCSQYEGLVEMASICALCNDSSLDY--NESKGV-FEKVGEATETALCCLVEKMN 447
Query 238 LFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVLSRNSKTKRN-- 295
+F D + + +R A C K + TLEFSRDRKSMSV +K R+
Sbjct 448 VF-DTDLRGLTSAERATA----CCSVIKQLMRKELTLEFSRDRKSMSVFCSPNKLTRSAS 502
Query 296 --ELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDV--AGMARGALRTLALAVR 351
++FVKGAPE++L RC + + G VP+S R+ +L+ V G R LR LA+A R
Sbjct 503 GAKMFVKGAPESVLERCRWIRVSGGTRVPLSSDLREQLLSTVREWGSGRDTLRCLAMATR 562
Query 352 LDAGPLADYGGETTQASRSL-LEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRD 410
D+ P R+L LE+ A ++ ES L F+G VG+ DPPR EV +A+ CR
Sbjct 563 -DSPP----------DPRTLNLENSAAFSEYESDLTFVGCVGMLDPPRKEVLNAVRMCRQ 611
Query 411 AGIRVVMITGDNKDTAEAVADLVHIREGFDKTF-------PSYTGKEFEALSASEKMRVL 463
AGIRV+MITGDNK TA ++ V I ++ TG+EF+ L + +
Sbjct 612 AGIRVIMITGDNKGTALSICRQVGIITEQEEEEAEGGLYGSGLTGREFDELPPHLQRQAC 671
Query 464 SSPGGAIFSRTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVA 523
+ F+R EP HK IV+ L+ L + TAMTGDGVNDAPALK+A+IG+AMG +GT VA
Sbjct 672 RT--ARCFARVEPTHKSRIVEYLQSLSDITAMTGDGVNDAPALKKAEIGIAMG-SGTAVA 728
Query 524 KEASDMVLADDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
K AS+M+LADDNFSTIV+AVEEGR+IYNNMK FIRYLISSNIGEV IF+TAALG+P
Sbjct 729 KSASEMILADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVCIFLTAALGMP 785
> mmu:11938 Atp2a2, 9530097L16Rik, D5Wsu150e, KIAA4195, SERCA2,
SERCA2B, mKIAA4195; ATPase, Ca++ transporting, cardiac muscle,
slow twitch 2 (EC:3.6.3.8); K05853 Ca2+ transporting ATPase,
sarcoplasmic/endoplasmic reticulum [EC:3.6.3.8]
Length=1044
Score = 491 bits (1263), Expect = 5e-138, Method: Compositional matrix adjust.
Identities = 295/589 (50%), Positives = 386/589 (65%), Gaps = 41/589 (6%)
Query 2 TGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDA 61
TG+ T+IG I+ E ++ ++PLQQKLDEFGE LSKVI +C+ VW+INIGHF+D
Sbjct 226 TGVNTEIGKIR---DEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDP 282
Query 62 VHG-SALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETL 120
VHG S +RG IYYFKIAVALAVAAIPEGLPAVITTCLALGTR+MAKKNAIVR L SVETL
Sbjct 283 VHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETL 342
Query 121 GCTTVICSDKTGTLTTNEMTCVRFCVVGQ---SSTEVDVFTVDGTGFCATGSVSREMRGG 177
GCT+VICSDKTGTLTTN+M+ R ++ + + ++ F++ G+ + G V ++
Sbjct 343 GCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDTCSLNEFSITGSTYAPIGEVQKD---- 398
Query 178 AKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLG 237
+ + HQ L ATIC + + + YE++GE TE AL LVEK+
Sbjct 399 ---DKPVKCHQ--YDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMN 453
Query 238 LFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVL---SRNSKTKR 294
+F D ++ + +R A + K E+ TLEFSRDRKSMSV ++ S+T
Sbjct 454 VF-DTELKGLSKIERANACNSVIKQLMKKEF----TLEFSRDRKSMSVYCTPNKPSRTSM 508
Query 295 NELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDVAGMARGA--LRTLALAVRL 352
+++FVKGAPE ++ RC T + VPM+ ++ +++ + G+ LR LALA
Sbjct 509 SKMFVKGAPEGVIDRC-THIRVGSTKVPMTPGVKQKIMSVIREWGSGSDTLRCLALATH- 566
Query 353 DAGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAG 412
PL + LED A + E++L F+G VG+ DPPR EV S++ CR AG
Sbjct 567 -DNPL--------KREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAG 617
Query 413 IRVVMITGDNKDTAEAVADLVHIR-EGFDKTFPSYTGKEFEALSASEKMRVLSSPGGAIF 471
IRV+MITGDNK TA A+ + I + D T ++TG+EF+ LS S + + F
Sbjct 618 IRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELSPSAQRD--ACLNARCF 675
Query 472 SRTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVL 531
+R EP HK IV+ L+ E TAMTGDGVNDAPALK+++IG+AMG +GT VAK AS+MVL
Sbjct 676 ARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKSEIGIAMG-SGTAVAKTASEMVL 734
Query 532 ADDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
ADDNFSTIV+AVEEGR+IYNNMK FIRYLISSN+GEV IF+TAALG P
Sbjct 735 ADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFP 783
> dre:568671 atp2a3, si:dkey-205l20.1; ATPase, Ca++ transporting,
ubiquitous; K05853 Ca2+ transporting ATPase, sarcoplasmic/endoplasmic
reticulum [EC:3.6.3.8]
Length=970
Score = 489 bits (1260), Expect = 1e-137, Method: Compositional matrix adjust.
Identities = 296/587 (50%), Positives = 387/587 (65%), Gaps = 39/587 (6%)
Query 2 TGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDA 61
TG++T+IG I+ ++ ++ ++PLQQKLDEFG+ LSKVI +C+ VW+INIGHF+D
Sbjct 191 TGVSTEIGKIR---NQMAATEQEKTPLQQKLDEFGQQLSKVISLICIAVWVINIGHFADP 247
Query 62 VHG-SALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETL 120
VHG S +RG IYYFKIAVALAVAAIPEGLPAVITTCLALGTR+MAKKNAIVR L SVETL
Sbjct 248 VHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETL 307
Query 121 GCTTVICSDKTGTLTTNEMTCVRFCVVGQ---SSTEVDVFTVDGTGFCATGSVSREMRGG 177
GCT+VICSDKTGTLTTN+M+ R VV + SS + FT+ G+ + G V +
Sbjct 308 GCTSVICSDKTGTLTTNQMSVCRMFVVNKADDSSCSLHEFTISGSTYAPEGEVLK----- 362
Query 178 AKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLG 237
Q G L L ++CN++ L+ ++G YE++GE TE AL LVEK+
Sbjct 363 -ADKQVQCGDYDGLVELATICSLCNDSSLDY--NEAKGV-YEKVGEATETALTTLVEKMN 418
Query 238 LFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVL-SRNSKTKRNE 296
+F + +S + R AA + ++ TLEFSRDRKSMSV + N +++
Sbjct 419 VFKTD-LSGLSKVDRAAACNLIIRQLMQKKF----TLEFSRDRKSMSVYCTPNGTNSQSK 473
Query 297 LFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDV--AGMARGALRTLALAVRLDA 354
+FVKGAPE ++ RC+ + + + P++ A ++ +++ + G R LR LALA R D+
Sbjct 474 MFVKGAPEGVIDRCQFVRV-GKERFPLTMAVKEELMSTIRDWGTGRDTLRCLALATR-DS 531
Query 355 GPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAGIR 414
P D + LE+ +A ESSL F+G VG+ DPPR EV +I C AGIR
Sbjct 532 PPAVD---------KMDLENAGKFAEYESSLTFVGCVGMLDPPRKEVIGSIKLCNKAGIR 582
Query 415 VVMITGDNKDTAEAVADLVHI-REGFDKTFPSYTGKEFEALSASEKMRVLSSPGGAIFSR 473
V+MITGDNK TA A+ + I E D +YTG+EF+ L+ + + F+R
Sbjct 583 VIMITGDNKGTAVAICRRIGIFSENEDVEGRAYTGREFDDLAPEAQREAVKR--ARCFAR 640
Query 474 TEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLAD 533
EP HK IV L+ E TAMTGDGVNDAPALK+A+IG+AMG +GT VAK AS+MVL+D
Sbjct 641 VEPAHKSKIVAYLQSFDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSASEMVLSD 699
Query 534 DNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
DNFSTIV+AVEEGR+IYNNMK FIRYLISSN+GEV IF+TA LG+P
Sbjct 700 DNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAILGLP 746
> xla:495046 hypothetical LOC495046; K05853 Ca2+ transporting
ATPase, sarcoplasmic/endoplasmic reticulum [EC:3.6.3.8]
Length=1042
Score = 488 bits (1257), Expect = 2e-137, Method: Compositional matrix adjust.
Identities = 301/592 (50%), Positives = 394/592 (66%), Gaps = 47/592 (7%)
Query 2 TGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDA 61
TG+ T+IG I+ E ++ ++PLQQKLDEFGE LSKVI +C+ VW+INIGHF+D
Sbjct 226 TGVNTEIGKIR---DEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDP 282
Query 62 VHG-SALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETL 120
VHG S +RG IYYFKIAVALAVAAIPEGLPAVITTCLALGTR+MAKKNAIVR L SVETL
Sbjct 283 VHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETL 342
Query 121 GCTTVICSDKTGTLTTNEMTCVRFCVVGQSSTE---VDVFTVDGTGFCATGSVSREMRGG 177
GCT+VICSDKTGTLTTN+M+ R +V + + ++ F + G+ + G V
Sbjct 343 GCTSVICSDKTGTLTTNQMSVCRMFIVDKVEGDNCFLNEFNITGSTYAPMGEV------- 395
Query 178 AKGSQSLTGHQAV-LSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKL 236
K + + HQ L L +CN++ L+ ++G YE++GE TE AL LVEK+
Sbjct 396 LKDDKLVKCHQYDGLVELATICALCNDSSLDF--NEAKGV-YEKVGEATETALTCLVEKM 452
Query 237 GLFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVL---SRNSKTK 293
+F D ++ + +R A + K E+ TLEFSRDRKSMSV ++ S+T
Sbjct 453 NVF-DTELKGLSRIERANACNSVIKQLMKKEF----TLEFSRDRKSMSVYCTPNKPSRTS 507
Query 294 RNELFVKGAPETLLTRCETMMLPNGDV-VPMSEAARKVVLTDV--AGMARGALRTLALAV 350
+++FVKGAPE L+ RC + + G V +P++ ++ +++ + G R LR LALA
Sbjct 508 MSKMFVKGAPEGLIERCTHIRV--GSVKMPLTAGIKQKLMSVIREWGTGRDTLRCLALAT 565
Query 351 RLDAGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRD 410
D P + LED + E++L F+G VG+ DPPR EV +++ CR
Sbjct 566 H-DNPP---------RKEEMNLEDSNNFINYETNLTFVGCVGMLDPPRTEVAASLKICRQ 615
Query 411 AGIRVVMITGDNKDTAEAVADLVHI-REGFDKTFPSYTGKEFEALS-ASEKMRVLSSPGG 468
AGIRV+MITGDNK TA A+ V I RE D + ++TG+EF+ LS A+++ L++
Sbjct 616 AGIRVIMITGDNKGTAVAICRRVGIFREDEDVSERAFTGREFDELSLAAQRDACLNA--- 672
Query 469 AIFSRTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASD 528
F+R EP HK IV+ L+ E TAMTGDGVNDAPALK+A+IG+AMG +GT VAK AS+
Sbjct 673 RCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKTASE 731
Query 529 MVLADDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
MVLADDNFSTIV+AVEEGR+IYNNMK FIRYLISSN+GEV IF+TAALG P
Sbjct 732 MVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFP 783
> ath:AT1G10130 ECA3; ECA3 (ENDOPLASMIC RETICULUM-TYPE CALCIUM-TRANSPORTING
ATPASE 3); calcium-transporting ATPase/ calmodulin
binding / manganese-transporting ATPase/ peroxidase; K01537
Ca2+-transporting ATPase [EC:3.6.3.8]
Length=998
Score = 485 bits (1249), Expect = 2e-136, Method: Compositional matrix adjust.
Identities = 284/577 (49%), Positives = 376/577 (65%), Gaps = 44/577 (7%)
Query 14 AVHEAG-ESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDAVHGSALRGCIY 72
++H++ ++DD +PL++KLDEFG L+KVI +CV+VW++NIGHFSD HG +G I+
Sbjct 231 SIHDSMLQTDDEATPLKKKLDEFGSFLAKVIAGICVLVWVVNIGHFSDPSHGGFFKGAIH 290
Query 73 YFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETLGCTTVICSDKTG 132
YFKIAVALAVAAIPEGLPAV+TTCLALGT+KMA+ NAIVR L SVETLGCTTVICSDKTG
Sbjct 291 YFKIAVALAVAAIPEGLPAVVTTCLALGTKKMARLNAIVRSLPSVETLGCTTVICSDKTG 350
Query 133 TLTTNEMTCVRFCVV--GQSSTEVDVFTVDGTGFCATGSVSREMRGGAKGSQ-SLTGHQA 189
TLTTN M+ + CVV + ++ FTV GT + G+V + G Q L
Sbjct 351 TLTTNMMSVSKICVVQSAEHGPMINEFTVSGTTYAPEGTVF-----DSNGMQLDLPAQSP 405
Query 190 VLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLGLFSDEQISRRAN 249
L L C+++CN++ L P + YE++GE TE AL VL EK+GL + + N
Sbjct 406 CLHHLAMCSSLCNDSILQYNP---DKDSYEKIGESTEVALRVLAEKVGLPGFDSMPSALN 462
Query 250 --TKRTAANPTPFCD-YWKGEYKDLATLEFSRDRKSMSVLSRNSKTKRNELFVKGAPETL 306
+K A+ +C+ YW+ ++K + LEF+RDRK MSVL S + + +F KGAPE++
Sbjct 463 MLSKHERAS---YCNHYWENQFKKVYVLEFTRDRKMMSVLC--SHKQMDVMFSKGAPESI 517
Query 307 LTRCETMMLPNGD--VVPMSEAARKVVLTDVAGMARGALRTLALAVRLDAGPLADYGGET 364
+ RC +L NGD VVP++ A R + + LR LALA + +G +T
Sbjct 518 IARCNK-ILCNGDGSVVPLTAAGRAELESRFYSFGDETLRCLALAFK-----TVPHGQQT 571
Query 365 TQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAGIRVVMITGDNKD 424
E+ L FIG+VG+ DPPR EV A+L C AGIRV+++TGDNK
Sbjct 572 ISYDN------------ENDLTFIGLVGMLDPPREEVRDAMLACMTAGIRVIVVTGDNKS 619
Query 425 TAEAVADLVHIREGF-DKTFPSYTGKEFEALSASEKMRVLSSPGGAIFSRTEPKHKQLIV 483
TAE++ + + D + SYT EFE L A ++ L +FSR EP HK+++V
Sbjct 620 TAESLCRKIGAFDNLVDFSGMSYTASEFERLPAVQQTLALRR--MTLFSRVEPSHKRMLV 677
Query 484 KLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLADDNFSTIVSAV 543
+ L++ E AMTGDGVNDAPALK+ADIG+AMG +GT VAK ASDMVLADDNF++IV+AV
Sbjct 678 EALQKQNEVVAMTGDGVNDAPALKKADIGIAMG-SGTAVAKSASDMVLADDNFASIVAAV 736
Query 544 EEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
EGR+IYNN K FIRY+ISSNIGEV IF+ A LG+P
Sbjct 737 AEGRAIYNNTKQFIRYMISSNIGEVVCIFVAAVLGIP 773
> xla:446229 atp2a1, atp2a, atp2a2, serca1; ATPase, Ca++ transporting,
cardiac muscle, fast twitch 1 (EC:3.6.3.8); K05853
Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum
[EC:3.6.3.8]
Length=1042
Score = 485 bits (1248), Expect = 2e-136, Method: Compositional matrix adjust.
