bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: egene_temp_file_orthology_annotation_similarity_blast_database_966
164,496 sequences; 82,071,388 total letters
Query= Eace_0125_orf1
Length=180
Score E
Sequences producing significant alignments: (Bits) Value
tgo:TGME49_086470 cAMP-dependent protein kinase catalytic subu... 288 1e-77
cel:ZK909.2 kin-1; protein KINase family member (kin-1); K0434... 181 1e-45
tgo:TGME49_026030 cAMP-dependent protein kinase catalytic subu... 181 1e-45
xla:380388 prkacb, MGC53163, XPKAbeta, kin-1, pkacb, prkacba; ... 180 3e-45
hsa:5567 PRKACB, DKFZp781I2452, MGC41879, MGC9320, PKACB; prot... 178 1e-44
sce:YPL203W TPK2, PKA2, PKA3, YKR1; Tpk2p (EC:2.7.11.11); K043... 177 1e-44
dre:563147 prkacbb, MGC110804, prkacb, wu:fz54b03, zgc:110804;... 177 2e-44
sce:YKL166C TPK3; Tpk3p (EC:2.7.11.11); K04345 protein kinase ... 177 3e-44
mmu:18749 Prkacb, Pkacb; protein kinase, cAMP dependent, catal... 176 3e-44
mmu:18747 Prkaca, Cs, PKA, PKCD, Pkaca; protein kinase, cAMP d... 174 1e-43
dre:393998 prkacba, MGC64054, Prkacb, zgc:64054; protein kinas... 174 1e-43
dre:445076 prkacab, zgc:91856; protein kinase, cAMP-dependent,... 173 2e-43
pfa:PFI1685w PfPKAc, PfPKA, PKA; cAMP-dependent protein kinase... 172 4e-43
dre:564064 prkacaa, zgc:158799; protein kinase, cAMP-dependent... 172 5e-43
hsa:5566 PRKACA, MGC102831, MGC48865, PKACA; protein kinase, c... 172 6e-43
hsa:5613 PRKX, PKX1; protein kinase, X-linked (EC:2.7.11.1); K... 170 2e-42
sce:YJL164C TPK1, PKA1, SRA3; Tpk1p (EC:2.7.11.11); K04345 pro... 169 5e-42
xla:446502 prkacbb, MGC80071; protein kinase, cAMP-dependent, ... 168 8e-42
xla:100101276 prkaca; protein kinase, cAMP-dependent, catalyti... 168 9e-42
bbo:BBOV_III005740 17.m07511; protein kinase domain containing... 164 2e-40
cpv:cgd3_3040 protein kinase, cAMP-dependent, catalytic chain ... 164 2e-40
mmu:19108 Prkx, PKX1, Pkare; protein kinase, X-linked (EC:2.7.... 163 3e-40
dre:561941 protein kinase, X-linked-like; K04345 protein kinas... 162 5e-40
hsa:5568 PRKACG, KAPG, PKACg; protein kinase, cAMP-dependent, ... 162 7e-40
bbo:BBOV_I004190 19.m02221; cAMP-dependent protein kinase (EC:... 160 3e-39
cel:F47F2.1 hypothetical protein; K04345 protein kinase A [EC:... 155 7e-38
tgo:TGME49_072540 protein kinase, putative (EC:2.7.11.11 2.4.1... 154 1e-37
tpv:TP02_0378 cAMP-dependent protein kinase; K04345 protein ki... 151 1e-36
cpv:cgd8_750 cyclic nucleotide (cGMP)-dependent protein kinase... 151 1e-36
tpv:TP02_0727 cAMP-dependent protein kinase catalytic subunit;... 150 3e-36
tgo:TGME49_028420 cAMP-dependent protein kinase catalytic subu... 148 1e-35
pfa:PFL2250c PKB; rac-beta serine/threonine protein kinase, Pf... 147 3e-35
tgo:TGME49_111360 cGMP-dependent protein kinase, putative (EC:... 146 5e-35
bbo:BBOV_I004690 19.m02237; cGMP dependent protein kinase (EC:... 145 6e-35
hsa:5584 PRKCI, DXS1179E, MGC26534, PKCI, nPKC-iota; protein k... 145 1e-34
mmu:18759 Prkci, 2310021H13Rik, AI427505, KIAA4165, PKClambda,... 145 1e-34
tgo:TGME49_067540 protein kinase, putative (EC:4.1.1.70 2.7.11... 145 1e-34
cel:W10G6.2 sgk-1; Serum- and Glucocorticoid- inducible kinase... 143 3e-34
tpv:TP03_0511 cGMP-dependent protein kinase (EC:2.7.1.37); K07... 143 3e-34
xla:399130 sgk1-a, Sgk, sgk-A, sgk1; serum/glucocorticoid regu... 142 4e-34
dre:117507 prkci, aPKC[l], hal, has; protein kinase C, iota (E... 142 4e-34
pfa:PF14_0346 PKG; cGMP-dependent protein kinase (EC:2.7.11.12... 142 8e-34
dre:560549 akt3a, akt3, si:ch211-221n23.2; v-akt murine thymom... 142 9e-34
hsa:5590 PRKCZ, PKC-ZETA, PKC2; protein kinase C, zeta (EC:2.7... 140 2e-33
mmu:18762 Prkcz, AI098070, C80388, Pkcz, R74924, aPKCzeta, zet... 140 2e-33
hsa:208 AKT2, PKBB, PKBBETA, PRKBB, RAC-BETA; v-akt murine thy... 140 3e-33
dre:324140 sgk1, cb1083, sgk, wu:fc20a09; serum/glucocorticoid... 139 4e-33
mmu:23797 Akt3, AI851531, D930002M15Rik, Nmf350; thymoma viral... 139 4e-33
hsa:10000 AKT3, DKFZp434N0250, PKB-GAMMA, PKBG, PRKBG, RAC-PK-... 139 4e-33
cel:C12D8.10 akt-1; AKT kinase family member (akt-1); K04456 R... 139 4e-33
> tgo:TGME49_086470 cAMP-dependent protein kinase catalytic subunit
(EC:2.7.11.11); K04345 protein kinase A [EC:2.7.11.11]
Length=514
Score = 288 bits (736), Expect = 1e-77, Method: Compositional matrix adjust.
Identities = 134/178 (75%), Positives = 154/178 (86%), Gaps = 0/178 (0%)
Query 3 SEVLHMVREELQQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKV 62
S++L VR +L R L I DF+F+ TVGTGSFGRVCIVDL+ A WYPPMALKILSK K+
Sbjct 181 SQILSQVRYDLLARNLSIDDFLFHETVGTGSFGRVCIVDLRGAAGWYPPMALKILSKHKI 240
Query 63 ITMKQVEHVKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVP 122
+ MKQVEHVKDE+RIL+ HPFIVNLLA+FQDEKRLF+LMEYVNGGELFS+LR++ +P
Sbjct 241 VKMKQVEHVKDEKRILSSIEHPFIVNLLAAFQDEKRLFILMEYVNGGELFSHLRRRNCIP 300
Query 123 VEQARLYAAEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
+QARLYAAEITLAFQY+H+R IVYRDLKPENLLID+QGHIKITDFGF KVV RTWT
Sbjct 301 TDQARLYAAEITLAFQYLHQRHIVYRDLKPENLLIDSQGHIKITDFGFAKVVKDRTWT 358
> cel:ZK909.2 kin-1; protein KINase family member (kin-1); K04345
protein kinase A [EC:2.7.11.11]
Length=381
Score = 181 bits (460), Expect = 1e-45, Method: Compositional matrix adjust.
