bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: egene_temp_file_orthology_annotation_similarity_blast_database_966
164,496 sequences; 82,071,388 total letters
Query= Eace_0392_orf1
Length=206
Score E
Sequences producing significant alignments: (Bits) Value
pfa:PF14_0625 plasmepsin VIII (EC:3.4.17.4) 94.7 2e-19
pfa:PFC0495w plasmepsin VI (EC:3.4.23.-); K01386 [EC:3.4.23.-] 94.4 3e-19
tgo:TGME49_009620 eukaryotic aspartyl protease, putative (EC:3... 93.6 4e-19
cpv:cgd6_3820 membrane bound aspartyl proteinase with a signal... 89.0 1e-17
tgo:TGME49_062940 eukaryotic aspartyl protease, putative (EC:3... 86.3 7e-17
dre:114367 nots, LAP, MGC192423, ctsel, zgc:103608; nothepsin 78.2 2e-14
xla:373572 ctse-a, CE1, cate, ce1-A, ce2, ctse; cathepsin E (E... 77.8 2e-14
bbo:BBOV_III003510 17.m07331; eukaryotic aspartyl protease fam... 77.0 4e-14
xla:373573 ctse-b, CE2, cate, ce1, ce2-A; cathepsin E (EC:3.4.... 77.0 4e-14
mmu:13034 Ctse, A430072O03Rik, C920004C08Rik, CE, CatE; cathep... 76.6 5e-14
mmu:109820 Pgc, 2210410L06Rik, MGC117575, Upg-1, Upg1; progast... 71.2 2e-12
xla:373563 pgc-A; pepsinogen C (EC:3.4.23.3); K01377 gastricsi... 69.3 9e-12
ath:AT1G11910 aspartyl protease family protein; K08245 phyteps... 69.3 9e-12
hsa:1510 CTSE, CATE; cathepsin E (EC:3.4.23.34); K01382 cathep... 68.9 1e-11
xla:373564 pga4, pga-A; pepsinogen 4, group I (pepsinogen A); ... 68.2 2e-11
ath:AT1G62290 aspartyl protease family protein; K08245 phyteps... 66.2 7e-11
hsa:5222 PGA5, PGA3, PGA4; pepsinogen 5, group I (pepsinogen A... 65.9 9e-11
tpv:TP03_0056 cathepsin E (EC:3.4.23.34); K01386 [EC:3.4.23.-] 64.7 2e-10
hsa:643834 PGA3, DKFZp666J2410, PGA4, PGA5; pepsinogen 3, grou... 63.9 3e-10
hsa:643847 PGA4, FLJ58952, FLJ77962, PGA3, PGA5; pepsinogen 4,... 63.9 3e-10
xla:443721 ctsd; cathepsin D (EC:3.4.23.5); K01379 cathepsin D... 62.4 1e-09
ath:AT4G04460 aspartyl protease family protein; K08245 phyteps... 60.1 5e-09
xla:443829 MGC82347 protein; K01379 cathepsin D [EC:3.4.23.5] 59.7 6e-09
mmu:16541 Napsa, KAP, Kdap, NAP1, SNAPA, pronapsin; napsin A a... 59.3 8e-09
dre:65225 ctsd, catD, fb93e11, fj17b09, wu:fb93e11, wu:fj17b09... 59.3 9e-09
mmu:58803 Pga5, 1110035E17Rik, Pepf; pepsinogen 5, group I (EC... 58.5 2e-08
xla:398557 cathepsin D (EC:3.4.23.5); K01379 cathepsin D [EC:3... 56.2 9e-08
hsa:9476 NAPSA, KAP, Kdap, NAP1, NAPA, SNAPA; napsin A asparti... 55.8 9e-08
mmu:19701 Ren1, D19352, Ren, Ren-1, Ren-A, Ren1c, Ren1d, Rn-1,... 55.8 9e-08
mmu:100044656 renin-1-like 55.8 9e-08
xla:398994 napsa, MGC68767, kap, kdap, nap1, napa, snapa; naps... 55.1 2e-07
ath:AT1G69100 aspartic-type endopeptidase 54.7 2e-07
mmu:19702 Ren2, Ren, Ren-2, Ren-B, Rn-2, Rnr; renin 2 tandem d... 54.7 2e-07
cel:R12H7.2 asp-4; ASpartyl Protease family member (asp-4); K0... 54.7 2e-07
mmu:229697 Cym, Gm131; chymosin (EC:3.4.23.4); K01378 chymosin... 53.9 3e-07
hsa:5972 REN, FLJ10761, HNFJ2; renin (EC:3.4.23.15); K01380 re... 53.9 4e-07
dre:336746 fa94d12, wu:fa94d12; zgc:63831; K01379 cathepsin D ... 53.5 5e-07
hsa:1509 CTSD, CLN10, CPSD, MGC2311; cathepsin D (EC:3.4.23.5)... 51.2 3e-06
mmu:13033 Ctsd, CD, CatD; cathepsin D (EC:3.4.23.5); K01379 ca... 51.2 3e-06
dre:405786 ren; renin (EC:3.4.23.15); K01380 renin [EC:3.4.23.15] 49.3 9e-06
pfa:PF14_0076 plasmepsin I; K06007 plasmepsin I [EC:3.4.23.38] 49.3 1e-05
pfa:PF14_0075 plasmepsin IV 47.8 3e-05
cel:H22K11.1 asp-3; ASpartyl Protease family member (asp-3); K... 47.4 3e-05
sce:YPL154C PEP4, PHO9, PRA1, yscA; Pep4p (EC:3.4.23.25); K013... 46.6 6e-05
dre:100330180 cathepsin D-like 46.2 7e-05
hsa:5225 PGC, FLJ99563, PEPC, PGII; progastricsin (pepsinogen ... 45.8 1e-04
pfa:PF14_0077 plasmepsin II; K06008 plasmepsin II [EC:3.4.23.39] 45.4 1e-04
ath:AT4G22050 aspartyl protease family protein 43.5 5e-04
tpv:TP01_0692 pepsinogen; K06002 pepsin A [EC:3.4.23.1] 42.7 0.001
tgo:TGME49_046550 eukaryotic aspartyl protease, putative (EC:3... 41.6 0.002
> pfa:PF14_0625 plasmepsin VIII (EC:3.4.17.4)
Length=385
Score = 94.7 bits (234), Expect = 2e-19, Method: Compositional matrix adjust.
Identities = 56/204 (27%), Positives = 96/204 (47%), Gaps = 33/204 (16%)
Query 32 FAAGSSNTWVPSISCHVTSC---------------------------ASGYIESVTGRDS 64
F GS+N W+PS +C +C +G I D
Sbjct 79 FDTGSTNLWIPSKNCFTRACYNKRKYDHKISKNYKLVKKKDPVEILFGTGEIHIAYVTDD 138
Query 65 LHLENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQHEQGSSSLIHLLLEAGAIKRA 124
+HL + + + FG + PFS++ FDG+ GLG ++ LI+ + +++
Sbjct 139 IHLGDIKVKNQEFGLASYISDDPFSDMQFDGLFGLGISD-DKKKKQLIYDSIPKNILEKN 197
Query 125 MFSIALPLSASSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDEATV 184
MF+I P + G ITFGG++ ++++ ++I WF + + K W +++ + I++ +
Sbjct 198 MFAIYYPKNVDDDGAITFGGYDKKFIRE-NSSIEWFDVTSS--KYWAIQMKGLKINDVFL 254
Query 185 GVCTPQLP--CTAVIDTGTSGIGG 206
VC+ C AVIDTGTS I G
Sbjct 255 DVCSKNHEGFCQAVIDTGTSSIAG 278
> pfa:PFC0495w plasmepsin VI (EC:3.4.23.-); K01386 [EC:3.4.23.-]
Length=432
Score = 94.4 bits (233), Expect = 3e-19, Method: Compositional matrix adjust.