Identities = 298/592 (50%), Positives = 390/592 (65%), Gaps = 47/592 (7%)
Query 2 TGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDA 61
TG+ T+IG I+ E ++ ++PLQQKLDEFGE LSKVI +C+ VW+INIGHF+D
Sbjct 226 TGVNTEIGKIR---DEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDP 282
Query 62 VHG-SALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETL 120
VHG S +RG IYYFKIAVALAVAAIPEGLPAVITTCLALGTR+MAKKNAIVR L SVETL
Sbjct 283 VHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETL 342
Query 121 GCTTVICSDKTGTLTTNEMTCVRFCVVGQSSTE---VDVFTVDGTGFCATGSVSREMRGG 177
GCT+VICSDKTGTLTTN+M+ R +V + + ++ F + G+ + G V
Sbjct 343 GCTSVICSDKTGTLTTNQMSVCRMFIVDRVEGDNCFLNEFNITGSTYAPMGEV------- 395
Query 178 AKGSQSLTGHQAV-LSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKL 236
K + + HQ L L +CN++ L+ ++G YE++GE TE AL LVEK+
Sbjct 396 LKDDKLVKCHQYDGLVELATICALCNDSSLDF--NEAKGV-YEKVGEATETALTCLVEKM 452
Query 237 GLFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVL---SRNSKTK 293
+F D + + +R A + K E+ TLEFSRDRKSMS ++ S+T
Sbjct 453 NVF-DTDLKGLSRIERANACNSVIKQLMKKEF----TLEFSRDRKSMSAYCTPNKPSRTS 507
Query 294 RNELFVKGAPETLLTRCETMMLPNGDV-VPMSEAARKVVLTDV--AGMARGALRTLALAV 350
+++FVKGAPE L+ RC + + G V + ++ ++ +++ + G R LR LALA
Sbjct 508 MSKMFVKGAPEGLIDRCTHIRV--GSVKMALTPGIKQKIMSVIREWGTGRDTLRCLALAT 565
Query 351 RLDAGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRD 410
+ + LED + E++L F+G VG+ DPPR EV +++ CR
Sbjct 566 HDNPA----------RKEEMNLEDSNNFINYETNLTFVGCVGMLDPPRTEVAASVKMCRQ 615
Query 411 AGIRVVMITGDNKDTAEAVADLVHI-REGFDKTFPSYTGKEFEALS-ASEKMRVLSSPGG 468
AGIRV+MITGDNK TA A+ V I RE D T ++TG+EF+ LS A+++ L++
Sbjct 616 AGIRVIMITGDNKGTAVAICRRVGIFREDDDVTDKAFTGREFDELSPAAQRDACLNA--- 672
Query 469 AIFSRTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASD 528
F+R EP HK IV+ L+ E TAMTGDGVNDAPALK+A+IG+AMG +GT VAK AS+
Sbjct 673 RCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKTASE 731
Query 529 MVLADDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
MVLADDNFSTIV+AVEEGR+IYNNMK FIRYLISSN+GEV IF+TAALG P
Sbjct 732 MVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFP 783
> dre:260440 atp2a1, MGC92110, cb279, serca, serca1, wu:cegs655,
wu:fb17h11, wu:fb19b10, zgc:92110; ATPase, Ca++ transporting,
cardiac muscle, fast twitch 1 (EC:3.6.3.8); K05853 Ca2+
transporting ATPase, sarcoplasmic/endoplasmic reticulum [EC:3.6.3.8]
Length=994
Score = 484 bits (1246), Expect = 4e-136, Method: Compositional matrix adjust.
Identities = 299/591 (50%), Positives = 383/591 (64%), Gaps = 44/591 (7%)
Query 2 TGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDA 61
TG++T+IG I+ + ++ ++PLQQKLDEFGE LSKVI +CV VWLINIGHF+D
Sbjct 226 TGVSTEIGKIR---DQMAATEQEKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDP 282
Query 62 VHG-SALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETL 120
VHG S +RG +YYFKIAVALAVAAIPEGLPAVITTCLALGTR+MAKKNAIVR L SVETL
Sbjct 283 VHGGSWIRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETL 342
Query 121 GCTTVICSDKTGTLTTNEMTCVRFCVV----GQSSTEVDVFTVDGTGFCATGSVSREMRG 176
GCT+VICSDKTGTLTTN+M + V+ G+S T +D + + G+ + G V++
Sbjct 343 GCTSVICSDKTGTLTTNQMCVTKMFVIEKVEGESVT-LDQYDISGSKYTPEGEVTK---- 397
Query 177 GAKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKL 236
G G L L +CN++ L+ S+G YE++GE TE AL LVEK+
Sbjct 398 --NGLPVKCGQFDGLVELATICALCNDSSLDY--NESKGI-YEKVGEATETALCCLVEKM 452
Query 237 GLFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVLSRNSKTKR-- 294
+F+ + R +K AN C K K TLEFSRDRKSMSV +K +
Sbjct 453 NVFNTDV---RGLSKVERANTC--CAVIKQLMKKDFTLEFSRDRKSMSVYCSPAKASKAP 507
Query 295 --NELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDVA--GMARGALRTLALAV 350
N++FVKGAPE ++ RC + + VP++ + ++ + G R LR LALA
Sbjct 508 VGNKMFVKGAPEGVIDRCAYVRV-GTTRVPLTGPVKDKIMAVIKEWGTGRDTLRCLALAT 566
Query 351 RLDAGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRD 410
R PL + LED +A E+ L F+G VG+ DPPR EV +I CR
Sbjct 567 R--DNPL--------RPEEMNLEDSTKFAEYETDLTFVGCVGMLDPPRKEVVGSIELCRA 616
Query 411 AGIRVVMITGDNKDTAEAVADLVHI-REGFDKTFPSYTGKEFEALSASEKMRVLSSPGGA 469
AGIRV+MITGDNK TA A+ + I + D T ++TG+EF+ L ++ +
Sbjct 617 AGIRVIMITGDNKGTAVAICRRIGIFSDDEDVTGRAFTGREFDDLPLPQQREAVRK--AC 674
Query 470 IFSRTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDM 529
++R EP HK IV+ L+ E TAMTGDGVNDAPALK+A+IG+AMG +GT VAK AS+M
Sbjct 675 CYARVEPSHKSKIVEFLQGFDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSASEM 733
Query 530 VLADDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
VLADDNFS+IV+AVEEGR+IYNNMK FIRYLISSN+GEV IF+TAALG+P
Sbjct 734 VLADDNFSSIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLP 784
> xla:495440 atp2a3, serca3; ATPase, Ca++ transporting, ubiquitous
(EC:3.6.3.8); K05853 Ca2+ transporting ATPase, sarcoplasmic/endoplasmic
reticulum [EC:3.6.3.8]
Length=1033
Score = 482 bits (1241), Expect = 1e-135, Method: Compositional matrix adjust.
Identities = 294/594 (49%), Positives = 388/594 (65%), Gaps = 50/594 (8%)
Query 2 TGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDA 61
TG+ T+IG I+ ++ ++ ++PLQQKLDEFG+ LSKVI +CV VW+INIGHF+D
Sbjct 226 TGIYTEIGKIR---NQMVATEPEKTPLQQKLDEFGQQLSKVISLICVAVWVINIGHFNDP 282
Query 62 VHG-SALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETL 120
VHG S RG IYYFKIAVALAVAAIPEGLPAVITTCLALGTR+MAKKNAIVR L SVETL
Sbjct 283 VHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETL 342
Query 121 GCTTVICSDKTGTLTTNEMTCVRFCVVGQ---SSTEVDVFTVDGTGFCATGSVSREMRGG 177
GCT+VICSDKTGTLTTN+M+ R V+ + + F++ G+ + G + ++
Sbjct 343 GCTSVICSDKTGTLTTNQMSVSRMFVIEKIEGVNCSFHEFSITGSTYAPEGHILKDEEPV 402
Query 178 AKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLG 237
G + ++ CA +CN++ L+ S+G YE++GE TE AL LVEK+
Sbjct 403 NCGQ-----YDGLVELATICA-LCNDSSLDF--NESKGV-YEKVGEATETALTCLVEKMN 453
Query 238 LFSDE--QISR--RANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVL----SRN 289
+F+ +S+ RANT + K K TLEFSRDRKSMSV + N
Sbjct 454 VFNTNLSTLSKVERANTCNSVI---------KKLMKKECTLEFSRDRKSMSVYCNSEAPN 504
Query 290 SKTKRNELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDVAGMARG--ALRTLA 347
S +++FVKGAPE+++ RC + + + +P++ +AR+ +++ + G LR LA
Sbjct 505 SGHSASKMFVKGAPESVIERCNYVRVGSTK-LPLTPSAREKIMSKIRDWGTGIDTLRCLA 563
Query 348 LAVRLDAGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQ 407
LA R L D LED + E++L F+G VG+ DPPR EV ++I
Sbjct 564 LATRDVPPKLEDLQ----------LEDSTKFINYETNLTFVGCVGMLDPPRKEVSTSIEL 613
Query 408 CRDAGIRVVMITGDNKDTAEAVADLVHIREGF-DKTFPSYTGKEFEALSASEKMRVLSSP 466
C+ AGI+V+MITGDNK TA A+ + I + D T +YTG+EF+ LS ++ S
Sbjct 614 CKKAGIKVIMITGDNKGTAVAICRKIGIFSEYEDITDKAYTGREFDDLSPEKQREACRS- 672
Query 467 GGAIFSRTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEA 526
F+R EP HK IV+ L+ E TAMTGDGVNDAPALK+A+IG+AMG +GT VAK A
Sbjct 673 -ARCFARVEPAHKSKIVEYLQSYNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSA 730
Query 527 SDMVLADDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
++MVLADDNFS+IVSAVEEGR+IYNNMK FIRYLISSN+GEV IF+TA LG+P
Sbjct 731 AEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAILGLP 784
> mmu:53313 Atp2a3, SERCA3b, Serca3; ATPase, Ca++ transporting,
ubiquitous (EC:3.6.3.8); K05853 Ca2+ transporting ATPase,
sarcoplasmic/endoplasmic reticulum [EC:3.6.3.8]
Length=999
Score = 473 bits (1216), Expect = 1e-132, Method: Compositional matrix adjust.
Identities = 286/590 (48%), Positives = 379/590 (64%), Gaps = 42/590 (7%)
Query 2 TGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDA 61
TG+ T++G I++ + + ++PLQ+KLDEFG LS I +CV VW+INIGHF+D
Sbjct 226 TGLQTELGKIRS---QMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADP 282
Query 62 VHG-SALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETL 120
HG S LRG +YYFKIAVALAVAAIPEGLPAVITTCLALGTR+MA+KNAIVR L SVETL
Sbjct 283 AHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETL 342
Query 121 GCTTVICSDKTGTLTTNEMTCVRFCVVGQS---STEVDVFTVDGTGFCATGSVSREMRGG 177
GCT+VICSDKTGTLTTN+M+ R VV ++ + + FT+ GT + G V
Sbjct 343 GCTSVICSDKTGTLTTNQMSVCRMFVVAEAEAGTCRLHEFTISGTTYTPEGEVR------ 396
Query 178 AKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLG 237
+G Q + Q L ATIC + + + YE++GE TE AL LVEK+
Sbjct 397 -QGEQPVRCGQ--FDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMN 453
Query 238 LFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVL----SRNSKTK 293
+F D + + +R A + + E+ TLEFSRDRKSMSV + K +
Sbjct 454 VF-DTDLKGLSRVERAGACNSVIKQLMRKEF----TLEFSRDRKSMSVYCTPTRADPKVQ 508
Query 294 RNELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDVAGMARGA--LRTLALAVR 351
+++FVKGAPE+++ RC ++ + P+S +R+ +L + G+ LR LALA R
Sbjct 509 GSKMFVKGAPESVIERCSSVRV-GSRTAPLSTTSREHILAKIRDWGSGSDTLRCLALATR 567
Query 352 LDAGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDA 411
D P + L+D + + E+ L F+G VG+ DPPRPEV + I +C A
Sbjct 568 -DTPP---------RKEDMHLDDCSRFVQYETDLTFVGCVGMLDPPRPEVAACITRCSRA 617
Query 412 GIRVVMITGDNKDTAEAVADLVHIR-EGFDKTFPSYTGKEFEALSASEKMRVLSSPGGAI 470
GIRVVMITGDNK TA A+ + I + D +YTG+EF+ LS ++ + +
Sbjct 618 GIRVVMITGDNKGTAVAICRRLGIFGDTEDVLGKAYTGREFDDLSPEQQRQACRT--ARC 675
Query 471 FSRTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMV 530
F+R EP HK IV+ L+ E TAMTGDGVNDAPALK+A+IG+AMG +GT VAK A++MV
Sbjct 676 FARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMV 734
Query 531 LADDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
L+DDNF++IV+AVEEGR+IYNNMK FIRYLISSN+GEV IF+TA LG+P
Sbjct 735 LSDDNFASIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAILGLP 784
> hsa:489 ATP2A3, SERCA3; ATPase, Ca++ transporting, ubiquitous
(EC:3.6.3.8); K05853 Ca2+ transporting ATPase, sarcoplasmic/endoplasmic
reticulum [EC:3.6.3.8]
Length=999
Score = 472 bits (1215), Expect = 2e-132, Method: Compositional matrix adjust.
Identities = 288/590 (48%), Positives = 381/590 (64%), Gaps = 42/590 (7%)
Query 2 TGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDA 61
TG+ T++G I++ + + ++PLQ+KLDEFG LS I +CV VW+INIGHF+D
Sbjct 226 TGLHTELGKIRS---QMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADP 282
Query 62 VHG-SALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETL 120
HG S LRG +YYFKIAVALAVAAIPEGLPAVITTCLALGTR+MA+KNAIVR L SVETL
Sbjct 283 AHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETL 342
Query 121 GCTTVICSDKTGTLTTNEMTCVRFCVVGQS---STEVDVFTVDGTGFCATGSVSREMRGG 177
GCT+VICSDKTGTLTTN+M+ R VV ++ S + FT+ GT + G V
Sbjct 343 GCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGSCLLHEFTISGTTYTPEGEVR------ 396
Query 178 AKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLG 237
+G Q + Q L ATIC + + + YE++GE TE AL LVEK+
Sbjct 397 -QGDQPVRCGQ--FDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMN 453
Query 238 LFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVL---SRNSKTKR 294
+F D + + +R A T + E+ TLEFSRDRKSMSV +R T +
Sbjct 454 VF-DTDLQALSRVERAGACNTVIKQLMRKEF----TLEFSRDRKSMSVYCTPTRPHPTGQ 508
Query 295 -NELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDVAGMARGA--LRTLALAVR 351
+++FVKGAPE+++ RC ++ + P++ +R+ +L + G+ LR LALA R
Sbjct 509 GSKMFVKGAPESVIERCSSVRV-GSRTAPLTPTSREQILAKIRDWGSGSDTLRCLALATR 567
Query 352 LDAGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDA 411
DA P + L+D + + E+ L F+G VG+ DPPRPEV + I +C A
Sbjct 568 -DAPP---------RKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQA 617
Query 412 GIRVVMITGDNKDTAEAVADLVHIR-EGFDKTFPSYTGKEFEALSASEKMRVLSSPGGAI 470
GIRVVMITGDNK TA A+ + I + D +YTG+EF+ LS ++ + +
Sbjct 618 GIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQACRT--ARC 675
Query 471 FSRTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMV 530
F+R EP HK IV+ L+ E TAMTGDGVNDAPALK+A+IG+AMG +GT VAK A++MV
Sbjct 676 FARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMV 734
Query 531 LADDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
L+DDNF++IV+AVEEGR+IY+NMK FIRYLISSN+GEV IF+TA LG+P
Sbjct 735 LSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLP 784
> cpv:cgd7_4190 cation-transporting P-type ATpase with 11 or more
transmembrane domains ; K01537 Ca2+-transporting ATPase
[EC:3.6.3.8]
Length=1129
Score = 411 bits (1057), Expect = 3e-114, Method: Compositional matrix adjust.