Identities = 90/184 (48%), Positives = 125/184 (67%), Gaps = 10/184 (5%)
Query 4 EVLHMVREELQQR-------KLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKI 56
E L RE+ +QR + DF T+GTGSFGRV +V +Q+ +Y A+KI
Sbjct 48 EFLDKAREDFKQRWENPAQNTACLDDFDRIKTLGTGSFGRVMLVKHKQSGNYY---AMKI 104
Query 57 LSKQKVITMKQVEHVKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLR 116
L KQKV+ +KQVEH +E+RIL PF+VN+ SF+D L++++E+++GGE+FS+LR
Sbjct 105 LDKQKVVKLKQVEHTLNEKRILQAIDFPFLVNMTFSFKDNSNLYMVLEFISGGEMFSHLR 164
Query 117 KQISVPVEQARLYAAEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVG 176
+ +R YAA+I LAF+Y+H ++YRDLKPENLLID+ G++KITDFGF K V G
Sbjct 165 RIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDSTGYLKITDFGFAKRVKG 224
Query 177 RTWT 180
RTWT
Sbjct 225 RTWT 228
> tgo:TGME49_026030 cAMP-dependent protein kinase catalytic subunit,
putative (EC:2.7.11.11); K04345 protein kinase A [EC:2.7.11.11]
Length=343
Score = 181 bits (459), Expect = 1e-45, Method: Compositional matrix adjust.
Identities = 87/174 (50%), Positives = 124/174 (71%), Gaps = 1/174 (0%)
Query 7 HMVREELQQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMK 66
H R L K + +F F T+GTGSFGRV + ++ + PP+A+K L K VI K
Sbjct 18 HSQRGRLPPNKCVMSNFNFGPTLGTGSFGRVFMAK-RKDDPHAPPVAIKRLKKAAVIRQK 76
Query 67 QVEHVKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQA 126
QV+H+ E+RIL +HPF VN+L +F+D++ L+++MEYV GGE F+ LRK + A
Sbjct 77 QVDHILSEKRILQMINHPFTVNMLGTFKDDRYLYIVMEYVIGGEFFTLLRKTRRFENDAA 136
Query 127 RLYAAEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
R YAA++TL F+Y+H+R+I+YRDLKPENLL+DA+G++K+TDFGF KV+ RT+T
Sbjct 137 RFYAAQVTLIFEYLHDRNIIYRDLKPENLLVDAEGYLKLTDFGFAKVIEYRTYT 190
> xla:380388 prkacb, MGC53163, XPKAbeta, kin-1, pkacb, prkacba;
protein kinase, cAMP-dependent, catalytic, beta; K04345 protein
kinase A [EC:2.7.11.11]
Length=351
Score = 180 bits (456), Expect = 3e-45, Method: Compositional matrix adjust.
Identities = 89/170 (52%), Positives = 118/170 (69%), Gaps = 3/170 (1%)
Query 11 EELQQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEH 70
E Q + DF T+GTGSFGRV +V + AE++Y A+KIL KQKV+ +KQ+EH
Sbjct 32 ETPPQNTASLDDFDRMKTLGTGSFGRVMLVKHKGAEQYY---AMKILDKQKVVKLKQIEH 88
Query 71 VKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYA 130
+E+RIL + PF+V L SF+D L+++MEYV GGE+FS+LR+ AR YA
Sbjct 89 TLNEKRILQAVNFPFLVRLEYSFKDNSNLYMIMEYVPGGEMFSHLRRIGRFSEPHARFYA 148
Query 131 AEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
A+I L F+Y+H ++YRDLKPENLLID QG+I++TDFGF K V GRTWT
Sbjct 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT 198
> hsa:5567 PRKACB, DKFZp781I2452, MGC41879, MGC9320, PKACB; protein
kinase, cAMP-dependent, catalytic, beta (EC:2.7.11.11);
K04345 protein kinase A [EC:2.7.11.11]
Length=351
Score = 178 bits (451), Expect = 1e-44, Method: Compositional matrix adjust.
Identities = 87/170 (51%), Positives = 118/170 (69%), Gaps = 3/170 (1%)
Query 11 EELQQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEH 70
E Q ++DF T+GTGSFGRV +V + E++Y A+KIL KQKV+ +KQ+EH
Sbjct 32 ENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYY---AMKILDKQKVVKLKQIEH 88
Query 71 VKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYA 130
+E+RIL + PF+V L +F+D L+++MEYV GGE+FS+LR+ AR YA
Sbjct 89 TLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYA 148
Query 131 AEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
A+I L F+Y+H ++YRDLKPENLLID QG+I++TDFGF K V GRTWT
Sbjct 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWT 198
> sce:YPL203W TPK2, PKA2, PKA3, YKR1; Tpk2p (EC:2.7.11.11); K04345
protein kinase A [EC:2.7.11.11]
Length=380
Score = 177 bits (450), Expect = 1e-44, Method: Compositional matrix adjust.
Identities = 85/164 (51%), Positives = 112/164 (68%), Gaps = 3/164 (1%)
Query 17 KLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEHVKDERR 76
K + DF T+GTGSFGRV +V +Y A+K+L KQ+V+ MKQVEH DERR
Sbjct 64 KYTLHDFQIMRTLGTGSFGRVHLVRSVHNGRYY---AIKVLKKQQVVKMKQVEHTNDERR 120
Query 77 ILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAEITLA 136
+L HPF++ + +FQD + +F++M+Y+ GGELFS LRK P A+ YAAE+ LA
Sbjct 121 MLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVILA 180
Query 137 FQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
+Y+H +I+YRDLKPEN+L+D GHIKITDFGF K V TWT
Sbjct 181 LEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEVQTVTWT 224
> dre:563147 prkacbb, MGC110804, prkacb, wu:fz54b03, zgc:110804;
protein kinase, cAMP-dependent, catalytic, beta b; K04345
protein kinase A [EC:2.7.11.11]
Length=351
Score = 177 bits (448), Expect = 2e-44, Method: Compositional matrix adjust.
Identities = 87/170 (51%), Positives = 118/170 (69%), Gaps = 3/170 (1%)
Query 11 EELQQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEH 70
E QQ + DF T+GTGSFGRV +V + ++++Y A+K+L KQKV+ +KQVEH
Sbjct 32 ESPQQSTTCLDDFDRQKTLGTGSFGRVLLVKHKASDQYY---AMKVLDKQKVVKLKQVEH 88
Query 71 VKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYA 130
+E+RIL S PF+V L +F+D L+++MEYV GGE+FS+LR+ AR YA
Sbjct 89 TLNEKRILQAVSFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYA 148
Query 131 AEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
A+I L F+Y+H ++YRDLKPENLLID G+I++TDFGF K V GRTWT
Sbjct 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQHGYIQVTDFGFAKRVKGRTWT 198
> sce:YKL166C TPK3; Tpk3p (EC:2.7.11.11); K04345 protein kinase
A [EC:2.7.11.11]
Length=398
Score = 177 bits (448), Expect = 3e-44, Method: Compositional matrix adjust.
Identities = 83/164 (50%), Positives = 112/164 (68%), Gaps = 3/164 (1%)
Query 17 KLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEHVKDERR 76
K + DF T+GTGSFGRV ++ +Y ALK L K ++ +KQVEH DERR
Sbjct 82 KYSLSDFQILRTLGTGSFGRVHLIRSNHNGRFY---ALKTLKKHTIVKLKQVEHTNDERR 138
Query 77 ILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAEITLA 136
+L+ SHPFI+ + +FQD +++F++M+Y+ GGELFS LRK P A+ YAAE+ LA
Sbjct 139 MLSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLA 198
Query 137 FQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
+Y+H + I+YRDLKPEN+L+D GHIKITDFGF K V T+T
Sbjct 199 LEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYT 242
> mmu:18749 Prkacb, Pkacb; protein kinase, cAMP dependent, catalytic,
beta (EC:2.7.11.11); K04345 protein kinase A [EC:2.7.11.11]
Length=338
Score = 176 bits (447), Expect = 3e-44, Method: Compositional matrix adjust.
Identities = 86/161 (53%), Positives = 115/161 (71%), Gaps = 3/161 (1%)
Query 20 IQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEHVKDERRILA 79
++DF T+GTGSFGRV +V + E++Y A+KIL KQKV+ +KQ+EH +E+RIL
Sbjct 28 LEDFERKKTLGTGSFGRVMLVKHKATEQYY---AMKILDKQKVVKLKQIEHTLNEKRILQ 84
Query 80 QPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAEITLAFQY 139
PF+V L SF+D L+++MEYV GGE+FS+LR+ AR YAA+I L F+Y
Sbjct 85 AVEFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY 144
Query 140 VHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
+H ++YRDLKPENLLID QG+I++TDFGF K V GRTWT
Sbjct 145 LHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWT 185
> mmu:18747 Prkaca, Cs, PKA, PKCD, Pkaca; protein kinase, cAMP
dependent, catalytic, alpha (EC:2.7.11.11); K04345 protein
kinase A [EC:2.7.11.11]
Length=351
Score = 174 bits (442), Expect = 1e-43, Method: Compositional matrix adjust.