Identities = 69/237 (29%), Positives = 103/237 (43%), Gaps = 45/237 (18%)
Query 6 HSESSLTRVRVGALSAVYVAVLKRYYFAAGSSNTWVPSISCHVTSCAS------------ 53
H+ + + VG V+ V F GSSN +PS C CAS
Sbjct 96 HNSQFIADIGVGNPPQVFKVV-----FDTGSSNLAIPSTKCIKGGCASHKKFNPNKSRTF 150
Query 54 ------------GYIESVTGR-------DSLHLENATLHDFAFGFVVQQPEYPFSELPFD 94
YI+ TG D ++L+ + G +++ +PFS+LPFD
Sbjct 151 TKNLKNNQESVYTYIQYGTGTSILEQSYDDVYLKGLKIKHQCIGLAIEESLHPFSDLPFD 210
Query 95 GIAGLGCPQ-----HEQGSSSLIHLLLEAGAIKRAMFSIALPLSASSAGEITFGGFNPSY 149
GI GLG + +S LI + + +KR +FS +P +G ITFG N Y
Sbjct 211 GIVGLGFSDPDFRSQNKYASPLIETIKKQNLLKRNIFSFYVPKKLEKSGAITFGKANKKY 270
Query 150 VQKGTAAIAWFPLLPNPRKKWELRLWDVLIDEATVGVCTPQLPCTAVIDTGTSGIGG 206
+G +I WFP++ WE+ L D+ + + +C + C A IDTG+S I G
Sbjct 271 TVEG-KSIEWFPVI--SLYYWEINLLDIQLSHKNLFLCESK-KCRAAIDTGSSLITG 323
> tgo:TGME49_009620 eukaryotic aspartyl protease, putative (EC:3.4.23.34)
Length=432
Score = 93.6 bits (231), Expect = 4e-19, Method: Compositional matrix adjust.
Identities = 70/225 (31%), Positives = 100/225 (44%), Gaps = 53/225 (23%)
Query 32 FAAGSSNTWVPSISCHVTSCA------------------SGYIESVT-----GR------ 62
F GS + W+PS C +SC +G+ E VT GR
Sbjct 86 FDTGSHHFWIPSNECQASSCRAHSRFDGSRSSSFRHHSNNGWNECVTVTFGTGRVVYRKA 145
Query 63 -DSLHLENATLHDFAFGFVVQQPEYPFSELPFDGIAGLG---------C---------PQ 103
+++ + +A + A G VV Q + PF +LPFDGI GLG C
Sbjct 146 LEAIRIGDAAIPSQAVGLVVDQTDEPFVDLPFDGIVGLGEYFVVYTGMCLSRSSCLAGSY 205
Query 104 HEQGSSSLIHLLLEAGAIKRAMFSIALPLSASSAGEITFGGFNPSYVQKGTAAIAWFPLL 163
G L+ L I +F++ L G I+FGGF+P +VQ+G I WF L
Sbjct 206 ERSGQKDLLDNLKTERVIADKIFAVYLSRRRVMGGVISFGGFDPRFVQQG-KNIQWFATL 264
Query 164 PNPRKKWELRLWDVLIDEATVGVC--TPQLPCTAVIDTGTSGIGG 206
P++ W + L D +D + +C + + C AV+DTGTS IGG
Sbjct 265 --PQEGWAIPLIDFKVDGVRLHLCFDSAESRCVAVLDTGTSSIGG 307
> cpv:cgd6_3820 membrane bound aspartyl proteinase with a signal
peptide plus transmembrane domain
Length=467
Score = 89.0 bits (219), Expect = 1e-17, Method: Compositional matrix adjust.
Identities = 58/221 (26%), Positives = 98/221 (44%), Gaps = 41/221 (18%)
Query 13 RVRVGALSAVYVAVLKRYYFAAGSSNTWVPSISCHVTSCA-------------------- 52
++ VG +V + F GSS+ W+PSI C C
Sbjct 99 KIEVGTPPREFVVI-----FDTGSSSVWIPSIECKHKGCEPHNKYDPKLSTSYQKLGDGS 153
Query 53 -SGYIESVT-------GRDSLHLENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQH 104
YI+ T G++ +++ + D +FG +++ PF+ELPFDG+ GLG P
Sbjct 154 LETYIQYGTGSCVLKFGKEVINIGKLKIEDQSFGMAIEESTSPFAELPFDGLVGLGFPDK 213
Query 105 EQGSS---SLIHLLLEAGAIKRAMFSIALPLSASSAGEITFGGFNPSYVQKGTAAIAWFP 161
+ +++ + E + R +F + + +S+ G I+FG +P Y G I W
Sbjct 214 NSKKNNIPTIVENIKERNILPRNLFGVYISRDSSTPGSISFGAADPKYTISG-QKITWHR 272
Query 162 LLPNPRKKWELRLWDVLIDEATVGVCTPQLPCTAVIDTGTS 202
L + WE+++ D+ I+ + C C A IDTG+S
Sbjct 273 LTGS--HYWEIKIKDIKINGVSTNYCFGD--CKAAIDTGSS 309
> tgo:TGME49_062940 eukaryotic aspartyl protease, putative (EC:3.4.23.34)
Length=469
Score = 86.3 bits (212), Expect = 7e-17, Method: Compositional matrix adjust.
Identities = 61/238 (25%), Positives = 107/238 (44%), Gaps = 46/238 (19%)
Query 6 HSESSLTRVRVGALSAVYVAVLKRYYFAAGSSNTWVPSISCHVTSC-------------- 51
H+ ++VG ++ V F GSSN W+P+ C C
Sbjct 100 HNSQYFGEIQVGTPPVSFIVV-----FDTGSSNLWIPASECKQGGCVPHTRFDPKTSSTY 154
Query 52 ----------ASGYIESVTG-------RDSLHLENATLHDFAFGFVVQQPEYPFSELPFD 94
A +I+ TG +D++ + + + G +Q+ +PF++LPFD
Sbjct 155 LPINAGAGEPAIAFIQYGTGACVLRMAKDTVSIGGIRVQNQTLGLALQESVHPFADLPFD 214
Query 95 GIAGLGCPQ--HEQG----SSSLIHLLLEAGAIKRAMFSIALPLSASSAGEITFGGFNPS 148
G+ GLG P E+G + L+ +++ +KR F++ + + GEITFG NP
Sbjct 215 GLVGLGFPDVAGEEGLPPDALPLVDSMMKQKLLKRNAFAVYMSEDLNQPGEITFGSVNPR 274
Query 149 YVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDEATVGVCTPQLPCTAVIDTGTSGIGG 206
+ +G WFP++ WE+ + + ++ ++G C + C A +DTG+S I G
Sbjct 275 HTFEGHKP-QWFPVI--SLDYWEVGVHGLRLNRKSLGFCE-RTRCKAAVDTGSSLITG 328
> dre:114367 nots, LAP, MGC192423, ctsel, zgc:103608; nothepsin
Length=416
Score = 78.2 bits (191), Expect = 2e-14, Method: Compositional matrix adjust.