Identities = 228/462 (49%), Positives = 302/462 (65%), Gaps = 35/462 (7%)
Query 2 TGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDA 61
TGM T+IG IQ+AV +A ES + +PL +K+DEFGE LSKVI +C++VW+IN +F D
Sbjct 232 TGMQTEIGAIQSAVQKASESTE-DTPLGKKIDEFGEILSKVIAVICLIVWVINFRNFQDP 290
Query 62 VHGSALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETLG 121
HGS + G IYY KIAVALAVAAIPEGLPAVITTCLALGTRKMA++NAIVRRL SVETLG
Sbjct 291 AHGSTINGAIYYLKIAVALAVAAIPEGLPAVITTCLALGTRKMAQRNAIVRRLPSVETLG 350
Query 122 CTTVICSDKTGTLTTNEMTCVRFCVVGQSSTEVDVFTVDGTGFCATGSVSREMRGGAKGS 181
CTTVICSDKTGTLTT+EM CV+F V +S +D +TV+G + G++ M G K
Sbjct 351 CTTVICSDKTGTLTTSEMCCVQF-FVPRSFISIDKYTVEGHSYTPIGAI--WMSDGVKTP 407
Query 182 ---QSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLGL 238
+++T L W+ +C +CN + LN+ ++ GEPTE AL VLVEKLG
Sbjct 408 KEFENITAEDINLQWMAKCLALCNTSQLNLVE-----DKFKIQGEPTEGALRVLVEKLGC 462
Query 239 FSDEQISRRANTK---RTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVLSRNSKT--- 292
D +++++ K RT+ + F DYW + TLEF RDRKSMSVL R++
Sbjct 463 -PDIRLNQKYQNKEGSRTSKTSSIFNDYWCTGVNLITTLEFHRDRKSMSVLCRDTGNVNV 521
Query 293 ---------------KRNELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDVAG 337
N L+VKGAPE +L RC + M+P+G + P++++ + +VL V
Sbjct 522 QLVTHRSSGETDTYENSNVLYVKGAPEGILDRCSSFMMPDGTIEPITDSFKSLVLDKVVN 581
Query 338 MARGALRTLALAVRLD-AGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDP 396
MA LRTLA AV++D G L+ Y G+ +LL D + + +E LCFIGV+G++DP
Sbjct 582 MADNVLRTLACAVKVDNLGELSTYNGQPKSKGAALLSDPSNFVNIEKDLCFIGVMGIYDP 641
Query 397 PRPEVGSAILQCRDAGIRVVMITGDNKDTAEAVADLVHIREG 438
PRP V +AI +C+ AGIRV MITGDN++TAEA+A + I G
Sbjct 642 PRPGVKNAIQRCQKAGIRVFMITGDNRNTAEAIASSIGILRG 683
Score = 225 bits (573), Expect = 4e-58, Method: Compositional matrix adjust.
Identities = 107/138 (77%), Positives = 124/138 (89%), Gaps = 0/138 (0%)
Query 443 FPSYTGKEFEALSASEKMRVLSSPGGAIFSRTEPKHKQLIVKLLKELGETTAMTGDGVND 502
+ S TG+EFE LS ++K++VL G +FSRTEP+HKQ+IV+LL ELGE TAMTGDGVND
Sbjct 748 YCSLTGREFEELSEADKLKVLKESYGVVFSRTEPRHKQVIVQLLSELGEITAMTGDGVND 807
Query 503 APALKQADIGVAMGIAGTEVAKEASDMVLADDNFSTIVSAVEEGRSIYNNMKAFIRYLIS 562
APALKQADIG++MGI GT+VAKEASDMVLADDNF TIV+AVE+GRSIY NMKAFIRYLIS
Sbjct 808 APALKQADIGISMGITGTDVAKEASDMVLADDNFETIVAAVEQGRSIYMNMKAFIRYLIS 867
Query 563 SNIGEVASIFMTAALGVP 580
SNIGEVASIF+TAALG+P
Sbjct 868 SNIGEVASIFLTAALGIP 885
> pfa:PFA_0310c calcium-transporting ATPase, putative (EC:3.6.3.8);
K01537 Ca2+-transporting ATPase [EC:3.6.3.8]
Length=1228
Score = 315 bits (807), Expect = 3e-85, Method: Compositional matrix adjust.
Identities = 168/338 (49%), Positives = 219/338 (64%), Gaps = 29/338 (8%)
Query 257 PTPFCDYWKGEYKDLATLEFSRDRKSMSVLSRNSKTKRNELFVKGAPETLLTRCETMMLP 316
P+ W+ E K + +EF+R+RK MSV+ N K K L+ KGAPE ++ C+ +
Sbjct 674 PSECISSWRNECKQIKIIEFTRERKLMSVIVENKK-KEIILYCKGAPENIIKNCKYYLTK 732
Query 317 NGDVVPMSEAARKVVLTDVAGMARGALRTLALAVRLDAGPLADYGGETTQASRSL-LEDQ 375
N D+ P++E + + + M + ALRTL+ A + +S+ L +++
Sbjct 733 N-DIRPLNETLKNEIHNKIQNMGKRALRTLSFAYK-------------KLSSKDLNIKNT 778
Query 376 AGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAGIRVVMITGDNKDTAEAVADLVHI 435
Y LE L ++G +G+ DPPR VG AI C AGIRV MITGDN +TA A+A ++I
Sbjct 779 DDYYKLEQDLIYLGGLGIIDPPRKYVGRAIRLCHMAGIRVFMITGDNINTARAIAKEINI 838
Query 436 ---REGFDKT----------FPSYTGKEFEALSASEKMRVLSSPGGAIFSRTEPKHKQLI 482
EG D+ Y G+EFE S ++ +L + +F RTEPKHK+ I
Sbjct 839 LNKNEGDDEKDNYTNNKNTQICCYNGREFEDFSLEKQKHILKNTPRIVFCRTEPKHKKQI 898
Query 483 VKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLADDNFSTIVSA 542
VK+LK+LGET AMTGDGVNDAPALK ADIG+AMGI GTEVAKEASD+VLADDNF+TIV A
Sbjct 899 VKVLKDLGETVAMTGDGVNDAPALKSADIGIAMGINGTEVAKEASDIVLADDNFNTIVEA 958
Query 543 VEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
++EGR IYNNMKAFIRYLISSNIGEVASIF+TA LG+P
Sbjct 959 IKEGRCIYNNMKAFIRYLISSNIGEVASIFITALLGIP 996
Score = 209 bits (533), Expect = 2e-53, Method: Compositional matrix adjust.
Identities = 98/130 (75%), Positives = 112/130 (86%), Gaps = 1/130 (0%)
Query 3 GMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDAV 62
GM T+IG IQ AV E+ S+DTQ+PLQ K+D FG+ LSK+I +CV VW+IN HFSD +
Sbjct 233 GMKTEIGHIQHAVIESN-SEDTQTPLQIKIDLFGQQLSKIIFVICVTVWIINFKHFSDPI 291
Query 63 HGSALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETLGC 122
HGS L GC+YYFKI+VALAVAAIPEGLPAVITTCLALGTR+M KKNAIVR+LQSVETLGC
Sbjct 292 HGSFLYGCLYYFKISVALAVAAIPEGLPAVITTCLALGTRRMVKKNAIVRKLQSVETLGC 351
Query 123 TTVICSDKTG 132
TTVICSDKTG
Sbjct 352 TTVICSDKTG 361
> tpv:TP02_0524 calcium-transporting ATPase; K01537 Ca2+-transporting
ATPase [EC:3.6.3.8]
Length=1277
Score = 309 bits (792), Expect = 2e-83, Method: Compositional matrix adjust.
Identities = 181/381 (47%), Positives = 227/381 (59%), Gaps = 58/381 (15%)
Query 257 PTPFCDYWKGEYKDLATLEFSRDRKSMSVL-SRNSKTKRNE------------------- 296
PTP ++ ATLEF R RK MSV+ S N T N
Sbjct 582 PTPISALYRKYLIKEATLEFCRTRKMMSVICSHNMNTGGNTSNTGTGGSSRGSGRNSSTR 641
Query 297 ----LFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDVAGMARGALRTLALAVRL 352
L+ KGAPE+++ C + MLP+G V ++++ + +L V +A ALR LA + R
Sbjct 642 GKMYLYSKGAPESIMEVCTSYMLPDGSVNKLAKSEKNEILDHVKQLANEALRVLAFSYRQ 701
Query 353 DAGPLADYGGETTQASRSL---------LEDQAGYAALESSLCFIGVVGLFDPPRPEVGS 403
+ D T ++ + ++ ++ +E + F+G+VG+ DPPRPEV
Sbjct 702 ASQKDLDLYNSLTHSNSNSQNTQSNNNSVKTSNVFSRIEKDMTFLGLVGIMDPPRPEVKD 761
Query 404 AILQCRDAGIRVVMITGDNKDTAEAVADLVHI-------------REGFDKT-------- 442
+I +C AGIRV+MITGDNK TAEA+A V I F T
Sbjct 762 SISKCMRAGIRVIMITGDNKLTAEAIARKVGIIKPTHRMSNSDPRSPTFSPTHSPILYPR 821
Query 443 ---FPSYTGKEFEALSASEKMRVLSSPGGAIFSRTEPKHKQLIVKLLKELGETTAMTGDG 499
F S TGKEFE+LS S+ R L + +FSRTEPKHKQ IV +LKELGE AMTGDG
Sbjct 822 TSLFSSLTGKEFESLS-SDAQRQLLTKSCLVFSRTEPKHKQSIVSILKELGEIVAMTGDG 880
Query 500 VNDAPALKQADIGVAMGIAGTEVAKEASDMVLADDNFSTIVSAVEEGRSIYNNMKAFIRY 559
VNDAPALK ADIGV+MG+ GTEVAKEASDM+LADDNF TIV+A+EEGR IY+NMKAFIRY
Sbjct 881 VNDAPALKMADIGVSMGVNGTEVAKEASDMILADDNFKTIVAAIEEGRCIYSNMKAFIRY 940
Query 560 LISSNIGEVASIFMTAALGVP 580
LISSNIGEV SIFMTA LG+P
Sbjct 941 LISSNIGEVVSIFMTAMLGIP 961
Score = 213 bits (542), Expect = 2e-54, Method: Compositional matrix adjust.
Identities = 129/249 (51%), Positives = 163/249 (65%), Gaps = 20/249 (8%)
Query 3 GMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDAV 62
GM T+IG IQ+AV EA +++T +PLQ+ L +FG +LSKVI +C++VWLIN+ +F+D
Sbjct 235 GMNTEIGTIQSAVIEAS-TENTATPLQKMLHDFGNSLSKVISIICLLVWLINVKNFNDPA 293
Query 63 HGSALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETLGC 122
HGS +RGCIYYFKIA+ALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVR+L S+ETLGC
Sbjct 294 HGSVVRGCIYYFKIAIALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRKLPSIETLGC 353
Query 123 TTVICSDKTGTLTTNEMTCVRFCVVGQSSTEVDVFTVDGTGFCATGSVSREMRGGAKGS- 181
TTVICSDKTGTLTTN+MT V + Q + + G G R GG S
Sbjct 354 TTVICSDKTGTLTTNKMTTVVVNLFNQQNKLRYIHMPHGDGI-------RVTMGGFGDSG 406
Query 182 ----QSLTGHQAVLSW-LCRCATICNEAHLNVAPGSSE------GSHYERMGEPTEAALL 230
QS G L+ +CA++C++ ++ S G GEPTE A++
Sbjct 407 MCVAQSFDGPVENLTHTFLKCASLCSDVTISTTNLHSRKHNTGVGGDLVLEGEPTEVAII 466
Query 231 VLVEKLGLF 239
+V LG F
Sbjct 467 EMVNNLGKF 475
> hsa:27032 ATP2C1, ATP2C1A, BCPM, HHD, KIAA1347, PMR1, SPCA1,
hSPCA1; ATPase, Ca++ transporting, type 2C, member 1 (EC:3.6.3.8);
K01537 Ca2+-transporting ATPase [EC:3.6.3.8]
Length=888
Score = 297 bits (761), Expect = 7e-80, Method: Compositional matrix adjust.
Identities = 204/564 (36%), Positives = 293/564 (51%), Gaps = 100/564 (17%)
Query 25 QSPLQQKLDEFGEALS----KVICAVCVVVWLINIGHFSDAVHGSALRGCIYYFKIAVAL 80
++PLQ+ +D G+ LS +I + +V WL+ + + F I+V+L
Sbjct 255 KTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLG-------------KDILEMFTISVSL 301
Query 81 AVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETLGCTTVICSDKTGTLTTNEMT 140
AVAAIPEGLP V+T LALG +M KK AIV++L VETLGC VICSDKTGTLT NEMT
Sbjct 302 AVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMT 361
Query 141 CVRFCVVGQSSTEVDVFTVDGTGFCATGSVSREMRGGAKGSQSLTG-HQAVLSWLCRCAT 199
+FT DG TG + + G + +S +
Sbjct 362 VTH------------IFTSDGLHAEVTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGC 409
Query 200 ICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLGLFSDEQISRRANTKRTAANPTP 259
+CN+A + + MG+PTE AL+ L K+GL +Q
Sbjct 410 VCNDAVIR---------NNTLMGKPTEGALIALAMKMGLDGLQQ---------------- 444
Query 260 FCDYW-KGEYKDLATLEFSRDRKSMSV--LSRNSKTKRNELFVKGAPETLLTRCETMMLP 316
DY K EY FS ++K M+V + R + + F+KGA E ++ C T
Sbjct 445 --DYIRKAEYP------FSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYCTTYQ-S 495
Query 317 NGDVVPMSEAARKVVLTDVAGMARGALRTLALAVRLDAGPLADYGGETTQASRSLLEDQA 376
G + +++ R V + A M LR LALA +GP E Q
Sbjct 496 KGQTLTLTQQQRDVYQQEKARMGSAGLRVLALA----SGP------ELGQ---------- 535
Query 377 GYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAGIRVVMITGDNKDTAEAVADLVHIR 436
L F+G+VG+ DPPR V A+ +G+ + MITGD+++TA A+A + +
Sbjct 536 --------LTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGL- 586
Query 437 EGFDKTFPSYTGKEFEALSASEKMRVLSSPGGAIFSRTEPKHKQLIVKLLKELGETTAMT 496
+ KT S +G+E +A+ + +++ P A+F R P+HK I+K L++ G AMT
Sbjct 587 --YSKTSQSVSGEEIDAMDVQQLSQIV--PKVAVFYRASPRHKMKIIKSLQKNGSVVAMT 642
Query 497 GDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLADDNFSTIVSAVEEGRSIYNNMKAF 556
GDGVNDA ALK ADIGVAMG GT+V KEA+DM+L DD+F TI+SA+EEG+ IYNN+K F
Sbjct 643 GDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNF 702
Query 557 IRYLISSNIGEVASIFMTAALGVP 580
+R+ +S++I + I + + P
Sbjct 703 VRFQLSTSIAALTLISLATLMNFP 726
> mmu:235574 Atp2c1, 1700121J11Rik, ATP2C1A, AW061228, BCPM, D930003G21Rik,
HHD, MGC58010, SPCA, pmr1; ATPase, Ca++-sequestering
(EC:3.6.3.8); K01537 Ca2+-transporting ATPase [EC:3.6.3.8]
Length=918
Score = 292 bits (747), Expect = 3e-78, Method: Compositional matrix adjust.