Identities = 87/170 (51%), Positives = 116/170 (68%), Gaps = 3/170 (1%)
Query 11 EELQQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEH 70
E Q Q+ F T+GTGSFGRV +V +++ Y A+KIL KQKV+ +KQ+EH
Sbjct 32 ETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHY---AMKILDKQKVVKLKQIEH 88
Query 71 VKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYA 130
+E+RIL + PF+V L SF+D L+++MEYV GGE+FS+LR+ AR YA
Sbjct 89 TLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYA 148
Query 131 AEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
A+I L F+Y+H ++YRDLKPENLLID QG+I++TDFGF K V GRTWT
Sbjct 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT 198
> dre:393998 prkacba, MGC64054, Prkacb, zgc:64054; protein kinase,
cAMP-dependent, catalytic, beta a; K04345 protein kinase
A [EC:2.7.11.11]
Length=395
Score = 174 bits (442), Expect = 1e-43, Method: Compositional matrix adjust.
Identities = 85/170 (50%), Positives = 120/170 (70%), Gaps = 4/170 (2%)
Query 12 ELQQRKLQ-IQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEH 70
E QQ+ + DF T+GTGSFGRV +V +Q+E+++ A+KIL K KV+ +KQ+EH
Sbjct 76 ECQQKSTACLDDFDKLKTLGTGSFGRVMLVKHKQSEQYF---AMKILDKLKVVKLKQIEH 132
Query 71 VKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYA 130
+E++IL S PF+V L +F+D L+++M Y+ GGE+FS+LR+ + AR YA
Sbjct 133 TLNEKKILQAVSFPFLVKLECAFKDNSNLYMVMRYIQGGEMFSHLRRIGRFSEQNARFYA 192
Query 131 AEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
A+I L F+Y+H ++YRDLKPENLLID QG+I++TDFGF K V GRTWT
Sbjct 193 AQIVLTFEYLHMLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWT 242
> dre:445076 prkacab, zgc:91856; protein kinase, cAMP-dependent,
catalytic, alpha, genome duplicate b (EC:2.7.11.11); K04345
protein kinase A [EC:2.7.11.11]
Length=351
Score = 173 bits (439), Expect = 2e-43, Method: Compositional matrix adjust.
Identities = 86/170 (50%), Positives = 118/170 (69%), Gaps = 3/170 (1%)
Query 11 EELQQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEH 70
E Q ++DF T+GTGSFGRV +V ++ + Y A+KIL+KQKV+ +KQ+EH
Sbjct 32 ENPAQNTACLEDFDRLKTLGTGSFGRVMLVRHRETGQHY---AMKILNKQKVVKLKQIEH 88
Query 71 VKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYA 130
+E+RIL S PF+V L SF+D L+++M+YV GGE+FS+LR+ AR YA
Sbjct 89 TLNEKRILQAVSFPFLVRLEYSFKDNTNLYMVMQYVQGGEMFSHLRRIGRFSEPHARFYA 148
Query 131 AEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
++I L F+Y+H ++YRDLKPENLLID QG+I++TDFGF K V GRTWT
Sbjct 149 SQIVLTFEYLHALDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT 198
> pfa:PFI1685w PfPKAc, PfPKA, PKA; cAMP-dependent protein kinase
catalytic subunit; K04345 protein kinase A [EC:2.7.11.11]
Length=342
Score = 172 bits (437), Expect = 4e-43, Method: Compositional matrix adjust.
Identities = 83/167 (49%), Positives = 115/167 (68%), Gaps = 2/167 (1%)
Query 14 QQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEHVKD 73
++ K++ +DF F T+GTGSFGRV + + YPP+A+K K K+I KQV+HV
Sbjct 25 KKNKMKYEDFNFIRTLGTGSFGRVILATYKNGN--YPPVAIKRFEKCKIIRQKQVDHVFS 82
Query 74 ERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAEI 133
ER+IL +HPF VNL SF+D+ L+L++E+V GGE F++LR+ P + YAA+I
Sbjct 83 ERKILNYINHPFCVNLHGSFKDDSYLYLVLEFVIGGEFFTFLRRNKRFPNDVGCFYAAQI 142
Query 134 TLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
L F+Y+ +IVYRDLKPENLL+D G IK+TDFGF K+V RT+T
Sbjct 143 VLIFEYLQSLNIVYRDLKPENLLLDKDGFIKMTDFGFAKIVETRTYT 189
> dre:564064 prkacaa, zgc:158799; protein kinase, cAMP-dependent,
catalytic, alpha, genome duplicate a (EC:2.7.11.11); K04345
protein kinase A [EC:2.7.11.11]
Length=352
Score = 172 bits (436), Expect = 5e-43, Method: Compositional matrix adjust.
Identities = 86/170 (50%), Positives = 116/170 (68%), Gaps = 3/170 (1%)
Query 11 EELQQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEH 70
E Q + F T+GTGSFGRV +V +++ + + A+KIL KQKV+ +KQ+EH
Sbjct 33 ENPAQNTASLDHFERLKTLGTGSFGRVMLVKHKESGQHF---AMKILDKQKVVKLKQIEH 89
Query 71 VKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYA 130
+E+RIL S PF+V L SF+D L+++MEYV GGE+FS+LR+ AR YA
Sbjct 90 TLNEKRILQAVSFPFLVRLEHSFKDNTNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYA 149
Query 131 AEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
A+I L F+Y+H ++YRDLKPENLLID QG+I++TDFGF K V GRTWT
Sbjct 150 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT 199
> hsa:5566 PRKACA, MGC102831, MGC48865, PKACA; protein kinase,
cAMP-dependent, catalytic, alpha (EC:2.7.11.11); K04345 protein
kinase A [EC:2.7.11.11]
Length=351
Score = 172 bits (436), Expect = 6e-43, Method: Compositional matrix adjust.
Identities = 86/170 (50%), Positives = 114/170 (67%), Gaps = 3/170 (1%)
Query 11 EELQQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEH 70
E Q + F T+GTGSFGRV +V ++ Y A+KIL KQKV+ +KQ+EH
Sbjct 32 ESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHY---AMKILDKQKVVKLKQIEH 88
Query 71 VKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYA 130
+E+RIL + PF+V L SF+D L+++MEYV GGE+FS+LR+ AR YA
Sbjct 89 TLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYA 148
Query 131 AEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
A+I L F+Y+H ++YRDLKPENLLID QG+I++TDFGF K V GRTWT
Sbjct 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT 198
> hsa:5613 PRKX, PKX1; protein kinase, X-linked (EC:2.7.11.1);
K04345 protein kinase A [EC:2.7.11.11]
Length=358
Score = 170 bits (431), Expect = 2e-42, Method: Compositional matrix adjust.
Identities = 82/162 (50%), Positives = 113/162 (69%), Gaps = 3/162 (1%)
Query 19 QIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEHVKDERRIL 78
+QDF TVGTG+FGRV +V + A+ ++ ALK++S VI +KQ +HV +E+ +L
Sbjct 45 SLQDFDTLATVGTGTFGRVHLVKEKTAKHFF---ALKVMSIPDVIRLKQEQHVHNEKSVL 101
Query 79 AQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAEITLAFQ 138
+ SHPF++ L ++ DE+ L++LMEYV GGELFSYLR + Y+AEI A +
Sbjct 102 KEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIE 161
Query 139 YVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
Y+H + IVYRDLKPEN+L+D GHIK+TDFGF K +V RTWT
Sbjct 162 YLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWT 203
> sce:YJL164C TPK1, PKA1, SRA3; Tpk1p (EC:2.7.11.11); K04345 protein
kinase A [EC:2.7.11.11]
Length=397
Score = 169 bits (428), Expect = 5e-42, Method: Compositional matrix adjust.