Identities = 59/202 (29%), Positives = 89/202 (44%), Gaps = 32/202 (15%)
Query 32 FAAGSSNTWVPSISCHVTSCA-------------------------SGYIESVTGRDSLH 66
F GSS+ WVPS C +CA SG++ V RD L
Sbjct 103 FDTGSSDLWVPSSYCVTQACALHNKFKAFESSTYTHDGRVFGIHYGSGHLLGVMARDELK 162
Query 67 LENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQ-HEQGSSSLIHLLLEAGAIKRAM 125
+ + + + FG V +P + F FDG+ GLG PQ E+ S + ++E + + +
Sbjct 163 VGSVRVQNQVFGEAVYEPGFSFVLAQFDGVLGLGFPQLAEEKGSPVFDTMMEQNMLDQPV 222
Query 126 FSIALPLSASS-AGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDEATV 184
FS L + S GE+ FG + S + I W P+ + W+++L V + A
Sbjct 223 FSFYLTNNGSGFGGELVFGANDES---RFLPPINWIPV--TQKGYWQIKLDAVKVQGALS 277
Query 185 GVCTPQLPCTAVIDTGTSGIGG 206
C A++DTGTS IGG
Sbjct 278 FSDRSVQGCQAIVDTGTSLIGG 299
> xla:373572 ctse-a, CE1, cate, ce1-A, ce2, ctse; cathepsin E
(EC:3.4.23.34); K01382 cathepsin E [EC:3.4.23.34]
Length=397
Score = 77.8 bits (190), Expect = 2e-14, Method: Compositional matrix adjust.
Identities = 60/203 (29%), Positives = 96/203 (47%), Gaps = 36/203 (17%)
Query 32 FAAGSSNTWVPSISCHVTSCA-------------------------SGYIESVTGRDSLH 66
F GSSN WVPS+ C +CA +G + V G D++
Sbjct 91 FDTGSSNLWVPSVYCISQACAQHDRFQPQLSSTYESNGNNFSLQYGTGSLSGVIGIDAVT 150
Query 67 LENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQHEQGSSS-LIHLLLEAGAIKRAM 125
+E + + FG V +P F + FDGI GLG P G + + ++ ++ M
Sbjct 151 VEGILVQNQQFGESVSEPGSTFVDAEFDGILGLGYPSIAVGDCTPVFDNMIAQNLVELPM 210
Query 126 FSIALPLSASSA--GEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDEAT 183
FS+ + + +SA GE+ FGGF+ S + + + W P+ + W+++L +V I+
Sbjct 211 FSVYMSRNPNSAVGGELVFGGFDAS---RFSGQLNWVPV--TNQGYWQIQLDNVQIN-GE 264
Query 184 VGVCTPQLPCTAVIDTGTSGIGG 206
V C+ C A++DTGTS I G
Sbjct 265 VLFCSGG--CQAIVDTGTSLITG 285
> bbo:BBOV_III003510 17.m07331; eukaryotic aspartyl protease family
protein
Length=521
Score = 77.0 bits (188), Expect = 4e-14, Method: Compositional matrix adjust.
Identities = 58/226 (25%), Positives = 97/226 (42%), Gaps = 43/226 (19%)
Query 13 RVRVGALSAVYVAVLKRYYFAAGSSNTWVPSISCHVTSC--------------------- 51
+ VG +V V F GSS W+PS C T C
Sbjct 152 EIEVGTPPEKFVVV-----FDTGSSQLWIPSKECSSTGCSTHRKFDAKGSSTYKKAPLDA 206
Query 52 ASGYIESVTGR-------DSLHLENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCP-- 102
A+ YI+ TG D++ + + + + G + ++PF +LPFDG+ GLG P
Sbjct 207 ANAYIQYGTGECVLALGSDTVKIGPLEVKNQSIGLATYESDHPFGDLPFDGLVGLGFPDK 266
Query 103 --QHEQGSSSLIHLLLEAGAIKRAMFSIALPLSASSAGEITFGGFNPSYVQKGTAAIAWF 160
+ G L+ +++ + R + + + + G ++FG +P YV G + WF
Sbjct 267 MYKDTDGMLPLLDNIMQQKLLNRNLVAFYMSKDKTQPGSMSFGSIDPRYVLPGHSP-WWF 325
Query 161 PLLPNPRKKWELRLWDVLIDEATVGVCTPQLPCTAVIDTGTSGIGG 206
P++ WE+ + +LID + + + A IDTG+S I G
Sbjct 326 PVVAT--DFWEIAMEAILIDGKPMKL---ENKYNAAIDTGSSLISG 366
> xla:373573 ctse-b, CE2, cate, ce1, ce2-A; cathepsin E (EC:3.4.23.34);
K01382 cathepsin E [EC:3.4.23.34]
Length=397
Score = 77.0 bits (188), Expect = 4e-14, Method: Compositional matrix adjust.
Identities = 59/203 (29%), Positives = 94/203 (46%), Gaps = 36/203 (17%)
Query 32 FAAGSSNTWVPSISCHVTSCA-------------------------SGYIESVTGRDSLH 66
F GSSN WVPS+ C +CA +G + V G DS+
Sbjct 91 FDTGSSNLWVPSVYCISPACAQHNRFQPQLSSTYESNGNNFSLQYGTGSLSGVIGIDSVT 150
Query 67 LENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQHEQGSSS-LIHLLLEAGAIKRAM 125
+E + + FG V +P F + FDGI GLG P G + + ++ ++ M
Sbjct 151 VEGILVQNQQFGESVSEPGSTFVDASFDGILGLGYPSIAVGGCTPVFDNMIAQNLVELPM 210
Query 126 FSIALPLSASS--AGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDEAT 183
FS+ + +S GE+ FGGF+ S + + + W P+ + W+++L ++ I+
Sbjct 211 FSVYMSRDPNSPVGGELVFGGFDAS---RFSGQLNWVPV--TNQGYWQIQLDNIQINGEV 265
Query 184 VGVCTPQLPCTAVIDTGTSGIGG 206
V C+ C A++DTGTS I G
Sbjct 266 V-FCSGG--CQAIVDTGTSMITG 285
> mmu:13034 Ctse, A430072O03Rik, C920004C08Rik, CE, CatE; cathepsin
E (EC:3.4.23.34); K01382 cathepsin E [EC:3.4.23.34]
Length=397
Score = 76.6 bits (187), Expect = 5e-14, Method: Compositional matrix adjust.
Identities = 58/203 (28%), Positives = 91/203 (44%), Gaps = 36/203 (17%)
Query 32 FAAGSSNTWVPSISCHVTSC-------------------------ASGYIESVTGRDSLH 66
F GSSN WVPS+ C +C +G + + G D +
Sbjct 96 FDTGSSNLWVPSVYCTSPACKAHPVFHPSQSDTYTEVGNHFSIQYGTGSLTGIIGADQVS 155
Query 67 LENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQHEQGS-SSLIHLLLEAGAIKRAM 125
+E T+ FG V++P F FDGI GLG P G + + ++ + M
Sbjct 156 VEGLTVDGQQFGESVKEPGQTFVNAEFDGILGLGYPSLAAGGVTPVFDNMMAQNLVALPM 215
Query 126 FSIALPLS--ASSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDEAT 183
FS+ L S E+TFGG++PS+ + ++ W P+ + W++ L + + + T
Sbjct 216 FSVYLSSDPQGGSGSELTFGGYDPSHF---SGSLNWIPV--TKQAYWQIALDGIQVGD-T 269
Query 184 VGVCTPQLPCTAVIDTGTSGIGG 206
V C+ C A++DTGTS I G
Sbjct 270 VMFCSEG--CQAIVDTGTSLITG 290
> mmu:109820 Pgc, 2210410L06Rik, MGC117575, Upg-1, Upg1; progastricsin
(pepsinogen C) (EC:3.4.23.3); K01377 gastricsin [EC:3.4.23.3]
Length=392
Score = 71.2 bits (173), Expect = 2e-12, Method: Compositional matrix adjust.