Identities = 202/563 (35%), Positives = 290/563 (51%), Gaps = 98/563 (17%)
Query 25 QSPLQQKLDEFGEALS----KVICAVCVVVWLINIGHFSDAVHGSALRGCIYYFKIAVAL 80
++PLQ+ +D G+ LS +I + +V WL+ + + F I+V+L
Sbjct 254 KTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLG-------------KDILEMFTISVSL 300
Query 81 AVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETLGCTTVICSDKTGTLTTNEMT 140
AVAAIPEGLP V+T LALG +M KK AIV++L VETLGC VICSDKTGTLT NEMT
Sbjct 301 AVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMT 360
Query 141 CVRFCVVGQSSTEVDVFTVDGTGFCATGSVSREMRGGAKGSQSLTGHQAVLSWLCRCATI 200
E V G G+ G V + G + +S + +
Sbjct 361 VTHILTSDGLHAE-----VTGVGYNQFGEVIVD------GDVVHGFYNPAVSRIVEAGCV 409
Query 201 CNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLGLFSDEQISRRANTKRTAANPTPF 260
CN+A + + MG+PTE AL+ L K+GL +Q
Sbjct 410 CNDAVIR---------NNTLMGKPTEGALIALAMKMGLDGLQQ----------------- 443
Query 261 CDYW-KGEYKDLATLEFSRDRKSMSV--LSRNSKTKRNELFVKGAPETLLTRCETMMLPN 317
DY K EY FS ++K M+V + R + + F+KGA E ++ C T
Sbjct 444 -DYIRKAEYP------FSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYCTTYN-SK 495
Query 318 GDVVPMSEAARKVVLTDVAGMARGALRTLALAVRLDAGPLADYGGETTQASRSLLEDQAG 377
G + +++ R + + A M LR LALA +GP E Q
Sbjct 496 GQTLALTQQQRDLYQQEKARMGSAGLRVLALA----SGP------ELGQ----------- 534
Query 378 YAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAGIRVVMITGDNKDTAEAVADLVHIRE 437
L F+G+VG+ DPPR V A+ +G+ + MITGD+++TA A+A + +
Sbjct 535 -------LTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAIAIASRLGL-- 585
Query 438 GFDKTFPSYTGKEFEALSASEKMRVLSSPGGAIFSRTEPKHKQLIVKLLKELGETTAMTG 497
+ KT S +G+E + + +++ P A+F R P+HK I+K L++ G AMTG
Sbjct 586 -YSKTSQSVSGEEVDTMEVQHLSQIV--PKVAVFYRASPRHKMKIIKSLQKNGAVVAMTG 642
Query 498 DGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLADDNFSTIVSAVEEGRSIYNNMKAFI 557
DGVNDA ALK ADIGVAMG GT+V KEA+DM+L DD+F TI+SA+EEG+ IYNN+K F+
Sbjct 643 DGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFV 702
Query 558 RYLISSNIGEVASIFMTAALGVP 580
R+ +S++I + I + + P
Sbjct 703 RFQLSTSIAALTLISLATLMNFP 725
> cel:ZK256.1 pmr-1; PMR-type Golgi ATPase family member (pmr-1);
K01537 Ca2+-transporting ATPase [EC:3.6.3.8]
Length=978
Score = 291 bits (746), Expect = 3e-78, Method: Compositional matrix adjust.
Identities = 190/547 (34%), Positives = 288/547 (52%), Gaps = 85/547 (15%)
Query 25 QSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDAVHGSALRGCIYYFKIAVALAVAA 84
++PLQ+ +D+ G+ LS V V++LI G F R + F I V+LAVAA
Sbjct 318 KTPLQKSMDDLGKQLSIYSFGVIAVIFLI--GMFQG-------RNVVDMFTIGVSLAVAA 368
Query 85 IPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETLGCTTVICSDKTGTLTTNEMTCVRF 144
IPEGLP V+ LA+G +MAK+ A+V+++ +VETLGC TVICSDKTGTLT NEMT
Sbjct 369 IPEGLPIVVAVTLAIGVMRMAKRRAVVKKMPAVETLGCVTVICSDKTGTLTKNEMTAQAI 428
Query 145 CVVGQSSTEVDVFTVDGTGFCATGSVSREMRGGAKGSQSLTGHQAVLSWLCRCATICNEA 204
++ E + + G G+ A G V + +G Q + + +CN A
Sbjct 429 -----ATPEGKLAEITGIGYSAEGGVVQ-----YQGEQVHQWTHPEFARIIEAGLVCNNA 478
Query 205 HLNVAPGSSEGSHYERMGEPTEAALLVLVEKLGLFSDEQISRRANTKRTAANPTPFCDYW 264
+ + +G+PTE A++VL +K L +
Sbjct 479 TIEAD---------KLIGQPTEGAIVVLAKKAQL-----------------------EGV 506
Query 265 KGEYKDLATLEFSRDRKSMSVLSRNSKTKRNELFVKGAPETLLTRCETMMLPNGDVVPMS 324
+ EYK L + FS D K M V ++ + N F+KGA + +L +C T +
Sbjct 507 RSEYKRLREMPFSSDTKWMGVQCADAHGQ-NVYFIKGALDRVLDQCGTYYSSDNQRKQCD 565
Query 325 EAARKVVLTDVAGMARGALRTLALAVRLDAGPLADYGGETTQASRSLLEDQAGYAALESS 384
+ +R+ +L + + LR L LA GE+ Q S
Sbjct 566 QYSRQHILEIGKELGQKGLRVLGLA-----------RGESMQ-----------------S 597
Query 385 LCFIGVVGLFDPPRPEVGSAILQCRDAGIRVVMITGDNKDTAEAVADLVHIREGFDKTFP 444
L F+G++G+ DPPRP AI + +G+ V +ITGD +TA+++ + I D
Sbjct 598 LMFLGMIGMMDPPRPGAADAISIVKASGVDVKLITGDAMETAQSIGQSLGILSSSDSCL- 656
Query 445 SYTGKEFEALSASEKMRVLSSPGGAIFSRTEPKHKQLIVKLLKELGETTAMTGDGVNDAP 504
+G++ + +S + V+ +F R P+HK IVK L+ LGE AMTGDGVNDA
Sbjct 657 --SGQQVDQMSDHDLELVIRQV--TVFYRASPRHKLKIVKALQALGEVVAMTGDGVNDAV 712
Query 505 ALKQADIGVAMGIAGTEVAKEASDMVLADDNFSTIVSAVEEGRSIYNNMKAFIRYLISSN 564
ALK+ADIGVAMG+ GT+V KEA+DM+L DD+FST+ +A+EEG++IY+N+ F+R+ +S++
Sbjct 713 ALKKADIGVAMGVCGTDVCKEAADMILCDDDFSTMTAAIEEGKAIYHNITNFVRFQLSTS 772
Query 565 IGEVASI 571
+ ++ I
Sbjct 773 VAALSLI 779
> sce:YGL167C PMR1, BSD1, LDB1, SSC1; High affinity Ca2+/Mn2+
P-type ATPase required for Ca2+ and Mn2+ transport into Golgi;
involved in Ca2+ dependent protein sorting and processing;
mutations in human homolog ATP2C1 cause acantholytic skin
condition Hailey-Hailey disease (EC:3.6.3.8); K01537 Ca2+-transporting
ATPase [EC:3.6.3.8]
Length=950
Score = 288 bits (738), Expect = 3e-77, Method: Compositional matrix adjust.
Identities = 200/580 (34%), Positives = 297/580 (51%), Gaps = 74/580 (12%)
Query 2 TGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDA 61
TG T G A + ++PLQ +D+ G+ LS V V ++ L+ I
Sbjct 256 TGTNTSFG---AVFEMMNNIEKPKTPLQLTMDKLGKDLSLVSFIVIGMICLVGI------ 306
Query 62 VHGSALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETLG 121
+ G R + F+I+V+LAVAAIPEGLP ++T LALG +MAK+ AIVRRL SVETLG
Sbjct 307 IQG---RSWLEMFQISVSLAVAAIPEGLPIIVTVTLALGVLRMAKRKAIVRRLPSVETLG 363
Query 122 CTTVICSDKTGTLTTNEMTCVRFCVVGQSSTEVDVFTVDGTGFCATGSVSREMRGGAKGS 181
VICSDKTGTLT+N MT + + S +++V ++D ++ G K
Sbjct 364 SVNVICSDKTGTLTSNHMTVSKLWCLDSMSNKLNVLSLD------KNKKTKNSNGNLKNY 417
Query 182 QSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLGLFSD 241
+ + + +CN A S H +G PT+ ALL E+L F
Sbjct 418 LTEDVRETL-----TIGNLCNNA-------SFSQEHAIFLGNPTDVALL---EQLANFEM 462
Query 242 EQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVLSRNSKTKRNELFVKG 301
I + + + L F+ RK M+ N + ++VKG
Sbjct 463 PDI--------------------RNTVQKVQELPFNSKRKLMATKILNPVDNKCTVYVKG 502
Query 302 APETLLTRCETMMLPNGDVVPMSEAARKVVLTDVAG-MARGALRTLALAVRLDAGPLADY 360
A E +L + + G A+K + + A MA LR A L+D
Sbjct 503 AFERILEYSTSYLKSKGKKTEKLTEAQKATINECANSMASEGLRVFGFA----KLTLSD- 557
Query 361 GGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAGIRVVMITG 420
+S L ED L L F G++G+ DPPRP V AI Q G+ ++MITG
Sbjct 558 ------SSTPLTED------LIKDLTFTGLIGMNDPPRPNVKFAIEQLLQGGVHIIMITG 605
Query 421 DNKDTAEAVADLVHIREGFDKTFPSYTGKEFEALSASEKMRVLSSPGGAIFSRTEPKHKQ 480
D+++TA +A + I D +G + + +S + V+ IF+R P+HK
Sbjct 606 DSENTAVNIAKQIGI-PVIDPKLSVLSGDKLDEMSDDQLANVIDHVN--IFARATPEHKL 662
Query 481 LIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLADDNFSTIV 540
IV+ L++ G+ AMTGDGVNDAPALK +DIGV+MG GT+VAKEASDMVL DD+FSTI+
Sbjct 663 NIVRALRKRGDVVAMTGDGVNDAPALKLSDIGVSMGRIGTDVAKEASDMVLTDDDFSTIL 722
Query 541 SAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
+A+EEG+ I+NN++ F+ + +S+++ ++ + ++ A +P
Sbjct 723 TAIEEGKGIFNNIQNFLTFQLSTSVAALSLVALSTAFKLP 762
> dre:566794 atp2c1; ATPase, Ca++ transporting, type 2C, member
1; K01537 Ca2+-transporting ATPase [EC:3.6.3.8]
Length=925
Score = 283 bits (723), Expect = 2e-75, Method: Compositional matrix adjust.
Identities = 199/563 (35%), Positives = 281/563 (49%), Gaps = 98/563 (17%)
Query 25 QSPLQQKLDEFGEALS----KVICAVCVVVWLINIGHFSDAVHGSALRGCIYYFKIAVAL 80
++PLQ+ +D G+ LS +I + V WL G + + F I V+L
Sbjct 262 KTPLQKSMDLLGKQLSLYSLGIIGVIMFVGWL----------QGKYI---LDMFTIGVSL 308
Query 81 AVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETLGCTTVICSDKTGTLTTNEMT 140
AVAAIPEGLP V+T LALG +M KK AIV++L VETL C VICSDKTGTLT NEMT
Sbjct 309 AVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLSCCNVICSDKTGTLTKNEMT 368
Query 141 CVR-FCVVGQSSTEVDVFTVDGTGFCATGSVSREMRGGAKGSQSLTGHQAVLSWLCRCAT 199
F GQ + V G G+ +G + M G S T +S +
Sbjct 369 VTHLFTSDGQHA------EVTGIGYNNSGEIL--MDGEVVHGISNTS----ISKIVEVGC 416
Query 200 ICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLGLFSDEQISRRANTKRTAANPTP 259
+CN+A + H MG PTE AL+ L K+GL
Sbjct 417 VCNDAMIR---------HNTLMGRPTEGALIALAMKMGL--------------------- 446
Query 260 FCDYWKGEYKDLATLEFSRDRKSMS--VLSRNSKTKRNELFVKGAPETLLTRCETMMLPN 317
+ + E+ L + F+ ++K M+ V+ R + K +VKGA E ++ C T
Sbjct 447 --EGLQHEFVRLEEIPFTSEQKWMAVRVVHRTQRDKPGLFYVKGAYEQVIRFC-TSYNSK 503
Query 318 GDVVPMSEAARKVVLTDVAGMARGALRTLALAVRLDAGPLADYGGETTQASRSLLEDQAG 377
G +P++ R + M G LR LA A + G
Sbjct 504 GVTMPLNNQQRDFYQQQKSYMGSGGLRVLAFASGSEMG---------------------- 541
Query 378 YAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAGIRVVMITGDNKDTAEAVADLVHIRE 437
SL F+G+VG+ DPPR V A+ +G+ V M+TGD+++TA A+A + +
Sbjct 542 ------SLTFLGLVGIIDPPRAGVKEAVATLISSGVAVKMVTGDSEETAVAIASRLGL-- 593
Query 438 GFDKTFPSYTGKEFEALSASEKMRVLSSPGGAIFSRTEPKHKQLIVKLLKELGETTAMTG 497
+ K +G E + + +++ +F R P+HK IVK L+ +G AMTG
Sbjct 594 -YTKGSQCLSGDEVDQMDIQHLSQIVHRV--VVFYRASPRHKLKIVKSLQNIGAVVAMTG 650
Query 498 DGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLADDNFSTIVSAVEEGRSIYNNMKAFI 557
DGVNDA ALK ADIGVAMG GT+V KEA+DM+L DD+F TI+SA+EEG+ IYNN+K F+
Sbjct 651 DGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTILSAIEEGKGIYNNIKNFV 710
Query 558 RYLISSNIGEVASIFMTAALGVP 580
R+ +S++I + I + L P
Sbjct 711 RFQLSTSIAALTLISLATLLNFP 733
> xla:735042 atp2c2; ATPase, Ca++ transporting, type 2C, member
2 (EC:3.6.3.8); K01537 Ca2+-transporting ATPase [EC:3.6.3.8]
Length=916
Score = 276 bits (705), Expect = 2e-73, Method: Compositional matrix adjust.