Identities = 79/160 (49%), Positives = 113/160 (70%), Gaps = 3/160 (1%)
Query 21 QDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEHVKDERRILAQ 80
++F T+GTGSFGRV ++ + +Y A+K+L K+ V+ +KQVEH DER +L+
Sbjct 85 KNFQILRTLGTGSFGRVHLIRSRHNGRYY---AMKVLKKEIVVRLKQVEHTNDERLMLSI 141
Query 81 PSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAEITLAFQYV 140
+HPFI+ + +FQD +++F++M+Y+ GGELFS LRK P A+ YAAE+ LA +Y+
Sbjct 142 VTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYL 201
Query 141 HERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
H + I+YRDLKPEN+L+D GHIKITDFGF K V T+T
Sbjct 202 HSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYT 241
> xla:446502 prkacbb, MGC80071; protein kinase, cAMP-dependent,
catalytic, beta b; K04345 protein kinase A [EC:2.7.11.11]
Length=351
Score = 168 bits (426), Expect = 8e-42, Method: Compositional matrix adjust.
Identities = 85/170 (50%), Positives = 114/170 (67%), Gaps = 3/170 (1%)
Query 11 EELQQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEH 70
E Q + F T+GTGSFGRV +V + +E A+KIL KQKV+ +KQ+EH
Sbjct 32 ENPAQNTAHLDQFERIKTLGTGSFGRVMLV---RQKENGSHFAMKILDKQKVVKLKQIEH 88
Query 71 VKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYA 130
+E+RIL + PF+V L SF+D L+++MEYV GGE+FS+LR+ AR YA
Sbjct 89 TLNEKRILQAVNFPFLVRLEYSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYA 148
Query 131 AEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
++I L F+Y+H ++YRDLKPENLLID QG+I++TDFGF K V GRTWT
Sbjct 149 SQIVLTFEYLHALDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT 198
> xla:100101276 prkaca; protein kinase, cAMP-dependent, catalytic,
alpha (EC:2.7.11.1); K04345 protein kinase A [EC:2.7.11.11]
Length=351
Score = 168 bits (426), Expect = 9e-42, Method: Compositional matrix adjust.
Identities = 84/170 (49%), Positives = 114/170 (67%), Gaps = 3/170 (1%)
Query 11 EELQQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEH 70
E Q + F T+GTGSFGRV +V ++ + A+KIL KQKV+ +KQ+EH
Sbjct 32 ESPAQNTANLDQFERMKTLGTGSFGRVMLVRHKENGSHF---AMKILDKQKVVKLKQIEH 88
Query 71 VKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYA 130
+E+RIL + PF+V L SF+D L+++MEYV GGE+FS+LR+ AR YA
Sbjct 89 TLNEKRILQAVNFPFLVRLEYSFKDNTNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYA 148
Query 131 AEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
++I L F+Y+H ++YRDLKPENLLID QG+I++TDFGF K V GRTWT
Sbjct 149 SQIVLTFEYLHALDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT 198
> bbo:BBOV_III005740 17.m07511; protein kinase domain containing
protein; K04345 protein kinase A [EC:2.7.11.11]
Length=359
Score = 164 bits (414), Expect = 2e-40, Method: Compositional matrix adjust.
Identities = 80/172 (46%), Positives = 114/172 (66%), Gaps = 0/172 (0%)
Query 9 VREELQQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQV 68
+R + KL+ +DF F T+GTG FGRV + + + P A+K L K +I KQV
Sbjct 35 LRTKNPPAKLRKEDFEFVRTLGTGGFGRVILAIPKGIDGITEPCAIKRLKKHSLIVQKQV 94
Query 69 EHVKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARL 128
+HV E+++L+ +HPFIVN+L +F+D L+++ME V GG+ F YLR + E A
Sbjct 95 DHVVSEKKLLSSVNHPFIVNMLGTFKDPHYLYIVMECVFGGDFFGYLRSVDKLESESAMF 154
Query 129 YAAEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
YAA+IT F Y+H +I+YRDLKPENLL+ + G++K+TDFGF KVV RT+T
Sbjct 155 YAAQITCIFDYMHSHNIIYRDLKPENLLVGSDGYLKLTDFGFAKVVELRTYT 206
> cpv:cgd3_3040 protein kinase, cAMP-dependent, catalytic chain
; K04345 protein kinase A [EC:2.7.11.11]
Length=392
Score = 164 bits (414), Expect = 2e-40, Method: Compositional matrix adjust.
Identities = 77/167 (46%), Positives = 115/167 (68%), Gaps = 3/167 (1%)
Query 14 QQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEHVKD 73
Q+K I DF T+GTGSFGRV + ++ Y A+K L K VI KQV+H+ +
Sbjct 76 NQKKYSIDDFQLIRTLGTGSFGRVFLSKHKEDNSIY---AIKRLKKSVVIRQKQVDHITN 132
Query 74 ERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAEI 133
E+ IL++ HPF+V + +F+D++ L+++ME+V GGE F+YLR+ E +R YAA++
Sbjct 133 EKAILSRIKHPFLVRMFGTFKDDRYLYIMMEFVIGGEFFTYLRRCRHFDNETSRFYAAQV 192
Query 134 TLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
L F+Y+H ++I+YRDLKPEN+LID G++K+TDFGF K + RT+T
Sbjct 193 VLMFEYLHGKNIIYRDLKPENILIDKDGYLKLTDFGFAKAIEYRTFT 239
> mmu:19108 Prkx, PKX1, Pkare; protein kinase, X-linked (EC:2.7.11.1);
K04345 protein kinase A [EC:2.7.11.11]
Length=355
Score = 163 bits (412), Expect = 3e-40, Method: Compositional matrix adjust.
Identities = 80/171 (46%), Positives = 115/171 (67%), Gaps = 3/171 (1%)
Query 10 REELQQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVE 69
R Q+ +QD+ TVGTG+FGRV +V + ++ ALKI+S VI +KQ +
Sbjct 33 RTSSQKAGHSLQDWDTIATVGTGTFGRVNLVKEKTGRQY---CALKIMSIPDVIRLKQEQ 89
Query 70 HVKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLY 129
HV++E+ +L + +HPF++ LL + D + L++LME+V GGELF+YLR + + Y
Sbjct 90 HVQNEKAVLKEINHPFLIKLLWTGHDNRFLYMLMEFVPGGELFTYLRNRGRFSSVASVFY 149
Query 130 AAEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
A EI A +Y+H + IVYRDLKPEN+L+D +GHIK+TDFGF K +V RTWT
Sbjct 150 ATEIVCAIEYLHSKEIVYRDLKPENILLDREGHIKLTDFGFAKKLVDRTWT 200
> dre:561941 protein kinase, X-linked-like; K04345 protein kinase
A [EC:2.7.11.11]
Length=357
Score = 162 bits (410), Expect = 5e-40, Method: Compositional matrix adjust.
Identities = 77/166 (46%), Positives = 110/166 (66%), Gaps = 3/166 (1%)
Query 15 QRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEHVKDE 74
R + D TVGTG+FGRV +V ++ ++ ALK + VI +KQ +HV +E
Sbjct 40 NRTYTLDDLDTIATVGTGTFGRVFLVKDKKTRGFF---ALKAMKIPDVIRLKQEQHVHNE 96
Query 75 RRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAEIT 134
+ +L + +HPF+V L + D++ L++LMEYVNGGELFSYLR + Y+AEI
Sbjct 97 KEVLTEVNHPFLVRLFWTHHDDRFLYMLMEYVNGGELFSYLRSRGHFSNSTGMFYSAEIV 156
Query 135 LAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
A +Y+H + IVYRDLKPEN+L+D++GHI++TDFGF K + RTWT
Sbjct 157 CAIEYLHSKEIVYRDLKPENILLDSEGHIRLTDFGFAKKLSERTWT 202
> hsa:5568 PRKACG, KAPG, PKACg; protein kinase, cAMP-dependent,
catalytic, gamma (EC:2.7.11.11); K04345 protein kinase A [EC:2.7.11.11]
Length=351
Score = 162 bits (409), Expect = 7e-40, Method: Compositional matrix adjust.