Identities = 52/198 (26%), Positives = 84/198 (42%), Gaps = 33/198 (16%)
Query 32 FAAGSSNTWVPSISCHVTSC-------------------------ASGYIESVTGRDSLH 66
F GSSN WV S+ C +C +G + G D+L
Sbjct 93 FDTGSSNLWVSSVYCQSEACTTHTRYNPSKSSTYYTQGQTFSLQYGTGSLTGFFGYDTLR 152
Query 67 LENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQ-HEQGSSSLIHLLLEAGAIKRAM 125
+++ + + FG +P F FDGI GL P G+++ + +L GA+ + +
Sbjct 153 VQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPGLSSGGATTALQGMLGEGALSQPL 212
Query 126 FSIAL-PLSASSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDEATV 184
F + L S+ G+I FGG + + T + W P+ W++ + D LI
Sbjct 213 FGVYLGSQQGSNGGQIVFGGVDENLY---TGELTWIPV--TQELYWQITIDDFLIGNQAS 267
Query 185 GVCTPQLPCTAVIDTGTS 202
G C+ C ++DTGTS
Sbjct 268 GWCSSS-GCQGIVDTGTS 284
> xla:373563 pgc-A; pepsinogen C (EC:3.4.23.3); K01377 gastricsin
[EC:3.4.23.3]
Length=383
Score = 69.3 bits (168), Expect = 9e-12, Method: Compositional matrix adjust.
Identities = 50/198 (25%), Positives = 84/198 (42%), Gaps = 34/198 (17%)
Query 32 FAAGSSNTWVPSISCHVTSC-------------------------ASGYIESVTGRDSLH 66
F GSSN WV S C +C +G + + G D++
Sbjct 84 FDTGSSNLWVASTYCQSQACTNHPLFNPSQSSTYSSNQQQFSLQYGTGSLTGILGYDTVT 143
Query 67 LENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQHE-QGSSSLIHLLLEAGAIKRAM 125
++N + FG +P F FDGI GL P G+++++ +++ + + +
Sbjct 144 IQNVAISQQEFGLSETEPGTNFVYAQFDGILGLAYPSIAVGGATTVMQGMMQQNLLNQPI 203
Query 126 FSIALP-LSASSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDEATV 184
F L S+ + GE+ FGG + +Y T I W P+ W++ + I+
Sbjct 204 FGFYLSGQSSQNGGEVAFGGVDQNYY---TGQIYWTPV--TSETYWQIGIQGFSINGQAT 258
Query 185 GVCTPQLPCTAVIDTGTS 202
G C+ C A++DTGTS
Sbjct 259 GWCSQ--GCQAIVDTGTS 274
> ath:AT1G11910 aspartyl protease family protein; K08245 phytepsin
[EC:3.4.23.40]
Length=506
Score = 69.3 bits (168), Expect = 9e-12, Method: Compositional matrix adjust.
Identities = 65/251 (25%), Positives = 102/251 (40%), Gaps = 56/251 (22%)
Query 5 NHSESSLTRVRVGALSAVYVAVLKRYY--------------------FAAGSSNTWVPSI 44
+ E L R+G V VLK Y F GSSN WVPS
Sbjct 52 SKQEKPLRAYRLGDSGDADVVVLKNYLDAQYYGEIAIGTPPQKFTVVFDTGSSNLWVPSS 111
Query 45 SCHVT-SC-------------------------ASGYIESVTGRDSLHLENATLHDFAFG 78
C+ + +C +G I D++ + + + D F
Sbjct 112 KCYFSLACLLHPKYKSSRSSTYEKNGKAAAIHYGTGAIAGFFSNDAVTVGDLVVKDQEFI 171
Query 79 FVVQQPEYPFSELPFDGIAGLGCPQHEQGSSSLI-HLLLEAGAIKRAMFSIALPLSAS-- 135
++P F FDGI GLG + G ++ + + +L+ G IK +FS L +A
Sbjct 172 EATKEPGITFVVAKFDGILGLGFQEISVGKAAPVWYNMLKQGLIKEPVFSFWLNRNADEE 231
Query 136 SAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDEATVGVCTPQLPCTA 195
GE+ FGG +P++ + + P+ + W+ + DVLI A G C + C+A
Sbjct 232 EGGELVFGGVDPNHFK---GKHTYVPV--TQKGYWQFDMGDVLIGGAPTGFC--ESGCSA 284
Query 196 VIDTGTSGIGG 206
+ D+GTS + G
Sbjct 285 IADSGTSLLAG 295
> hsa:1510 CTSE, CATE; cathepsin E (EC:3.4.23.34); K01382 cathepsin
E [EC:3.4.23.34]
Length=396
Score = 68.9 bits (167), Expect = 1e-11, Method: Compositional matrix adjust.
Identities = 54/203 (26%), Positives = 90/203 (44%), Gaps = 36/203 (17%)
Query 32 FAAGSSNTWVPSISCHVTSC-------------------------ASGYIESVTGRDSLH 66
F GSSN WVPS+ C +C +G + + G D +
Sbjct 95 FDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVS 154
Query 67 LENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQHEQGS-SSLIHLLLEAGAIKRAM 125
+E T+ FG V +P F + FDGI GLG P G + + ++ + M
Sbjct 155 VEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPM 214
Query 126 FSIALPLS--ASSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDEAT 183
FS+ + + + E+ FGG++ S+ + ++ W P+ + W++ L ++ + T
Sbjct 215 FSVYMSSNPEGGAGSELIFGGYDHSHF---SGSLNWVPV--TKQAYWQIALDNIQVG-GT 268
Query 184 VGVCTPQLPCTAVIDTGTSGIGG 206
V C+ C A++DTGTS I G
Sbjct 269 VMFCSEG--CQAIVDTGTSLITG 289
> xla:373564 pga4, pga-A; pepsinogen 4, group I (pepsinogen A);
K06002 pepsin A [EC:3.4.23.1]
Length=384
Score = 68.2 bits (165), Expect = 2e-11, Method: Compositional matrix adjust.
Identities = 52/201 (25%), Positives = 84/201 (41%), Gaps = 34/201 (16%)
Query 32 FAAGSSNTWVPSISCHVTSCA-------------------------SGYIESVTGRDSLH 66
F GS+N WVPS+ C +C+ +G + G D+L
Sbjct 89 FDTGSANLWVPSVYCSSQACSNHNRFNPQQSSTFQATNTPVSIQYGTGSMSGFLGYDTLQ 148
Query 67 LENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQHEQGSSS-LIHLLLEAGAIKRAM 125
+ N + + FG +P PFDGI GL P ++ + + G I + +
Sbjct 149 VGNIQISNQMFGLSESEPGSFLYYSPFDGILGLAFPSIASSQATPVFDNMWSQGLIPQNL 208
Query 126 FSIALPLSASSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDEATVG 185
FS+ L + + FGG + SY + ++ W PL W++ L V I+ +
Sbjct 209 FSVYLSSDGQTGSYVLFGGVDNSYY---SGSLNWVPL--TAETYWQITLDSVSINGQVIA 263
Query 186 VCTPQLPCTAVIDTGTSGIGG 206
C+ C A++DTGTS + G
Sbjct 264 -CSQS--CQAIVDTGTSLMTG 281
> ath:AT1G62290 aspartyl protease family protein; K08245 phytepsin
[EC:3.4.23.40]
Length=513
Score = 66.2 bits (160), Expect = 7e-11, Method: Compositional matrix adjust.