Identities = 191/565 (33%), Positives = 284/565 (50%), Gaps = 99/565 (17%)
Query 25 QSPLQQKLDEFGEALS----KVICAVCVVVWLINIGHFSDAVHGSALRGCIYYFKIAVAL 80
++PLQ+ +D G+ LS +I + ++ WL G L + F I V+L
Sbjct 253 KTPLQKSMDRLGKQLSLFSFGIIGLIMLIGWL----------QGKPL---LSMFTIGVSL 299
Query 81 AVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETLGCTTVICSDKTGTLTTNEMT 140
AVAAIPEGLP V+T LALG +MA K IV++L VETLGC VICSDKTGTLT NEMT
Sbjct 300 AVAAIPEGLPIVVTVTLALGVMRMANKRVIVKKLPIVETLGCCNVICSDKTGTLTANEMT 359
Query 141 CVRFCVVGQSSTEVDVFTVDGTGFCATGSVSREMRGGAKGSQSLTGHQAVLSWLCRCATI 200
+ EV +G G + E+ + S + L +
Sbjct 360 ATKLVTSDGLHAEVTGVGYEGKGHVNLLPSNEEVHEFSNVS---------IGKLVEAGCV 410
Query 201 CNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLGL--FSDEQISRRANTKRTAANPT 258
N A + MG+PTE AL+VL K+G SD I ++
Sbjct 411 ANNAVIQ---------KNTLMGQPTEGALIVLGMKMGFSNVSDNYIRKKE---------- 451
Query 259 PFCDYWKGEYKDLATLEFSRDRKSMSV--LSR-NSKTKRNELFVKGAPETLLTRCETMML 315
+ FS +++ M+V + R N K R L+ + E ++ C TM
Sbjct 452 ---------------IPFSSEQRWMAVKCIERYNKKQGRCMLYERELFEEVIQHC-TMYN 495
Query 316 PNGDVVPMSEAARKVVLTDVAGMARGALRTLALAVRLDAGPLADYGGETTQASRSLLEDQ 375
G +P++ + + + + + LR LALA + G
Sbjct 496 SGGRSLPITPQQKSLYIQEEKNLGMQGLRVLALASGSELG-------------------- 535
Query 376 AGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAGIRVVMITGDNKDTAEAVADLVHI 435
L F+G+VG+ DPPRP V A+ ++G+ V MITGD +TA+A+ + +
Sbjct 536 --------KLTFLGLVGIIDPPRPGVSEAVQILLESGVSVKMITGDALETAQAIGRSIGL 587
Query 436 REGFDKTFPSYTGKEFEALSASEKMRVLSSPGGAIFSRTEPKHKQLIVKLLKELGETTAM 495
G K + +G+E + + S +++ ++F RT PKHK I+K L++ G M
Sbjct 588 SNGHLK---AISGEELDQIDESALSSIVTKV--SVFYRTSPKHKLKIIKALQKTGAIVGM 642
Query 496 TGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLADDNFSTIVSAVEEGRSIYNNMKA 555
TGDGVNDA ALK ADIGVAMG GT+V+KEA+DM+L DDNFSTI++A+EEG+ I+ N+K
Sbjct 643 TGDGVNDAVALKSADIGVAMGKTGTDVSKEAADMILVDDNFSTIMNAIEEGKGIFYNIKN 702
Query 556 FIRYLISSNIGEVASIFMTAALGVP 580
F+R+ +S++I ++ I ++ + +P
Sbjct 703 FVRFQLSTSISALSLITLSTVMNLP 727
> hsa:479 ATP12A, ATP1AL1; ATPase, H+/K+ transporting, nongastric,
alpha polypeptide (EC:3.6.3.10); K01544 non-gastric H+/K+-exchanging
ATPase [EC:3.6.3.10]
Length=1045
Score = 268 bits (684), Expect = 7e-71, Method: Compositional matrix adjust.
Identities = 189/568 (33%), Positives = 281/568 (49%), Gaps = 94/568 (16%)
Query 53 INIGHFSDAVHGSALRGCIYYFKIAVALA--------------VAAIPEGLPAVITTCLA 98
I I HF V G A+ I +F IAV+L VA +PEGL A +T L+
Sbjct 307 IEIEHFVHIVAGVAVSIGILFFIIAVSLKYQVLDSIIFLIGIIVANVPEGLLATVTVTLS 366
Query 99 LGTRKMAKKNAIVRRLQSVETLGCTTVICSDKTGTLTTNEMTCVRFCVVGQSSTEVDVFT 158
L ++MAKKN +V+ L++VETLG T++ICSDKTGTLT N MT Q +F
Sbjct 367 LTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQ------IFV 420
Query 159 VDGTGFCATGSVSREMRGGAKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHY 218
D + + + R A L + T+CN A PG
Sbjct 421 ADTSEDHSNQVFDQSSRTWAS--------------LSKIITLCNRAEFK--PGQENVPIM 464
Query 219 ER--MGEPTEAALLVLVEKLGLFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEF 276
++ +G+ +E ALL E + D R+ N K PF +T +F
Sbjct 465 KKAVIGDASETALLKFSEVI--LGDVMEIRKRNRK---VAEIPFN----------STNKF 509
Query 277 SRDRKSMSVLSRNSKTKRNELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLT--- 333
M + KR + +KGAPE +L +C T+M+ NG+ P+ ++ K T
Sbjct 510 QLSIHEMD----DPHGKRFLMVMKGAPERILEKCSTIMI-NGEEHPLDKSTAKTFHTAYM 564
Query 334 DVAGMARGALRTLALAVRLDAGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGL 393
++ G+ L L + D P + S D + S+LCF+G++ +
Sbjct 565 ELGGLGERVLGFCHLYLPADEFP----------ETYSFDIDAMNFPT--SNLCFVGLLSM 612
Query 394 FDPPRPEVGSAILQCRDAGIRVVMITGDNKDTAEAVADLVHIREGFDKTFPSY------- 446
DPPR V A+ +CR AGI+V+M+TGD+ TA+A+A V I +T
Sbjct 613 IDPPRSTVPDAVTKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANSETVEDIAHRLNIA 672
Query 447 --------------TGKEFEALSASEKMRVLSSPGGAIFSRTEPKHKQLIVKLLKELGET 492
TG E + +S+ + +L++ +F+RT P+ K +IV+ +
Sbjct 673 VEQVNKRDAKAAVVTGMELKDMSSEQLDEILANYQEIVFARTSPQQKLIIVEGCQRQDAV 732
Query 493 TAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLADDNFSTIVSAVEEGRSIYNN 552
A+TGDGVND+PALK+ADIG+AMGIAG++ AK A+DMVL DDNF++IV+ VEEGR I++N
Sbjct 733 VAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGRLIFDN 792
Query 553 MKAFIRYLISSNIGEVASIFMTAALGVP 580
+K I Y ++ NI E+ + +G+P
Sbjct 793 LKKTIAYSLTKNIAELCPFLIYIIVGLP 820
> hsa:9914 ATP2C2, DKFZp686H22230, KIAA0703, SPCA2; ATPase, Ca++
transporting, type 2C, member 2 (EC:3.6.3.8); K01537 Ca2+-transporting
ATPase [EC:3.6.3.8]
Length=946
Score = 266 bits (679), Expect = 2e-70, Method: Compositional matrix adjust.
Identities = 200/586 (34%), Positives = 294/586 (50%), Gaps = 100/586 (17%)
Query 2 TGMATQIGLIQAAVHEAGESDDT-QSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSD 60
TG ++Q G V + ++++T ++PLQ+ +D G+ L+ + ++ LI
Sbjct 264 TGESSQFG----EVFKMMQAEETPKTPLQKSMDRLGKQLTLFSFGIIGLIMLIGWSQ--- 316
Query 61 AVHGSALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETL 120
G L + F I V+LAVAAIPEGLP V+ L LG +MAKK IV++L VETL
Sbjct 317 ---GKQL---LSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETL 370
Query 121 GCTTVICSDKTGTLTTNEMTCVRFCVVGQSSTEVDVFTVDGTG---FCATGSVSREMRGG 177
GC +V+CSDKTGTLT NEMT + EV DG G + V +E
Sbjct 371 GCCSVLCSDKTGTLTANEMTVTQLVTSDGLRAEVSGVGYDGQGTVCLLPSKEVIKEFSNV 430
Query 178 AKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLG 237
+ G L + N A + MG+PTE AL+ L K+
Sbjct 431 SVGK------------LVEAGCVANNAVIR---------KNAVMGQPTEGALMALAMKMD 469
Query 238 LFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSV-LSRNSKTKRNE 296
L SD K Y + FS ++K M+V S ++ + +
Sbjct 470 L-SD----------------------IKNSYIRKKEIPFSSEQKWMAVKCSLKTEDQEDI 506
Query 297 LFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDVAGMARGALRTLALAVRLDAGP 356
F+KGA E ++ C TM G +P++ R L + M LR LALA +GP
Sbjct 507 YFMKGALEEVIRYC-TMYNNGGIPLPLTPQQRSFCLQEEKRMGSLGLRVLALA----SGP 561
Query 357 LADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAGIRVV 416
+ G L F+G+VG+ DPPR V A+ ++G+ V
Sbjct 562 --ELG----------------------RLTFLGLVGIIDPPRVGVKEAVQVLSESGVSVK 597
Query 417 MITGDNKDTAEAVADLVHIREGFDKTFPSYTGKEFEALSASEKMRVLSSPGG--AIFSRT 474
MITGD +TA A+ + + G + +G+E +++ E L+ G ++F RT
Sbjct 598 MITGDALETALAIGRNIGLCNG---KLQAMSGEEVDSVEKGE----LADRVGKVSVFFRT 650
Query 475 EPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLADD 534
PKHK I+K L+E G AMTGDGVNDA ALK ADIG+AMG GT+V+KEA++M+L DD
Sbjct 651 SPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSKEAANMILVDD 710
Query 535 NFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
+FS I++AVEEG+ I+ N+K F+R+ +S++I ++ I ++ +P
Sbjct 711 DFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLP 756
> dre:64613 atp1a1a.2, atp1a1l2, atp[a]1A2b, cb703, zgc:110523;
ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide
Length=1023
Score = 265 bits (678), Expect = 3e-70, Method: Compositional matrix adjust.
Identities = 181/581 (31%), Positives = 282/581 (48%), Gaps = 87/581 (14%)
Query 25 QSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDAVHGSALRGCIYYFKIAVALAVAA 84
Q+P+ ++++ F +S V + V +++++ + G A + + + + VA
Sbjct 281 QTPIAREIEHFIHIISAVSIFLGVTFFVLSL------ILGYAWIEAVVFL---IGIIVAN 331
Query 85 IPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETLGCTTVICSDKTGTLTTNEMTCVRF 144
+PEGLPA +T CL L ++MAKKN +V+ L++VETLG TT ICSDKTGTLT N MT
Sbjct 332 VPEGLPATVTVCLTLTAKRMAKKNCLVKNLEAVETLGSTTTICSDKTGTLTQNRMTVAHM 391
Query 145 CVVGQSSTEVDVFTVDGTGFCATGSVSREMRGGAKGSQSLTGHQAVLSW--LCRCATICN 202
Q GT F ++ +W L R A +CN
Sbjct 392 WFDSQIHEADTTENQSGTSF----------------------DRSSPTWAALARVAGLCN 429
Query 203 EAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLGLFSDEQISRRANTKRTAANPTPFCD 262
A + E G+ +E+ALL +E L I R
Sbjct 430 RAVFRAEQSHLPVLNRETAGDASESALLKCIE---LCCGSVIEMRE-------------- 472
Query 263 YWKGEYKDLATLEFSRDRKSMSVLSRN--SKTKRNELFVKGAPETLLTRCETMMLPNGDV 320
+Y+ + + F+ K + +N S ++ L +KGAPE +L RC T+++ NG
Sbjct 473 ----KYRKICEIPFNSTNKYQLSVHKNPSSSGTKHLLVMKGAPERILDRCSTILI-NGKE 527
Query 321 VPMSEAARKVVLTDVAGMARGALRTLALAVRLDAGPLADYGGETTQASRSLLEDQAGYAA 380
PM + + + + R L Y Q D
Sbjct 528 QPMDDENKDSFQSAYVELGGLGERVLGFC---------QYNLPDDQFPEGFAFDPEDVNF 578
Query 381 LESSLCFIGVVGLFDPPRPEVGSAILQCRDAGIRVVMITGDNKDTAEAVADLVHIREGFD 440
+LCF+G++ + DPPR V A+ +CR AGI+V+M+TGD+ TA+A+A V I +
Sbjct 579 PTENLCFLGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGN 638
Query 441 KTFPSYT---------------------GKEFEALSASEKMRVLSSPGGAIFSRTEPKHK 479
+T G E + ++ S+ +L +F+RT P+ K
Sbjct 639 ETVEDIAARMNIPVGEVNPREAKACVVHGGELKNMNDSDLDEILRYHTEIVFARTSPQQK 698
Query 480 QLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLADDNFSTI 539
+IV+ + G A+TGDGVND+PALK+ADIGVAMGI+G++V+K+A+DM+L DDNF++I
Sbjct 699 LIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGISGSDVSKQAADMILLDDNFASI 758
Query 540 VSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
V+ VEEGR I++N+K I Y ++S I E++ M +G+P
Sbjct 759 VTGVEEGRLIFDNLKKSIAYTLTSKIPEMSPFLMFVVVGIP 799
> hsa:495 ATP4A, ATP6A; ATPase, H+/K+ exchanging, alpha polypeptide
(EC:3.6.3.10); K01542 H+/K+-exchanging ATPase alpha polypeptide
[EC:3.6.3.10]
Length=1035
Score = 264 bits (674), Expect = 7e-70, Method: Compositional matrix adjust.
Identities = 190/565 (33%), Positives = 281/565 (49%), Gaps = 88/565 (15%)
Query 53 INIGHFSDAVHGSALRGCIYYFKIAV--------------ALAVAAIPEGLPAVITTCLA 98
I I HF D + G A+ +F +A+ A+ VA +PEGL A +T CL+
Sbjct 297 IEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLS 356
Query 99 LGTRKMAKKNAIVRRLQSVETLGCTTVICSDKTGTLTTNEMTCVRFCVVGQSSTEVDVFT 158
L +++A KN +V+ L++VETLG T+VICSDKTGTLT N MT V + + T
Sbjct 357 LTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMT------VSHLWFDNHIHT 410
Query 159 VDGTGFCATGSVSREMRGGAKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHY 218
D T E + G QS +A LCR T+CN A +
Sbjct 411 ADTT----------EDQSGQTFDQSSETWRA----LCRVLTLCNRAAFKSGQDAVPVPKR 456
Query 219 ERMGEPTEAALLVLVEKLGLFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEF-S 277
+G+ +E ALL E T N + D + + + F S
Sbjct 457 IVIGDASETALLKFSE-----------------LTLGNAMGYRD----RFPKVCEIPFNS 495
Query 278 RDRKSMSVLS-RNSKTKRNELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDVA 336
++ +S+ + + + R+ L +KGAPE +L RC ++++ G +P+ E R+ T A
Sbjct 496 TNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILI-KGQELPLDEQWREAFQT--A 552
Query 337 GMARGALRTLALAVRLDAGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDP 396
++ G L L G Y E + +A S LCF G+V + DP
Sbjct 553 YLSLGGLGERVL------GFCQLYLNEKDYPPGYAFDVEAMNFP-SSGLCFAGLVSMIDP 605
Query 397 PRPEVGSAILQCRDAGIRVVMITGDNKDTAEAVADLVHIREGFDKTFPSY---------- 446
PR V A+L+CR AGIRV+M+TGD+ TA+A+A V I +T
Sbjct 606 PRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQ 665
Query 447 -----------TGKEFEALSASEKMRVLSSPGGAIFSRTEPKHKQLIVKLLKELGETTAM 495
G + + + SE + L + +F+RT P+ K +IV+ + LG A+
Sbjct 666 VNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAV 725
Query 496 TGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLADDNFSTIVSAVEEGRSIYNNMKA 555
TGDGVND+PALK+ADIGVAMGIAG++ AK A+DM+L DDNF++IV+ VE+GR I++N+K
Sbjct 726 TGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKK 785
Query 556 FIRYLISSNIGEVASIFMTAALGVP 580
I Y ++ NI E+ + + VP
Sbjct 786 SIAYTLTKNIPELTPYLIYITVSVP 810
> dre:64614 atp1a1a.3, atp1a1l3, atp[a]1A2a; ATPase, Na+/K+ transporting,
alpha 1a.3 polypeptide
Length=1024
Score = 263 bits (673), Expect = 1e-69, Method: Compositional matrix adjust.