Identities = 82/153 (53%), Positives = 108/153 (70%), Gaps = 3/153 (1%)
Query 28 TVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEHVKDERRILAQPSHPFIV 87
T+G GSFGRV +V Q+ Y A+KIL+KQKV+ MKQVEH+ +E+RIL PF+V
Sbjct 49 TLGMGSFGRVMLVRHQETGGHY---AMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLV 105
Query 88 NLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAEITLAFQYVHERSIVY 147
L SF+D L+L+MEYV GGE+FS L++ A YAA++ LA QY+H +++
Sbjct 106 KLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIH 165
Query 148 RDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
RDLKPENLLID QG++++TDFGF K V GRTWT
Sbjct 166 RDLKPENLLIDQQGYLQVTDFGFAKRVKGRTWT 198
> bbo:BBOV_I004190 19.m02221; cAMP-dependent protein kinase (EC:2.7.11.1);
K04345 protein kinase A [EC:2.7.11.11]
Length=416
Score = 160 bits (404), Expect = 3e-39, Method: Compositional matrix adjust.
Identities = 81/165 (49%), Positives = 109/165 (66%), Gaps = 1/165 (0%)
Query 17 KLQIQDFVFYGTVGTGSFGRVCIVDLQQA-EEWYPPMALKILSKQKVITMKQVEHVKDER 75
KL I +F VGTGS+ VCI L + ALKIL K KVI +QV H+++ER
Sbjct 98 KLDISNFDIGPIVGTGSYATVCIATLNTGPKSQRATFALKILHKTKVIAERQVMHLRNER 157
Query 76 RILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAEITL 135
IL+ HPFIVN + SFQD+ +++L+EYV+GGELFSY+ K ++ AR Y A+ L
Sbjct 158 HILSTVRHPFIVNYVKSFQDDINVYILLEYVSGGELFSYIYKYGALGHTVARFYTAQAIL 217
Query 136 AFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
A ++H + IVYRDLKPEN+L+D GHI++ DFGF K V +T+T
Sbjct 218 AIDFLHFKGIVYRDLKPENMLLDQDGHIRLVDFGFAKEVKHKTYT 262
> cel:F47F2.1 hypothetical protein; K04345 protein kinase A [EC:2.7.11.11]
Length=398
Score = 155 bits (392), Expect = 7e-38, Method: Compositional matrix adjust.
Identities = 74/153 (48%), Positives = 104/153 (67%), Gaps = 3/153 (1%)
Query 28 TVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEHVKDERRILAQPSHPFIV 87
T+G G+FGRV + + Y ALK+L+ ++V+ M+Q +HV +E+R+L Q HPFIV
Sbjct 95 TIGKGTFGRVELARDKITGAHY---ALKVLNIRRVVDMRQTQHVHNEKRVLLQLKHPFIV 151
Query 88 NLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAEITLAFQYVHERSIVY 147
+ AS +D L+++ME+V GGE+FSYLR S AR YA+EI A +Y+H IVY
Sbjct 152 KMYASEKDSNHLYMIMEFVPGGEMFSYLRASRSFSNSMARFYASEIVCALEYIHSLGIVY 211
Query 148 RDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
RDLKPENL++ +GHIK+ DFGF K + RT+T
Sbjct 212 RDLKPENLMLSKEGHIKMADFGFAKELRDRTYT 244
> tgo:TGME49_072540 protein kinase, putative (EC:2.7.11.11 2.4.1.119
3.1.3.48)
Length=1743
Score = 154 bits (389), Expect = 1e-37, Method: Composition-based stats.
Identities = 68/122 (55%), Positives = 91/122 (74%), Gaps = 0/122 (0%)
Query 51 PMALKILSKQKVITMKQVEHVKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGE 110
PMALK++ K++V+ + Q +HV ER+IL Q HPFIVN++ SFQD + ++LLME+VNGGE
Sbjct 212 PMALKVMKKRQVLALGQEKHVIAERKILQQLRHPFIVNMICSFQDRRHIYLLMEFVNGGE 271
Query 111 LFSYLRKQISVPVEQARLYAAEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGF 170
LFS LR + ++ AR Y AEI LA Y+H IVYRDLKPEN+L+D GH+K+ DFGF
Sbjct 272 LFSLLRSEGTLTENSARFYIAEIILALNYLHASMIVYRDLKPENILLDHIGHVKLVDFGF 331
Query 171 VK 172
+
Sbjct 332 AR 333
> tpv:TP02_0378 cAMP-dependent protein kinase; K04345 protein
kinase A [EC:2.7.11.11]
Length=352
Score = 151 bits (382), Expect = 1e-36, Method: Compositional matrix adjust.
Identities = 74/170 (43%), Positives = 110/170 (64%), Gaps = 0/170 (0%)
Query 11 EELQQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEH 70
E + + + + F +G G FG+V + +Q + A+K L K +I KQV+H
Sbjct 33 EPIPKEVFEPRSIKFLKLLGEGGFGKVFLALQEQEDSTTELCAVKRLEKYPLIAQKQVDH 92
Query 71 VKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYA 130
+ E ++L SHPFIVNLL S++D+ L+L+MEYV+GG+ F+YLRK + A YA
Sbjct 93 IISENKLLGSVSHPFIVNLLGSYKDDYYLYLVMEYVSGGDFFAYLRKNDRLKSYDAMFYA 152
Query 131 AEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
A++T F+Y+H+ +I+YRDLKPENLL+ + G++K+ DFGF KVV RT T
Sbjct 153 AQVTAMFEYLHDNNIIYRDLKPENLLLCSDGYLKLADFGFAKVVEFRTHT 202
> cpv:cgd8_750 cyclic nucleotide (cGMP)-dependent protein kinase
with 3 cNMP binding domains and a Ser/Thr kinase domain ;
K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=965
Score = 151 bits (381), Expect = 1e-36, Method: Compositional matrix adjust.
Identities = 75/171 (43%), Positives = 114/171 (66%), Gaps = 3/171 (1%)
Query 10 REELQQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVE 69
R +LQ+ ++Q+ D T+G G+FG V +V+ ++ Y ALK +SK +++ +
Sbjct 609 RIKLQETRVQMSDLKILQTIGKGTFGVVYMVENIKSGNKY---ALKKISKSRILALNMQA 665
Query 70 HVKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLY 129
HVK ER ILA HPFI+ L+ +F+D + ++LL E + GGEL+ L++ + QA+ Y
Sbjct 666 HVKLERSILALNDHPFIIKLVRTFKDSENIYLLTELIPGGELYDALQRIGLLTRYQAQFY 725
Query 130 AAEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
I LA +Y+HERSIVYRDLKPEN+L+D+QG+IK+ DFG K + GR++T
Sbjct 726 IGSIILALEYLHERSIVYRDLKPENILLDSQGYIKLIDFGCAKKIAGRSYT 776
> tpv:TP02_0727 cAMP-dependent protein kinase catalytic subunit;
K04345 protein kinase A [EC:2.7.11.11]
Length=511
Score = 150 bits (378), Expect = 3e-36, Method: Compositional matrix adjust.