Identities = 58/204 (28%), Positives = 88/204 (43%), Gaps = 36/204 (17%)
Query 32 FAAGSSNTWVPSISCHVT-SC-------------------------ASGYIESVTGRDSL 65
F GSSN WVPS C + SC SG I D++
Sbjct 106 FDTGSSNLWVPSGKCFFSLSCYFHAKYKSSRSSTYKKSGKRAAIHYGSGSISGFFSYDAV 165
Query 66 HLENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQHEQGSSSLI-HLLLEAGAIKRA 124
+ + + D F +P F FDG+ GLG + G+++ + + +L+ G IKR
Sbjct 166 TVGDLVVKDQEFIETTSEPGLTFLVAKFDGLLGLGFQEIAVGNATPVWYNMLKQGLIKRP 225
Query 125 MFSIALPLSASS--AGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDEA 182
+FS L S GEI FGG +P + + + P+ R W+ + +VLI
Sbjct 226 VFSFWLNRDPKSEEGGEIVFGGVDPKHFR---GEHTFVPV--TQRGYWQFDMGEVLIAGE 280
Query 183 TVGVCTPQLPCTAVIDTGTSGIGG 206
+ G C C+A+ D+GTS + G
Sbjct 281 STGYCGSG--CSAIADSGTSLLAG 302
> hsa:5222 PGA5, PGA3, PGA4; pepsinogen 5, group I (pepsinogen
A) (EC:3.4.23.1); K06002 pepsin A [EC:3.4.23.1]
Length=388
Score = 65.9 bits (159), Expect = 9e-11, Method: Compositional matrix adjust.
Identities = 49/201 (24%), Positives = 83/201 (41%), Gaps = 34/201 (16%)
Query 32 FAAGSSNTWVPSISCHVTSC-------------------------ASGYIESVTGRDSLH 66
F GSSN WVPS+ C +C +G + + G D++
Sbjct 93 FDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQ 152
Query 67 LENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQ-HEQGSSSLIHLLLEAGAIKRAM 125
+ + + FG +P PFDGI GL P G++ + + G + + +
Sbjct 153 VGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDL 212
Query 126 FSIALPLSASSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDEATVG 185
FS+ L S + FGG + SY T ++ W P+ W++ + + ++ T+
Sbjct 213 FSVYLSADDKSGSVVIFGGIDSSYY---TGSLNWVPV--TVEGYWQITVDSITMNGETIA 267
Query 186 VCTPQLPCTAVIDTGTSGIGG 206
C A++DTGTS + G
Sbjct 268 CAE---GCQAIVDTGTSLLTG 285
> tpv:TP03_0056 cathepsin E (EC:3.4.23.34); K01386 [EC:3.4.23.-]
Length=513
Score = 64.7 bits (156), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 63/236 (26%), Positives = 95/236 (40%), Gaps = 56/236 (23%)
Query 13 RVRVGALSAVYVAVLKRYYFAAGSSNTWVPSISC--HVTS-CA----------------- 52
++VG +V V F GSS W+PS +C H ++ CA
Sbjct 164 EIQVGTPPKSFVVV-----FDTGSSQLWIPSKACLNHSSNGCARHRMFDSSASTTYEPMM 218
Query 53 ------SGYIESVTGR-------DSLHLENATLHDFAFGFVVQQPEYPFSELPFDGIAGL 99
S YI TG D++ + + + + G V + E+PF +LPFDG+ GL
Sbjct 219 KGDEMMSEYIRYGTGECVLALGFDNVKIGSLNVKHQSIGLSVLESEHPFGDLPFDGLVGL 278
Query 100 GCPQHEQGSSSLIHLLLEA---------GAIKRAMFSIALPLSASSAGEITFGGFNPSYV 150
G P E S + + ++ + R L S G ++FG +P YV
Sbjct 279 GFPDTELKESKKLTPIFDSIRNQVPLTYSTVNRIFNCYNL---TKSPGSLSFGSIDPKYV 335
Query 151 QKGTAAIAWFPLLPNPRKKWELRLWDVLIDEATVGVCTPQLPCTAVIDTGTSGIGG 206
G WFP++ WE+ + +L+D V A IDTG+S I G
Sbjct 336 LPGHKP-WWFPVVKT--DYWEIEVSSLLVDGEPVQF---DRKYNAAIDTGSSLISG 385
> hsa:643834 PGA3, DKFZp666J2410, PGA4, PGA5; pepsinogen 3, group
I (pepsinogen A) (EC:3.4.23.1); K06002 pepsin A [EC:3.4.23.1]
Length=388
Score = 63.9 bits (154), Expect = 3e-10, Method: Compositional matrix adjust.
Identities = 48/201 (23%), Positives = 82/201 (40%), Gaps = 34/201 (16%)
Query 32 FAAGSSNTWVPSISCHVTSC-------------------------ASGYIESVTGRDSLH 66
F GSSN WVPS+ C +C +G + + G D++
Sbjct 93 FDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQ 152
Query 67 LENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQ-HEQGSSSLIHLLLEAGAIKRAM 125
+ + + FG +P PFDGI GL P G++ + + G + + +
Sbjct 153 VGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDL 212
Query 126 FSIALPLSASSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDEATVG 185
FS+ L S + FGG + SY T ++ W P+ W++ + + ++ +
Sbjct 213 FSVYLSADDQSGSVVIFGGIDSSYY---TGSLNWVPV--TVEGYWQITVDSITMNGEAIA 267
Query 186 VCTPQLPCTAVIDTGTSGIGG 206
C A++DTGTS + G
Sbjct 268 CAE---GCQAIVDTGTSLLTG 285
> hsa:643847 PGA4, FLJ58952, FLJ77962, PGA3, PGA5; pepsinogen
4, group I (pepsinogen A) (EC:3.4.23.1); K06002 pepsin A [EC:3.4.23.1]
Length=388
Score = 63.9 bits (154), Expect = 3e-10, Method: Compositional matrix adjust.
Identities = 48/201 (23%), Positives = 82/201 (40%), Gaps = 34/201 (16%)
Query 32 FAAGSSNTWVPSISCHVTSC-------------------------ASGYIESVTGRDSLH 66
F GSSN WVPS+ C +C +G + + G D++
Sbjct 93 FDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQ 152
Query 67 LENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQ-HEQGSSSLIHLLLEAGAIKRAM 125
+ + + FG +P PFDGI GL P G++ + + G + + +
Sbjct 153 VGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDL 212
Query 126 FSIALPLSASSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDEATVG 185
FS+ L S + FGG + SY T ++ W P+ W++ + + ++ +
Sbjct 213 FSVYLSADDQSGSVVIFGGIDSSYY---TGSLNWVPV--TVEGYWQITVDSITMNGEAIA 267
Query 186 VCTPQLPCTAVIDTGTSGIGG 206
C A++DTGTS + G
Sbjct 268 CAE---GCQAIVDTGTSLLTG 285
> xla:443721 ctsd; cathepsin D (EC:3.4.23.5); K01379 cathepsin
D [EC:3.4.23.5]
Length=399
Score = 62.4 bits (150), Expect = 1e-09, Method: Compositional matrix adjust.
Identities = 56/207 (27%), Positives = 91/207 (43%), Gaps = 42/207 (20%)
Query 32 FAAGSSNTWVPSISC------------HVTSCASGYIE------------SVTG---RDS 64
F GSSN WVPS+ C + +S +S Y+ S+TG +D+
Sbjct 96 FDTGSSNLWVPSVHCSFWDIACWLHHKYDSSKSSTYVNNGTAFAIQYGSGSLTGYLSKDT 155
Query 65 LHLENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQHE-QGSSSLIHLLLEAGAIKR 123
+ + + + F V+QP F FDGI G+G P+ G + ++E +
Sbjct 156 VTIGDLAVKGQLFAEAVKQPGITFVAAKFDGILGMGYPRISVDGVPPVFDDIMEQKLVDS 215
Query 124 AMFSIALPLSASS--AGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDE 181
+FS L + + GE+ GG +P+Y F + RK + W + +D+
Sbjct 216 NLFSFYLNRNPDTQPGGELLLGGTDPTYYTGD------FSYMNVTRKAY----WQIRMDQ 265
Query 182 ATVG--VCTPQLPCTAVIDTGTSGIGG 206
+VG + + C A++DTGTS I G
Sbjct 266 LSVGDQLTLCKGGCEAIVDTGTSLITG 292
> ath:AT4G04460 aspartyl protease family protein; K08245 phytepsin
[EC:3.4.23.40]
Length=508
Score = 60.1 bits (144), Expect = 5e-09, Method: Compositional matrix adjust.