Identities = 190/584 (32%), Positives = 290/584 (49%), Gaps = 93/584 (15%)
Query 25 QSPLQQKLDEFGEALS--KVICAVCVVVWLINIGHFSDAVHGSALRGCIYYFKIAVALAV 82
Q+P+ ++++ F ++ V + +V + +G+ + L G I+ + + V
Sbjct 282 QTPIAREIEHFIHIITGVAVFLGLTFLVLSLILGY-------NWLEGVIFL----IGIIV 330
Query 83 AAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETLGCTTVICSDKTGTLTTNEMTCV 142
A +PEGLPA +T CL L ++MAKKN +V+ L++VETLG TT ICSDKTGTLT N MT
Sbjct 331 ANVPEGLPATVTVCLTLTAKRMAKKNCLVKNLEAVETLGSTTTICSDKTGTLTQNRMT-- 388
Query 143 RFCVVGQSSTEVDVFTVDGTGFCATGSVSREMRGGAKGSQSLTGHQAVLSWLCRCATICN 202
V + + D T E + GA +S A S L R A +CN
Sbjct 389 ----VAHMWFDNHIHIADTT----------ENQTGASFDRS----SATWSALARVAGLCN 430
Query 203 EAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLGLFSDEQISRRANTKRTAANPTPFCD 262
A + G+ +E+ALL +E L R N
Sbjct 431 RAVFQSNQSHIPVLKRDTAGDASESALLKCIE---LSCGSVAEMREN------------- 474
Query 263 YWKGEYKDLATLEFSRDRKSMSVLSRN--SKTKRNELFVKGAPETLLTRCETMMLPNGDV 320
Y LA + F+ K + +N S ++ L +KGAPE +L RC T+ + G
Sbjct 475 -----YTKLAEIPFNSTNKYQVSIHKNPNSSEPKHLLVMKGAPERILERCSTIFI-QGKE 528
Query 321 VPMSEAARKVV---LTDVAGMARGALRTLALAVRLDAGPLADYGGETTQASRSLLEDQAG 377
PM + + ++ G+ L + D P + +T + +
Sbjct 529 QPMDDEMKDAFQNAYLELGGLGERVLGFCHFCLPDDQFP-EGFAFDTEEMNFP------- 580
Query 378 YAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAGIRVVMITGDNKDTAEAVADLVHI-R 436
+LCF+G++ + DPPR V A+ +CR AGI+V+M+TGD+ TA+A+A V I
Sbjct 581 ----TENLCFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKGVGIIS 636
Query 437 EG--------------FDKTFPS------YTGKEFEALSASEKMRVLSSPGGAIFSRTEP 476
EG D+ P G E + ++ + VL +F+RT P
Sbjct 637 EGNETVDDIAARLKIHIDEVNPRDAKACVIHGGELKNMTDEQLDDVLQHHTEIVFARTSP 696
Query 477 KHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLADDNF 536
+ K +IV+ + G A+TGDGVND+PALK+ADIGVAMGIAG++V+K+A+DM+L DDNF
Sbjct 697 QQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNF 756
Query 537 STIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
++IV+ VEEGR I++N+K I Y ++S I E++ M +G+P
Sbjct 757 ASIVTGVEEGRLIFDNLKKSIAYTLTSKIPEMSPFLMFVLVGIP 800
> mmu:69047 Atp2c2, 1810010G06Rik, KIAA0703, Spca2, mKIAA0703;
ATPase, Ca++ transporting, type 2C, member 2 (EC:3.6.3.8);
K01537 Ca2+-transporting ATPase [EC:3.6.3.8]
Length=944
Score = 261 bits (666), Expect = 7e-69, Method: Compositional matrix adjust.
Identities = 202/591 (34%), Positives = 303/591 (51%), Gaps = 110/591 (18%)
Query 2 TGMATQIGLIQAAVHEAGESDDT-QSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSD 60
TG +Q G V + +++T ++PLQ+ +D+ G+ L+ I + ++ L+ +G
Sbjct 262 TGEQSQFG----EVFKMMRAEETPKTPLQKSMDKLGKQLT--IFSFGIIGLLMLVGW--- 312
Query 61 AVHGSALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETL 120
V G + F + V+LAVAAIPEGLP V+ L LG +MAKK IV++L VETL
Sbjct 313 -VQGKPF---LSMFTVGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETL 368
Query 121 GCTTVICSDKTGTLTTNEMTCVRFCVVGQSSTEVDVFTVDGTGFCATGSV----SREMRG 176
GC VICSDKTGTLT NEMT + E V G G+ G+V S+E+
Sbjct 369 GCCNVICSDKTGTLTANEMTATQLVTSDGFHAE-----VSGVGYSGEGTVCLLPSKEV-- 421
Query 177 GAKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKL 236
KG +++ + L + N A + MG+PTE AL+VL K+
Sbjct 422 -IKGFDNVS-----VGKLVEAGCVANNAVIR---------KNAVMGQPTEGALVVLAMKM 466
Query 237 GLFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSV-LSRNSKTKRN 295
L S K Y + FS ++K M+V S+ +
Sbjct 467 NLGS-----------------------IKDSYVRKKEIPFSSEQKWMAVRCGPKSEDGED 503
Query 296 ELFVKGAPETLLTRCETMMLPNGDV-VPMSEAARKVVLTDVAGMARGALRTLALAVRLDA 354
F+KGA E ++ C M NG + +P++ + + M LR LALA +
Sbjct 504 IYFMKGAFEEVIHHCS--MYNNGGIPLPLTPQQKSYCQQEEKKMGSLGLRVLALA----S 557
Query 355 GPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAGIR 414
GP + G L F+G+VG+ DPPR V A+ ++G+
Sbjct 558 GP--ELG----------------------RLTFLGLVGIIDPPRAGVKEAVQVLSESGVS 593
Query 415 VVMITGDNKDTAEAVADLVHIREGFDKTFPSYTGKEFE-----ALSASEKMRVLSSPGGA 469
V M+TGD +TA A+ + + ++ + +G+E E AL+A ++R +S
Sbjct 594 VKMVTGDALETALAIGRTIGL---CNEKLKAMSGEEVEGTEQGALAA--RVRQVS----- 643
Query 470 IFSRTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDM 529
+F RT PKHK I+K L+E G AMTGDGVND+ ALK ADIG+AMG GT+V+KEA++M
Sbjct 644 VFFRTSPKHKVKIIKALQESGAIVAMTGDGVNDSVALKSADIGIAMGQTGTDVSKEAANM 703
Query 530 VLADDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
+L DD+FS I+SAVEEG+ I+ N+K F+R+ +S++I ++ I ++ +P
Sbjct 704 ILVDDDFSAIMSAVEEGKGIFYNIKNFVRFQLSTSIAALSLITLSTVCNLP 754
> xla:399450 atp4a; ATPase, H+/K+ exchanging, alpha polypeptide
(EC:3.6.3.10); K01542 H+/K+-exchanging ATPase alpha polypeptide
[EC:3.6.3.10]
Length=1031
Score = 260 bits (664), Expect = 1e-68, Method: Compositional matrix adjust.
Identities = 184/570 (32%), Positives = 285/570 (50%), Gaps = 96/570 (16%)
Query 53 INIGHFSDAVHGSALRGCIYYFKIAV--------------ALAVAAIPEGLPAVITTCLA 98
I I HF D + G A+ +F +A+ A+ VA +PEGL A +T CL+
Sbjct 293 IEIEHFVDIIAGLAIFFGATFFVVAMVIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLS 352
Query 99 LGTRKMAKKNAIVRRLQSVETLGCTTVICSDKTGTLTTNEMTCVRFCVVGQSSTEVDVFT 158
L +++A+KN +V+ L++VETLG T+VICSDKTGTLT N MT V + + +
Sbjct 353 LTAKRLARKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMT------VSHLWFDNHIHS 406
Query 159 VDGTGFCATGSVSREMRGGAKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHY 218
D T E + G Q+ +A L + ++CN A
Sbjct 407 ADTT----------EDQSGQSFDQTSDTWRA----LSKVVSLCNRAFFKSGQDGIPVPKR 452
Query 219 ERMGEPTEAALLVLVEKLGLFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEF-S 277
+G+ +E AL+ E T N + + +K + + F S
Sbjct 453 IVIGDASETALVKFSEI-----------------TVGNVMEY----RERFKKVTEVPFNS 491
Query 278 RDRKSMSVLS-RNSKTKRNELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLT--- 333
++ +S+ ++ R + +KGAPE +L RC T+M+ G +P+ E ++ T
Sbjct 492 TNKFQLSIHELQDPLDLRYLMVMKGAPERILERCSTIMI-KGQELPLDEQWKEAFQTAYM 550
Query 334 DVAGMARGALRTLALAVRLDAGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGL 393
D+ G+ L L + + SR D S LCF G++ +
Sbjct 551 DLGGLGERVLGFCHLYLN------------EKEYSRGFNFDTEEMNFPTSGLCFAGLISM 598
Query 394 FDPPRPEVGSAILQCRDAGIRVVMITGDNKDTAEAVADLVHIREGFDKTFPSY------- 446
DPPR V A+++CR AGIRV+M+TGD+ TA+A+A V I +T
Sbjct 599 IDPPRATVPDAVMKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRIP 658
Query 447 --------------TGKEFEALSASEKMRVLSSPGGAIFSRTEPKHKQLIVKLLKELGET 492
G + + +S+ E + L +F+RT P+ K +IV+ ++LG
Sbjct 659 VEQVNKRDARACVINGGQLKEMSSEELVEALKLHPEMVFARTSPQQKLIIVESCQKLGAI 718
Query 493 TAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLADDNFSTIVSAVEEGRSIYNN 552
A+TGDGVND+PALK+ADIGVAMGIAG++ AK A+DM+L DDNF++IV+ VE+GR I++N
Sbjct 719 VAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDN 778
Query 553 MKAFIRYLISSNIGEVAS--IFMTAALGVP 580
+K I Y ++ NI E+A I++TA++ +P
Sbjct 779 LKKSIAYTLTKNIPELAPYLIYITASVPLP 808
> xla:733327 hypothetical protein LOC733327
Length=1031
Score = 259 bits (663), Expect = 1e-68, Method: Compositional matrix adjust.
Identities = 184/570 (32%), Positives = 283/570 (49%), Gaps = 96/570 (16%)
Query 53 INIGHFSDAVHGSALRGCIYYFKIAV--------------ALAVAAIPEGLPAVITTCLA 98
I I HF D + G A+ +F +A+ A+ VA +PEGL A +T CL+
Sbjct 293 IEIEHFVDIIAGLAIFFGATFFVVAMVIGYPFLRAMVFFMAIVVAYVPEGLLATVTVCLS 352
Query 99 LGTRKMAKKNAIVRRLQSVETLGCTTVICSDKTGTLTTNEMTCVRFCVVGQSSTEVDVFT 158
L +++A+KN +V+ L++VETLG T+VICSDKTGTLT N MT Q + +
Sbjct 353 LTAKRLARKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNQ------IHS 406
Query 159 VDGTGFCATGSVSREMRGGAKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHY 218
D T E + G Q+ +A L + ++CN A
Sbjct 407 ADTT----------EDQSGQSFDQTSDTWRA----LSKVVSLCNRAFFKSGQDGIPVPKR 452
Query 219 ERMGEPTEAALLVLVEKLGLFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEF-S 277
+G+ +E AL+ E T N + + +K + + F S
Sbjct 453 IVIGDASETALVKFSEI-----------------TVGNVMEY----RERFKKVTEVPFNS 491
Query 278 RDRKSMSVLS-RNSKTKRNELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLT--- 333
++ +S+ ++ R L +KGAPE +L RC T+M+ G +P+ E ++ T
Sbjct 492 TNKFQLSIHELQDPLDLRYLLVMKGAPERILERCSTIMI-KGQELPLDEQWKEAFQTAYM 550
Query 334 DVAGMARGALRTLALAVRLDAGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGL 393
D+ G+ L L + P R D + LCF G++ +
Sbjct 551 DLGGLGERVLGFCHLYLNEKEYP------------RGFNFDTEEMNFPTNDLCFAGLISM 598
Query 394 FDPPRPEVGSAILQCRDAGIRVVMITGDNKDTAEAVADLVHIREGFDKTFPSY------- 446
DPPR V A+++CR AGIRV+M+TGD+ TA+A+A V I +T
Sbjct 599 IDPPRATVPDAVMKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRIP 658
Query 447 --------------TGKEFEALSASEKMRVLSSPGGAIFSRTEPKHKQLIVKLLKELGET 492
G + + +S+ E + L +F+RT P+ K +IV+ ++LG
Sbjct 659 VEQVNKRDARACVINGGQLKEMSSEELVEALKLHPEMVFARTSPQQKLIIVESCQKLGAI 718
Query 493 TAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLADDNFSTIVSAVEEGRSIYNN 552
A+TGDGVND+PALK+ADIGVAMGIAG++ AK A+DM+L DDNF++IV+ VE+GR I++N
Sbjct 719 VAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDN 778
Query 553 MKAFIRYLISSNIGEVAS--IFMTAALGVP 580
+K I Y ++ NI E+A I++TA++ +P
Sbjct 779 LKKSIAYTLTKNIPELAPYLIYITASVPLP 808
> mmu:192113 Atp12a, Atp1al1, HKalpha2, MGC124416, cHKA; ATPase,
H+/K+ transporting, nongastric, alpha polypeptide (EC:3.6.3.10);
K01544 non-gastric H+/K+-exchanging ATPase [EC:3.6.3.10]
Length=1035
Score = 257 bits (656), Expect = 9e-68, Method: Compositional matrix adjust.
Identities = 180/543 (33%), Positives = 276/543 (50%), Gaps = 87/543 (16%)
Query 70 CIYYFKI-----AVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETLGCTT 124
C+ Y+ + +++ VA +PEGL A +T L+L ++MAKKN +V+ L++VETLG T+
Sbjct 323 CMKYYVLDAIIFLISIIVANVPEGLLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTS 382
Query 125 VICSDKTGTLTTNEMTCVRFCVVGQSSTEVDVFTVDGTGFCATGSVSREMRGGAKGSQSL 184
+ICSDKTGTLT N MT Q +F D + E + QS
Sbjct 383 IICSDKTGTLTQNRMTVAHLWFDNQ------IFVAD----------TSENQTKQAFDQS- 425
Query 185 TGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERM--GEPTEAALLVLVEKLGLFSDE 242
+G A LS + T+CN A PG +R+ G+ +E ALL E + D
Sbjct 426 SGTWASLS---KIITLCNRAEFR--PGQESVPIMKRVVVGDASETALLKFSEVI--LGDV 478
Query 243 QISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVL-SRNSKTKRNELFVKG 301
R+ N K PF S ++ +S+ + + KR + +KG
Sbjct 479 MDIRKRNHK---VAEIPFN---------------STNKFQLSIHETEDPNDKRFLMVMKG 520
Query 302 APETLLTRCETMMLPNGDVVPMSEAARKVVLT---DVAGMARGALRTLALAVRLDAGPLA 358
APE +L +C T+M+ NG P+ +++ T ++ G+ L L + D P
Sbjct 521 APERILEKCSTIMI-NGQEQPLDKSSADAFHTAYMELGGLGERVLGFCHLYLPADKFP-- 577
Query 359 DYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAGIRVVMI 418
S + D + S+LCF+G++ + DPPR V A+ +CR AGI+V+M+
Sbjct 578 --------QSYTFDVDSINFPT--SNLCFVGLLSMIDPPRSTVPDAVSKCRSAGIKVIMV 627
Query 419 TGDNKDTAEAVADLVHIREGFDKTFPSY---------------------TGKEFEALSAS 457
TGD+ TA+A+A V I ++T TG E + ++
Sbjct 628 TGDHPITAKAIAKSVGIISANNETVEDIAKRRNIAVEQVNKREAKAAVVTGMELKDMTPE 687
Query 458 EKMRVLSSPGGAIFSRTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGI 517
+ +L + +F+RT P+ K +IV+ + A+TGDGVND+PALK+ADIG+AMGI
Sbjct 688 QLDELLINYQEIVFARTSPQQKLIIVEGCQRQDAVVAVTGDGVNDSPALKKADIGIAMGI 747
Query 518 AGTEVAKEASDMVLADDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAAL 577
AG++ AK A+DMVL DDNF++IV+ VEEGR I++N+K I Y ++ NI E+ +
Sbjct 748 AGSDAAKNAADMVLLDDNFASIVTGVEEGRLIFDNLKKTIAYTLTKNIAELCPFLIYIVA 807
Query 578 GVP 580
G+P
Sbjct 808 GLP 810
> bbo:BBOV_IV010020 23.m06075; P-type ATPase4 (EC:3.6.3.8)
Length=1261
Score = 256 bits (655), Expect = 1e-67, Method: Compositional matrix adjust.