Identities = 84/211 (39%), Positives = 117/211 (55%), Gaps = 46/211 (21%)
Query 16 RKLQIQDFVFYGTVGTGSFGRVCIV---------DL---------------------QQA 45
+ + DF T+GTGS+ VCI DL Q +
Sbjct 149 KNCKRDDFEIGKTIGTGSYATVCIAKFTPNNRYFDLTRYLYPDIRENVNTSFARYTSQDS 208
Query 46 EEWY--------PPM-------ALKILSKQKVITMKQVEHVKDERRILAQPSHPFIVNLL 90
E+ Y PM +LKILSK K+I +Q+EHVK+E+ IL+ HPFIV L
Sbjct 209 EQGYYNQIHDIEKPMEPNEKIVSLKILSKNKIIEKRQLEHVKNEKNILSTLKHPFIVGYL 268
Query 91 ASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAEITLAFQYVHERSIVYRDL 150
SFQD L+ ++E+V GGELF+YLR+ + P E R YA+++ LA Y+H +VYRDL
Sbjct 269 GSFQDTLNLYFILEFVPGGELFTYLRRMHTFPPEYTRFYASQVLLALDYLHMNKLVYRDL 328
Query 151 KPENLLIDAQGHIKITDFGFVKVV-VGRTWT 180
KPEN+L+D G+I++ DFGF K + G+T+T
Sbjct 329 KPENILLDIMGYIRLVDFGFAKRLESGKTYT 359
> tgo:TGME49_028420 cAMP-dependent protein kinase catalytic subunit,
putative (EC:2.7.11.11); K04345 protein kinase A [EC:2.7.11.11]
Length=333
Score = 148 bits (374), Expect = 1e-35, Method: Compositional matrix adjust.
Identities = 75/166 (45%), Positives = 105/166 (63%), Gaps = 8/166 (4%)
Query 23 FVFYGTVGTGSFGRV--------CIVDLQQAEEWYPPMALKILSKQKVITMKQVEHVKDE 74
F F T+GTGSFGRV ++ + P +A+K+L K +I +K V+H+ +E
Sbjct 15 FEFGPTLGTGSFGRVKSAKYLKSTSTNVDDPTQVPPRVAVKLLKKAAIIKLKHVDHIINE 74
Query 75 RRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAEIT 134
++IL HP V SFQD + L+L+ME V GGE F++LRK + AR YAA+I
Sbjct 75 KKILLALDHPLTVRCFGSFQDSRYLYLVMELVPGGEFFTHLRKAKRFDNDTARFYAAQIV 134
Query 135 LAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
F Y+H ++I+YRDLKPEN+L+D G++K+TDFGF KVV RT T
Sbjct 135 DIFDYLHSQNIIYRDLKPENMLLDKDGYVKLTDFGFAKVVEFRTDT 180
> pfa:PFL2250c PKB; rac-beta serine/threonine protein kinase,
PfPKB (EC:2.7.1.-); K08286 protein-serine/threonine kinase [EC:2.7.11.-]
Length=735
Score = 147 bits (370), Expect = 3e-35, Method: Composition-based stats.
Identities = 68/159 (42%), Positives = 109/159 (68%), Gaps = 3/159 (1%)
Query 14 QQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEHVKD 73
++++++ + F + +G GS+G+V +V Q ++ Y A+KIL K+ +++ Q+EH K
Sbjct 394 RKKRIRPESFNYLKVIGEGSYGKVMLVKHVQNKKLY---AMKILRKENILSRNQLEHTKV 450
Query 74 ERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAEI 133
ER IL SHPFIV + +FQ +++L+ ++EY GGELF +L K E A+ Y++EI
Sbjct 451 ERNILKCVSHPFIVKMYYAFQTKQKLYFILEYCPGGELFFHLSKLREFSEETAKFYSSEI 510
Query 134 TLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVK 172
LA +Y+H+ +I+YRDLKPEN+L+D GHI++TDFG K
Sbjct 511 ILALEYLHDLNIIYRDLKPENVLLDELGHIRLTDFGLSK 549
> tgo:TGME49_111360 cGMP-dependent protein kinase, putative (EC:2.7.11.12);
K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=994
Score = 146 bits (368), Expect = 5e-35, Method: Compositional matrix adjust.
Identities = 74/171 (43%), Positives = 111/171 (64%), Gaps = 3/171 (1%)
Query 10 REELQQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVE 69
R +Q K++ QD VG G+FG V +V + Y ALK +S++ VI + Q +
Sbjct 671 RIRMQDTKVEFQDLQVVRVVGRGTFGTVKLVRHVPTDIRY---ALKCVSRRSVIALSQQQ 727
Query 70 HVKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLY 129
H++ ER I+A+ HPFI+ L+ +F+D++ L+ L E V GGEL+ +RK + QA+ Y
Sbjct 728 HIRLEREIMAENDHPFIIRLVRTFRDKEFLYFLTELVTGGELYDAIRKLGLLARSQAQFY 787
Query 130 AAEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
A I LA +Y+HER+I YRDLKPEN+L+D+QG++K+ DFG K + GR +T
Sbjct 788 LASIVLAIEYLHERNIAYRDLKPENILLDSQGYVKLIDFGCAKKMQGRAYT 838
> bbo:BBOV_I004690 19.m02237; cGMP dependent protein kinase (EC:2.7.11.1);
K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=887
Score = 145 bits (367), Expect = 6e-35, Method: Compositional matrix adjust.
Identities = 75/175 (42%), Positives = 111/175 (63%), Gaps = 7/175 (4%)
Query 10 REELQQRKLQIQDFVFYGTVG----TGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITM 65
R ++Q K+Q + T+G G+FG V +VD + + ALK +S++ + +
Sbjct 560 RIKMQDSKVQFHELKVIKTIGHGKDLGTFGTVKLVDHEPTGVRF---ALKCVSRKCIRAL 616
Query 66 KQVEHVKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQ 125
KQ +H+K ER I+AQ HPFI+ L+ +F+DE ++ L E + GGEL+ +RK + Q
Sbjct 617 KQQKHIKLEREIMAQNDHPFIIQLVKTFKDESNVYFLTELITGGELYDAIRKIGLLSRPQ 676
Query 126 ARLYAAEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
A+ Y A I LAF+Y+HER I YRDLKPEN+L+D QG+IK+ DFG K + GR +T
Sbjct 677 AQFYIASIVLAFEYLHERQIAYRDLKPENILLDEQGYIKLIDFGCAKKIKGRAYT 731
> hsa:5584 PRKCI, DXS1179E, MGC26534, PKCI, nPKC-iota; protein
kinase C, iota (EC:2.7.11.13); K06069 atypical protein kinase
C [EC:2.7.11.13]
Length=596
Score = 145 bits (365), Expect = 1e-34, Method: Compositional matrix adjust.
Identities = 69/156 (44%), Positives = 108/156 (69%), Gaps = 4/156 (2%)
Query 18 LQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEHVKDERRI 77
L +QDF +G GS+ +V +V L++ + Y A+K++ K+ V + ++ V+ E+ +
Sbjct 249 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIY---AMKVVKKELVNDDEDIDWVQTEKHV 305
Query 78 LAQPS-HPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAEITLA 136
Q S HPF+V L + FQ E RLF ++EYVNGG+L ++++Q +P E AR Y+AEI+LA
Sbjct 306 FEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLA 365
Query 137 FQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVK 172
Y+HER I+YRDLK +N+L+D++GHIK+TD+G K
Sbjct 366 LNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCK 401
> mmu:18759 Prkci, 2310021H13Rik, AI427505, KIAA4165, PKClambda,
Pkci, Pkcl, Prkcl, aPKClambda, mKIAA4165; protein kinase
C, iota (EC:2.7.11.13); K06069 atypical protein kinase C [EC:2.7.11.13]
Length=595
Score = 145 bits (365), Expect = 1e-34, Method: Compositional matrix adjust.
Identities = 69/156 (44%), Positives = 108/156 (69%), Gaps = 4/156 (2%)
Query 18 LQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEHVKDERRI 77
L +QDF +G GS+ +V +V L++ + Y A+K++ K+ V + ++ V+ E+ +
Sbjct 248 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIY---AMKVVKKELVNDDEDIDWVQTEKHV 304
Query 78 LAQPS-HPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAEITLA 136
Q S HPF+V L + FQ E RLF ++EYVNGG+L ++++Q +P E AR Y+AEI+LA
Sbjct 305 FEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLA 364
Query 137 FQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVK 172
Y+HER I+YRDLK +N+L+D++GHIK+TD+G K
Sbjct 365 LNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCK 400
> tgo:TGME49_067540 protein kinase, putative (EC:4.1.1.70 2.7.11.13)
Length=951
Score = 145 bits (365), Expect = 1e-34, Method: Composition-based stats.