Identities = 51/204 (25%), Positives = 86/204 (42%), Gaps = 36/204 (17%)
Query 32 FAAGSSNTWVPSISCHVT-SC-------------------------ASGYIESVTGRDSL 65
F GSSN W+PS C+++ +C +G I D +
Sbjct 104 FDTGSSNLWIPSTKCYLSVACYFHSKYKASQSSSYRKNGKPASIRYGTGAISGYFSNDDV 163
Query 66 HLENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQHEQGSSSLI-HLLLEAGAIKRA 124
+ + + + F +P F FDGI GLG + G+S+ + + ++E G +K
Sbjct 164 KVGDIVVKEQEFIEATSEPGITFLLAKFDGILGLGFKEISVGNSTPVWYNMVEKGLVKEP 223
Query 125 MFSIALPLSASS--AGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDEA 182
+FS L + GEI FGG +P + + + P+ + W+ + D+ I
Sbjct 224 IFSFWLNRNPKDPEGGEIVFGGVDPKHFK---GEHTFVPV--THKGYWQFDMGDLQIAGK 278
Query 183 TVGVCTPQLPCTAVIDTGTSGIGG 206
G C C+A+ D+GTS + G
Sbjct 279 PTGYCAK--GCSAIADSGTSLLTG 300
> xla:443829 MGC82347 protein; K01379 cathepsin D [EC:3.4.23.5]
Length=401
Score = 59.7 bits (143), Expect = 6e-09, Method: Compositional matrix adjust.
Identities = 55/207 (26%), Positives = 89/207 (42%), Gaps = 42/207 (20%)
Query 32 FAAGSSNTWVPSISCHV------------TSCASGYIESVT---------------GRDS 64
F GSSN WVPS+ C + +S +S Y+++ T +D+
Sbjct 98 FDTGSSNLWVPSVHCSMFDIACWMHHKYDSSKSSTYVKNGTEFAIQYGTGSLSGYLSKDT 157
Query 65 LHLENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQHE-QGSSSLIHLLLEAGAIKR 123
+ + N + + FG ++QP F FDGI G+ P G S + ++ ++
Sbjct 158 VTIGNLGIKEQLFGEAIKQPGVTFIAAKFDGILGMAYPIISVDGVSPVFDNIMAQKLVES 217
Query 124 AMFSIALPLSASS--AGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDE 181
+FS L + + GE+ GG +P Y F L RK + W + +D+
Sbjct 218 NVFSFYLNRNPDTQPGGELLLGGTDPKYY------TGDFHYLNVTRKAY----WQIHMDQ 267
Query 182 ATVG--VCTPQLPCTAVIDTGTSGIGG 206
VG + + C A++DTGTS I G
Sbjct 268 LGVGDQLTLCKGGCEAIVDTGTSLITG 294
> mmu:16541 Napsa, KAP, Kdap, NAP1, SNAPA, pronapsin; napsin A
aspartic peptidase; K08565 napsin-A [EC:3.4.23.-]
Length=419
Score = 59.3 bits (142), Expect = 8e-09, Method: Compositional matrix adjust.
Identities = 63/206 (30%), Positives = 90/206 (43%), Gaps = 40/206 (19%)
Query 32 FAAGSSNTWVPSISCHVTSCASGY--------------------IESVTGRDS--LHLEN 69
F GSSN WVPS CH S A + I+ TGR S L +N
Sbjct 90 FDTGSSNLWVPSTRCHFFSLACWFHHRFNPKASSSFRPNGTKFAIQYGTGRLSGILSQDN 149
Query 70 AT---LHD--FAFGFVVQQPEYPFSELPFDGIAGLGCPQHEQGS-SSLIHLLLEAGAIKR 123
T +HD FG + +P F+ FDGI GLG P G + ++E G +++
Sbjct 150 LTIGGIHDAFVTFGEALWEPSLIFALAHFDGILGLGFPTLAVGGVQPPLDAMVEQGLLEK 209
Query 124 AMFSIALPLSA--SSAGEITFGGFNPS-YVQKGTAAIAWFPLLPNPRKKWELRLWDVLID 180
+FS L + S GE+ GG +P+ YV T P W++ + V +
Sbjct 210 PVFSFYLNRDSEGSDGGELVLGGSDPAHYVPPLTFIPVTIP------AYWQVHMESVKVG 263
Query 181 EATVGVCTPQLPCTAVIDTGTSGIGG 206
+ +C C+A++DTGTS I G
Sbjct 264 TG-LSLCAQG--CSAILDTGTSLITG 286
> dre:65225 ctsd, catD, fb93e11, fj17b09, wu:fb93e11, wu:fj17b09;
cathepsin D (EC:3.4.23.5); K01379 cathepsin D [EC:3.4.23.5]
Length=399
Score = 59.3 bits (142), Expect = 9e-09, Method: Compositional matrix adjust.
Identities = 48/203 (23%), Positives = 83/203 (40%), Gaps = 42/203 (20%)
Query 32 FAAGSSNTWVPSISCHVTSCA---------------------------SGYIESVTGRDS 64
F GSSN WVPS+ C +T A SG + +D+
Sbjct 92 FDTGSSNLWVPSVHCSLTDIACLLHHKYNGGKSSTYVKNGTQFAIQYGSGSLSGYLSQDT 151
Query 65 LHLENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQHE-QGSSSLIHLLLEAGAIKR 123
+ + + FG ++QP F FDGI G+ P+ G + +++ +++
Sbjct 152 CTIGDIAVEKQIFGEAIKQPGVAFIAAKFDGILGMAYPRISVDGVPPVFDMMMSQKKVEK 211
Query 124 AMFSIALPLSASS--AGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDE 181
+FS L + + GE+ GG +P Y F + R+ + W + +D
Sbjct 212 NVFSFYLNRNPDTQPGGELLLGGTDPKYY------TGDFNYVDISRQAY----WQIHMDG 261
Query 182 ATV--GVCTPQLPCTAVIDTGTS 202
++ G+ + C A++DTGTS
Sbjct 262 MSIGSGLSLCKGGCEAIVDTGTS 284
> mmu:58803 Pga5, 1110035E17Rik, Pepf; pepsinogen 5, group I (EC:3.4.23.1);
K06002 pepsin A [EC:3.4.23.1]
Length=387
Score = 58.5 bits (140), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 57/222 (25%), Positives = 86/222 (38%), Gaps = 42/222 (18%)
Query 19 LSAVYVAVLK--------RYYFAAGSSNTWVPSISCHVTSCA------------------ 52
L VY+ ++ R GSS WVPSI C +CA
Sbjct 70 LDLVYIGIISIGTPPQEFRVVLDTGSSVLWVPSIYCSSPACAHHKAFNPLRSSTFLVSGR 129
Query 53 -------SGYIESVTGRDSLHLENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQ-H 104
SG + D++ + + T+ AFG +++P FDGI GLG P
Sbjct 130 PVNVAYGSGEMSGFLAYDTVRIGDLTVVAQAFGLSLEEPGIFMEYAVFDGILGLGYPNLG 189
Query 105 EQGSSSLIHLLLEAGAIKRAMFSIALPLSASSAGEITFGGFNPSYVQKGTAAIAWFPLLP 164
QG + + L G I + +F+ L + GG +PSY + W P+
Sbjct 190 LQGITPVFDNLWLQGLIPQNLFAFYLSSKDEKGSMLMLGGVDPSYYH---GELHWVPV-- 244
Query 165 NPRKKWELRLWDVLIDEATVGVCTPQLPCTAVIDTGTSGIGG 206
+ W+L + D + V C C ++DTGTS + G
Sbjct 245 SKPSYWQLAV-DSISMNGEVIACDGG--CQGIMDTGTSLLTG 283
> xla:398557 cathepsin D (EC:3.4.23.5); K01379 cathepsin D [EC:3.4.23.5]
Length=409
Score = 56.2 bits (134), Expect = 9e-08, Method: Compositional matrix adjust.