Identities = 215/643 (33%), Positives = 304/643 (47%), Gaps = 94/643 (14%)
Query 2 TGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINI-GHFSD 60
TGM TQ+G I + A D +PLQ L+ G + + V + + ++ I + D
Sbjct 322 TGMQTQVGHIATQLKSALSGSDV-TPLQSSLNSLGGIIGIISIFVLITIIVVAIVTKYED 380
Query 61 AVHGSALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETL 120
R + +AV AV+AIPEGLP V+T L+LG + MA +NA +R+L +VETL
Sbjct 381 PTRPDTNR-VLAIVLLAVGFAVSAIPEGLPMVVTISLSLGAKDMADRNANIRKLPAVETL 439
Query 121 GCTTVICSDKTGTLTTNEMTCVRFCVV-----GQSSTEVDVFTVDGTGFCATGSVSR--E 173
GC ++ICSDKTGTLT +MT + + G ++E+ + GF G V +
Sbjct 440 GCCSIICSDKTGTLTEGKMTSISAMIFHNEDDGWKASELQFYPT--MGFNPYGGVFKPEH 497
Query 174 MRGGAKGSQSLTGHQA-----VLSWLCRCATICNE----------AHLNVAPGSSEGSHY 218
+ K H A V + +C ++ A+LN E
Sbjct 498 LTDDFKAELQKQTHAAASFDNVTNNVCAKGNTSSDSKQIRACMLSAYLNSNSTRVEQDEA 557
Query 219 ER----MGEPTEAALLVLVEKLGLFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATL 274
+ MG TE ++V K G I N + P KDL +
Sbjct 558 SKAWVAMGNMTECPIIVASAKCG------IGSTINKSDATYDDHPML-------KDLE-V 603
Query 275 EFSRDRKSMSV--------------LSRNSKTKRNELFVKGAPETLLTRCETMMLPNGDV 320
F+ RK M L+ KT + +KGAP+ L + NG+
Sbjct 604 PFNSGRKMMVTIHKLKTENMFGDLNLTNGFKTYTHVATIKGAPDMLFKYRIVTVKRNGEE 663
Query 321 VPMSEAARKV----VLTDVAGMARGALRTLALAVRL-DAGPL------ADYGGETTQASR 369
+ A+ + L +V A L + AL V L PL A G E + +
Sbjct 664 CVIDWASGDIENNETLLNVMKKANNDLSSRALRVLLVGMFPLTAEDITALEGCEDSDSRL 723
Query 370 SLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAGIRVVMITGDNKDTAEAV 429
+ L + G+ S L +G +G DPPR V A+ C AG+RVVMITGD K TA A+
Sbjct 724 NWLLN--GHEHGSSPLVLLGFIGNLDPPRFGVKEAVATCGKAGVRVVMITGDQKPTATAI 781
Query 430 ADLVHIREGFDKTFPSYTGKEFEALSASEKMRVLSS------PGGAI---------FSRT 474
+ + FD Y G E + +M + + P G I F R
Sbjct 782 GKDIGLFNQFD-----YLGDENSGVIECSQMHINNDHFREYLPDGVIDSFTSRVSVFCRA 836
Query 475 EPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLADD 534
+P+ K +IVK LK G TAMTGDGVNDAPALK ADIGVAMGI GT+VAK A+DMVL DD
Sbjct 837 QPEDKVVIVKSLKRQGYLTAMTGDGVNDAPALKTADIGVAMGINGTDVAKGAADMVLLDD 896
Query 535 NFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAAL 577
NF TIV+++E GR+IY N++ F+ +L+ +NIGE+ ++T A+
Sbjct 897 NFCTIVNSIESGRTIYANIQKFVSFLLGTNIGEI--FYLTTAI 937
> dre:64611 atp1a3b, MGC109873, atp[a]3A, cb706, fj35g11, wu:fj35g11;
ATPase, Na+/K+ transporting, alpha 3b polypeptide; K01539
sodium/potassium-transporting ATPase subunit alpha [EC:3.6.3.9]
Length=1023
Score = 256 bits (654), Expect = 2e-67, Method: Compositional matrix adjust.
Identities = 184/567 (32%), Positives = 278/567 (49%), Gaps = 96/567 (16%)
Query 55 IGHFSDAVHGSALRGCIYYFKIAVALA--------------VAAIPEGLPAVITTCLALG 100
I HF + G A+ + +F +AV L VA +PEGL A +T CL L
Sbjct 288 IEHFIHIITGVAVFLGVSFFILAVILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLT 347
Query 101 TRKMAKKNAIVRRLQSVETLGCTTVICSDKTGTLTTNEMTCVRFCVVGQSSTEVDVFTVD 160
++MA+KN +V+ L++VETLG T+ ICSDKTGTLT N MT V + + D
Sbjct 348 AKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMT------VAHKWFDNQIHEAD 401
Query 161 GTGFCATGSVSREMRGGAKGSQSLTGHQAVLSW--LCRCATICNEAHLNVAPGSSEGSHY 218
T E + GA +S ++W L R A +CN A S
Sbjct 402 TT----------EDQSGASFDKS------SVTWVALARVAALCNRAVFKAGQDSLPILKR 445
Query 219 ERMGEPTEAALLVLVEKLGLFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSR 278
+ G+ +E+ALL +E L S + R K+ A PF S
Sbjct 446 DVAGDASESALLKCIE---LSSGSVKAMREKNKKVAE--IPFN---------------ST 485
Query 279 DRKSMSVL-SRNSKTKRNELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVV---LTD 334
++ +S+ + ++ R L +KGAPE +L RC T+ML G PM E ++ +
Sbjct 486 NKYQLSIHETEDNNDNRYLLVMKGAPERILDRCSTIML-QGKEQPMDEEMKEAFQNAYLE 544
Query 335 VAGMARGALRTLALAVRLDAGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLF 394
+ G+ L + + D P + D +LCF+G++ +
Sbjct 545 LGGLGERVLGFCHVLMPEDQYP------------KGFAFDTDDVNFQTDNLCFVGLMSMI 592
Query 395 DPPRPEVGSAILQCRDAGIRVVMITGDNKDTAEAVADLVHIREGFDKTFPSYT------- 447
DPPR V A+ +CR AGI+V+M+TGD+ TA+A+A V I ++T
Sbjct 593 DPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPV 652
Query 448 --------------GKEFEALSASEKMRVLSSPGGAIFSRTEPKHKQLIVKLLKELGETT 493
G + + S + VL + +F+RT P+ K +IV+ + G
Sbjct 653 SQVNPRDAKACVIHGTDLKDYSQEQIDEVLRNHTEIVFARTSPQQKLIIVEGCQRQGAIV 712
Query 494 AMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLADDNFSTIVSAVEEGRSIYNNM 553
A+TGDGVND+PALK+ADIGVAMGI+G++V+K+A+D +L DDNF++IV+ VEEGR I++N+
Sbjct 713 AVTGDGVNDSPALKKADIGVAMGISGSDVSKQAADTILLDDNFASIVTGVEEGRLIFDNL 772
Query 554 KAFIRYLISSNIGEVASIFMTAALGVP 580
K I Y ++SNI E+ + + +P
Sbjct 773 KKSIAYTLTSNIPEITPFLLFIIVNIP 799
> dre:245703 atp1a1a.5, cb709; ATPase, Na+/K+ transporting, alpha
1a.5 polypeptide
Length=1023
Score = 256 bits (653), Expect = 2e-67, Method: Compositional matrix adjust.
Identities = 186/580 (32%), Positives = 284/580 (48%), Gaps = 85/580 (14%)
Query 25 QSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDAVHGSALRGCIYYFKIAVALAVAA 84
Q+PL ++++ F ++ V + +I++ + + L G I+ + L VA
Sbjct 281 QTPLGREIEHFIHIITGVAVFLGTTFLIISV-----MLGFTWLEGIIFL----IGLIVAN 331
Query 85 IPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETLGCTTVICSDKTGTLTTNEMTCVRF 144
+PEGLP +T L L + MAKKN +V+ L++VETLG T+ ICSDKTGTLT N MT
Sbjct 332 VPEGLPCTVTVALTLTAKHMAKKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHM 391
Query 145 CVVGQSSTEVDVFTVDGTGFCATGSVSREMRGGAKGSQSLTGHQAVLSWLCRCATICNEA 204
Q + D T E + GA +S A S L R A +CN A
Sbjct 392 WFDNQ------IHIADTT----------ENQTGASFDRS----SATWSALARVAGLCNRA 431
Query 205 HLNVAPGSSEGSHYERMGEPTEAALLVLVEKLGLFSDEQISRRANTKRTAANPTPFCDYW 264
E G+ +E+ALL +E L R N + A P
Sbjct 432 VFQSNQSHLPVLRRETAGDASESALLKCIE---LCCGSVTGMRENYPKVAEIP------- 481
Query 265 KGEYKDLATLEFSRDRKSMSVLSRNSKTKRNELFVKGAPETLLTRCETMMLPNGDVVPMS 324
+ ++ + S NS ++ L +KGAPE +L RC T+++ G P+
Sbjct 482 ---FNSISKYQLSIHENP------NSSEPKHLLVMKGAPERILDRCSTILI-EGKEHPLD 531
Query 325 EAAR---KVVLTDVAGMARGALRTLALAVRLDAGPLADYGGETTQASRSLLEDQAGYAAL 381
+ + + + G+ L + D P + +T + +
Sbjct 532 DEMKEDFQNAYVQLGGLGERVLGFCHFCLPDDQFP-EGFAFDTEEMNFP----------- 579
Query 382 ESSLCFIGVVGLFDPPRPEVGSAILQCRDAGIRVVMITGDNKDTAEAVADLVHI-REG-- 438
+LCF+G++ + DPPR V A+ +CR AGI+V+M+TGD+ TA+A+A V I EG
Sbjct 580 TENLCFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNE 639
Query 439 ------------FDKTFPS------YTGKEFEALSASEKMRVLSSPGGAIFSRTEPKHKQ 480
D+ P G E + ++ + VL +F+RT P+ K
Sbjct 640 TVDDIAARLKIHIDEVNPRDAKACVIHGGELKNMTDEQLDDVLQHHTEIVFARTSPQQKL 699
Query 481 LIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLADDNFSTIV 540
+IV+ + G A+TGDGVND+PALK+ADIGVAMGIAG++V+K+A+DM+L DDNF++IV
Sbjct 700 IIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIV 759
Query 541 SAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
+ VEEGR I++N+K I Y +S+ I E++ M G+P
Sbjct 760 TGVEEGRLIFDNLKKSICYTLSTKIPEMSPFLMFVLAGIP 799
> mmu:27222 Atp1a4; ATPase, Na+/K+ transporting, alpha 4 polypeptide
(EC:3.6.3.9); K01539 sodium/potassium-transporting ATPase
subunit alpha [EC:3.6.3.9]
Length=1032
Score = 255 bits (652), Expect = 3e-67, Method: Compositional matrix adjust.
Identities = 172/529 (32%), Positives = 268/529 (50%), Gaps = 81/529 (15%)
Query 78 VALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETLGCTTVICSDKTGTLTTN 137
+ + VA +PEGL A +T CL L ++MA+KN +V+ L++VETLG T+ ICSDKTGTLT N
Sbjct 335 IGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQN 394
Query 138 EMTCVRFCVVGQSSTEVDVFTVDGTGFCATGSVSREMRGGAKGSQSLTGHQAVLSWLCRC 197
MT V + V+ D + TG ++ +L R
Sbjct 395 RMT------VAHLWFDKTVYEADTSEEQTTG-------------KTFPKSSDTWFYLARI 435
Query 198 ATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLGLFSDEQISRRANTKRTAANP 257
A +CN A S + G+ +E+ALL +E+ S ++ NP
Sbjct 436 AGLCNRADFKPHQESVPIAKRATTGDASESALLKFIEQ---------SYNPVSEMRQKNP 486
Query 258 TPFCDYWKGEYKDLATLEF-SRDRKSMSVLSRNSKTKRNELFVKGAPETLLTRCETMMLP 316
+A + F S ++ MS+ ++ + L +KGAPE + C + +L
Sbjct 487 K------------VAEIPFNSTNKYQMSIHLLEDNSEAHVLLMKGAPERIFDFCSSFLL- 533
Query 317 NGDVVPMSEAAR---KVVLTDVAGMARGALRTLALA-VRLDAGPLADYGGETTQASRSLL 372
NG PM E + + ++ G+ R L + L + + T + + +
Sbjct 534 NGQEYPMDEEMKMDFQNAYIELGGLGE---RVLGFCFLNLPSNFSKGFQFNTDELNFPM- 589
Query 373 EDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAGIRVVMITGDNKDTAEAVADL 432
+LCF G++ + DPPR V A+ +CR AGI+V+M+TGD+ TA+A+A
Sbjct 590 ----------ENLCFAGLISMIDPPRTAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKS 639
Query 433 VHI-REGFD------------------KTFPSYT--GKEFEALSASEKMRVLSSPGGAIF 471
V I EG D K+ + G E + + + + +L S +F
Sbjct 640 VGIISEGNDTAEDIAARLNIPISQVNNKSVKAIVVHGSELKDMESQQLDDILKSYKEIVF 699
Query 472 SRTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVL 531
+RT P+ K +IV+ + LG A+TGDGVND+PALK+ADIG+AMGI G++V+K+A+DM+L
Sbjct 700 ARTSPQQKLIIVEGCQRLGAIVAVTGDGVNDSPALKKADIGIAMGITGSDVSKQAADMIL 759
Query 532 ADDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
DDNF++IV+ VEEGR I++N+K I Y ++SNI E+ + L +P
Sbjct 760 LDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIILSIP 808
> xla:379283 atp12a-b, atp12ab, atp1al1; ATPase, H+/K+ transporting,
nongastric, alpha polypeptide; K01544 non-gastric H+/K+-exchanging
ATPase [EC:3.6.3.10]
Length=1042
Score = 255 bits (652), Expect = 3e-67, Method: Compositional matrix adjust.