Identities = 68/159 (42%), Positives = 102/159 (64%), Gaps = 3/159 (1%)
Query 14 QQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEHVKD 73
+ ++L +DF +G GS+G+V +V Q Y A+K+L K+ V+ QVEH +
Sbjct 450 RNKRLSPEDFQLLRVIGKGSYGKVMLVQFHQDGGVY---AMKMLRKEAVVRRNQVEHTRT 506
Query 74 ERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAEI 133
ER +LA SHPFIV + +FQ K+L+ ++EY GGELF +L + A YAAE+
Sbjct 507 ERDVLAWVSHPFIVQMHYAFQTRKKLYFVLEYCPGGELFFHLSRAGRFKEYAACFYAAEV 566
Query 134 TLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVK 172
LA +++H+ ++VYRDLKPEN+L+D GH+++TDFG K
Sbjct 567 LLALEHLHKYNVVYRDLKPENVLLDEHGHVRLTDFGLSK 605
> cel:W10G6.2 sgk-1; Serum- and Glucocorticoid- inducible kinase
homolog family member (sgk-1); K08792 serum/glucocorticoid-regulated
kinase, invertebrate [EC:2.7.11.1]
Length=463
Score = 143 bits (361), Expect = 3e-34, Method: Compositional matrix adjust.
Identities = 69/160 (43%), Positives = 111/160 (69%), Gaps = 4/160 (2%)
Query 14 QQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEHVKD 73
+++ DF + T+G GSFGRV V ++ ++ Y A+KILSK+ + +V+HV
Sbjct 126 ERKTATANDFDYLTTIGKGSFGRVYQVRHKETKKIY---AMKILSKEHIRKKNEVKHVMA 182
Query 74 ERRILAQP-SHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAE 132
ER +L HPF+V+L SFQ++++L+ +++++NGGELFS+L+++ ++R YAAE
Sbjct 183 ERNVLINNFKHPFLVSLHFSFQNKEKLYFVLDHLNGGELFSHLQREKHFSESRSRFYAAE 242
Query 133 ITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVK 172
I A Y+HE++I+YRDLKPENLL+D +G++ +TDFG K
Sbjct 243 IACALGYLHEKNIIYRDLKPENLLLDDKGYLVLTDFGLCK 282
> tpv:TP03_0511 cGMP-dependent protein kinase (EC:2.7.1.37); K07376
protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=892
Score = 143 bits (361), Expect = 3e-34, Method: Compositional matrix adjust.
Identities = 76/175 (43%), Positives = 113/175 (64%), Gaps = 10/175 (5%)
Query 6 LHMVREELQQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITM 65
LH VR+ + KL T+ +G+FG V +V Q ++ + ALK +SK+ ++
Sbjct 582 LHTVRQIGKGIKLS-------NTISSGTFGTVNLVVHQPSQLRF---ALKCVSKKLIVYN 631
Query 66 KQVEHVKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQ 125
KQ +++K E+ I+AQ HPFI+ L+ +F+DE+ ++ L E V GGELF LRK + Q
Sbjct 632 KQQKNIKMEKEIMAQNDHPFIIQLVKTFKDEENIYFLTELVTGGELFDALRKLELLKKPQ 691
Query 126 ARLYAAEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
A+ Y I LA +Y+HER I+YRDLKPEN+++D QG+IK+ DFG K + GRT+T
Sbjct 692 AQFYLGSIILALEYLHERQIIYRDLKPENVMLDHQGYIKLIDFGSAKKIEGRTFT 746
> xla:399130 sgk1-a, Sgk, sgk-A, sgk1; serum/glucocorticoid regulated
kinase 1 (EC:2.7.11.1); K13302 serum/glucocorticoid-regulated
kinase 1 [EC:2.7.11.1]
Length=434
Score = 142 bits (359), Expect = 4e-34, Method: Compositional matrix adjust.
Identities = 70/153 (45%), Positives = 102/153 (66%), Gaps = 4/153 (2%)
Query 21 QDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEHVKDERRILAQ 80
DF F +G GSFG+V + Q E++Y A+K+L K+ ++ K+ +H+ ER +L +
Sbjct 99 SDFQFLKIIGKGSFGKVLLARHQADEKFY---AVKVLQKKAILKKKEEKHIMSERNVLLK 155
Query 81 P-SHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAEITLAFQY 139
HPF+V L SFQ RL+ +++Y+NGGELF +L+++ +AR YAAEI A Y
Sbjct 156 NVKHPFLVGLHFSFQTTSRLYFILDYINGGELFYHLQRERCFLEPRARFYAAEIASALGY 215
Query 140 VHERSIVYRDLKPENLLIDAQGHIKITDFGFVK 172
+H +IVYRDLKPEN+L+D+QGHI +TDFG K
Sbjct 216 LHSLNIVYRDLKPENILLDSQGHIVLTDFGLCK 248
> dre:117507 prkci, aPKC[l], hal, has; protein kinase C, iota
(EC:2.7.11.13); K06069 atypical protein kinase C [EC:2.7.11.13]
Length=588
Score = 142 bits (359), Expect = 4e-34, Method: Compositional matrix adjust.
Identities = 69/156 (44%), Positives = 107/156 (68%), Gaps = 4/156 (2%)
Query 18 LQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEHVKDERRI 77
L + DF +G GS+ +V +V L++ E Y A+K++ K+ V + ++ V+ E+ +
Sbjct 241 LGLIDFDLLRVIGRGSYAKVLLVRLKKTERIY---AMKVVKKELVNDDEDIDWVQTEKHV 297
Query 78 LAQPS-HPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAEITLA 136
Q S HPF+V L + FQ E RLF ++EYVNGG+L ++++Q +P E AR Y+AEI+LA
Sbjct 298 FEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLA 357
Query 137 FQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVK 172
Y+HER I+YRDLK +N+L+D++GHIK+TD+G K
Sbjct 358 LNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCK 393
> pfa:PF14_0346 PKG; cGMP-dependent protein kinase (EC:2.7.11.12);
K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=853
Score = 142 bits (357), Expect = 8e-34, Method: Compositional matrix adjust.
Identities = 72/171 (42%), Positives = 108/171 (63%), Gaps = 3/171 (1%)
Query 10 REELQQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVE 69
R ++Q K+++ + +G G+FG V +V + + Y ALK +SK+ +I + Q
Sbjct 528 RIKMQDTKVEMDELETERIIGRGTFGTVKLVHHKPTKIRY---ALKCVSKRSIINLNQQN 584
Query 70 HVKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLY 129
++K ER I A+ HPFI+ L+ +F+D K + L E V GGEL+ +RK + QA+ Y
Sbjct 585 NIKLEREITAENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFY 644
Query 130 AAEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVGRTWT 180
I LA +Y+HER+IVYRDLKPEN+L+D QG++K+ DFG K V GR +T
Sbjct 645 LGSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYT 695
> dre:560549 akt3a, akt3, si:ch211-221n23.2; v-akt murine thymoma
viral oncogene homolog 3a (EC:2.7.11.1); K04456 RAC serine/threonine-protein
kinase [EC:2.7.11.1]
Length=479
Score = 142 bits (357), Expect = 9e-34, Method: Compositional matrix adjust.
Identities = 73/176 (41%), Positives = 107/176 (60%), Gaps = 8/176 (4%)
Query 2 SSEVLHMVREEL-----QQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKI 56
+S++ +M EE+ ++ + DF + +G G+FG+V +V + + ++Y A+KI
Sbjct 122 TSQIDNMGEEEMDTSISHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYY---AMKI 178
Query 57 LSKQKVITMKQVEHVKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLR 116
L K+ +I +V H E R+L HPF+ +L SFQ + RL +MEYVNGGELF +L
Sbjct 179 LKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS 238
Query 117 KQISVPVEQARLYAAEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVK 172
++ ++ R Y AEI A Y+H IVYRDLK ENL++D GHIKITDFG K
Sbjct 239 RERVFSEDRTRFYGAEIVSALDYLHSAKIVYRDLKLENLMLDKDGHIKITDFGLCK 294
> hsa:5590 PRKCZ, PKC-ZETA, PKC2; protein kinase C, zeta (EC:2.7.11.13);
K06069 atypical protein kinase C [EC:2.7.11.13]
Length=409
Score = 140 bits (354), Expect = 2e-33, Method: Compositional matrix adjust.