Identities = 57/210 (27%), Positives = 88/210 (41%), Gaps = 48/210 (22%)
Query 32 FAAGSSNTWVPSISCHV------------TSCASGYIE------------SVTG---RDS 64
F GSSN WV S+ C + +S +S Y++ S++G +D+
Sbjct 96 FDTGSSNLWVASVHCSMFDIACWMHRKYDSSKSSTYVKNGTEFAIQYGTGSISGYLSKDT 155
Query 65 LHLENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQHE-QGSSSLIHLLLEAGAIKR 123
+ + N + FG ++QP F FDGI G+ P G S ++ ++
Sbjct 156 VTIGNLGYKEQIFGEAIKQPGVTFIAAKFDGILGMAYPIISVDGVSPCFDNIMAQKLVES 215
Query 124 AMFSIALPLSASS--AGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDE 181
+FS L + + GE+ GG +P Y F L RK + W + +D+
Sbjct 216 NVFSFYLNRNPDTQPGGELLLGGTDPKYYTGD------FHYLNVTRKAY----WQIHMDQ 265
Query 182 ATVGVCTPQLP-----CTAVIDTGTSGIGG 206
VG QL C A++DTGTS I G
Sbjct 266 LGVG---DQLTLCKGGCEAIVDTGTSLITG 292
> hsa:9476 NAPSA, KAP, Kdap, NAP1, NAPA, SNAPA; napsin A aspartic
peptidase; K08565 napsin-A [EC:3.4.23.-]
Length=420
Score = 55.8 bits (133), Expect = 9e-08, Method: Compositional matrix adjust.
Identities = 55/210 (26%), Positives = 80/210 (38%), Gaps = 48/210 (22%)
Query 32 FAAGSSNTWVPSISCHVTSC---------------------------ASGYIESVTGRDS 64
F GSSN WVPS CH S +G ++ + D
Sbjct 95 FDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFAIQYGTGRVDGILSEDK 154
Query 65 LHLENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCP-QHEQGSSSLIHLLLEAGAIKR 123
L + FG + +P F+ FDGI GLG P +G + +L+E G + +
Sbjct 155 LTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEGVRPPMDVLVEQGLLDK 214
Query 124 AMFSIALPLSAS--SAGEITFGGFNPS-YVQKGTAAIAWFPLLPNPRKKWELRLWDVLID 180
+FS L GE+ GG +P+ Y+ T P W + ++
Sbjct 215 PVFSFYLNRDPEEPDGGELVLGGSDPAHYIPPLTFVPVTVP-----------AYWQIHME 263
Query 181 EATVG----VCTPQLPCTAVIDTGTSGIGG 206
VG +C C A++DTGTS I G
Sbjct 264 RVKVGPGLTLCAKG--CAAILDTGTSLITG 291
> mmu:19701 Ren1, D19352, Ren, Ren-1, Ren-A, Ren1c, Ren1d, Rn-1,
Rnr; renin 1 structural (EC:3.4.23.15); K01380 renin [EC:3.4.23.15]
Length=402
Score = 55.8 bits (133), Expect = 9e-08, Method: Compositional matrix adjust.
Identities = 52/202 (25%), Positives = 84/202 (41%), Gaps = 38/202 (18%)
Query 32 FAAGSSNTWVPSISCHVTSCA---------------------------SGYIESVTGRDS 64
F GS+N WVPS C A SG ++ +DS
Sbjct 101 FDTGSANLWVPSTKCSRLYLACGIHSLYESSDSSSYMENGSDFTIHYGSGRVKGFLSQDS 160
Query 65 LHLENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCP-QHEQGSSSLIHLLLEAGAIKR 123
+ + T+ FG V + P PF FDG+ G+G P Q G + + +L G +K
Sbjct 161 VTVGGITVTQ-TFGEVTELPLIPFMLAKFDGVLGMGFPAQAVGGVTPVFDHILSQGVLKE 219
Query 124 AMFSIALPL-SASSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDEA 182
+FS+ S GE+ GG +P + Q ++ + W++ + V + +
Sbjct 220 EVFSVYYNRGSHLLGGEVVLGGSDPQHYQGNFHYVSI-----SKTDSWQITMKGVSVGSS 274
Query 183 TVGVCTPQLPCTAVIDTGTSGI 204
T+ +C + C V+DTG+S I
Sbjct 275 TL-LC--EEGCAVVVDTGSSFI 293
> mmu:100044656 renin-1-like
Length=425
Score = 55.8 bits (133), Expect = 9e-08, Method: Compositional matrix adjust.
Identities = 54/203 (26%), Positives = 86/203 (42%), Gaps = 40/203 (19%)
Query 32 FAAGSSNTWVPSISCHVTSCASG------------YIESVTGRD-SLHLENATLHDF--- 75
F GS+N WVPS C A G Y+E+ G D ++H + + F
Sbjct 124 FDTGSANLWVPSTKCSRLYLACGIHSLYESSDSSSYMEN--GSDFTIHYGSGRVKGFLSQ 181
Query 76 ------------AFGFVVQQPEYPFSELPFDGIAGLGCP-QHEQGSSSLIHLLLEAGAIK 122
FG V + P PF FDG+ G+G P Q G + + +L G +K
Sbjct 182 DVVTVGGITVTQTFGEVTELPLIPFMLAKFDGVLGMGFPAQAVGGVTPVFDHILSQGVLK 241
Query 123 RAMFSIALPL-SASSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDE 181
+FS+ S GE+ GG +P + Q ++ + W++ + V +
Sbjct 242 EEVFSVYYNRGSHLLGGEVVLGGSDPQHYQGNFHYVSI-----SKTDSWQITMKGVSVGS 296
Query 182 ATVGVCTPQLPCTAVIDTGTSGI 204
+T+ +C + C V+DTG+S I
Sbjct 297 STL-LC--EEGCAVVVDTGSSFI 316
> xla:398994 napsa, MGC68767, kap, kdap, nap1, napa, snapa; napsin
A aspartic peptidase; K01379 cathepsin D [EC:3.4.23.5]
Length=392
Score = 55.1 bits (131), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 51/206 (24%), Positives = 85/206 (41%), Gaps = 40/206 (19%)
Query 32 FAAGSSNTWVPSISCHVTSCA---------------------------SGYIESVTGRDS 64
F GSSN WVPS+ C A +G + +D+
Sbjct 84 FDTGSSNLWVPSVKCSFFDFACWVHKKYRSQNSSTYRQNNTAFAIQYGTGSLSGFLSQDT 143
Query 65 LHLENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQHE-QGSSSLIHLLLEAGAIKR 123
+ + + + + F ++QP F FDGI G+G P G + +++ ++
Sbjct 144 VSIGSIEVANQTFAEAIKQPGIVFVFAHFDGILGMGYPDISVDGVVPVFDNMMQQNLLEE 203
Query 124 AMFSIALPLS--ASSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKK-WELRLWDVLID 180
+FS L A+ GE+ GG +P+Y F L R W+++ +V ++
Sbjct 204 NVFSFYLSRDPMATVGGELILGGTDPNYYTGD------FHYLNVTRMAYWQIKADEVRVN 257
Query 181 EATVGVCTPQLPCTAVIDTGTSGIGG 206
V +C + C A++DTGTS I G
Sbjct 258 NQLV-LC--KGGCQAIVDTGTSLITG 280
> ath:AT1G69100 aspartic-type endopeptidase
Length=367