Identities = 186/607 (30%), Positives = 299/607 (49%), Gaps = 92/607 (15%)
Query 1 RTGMATQIGLIQAAVHEAGESDDTQSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSD 60
TG T IG I + G + ++P+ +++ F ++ V ++ ++ ++I +
Sbjct 278 NTGDHTIIGRIASLASGVG---NEKTPIAVEIEHFVHIVAGVAVSIGILFFIIAM----- 329
Query 61 AVHGSALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETL 120
++ SAL I+ + + VA +PEGL A +T L+L ++MAKKN +V+ L++VETL
Sbjct 330 SMGYSALNSIIF----LIGIIVANVPEGLLATVTVTLSLTAKRMAKKNCLVKNLEAVETL 385
Query 121 GCTTVICSDKTGTLTTNEMTCVRFCVVGQSSTEVDVFTVDGTGFCATGSVSREMRGGAKG 180
G T+VICSDKTGTLT N MT D A S + +
Sbjct 386 GSTSVICSDKTGTLTQNRMTVAHLWF-------------DNHIHSADTSEEQTYHSFEQT 432
Query 181 SQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLGLFS 240
S++ T L + ++CN A G +G+ +E ALL E + +
Sbjct 433 SETWTA-------LIKIVSLCNRAEFKAGQGDVPIMKKVVVGDASETALLKFSE---VIT 482
Query 241 DEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDRKSMSVL-SRNSKTKRNELFV 299
+ R K+ PF S ++ +S+ + + + KR L +
Sbjct 483 GNIMEVRNRNKKVTE--IPFN---------------STNKFQLSIHKTDDPQDKRFLLVM 525
Query 300 KGAPETLLTRCETMMLPNGDVVPMSEAARKVVLT---DVAGMARGALRTLALAVRLDAGP 356
KGAPE +L +C T+M+ G P+ E ++ T ++ G+ L L + D P
Sbjct 526 KGAPERILDQCSTIMI-GGKEQPLDENMKESFQTAYMELGGLGERVLGFCHLYLPEDEYP 584
Query 357 LADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAGIRVV 416
S D S+LCF+G++ + DPPR V A+ +CR AGI+V+
Sbjct 585 ------------DSYPFDTESMNFPTSNLCFVGLMSMIDPPRSTVPDAVSKCRSAGIKVI 632
Query 417 MITGDNKDTAEAVADLVHIREGFDKTFPSY---------------------TGKEFEALS 455
M+TGD+ TA+A+A V I +T G E + +S
Sbjct 633 MVTGDHPITAKAIAKSVGIISAGSETVEDIAKRLNIPVEQVNKREAKAAVVNGGELKDMS 692
Query 456 ASEKMRVLSSPGGAIFSRTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAM 515
+ + +L +F+RT P+ K +IV+ ++ A+TGDGVND+PALK+ADIG+AM
Sbjct 693 SEDLHDILYHHSEIVFARTSPQQKLIIVEGCQKQNAVVAVTGDGVNDSPALKKADIGIAM 752
Query 516 GIAGTEVAKEASDMVLADDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVAS--IFM 573
GIAG++ AK A+DM+L DDNF++IV+ VEEGR I++N+K I Y ++ NI E+ I++
Sbjct 753 GIAGSDAAKNAADMILLDDNFASIVTGVEEGRLIFDNIKKTIGYTLTKNIAELCPFLIYI 812
Query 574 TAALGVP 580
A++ +P
Sbjct 813 IASIPLP 819
> mmu:11944 Atp4a; ATPase, H+/K+ exchanging, gastric, alpha polypeptide
(EC:3.6.3.10); K01542 H+/K+-exchanging ATPase alpha
polypeptide [EC:3.6.3.10]
Length=1025
Score = 255 bits (651), Expect = 4e-67, Method: Compositional matrix adjust.
Identities = 192/563 (34%), Positives = 273/563 (48%), Gaps = 93/563 (16%)
Query 53 INIGHFSDAVHGSALRGCIYYFKIAV--------------ALAVAAIPEGLPAVITTCLA 98
I I HF D + G A+ +F +A+ A+ VA +PEGL A +T CL+
Sbjct 296 IEIEHFVDIIAGLAILFGATFFVVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLS 355
Query 99 LGTRKMAKKNAIVRRLQSVETLGCTTVICSDKTGTLTTNEMTCVRFCVVGQSSTEVDVFT 158
L +++A KN +V+ L++VETLG T+VICSDKTGTLT N MT V + + T
Sbjct 356 LTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMT------VSHLWFDNHIHT 409
Query 159 VDGTGFCATGSVSREMRGGAKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHY 218
D T E + G QS +A LCR T+CN A +
Sbjct 410 ADTT----------EDQSGQTFDQSSETWRA----LCRVLTLCNRAAFKSGQDAVPVPKR 455
Query 219 ERMGEPTEAALLVLVEKLGLFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSR 278
+G+ +E ALL E L + R + PF K + + TLE R
Sbjct 456 IVIGDASETALLKFSE---LTLGNAMGYRDRFPKVCE--IPFNSINKFQLS-IHTLEDPR 509
Query 279 DRKSMSVLSRNSKTKRNELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLTDVAGM 338
D R+ L +KGAPE +L RC ++++ G +P+ E R+ T A +
Sbjct 510 D-------------SRHLLVMKGAPERVLERCSSILI-KGQELPLDEQWREAFQT--AYL 553
Query 339 ARGALRTLALAVRLDAGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPR 398
+ G L L G Y E + +A S LCF G+V + DPPR
Sbjct 554 SLGGLGERVL------GFCQLYLNEKDYPPGYAFDVEAMNFP-SSGLCFAGLVSMIDPPR 606
Query 399 PEVGSAILQCRDAGIRVVMITGDNKDTAEAVADLVHIREGFDKTFPSY------------ 446
V A+L+CR AGIRV+M+TGD+ TA+A+A V I +T
Sbjct 607 ATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRMPVDQVN 666
Query 447 ---------TGKEFEALSASEKMRVLSSPGGAIFSRTEPKHKQLIVKLLKELGETTAMTG 497
G + + + SE + L + +F+RT P+ K LG A+TG
Sbjct 667 RKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQK---------LGAIVAVTG 717
Query 498 DGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLADDNFSTIVSAVEEGRSIYNNMKAFI 557
DGVND+PALK+ADIGVAMGIAG++ AK A+DM+L DDNF++IV+ VE+GR I++N+K I
Sbjct 718 DGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSI 777
Query 558 RYLISSNIGEVASIFMTAALGVP 580
Y ++ NI E+ + + VP
Sbjct 778 AYTLTKNIPELTPYLIYITVSVP 800
> dre:64610 atp1a3a, atp[a]3B, cb705, wu:fj56a06; ATPase, Na+/K+
transporting, alpha 3a polypeptide; K01539 sodium/potassium-transporting
ATPase subunit alpha [EC:3.6.3.9]
Length=1023
Score = 254 bits (650), Expect = 5e-67, Method: Compositional matrix adjust.
Identities = 186/583 (31%), Positives = 288/583 (49%), Gaps = 91/583 (15%)
Query 25 QSPLQQKLDEFGEALSKVICAVCVVVWLINIGHFSDAVHGSALRGCIYYFKIAVALAVAA 84
++P+ ++++ F ++ V + V ++++I + S L I+ + + VA
Sbjct 281 KTPIAKEIEHFIHIITGVAVFLGVTFFILSI-----ILGYSWLEAVIFL----IGIIVAN 331
Query 85 IPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETLGCTTVICSDKTGTLTTNEMTCVRF 144
+PEGL A +T CL L ++MA+KN +V+ L++VETLG T+ ICSDKTGTLT N MT
Sbjct 332 VPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHM 391
Query 145 CVVGQSSTEVDVFTVDGTGFCATGSVSREMRGGAKGSQSLTGHQAVLSWLC--RCATICN 202
Q + D T E + GA +S +G +WL R A +CN
Sbjct 392 WFDNQ------IHEADTT----------EDQSGASFDKS-SG-----TWLALARVAALCN 429
Query 203 EAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLGLFSDEQISRRANTKRTAANPTPFCD 262
A S + G+ +E+ALL +E L + R K+ A PF
Sbjct 430 RAVFKAGQESLPILKRDVAGDASESALLKCIE---LSCGSVKAMRDKNKKVAE--IPFN- 483
Query 263 YWKGEYKDLATLEFSRDRKSMSVLSRNSKTKRNELFV-KGAPETLLTRCETMMLPNGDVV 321
S ++ +SV + + + L V KGAPE +L RC T+ L G
Sbjct 484 --------------STNKYQLSVHELDESEENHYLLVMKGAPERILDRCSTI-LQQGKEQ 528
Query 322 PMSEAARKVV---LTDVAGMARGALRTLALAVRLDAGPLADYGGETTQASRSLLEDQAGY 378
PM E ++ ++ G+ L L + D P + D
Sbjct 529 PMDEELKEAFQNAYLELGGLGERVLGFCHLVMPGDKYP------------KGFAFDTDDI 576
Query 379 AALESSLCFIGVVGLFDPPRPEVGSAILQCRDAGIRVVMITGDNKDTAEAVADLVHIREG 438
+LCF+G++ + DPPR V A+ +CR AGI+V+M+TGD+ TA+A+A V I
Sbjct 577 NFQTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISE 636
Query 439 FDKTFPSYT---------------------GKEFEALSASEKMRVLSSPGGAIFSRTEPK 477
++T G + + LS + VL + +F+RT P+
Sbjct 637 GNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDLSQDQMDEVLKNHTEIVFARTSPQ 696
Query 478 HKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLADDNFS 537
K +IV+ + G A+TGDGVND+PALK+ADIGVAMGI+G++V+K+A+DM+L DDNF+
Sbjct 697 QKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGISGSDVSKQAADMILLDDNFA 756
Query 538 TIVSAVEEGRSIYNNMKAFIRYLISSNIGEVASIFMTAALGVP 580
+IV+ VEEGR I++N+K I Y ++SNI E+ + +P
Sbjct 757 SIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLFFILVNIP 799
> xla:398752 atp1a2, MGC68460; ATPase, Na+/K+ transporting, alpha
2 polypeptide; K01539 sodium/potassium-transporting ATPase
subunit alpha [EC:3.6.3.9]
Length=1020
Score = 253 bits (647), Expect = 1e-66, Method: Compositional matrix adjust.
Identities = 179/540 (33%), Positives = 271/540 (50%), Gaps = 79/540 (14%)
Query 65 SALRGCIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRRLQSVETLGCTT 124
S L G I+ + + VA +PEGL A +T CL L ++MA+KN +V+ L++VETLG T+
Sbjct 314 SWLEGVIFL----IGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTS 369
Query 125 VICSDKTGTLTTNEMTCVRFCVVGQSSTEVDVFTVDGTGFCATGSVSREMRGGAKGSQSL 184
ICSDKTGTLT N MT Q + D T E + GA +
Sbjct 370 TICSDKTGTLTQNRMTVAHMWFDNQ------IHEADTT----------EDQSGA----TF 409
Query 185 TGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYERMGEPTEAALLVLVEKLGLFSDEQI 244
+ L R A +CN A V S + G+ +E+ALL +E +
Sbjct 410 DKRSPTWTALSRIAGLCNRAVFKVGQDKIPVSKRDTAGDASESALLKCIE---------L 460
Query 245 SRRANTKRTAANPTPFCDYWKGEYKDLATLEF-SRDRKSMSVLSRNSKTKRNELFVKGAP 303
S + K NP +A + F S ++ +SV R + + L +KGAP
Sbjct 461 SCGSVRKLRDRNPK------------VAEIPFNSTNKFQLSVHEREDSPEGHLLVMKGAP 508
Query 304 ETLLTRCETMMLPNGDVVPMSEAARKVVLTDVAGMARGALRTLALAVRLDAGPLADYGGE 363
E +L RC ++M+ +G P+ E + A G L L +
Sbjct 509 ERILDRCSSIMI-HGQEQPLDEEMKDAFQN--AYFELGGLGERVLG-------FCHFYLP 558
Query 364 TTQASRSLLEDQAGYAALESSLCFIGVVGLFDPPRPEVGSAILQCRDAGIRVVMITGDNK 423
+ R D + LCFIG++ + DPPR V A+ +CR AGI+V+M+TGD+
Sbjct 559 ADKFQRGFKFDSEDPNFPITDLCFIGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHP 618
Query 424 DTAEAVADLVHIREGFDKTFPSYT---------------------GKEFEALSASEKMRV 462
TA+A+A V I ++T G + + +++ + +
Sbjct 619 ITAKAIAKGVGIISEGNETVEDIADRLNIPVNQVNPREAKACVIHGSDLKDMTSEQLDDL 678
Query 463 LSSPGGAIFSRTEPKHKQLIVKLLKELGETTAMTGDGVNDAPALKQADIGVAMGIAGTEV 522
L + +F+RT P+ K +IV+ + G A+TGDGVND+PALK+ADIGVAMGIAG++V
Sbjct 679 LKNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDV 738
Query 523 AKEASDMVLADDNFSTIVSAVEEGRSIYNNMKAFIRYLISSNIGEVAS--IFMTAALGVP 580
+K+A+DM+L DDNF++IV+ VEEGR I++N+K I Y ++SNI E+ +F+ A + +P
Sbjct 739 SKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIIANIPLP 798
> cel:B0365.3 eat-6; EATing: abnormal pharyngeal pumping family
member (eat-6); K01539 sodium/potassium-transporting ATPase
subunit alpha [EC:3.6.3.9]
Length=996
Score = 253 bits (645), Expect = 2e-66, Method: Compositional matrix adjust.
Identities = 183/564 (32%), Positives = 272/564 (48%), Gaps = 95/564 (16%)
Query 55 IGHFSDAVHGSALRGCIYYFKIA--------------VALAVAAIPEGLPAVITTCLALG 100
I HF + G A+ I +F IA + + VA +PEGL A +T CL L
Sbjct 266 IEHFIHLITGVAVFLGISFFIIAFILGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLT 325
Query 101 TRKMAKKNAIVRRLQSVETLGCTTVICSDKTGTLTTNEMTCVRFCVVGQSSTEVDVFTVD 160
++MA KN +V+ L++VETLG T+ ICSDKTGTLT N MT V + + D
Sbjct 326 AKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMT------VAHMWYDETIHECD 379
Query 161 GTGFCATGSVSREMRGGAKGSQSLTGHQAVLSWLCRCATICNEAHLNVAPGSSEGSHYER 220
T S+E R GA L R A++CN A + +
Sbjct 380 TT----ETQTSQEKRTGAS-----------FEALVRIASLCNRAEFKAGQQDTPILRRDC 424
Query 221 MGEPTEAALLVLVEKLGLFSDEQISRRANTKRTAANPTPFCDYWKGEYKDLATLEFSRDR 280
G+ +E ALL E L I+ R K+ A P F+
Sbjct 425 TGDASEIALLKFTE---LTQGNVIAVREKNKKIAEIP------------------FNSTN 463
Query 281 KSMSVLSRNSKTKRNELFVKGAPETLLTRCETMMLPNGDVVPMSEAARKVVLT---DVAG 337
K + N L +KGAPE +L C T+ L NG +++ R+ T ++ G
Sbjct 464 KYQVSIHDNGD--HYLLVMKGAPERILDVCSTIFL-NGKESELTDKLREDFNTAYLELGG 520
Query 338 MARGALRTLALAVRLDAGPLADYGGETTQASRSLLEDQAGYAALESSLCFIGVVGLFDPP 397
M L + D P + + + + L +L F+G++ + DPP
Sbjct 521 MGERVLGFCDFVLPADKFP-KGFKFDVEEVNFPL-----------KNLRFVGLMSMIDPP 568
Query 398 RPEVGSAILQCRDAGIRVVMITGDNKDTAEAVA-------------DLVHIREGF--DKT 442
R V A+ +CR AGI+VVM+TGD+ TA+A+A + + IR G ++
Sbjct 569 RAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIISDGTETVEDIAIRRGIPVEEV 628
Query 443 FPS------YTGKEFEALSASEKMRVLSSPGGAIFSRTEPKHKQLIVKLLKELGETTAMT 496
P G + +S + ++ +F+RT P+ K +IV+ ++ G+ A+T
Sbjct 629 NPREAKAAVIHGSDLREMSEDQLAEIIKYHSEIVFARTSPQQKLMIVEGFQKQGQIVAVT 688
Query 497 GDGVNDAPALKQADIGVAMGIAGTEVAKEASDMVLADDNFSTIVSAVEEGRSIYNNMKAF 556
GDGVND+PALK+ADIGVAMGIAG++V+K+A+DM+L DDNF++IV VEEGR I++N+K
Sbjct 689 GDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKS 748
Query 557 IRYLISSNIGEVASIFMTAALGVP 580
I Y ++SNI E++ G+P
Sbjct 749 IAYTLTSNIPEISPFLTYILFGIP 772
Lambda K H
0.318 0.132 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 28949317320
Database: egene_temp_file_orthology_annotation_similarity_blast_database_966
Posted date: Sep 16, 2011 8:45 PM
Number of letters in database: 82,071,388
Number of sequences in database: 164,496
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40