Identities = 69/160 (43%), Positives = 109/160 (68%), Gaps = 4/160 (2%)
Query 18 LQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEHVKDERRI 77
L +QDF +G GS+ +V +V L++ ++ Y A+K++ K+ V + ++ V+ E+ +
Sbjct 64 LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIY---AMKVVKKELVHDDEDIDWVQTEKHV 120
Query 78 LAQ-PSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAEITLA 136
Q S+PF+V L + FQ RLFL++EYVNGG+L ++++Q +P E AR YAAEI +A
Sbjct 121 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180
Query 137 FQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVG 176
++HER I+YRDLK +N+L+DA GHIK+TD+G K +G
Sbjct 181 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLG 220
> mmu:18762 Prkcz, AI098070, C80388, Pkcz, R74924, aPKCzeta, zetaPKC;
protein kinase C, zeta (EC:2.7.11.13); K06069 atypical
protein kinase C [EC:2.7.11.13]
Length=409
Score = 140 bits (353), Expect = 2e-33, Method: Compositional matrix adjust.
Identities = 69/160 (43%), Positives = 109/160 (68%), Gaps = 4/160 (2%)
Query 18 LQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEHVKDERRI 77
L +QDF +G GS+ +V +V L++ ++ Y A+K++ K+ V + ++ V+ E+ +
Sbjct 64 LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIY---AMKVVKKELVHDDEDIDWVQTEKHV 120
Query 78 LAQ-PSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAEITLA 136
Q S+PF+V L + FQ RLFL++EYVNGG+L ++++Q +P E AR YAAEI +A
Sbjct 121 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180
Query 137 FQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVKVVVG 176
++HER I+YRDLK +N+L+DA GHIK+TD+G K +G
Sbjct 181 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLG 220
> hsa:208 AKT2, PKBB, PKBBETA, PRKBB, RAC-BETA; v-akt murine thymoma
viral oncogene homolog 2 (EC:2.7.11.1); K04456 RAC serine/threonine-protein
kinase [EC:2.7.11.1]
Length=481
Score = 140 bits (352), Expect = 3e-33, Method: Compositional matrix adjust.
Identities = 69/156 (44%), Positives = 96/156 (61%), Gaps = 3/156 (1%)
Query 17 KLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEHVKDERR 76
K+ + DF + +G G+FG+V +V + +Y A+KIL K+ +I +V H E R
Sbjct 146 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYY---AMKILRKEVIIAKDEVAHTVTESR 202
Query 77 ILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAEITLA 136
+L HPF+ L +FQ RL +MEY NGGELF +L ++ E+AR Y AEI A
Sbjct 203 VLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSA 262
Query 137 FQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVK 172
+Y+H R +VYRD+K ENL++D GHIKITDFG K
Sbjct 263 LEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCK 298
> dre:324140 sgk1, cb1083, sgk, wu:fc20a09; serum/glucocorticoid
regulated kinase 1 (EC:2.7.11.1); K13302 serum/glucocorticoid-regulated
kinase 1 [EC:2.7.11.1]
Length=433
Score = 139 bits (351), Expect = 4e-33, Method: Compositional matrix adjust.
Identities = 68/153 (44%), Positives = 102/153 (66%), Gaps = 4/153 (2%)
Query 21 QDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEHVKDERRILAQ 80
DF F +G GSFG+V + + E++Y A+K+L K+ ++ K+ +H+ ER +L +
Sbjct 98 SDFDFLKVIGKGSFGKVLLARHRSDEKFY---AVKVLQKKAILKKKEEKHIMSERNVLLK 154
Query 81 P-SHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYAAEITLAFQY 139
HPF+V L SFQ +L+ +++Y+NGGELF +L+++ +AR YAAEI A Y
Sbjct 155 NVKHPFLVGLHYSFQTTDKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGY 214
Query 140 VHERSIVYRDLKPENLLIDAQGHIKITDFGFVK 172
+H +IVYRDLKPEN+L+D+QGHI +TDFG K
Sbjct 215 LHSLNIVYRDLKPENILLDSQGHIILTDFGLCK 247
> mmu:23797 Akt3, AI851531, D930002M15Rik, Nmf350; thymoma viral
proto-oncogene 3 (EC:2.7.11.1); K04456 RAC serine/threonine-protein
kinase [EC:2.7.11.1]
Length=479
Score = 139 bits (351), Expect = 4e-33, Method: Compositional matrix adjust.
Identities = 72/176 (40%), Positives = 107/176 (60%), Gaps = 8/176 (4%)
Query 2 SSEVLHMVREEL-----QQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKI 56
+S++ ++ EE+ ++ + DF + +G G+FG+V +V + + ++Y A+KI
Sbjct 122 TSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYY---AMKI 178
Query 57 LSKQKVITMKQVEHVKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLR 116
L K+ +I +V H E R+L HPF+ +L SFQ + RL +MEYVNGGELF +L
Sbjct 179 LKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS 238
Query 117 KQISVPVEQARLYAAEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVK 172
++ ++ R Y AEI A Y+H IVYRDLK ENL++D GHIKITDFG K
Sbjct 239 RERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCK 294
> hsa:10000 AKT3, DKFZp434N0250, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma,
RAC-gamma, STK-2; v-akt murine thymoma viral oncogene
homolog 3 (protein kinase B, gamma) (EC:2.7.11.1); K04456
RAC serine/threonine-protein kinase [EC:2.7.11.1]
Length=479
Score = 139 bits (351), Expect = 4e-33, Method: Compositional matrix adjust.
Identities = 72/176 (40%), Positives = 107/176 (60%), Gaps = 8/176 (4%)
Query 2 SSEVLHMVREEL-----QQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKI 56
+S++ ++ EE+ ++ + DF + +G G+FG+V +V + + ++Y A+KI
Sbjct 122 TSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYY---AMKI 178
Query 57 LSKQKVITMKQVEHVKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLR 116
L K+ +I +V H E R+L HPF+ +L SFQ + RL +MEYVNGGELF +L
Sbjct 179 LKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS 238
Query 117 KQISVPVEQARLYAAEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVK 172
++ ++ R Y AEI A Y+H IVYRDLK ENL++D GHIKITDFG K
Sbjct 239 RERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCK 294
> cel:C12D8.10 akt-1; AKT kinase family member (akt-1); K04456
RAC serine/threonine-protein kinase [EC:2.7.11.1]
Length=541
Score = 139 bits (351), Expect = 4e-33, Method: Compositional matrix adjust.
Identities = 69/162 (42%), Positives = 102/162 (62%), Gaps = 3/162 (1%)
Query 11 EELQQRKLQIQDFVFYGTVGTGSFGRVCIVDLQQAEEWYPPMALKILSKQKVITMKQVEH 70
E ++ K+ ++DF F +G G+FG+V + ++ ++ Y A+KIL K +I ++V H
Sbjct 181 EAAKRDKITMEDFDFLKVLGKGTFGKVILCKEKRTQKLY---AIKILKKDVIIAREEVAH 237
Query 71 VKDERRILAQPSHPFIVNLLASFQDEKRLFLLMEYVNGGELFSYLRKQISVPVEQARLYA 130
E R+L + HPF+ L SFQ++ L +M++ NGGELF+++RK + +AR Y
Sbjct 238 TLTENRVLQRCKHPFLTELKYSFQEQHYLCFVMQFANGGELFTHVRKCGTFSEPRARFYG 297
Query 131 AEITLAFQYVHERSIVYRDLKPENLLIDAQGHIKITDFGFVK 172
AEI LA Y+H IVYRD+K ENLL+D GHIKI DFG K
Sbjct 298 AEIVLALGYLHRCDIVYRDMKLENLLLDKDGHIKIADFGLCK 339
Lambda K H
0.324 0.139 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 4859948100
Database: egene_temp_file_orthology_annotation_similarity_blast_database_966
Posted date: Sep 16, 2011 8:45 PM
Number of letters in database: 82,071,388
Number of sequences in database: 164,496
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40