Score = 54.7 bits (130), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 47/210 (22%), Positives = 93/210 (44%), Gaps = 42/210 (20%)
Query 32 FAAGSSNTWVPSI-------------------SCHVT-------SCASGYIESVTGRDSL 65
F GS++ WVPS +C + + +G + + +D++
Sbjct 64 FDTGSTDLWVPSKEWPEETDHKHPKFDKDASKTCRLMKGGEVNIAYETGSVVGILAQDNV 123
Query 66 HLENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQHE-QGSSSLIHLLLEAGAIKRA 124
++ + F+ + P+ F + FDG+ GLG QGS ++ +++ I +
Sbjct 124 NVGGVVIKSQDL-FLARNPDTYFRSVKFDGVIGLGIKSSRAQGSVTVWENMVKQKLITKP 182
Query 125 MFSIALPLSASSAGE------ITFGGFNPSYVQKGTAAIAWFPL-LPNPRKKWELRLWDV 177
+FS+ L GE I FGGF+P + + P+ L + R W++++ +
Sbjct 183 IFSLYLRPHKGDGGEDPNGGQIMFGGFDPKQFK---GEHVYVPMKLSDDR--WKIKMSKI 237
Query 178 LID-EATVGVCTPQLPCTAVIDTGTSGIGG 206
I+ + + C + CTA++D+G++ I G
Sbjct 238 YINGKPAINFCD-DVECTAMVDSGSTDIFG 266
> mmu:19702 Ren2, Ren, Ren-2, Ren-B, Rn-2, Rnr; renin 2 tandem
duplication of Ren1 (EC:3.4.23.15); K01380 renin [EC:3.4.23.15]
Length=424
Score = 54.7 bits (130), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 51/202 (25%), Positives = 83/202 (41%), Gaps = 38/202 (18%)
Query 32 FAAGSSNTWVPSISCHVTSCA---------------------------SGYIESVTGRDS 64
F GS+N WVPS C A SG ++ +DS
Sbjct 123 FDTGSANLWVPSTKCSRLYLACGIHSLYESSDSSSYMENGDDFTIHYGSGRVKGFLSQDS 182
Query 65 LHLENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCP-QHEQGSSSLIHLLLEAGAIKR 123
+ + T+ FG V + P PF FDG+ G+G P Q G + + +L G +K
Sbjct 183 VTVGGITVTQ-TFGEVTELPLIPFMLAQFDGVLGMGFPAQAVGGVTPVFDHILSQGVLKE 241
Query 124 AMFSIALPLSAS-SAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDEA 182
+FS+ GE+ GG +P + Q ++ + W++ + V + +
Sbjct 242 KVFSVYYNRGPHLLGGEVVLGGSDPEHYQGDFHYVSL-----SKTDSWQITMKGVSVGSS 296
Query 183 TVGVCTPQLPCTAVIDTGTSGI 204
T+ +C + C V+DTG+S I
Sbjct 297 TL-LC--EEGCEVVVDTGSSFI 315
> cel:R12H7.2 asp-4; ASpartyl Protease family member (asp-4);
K01379 cathepsin D [EC:3.4.23.5]
Length=444
Score = 54.7 bits (130), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 51/205 (24%), Positives = 79/205 (38%), Gaps = 39/205 (19%)
Query 32 FAAGSSNTWVPSISCHVTSCA---------------------------SGYIESVTGRDS 64
F GSSN W+PS C A +G ++ +DS
Sbjct 111 FDTGSSNLWIPSKKCPFYDIACMLHHRYDSKSSSTYKEDGRKMAIQYGTGSMKGFISKDS 170
Query 65 LHLENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQHE-QGSSSLIHLLLEAGAIKR 123
+ + D F +P F FDGI G+ P+ G + + L E +
Sbjct 171 VCVAGVCAEDQPFAEATSEPGITFVAAKFDGILGMAYPEIAVLGVQPVFNTLFEQKKVPS 230
Query 124 AMFSIALPLSASS--AGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDE 181
+FS L + S GEITFGG + ++ I + P+ + W+ ++ D ++
Sbjct 231 NLFSFWLNRNPDSEIGGEITFGGIDS---RRYVEPITYVPV--TRKGYWQFKM-DKVVGS 284
Query 182 ATVGVCTPQLPCTAVIDTGTSGIGG 206
+G C A+ DTGTS I G
Sbjct 285 GVLGCSN---GCQAIADTGTSLIAG 306
> mmu:229697 Cym, Gm131; chymosin (EC:3.4.23.4); K01378 chymosin
[EC:3.4.23.4]
Length=379
Score = 53.9 bits (128), Expect = 3e-07, Method: Compositional matrix adjust.
Identities = 47/203 (23%), Positives = 79/203 (38%), Gaps = 39/203 (19%)
Query 32 FAAGSSNTWVPSISCHVTSC-------------------------ASGYIESVTGRDSLH 66
F GSS WVPS+ C+ C +G +E D++
Sbjct 91 FDTGSSELWVPSVYCNSKVCRNHHRFDPSKSITFQNLSKPLFVQYGTGRMEGFLAYDTVT 150
Query 67 LENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQH-EQGSSSLIHLLLEAGAIKRAM 125
+ + + G Q+P F+ PFDGI GL P + S + ++ + + +
Sbjct 151 VSDIVVSHQTVGLSTQEPGDIFTYSPFDGILGLAYPTFASKYSVPIFDNMMNRHLVAQDL 210
Query 126 FSIALPLSASSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDEATVG 185
FS+ + + + +T G + SY ++ W P+ W +D T+
Sbjct 211 FSVYMSRNEQGS-MLTLGAIDQSYF---IGSLHWVPVTVQG-------YWQFTVDRITIN 259
Query 186 --VCTPQLPCTAVIDTGTSGIGG 206
V Q C AV+DTGT+ + G
Sbjct 260 GEVVACQGGCPAVLDTGTALLTG 282
> hsa:5972 REN, FLJ10761, HNFJ2; renin (EC:3.4.23.15); K01380
renin [EC:3.4.23.15]
Length=406
Score = 53.9 bits (128), Expect = 4e-07, Method: Compositional matrix adjust.
Identities = 53/206 (25%), Positives = 82/206 (39%), Gaps = 39/206 (18%)
Query 32 FAAGSSNTWVPSISCHVTSCASGYIESVTGRDS-----------LHLENATLHDF----- 75
F GSSN WVPS C A Y + DS L T+ F
Sbjct 103 FDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDI 162
Query 76 ----------AFGFVVQQPEYPFSELPFDGIAGLGCPQHEQGS-SSLIHLLLEAGAIKRA 124
FG V + P PF FDG+ G+G + G + + ++ G +K
Sbjct 163 ITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKED 222
Query 125 MFSIALPL----SASSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLID 180
+FS S S G+I GG +P + + + L+ W++++ V +
Sbjct 223 VFSFYYNRDSENSQSLGGQIVLGGSDPQHYE---GNFHYINLIKT--GVWQIQMKGVSVG 277
Query 181 EATVGVCTPQLPCTAVIDTGTSGIGG 206
+T+ +C + C A++DTG S I G
Sbjct 278 SSTL-LC--EDGCLALVDTGASYISG 300
> dre:336746 fa94d12, wu:fa94d12; zgc:63831; K01379 cathepsin
D [EC:3.4.23.5]
Length=412
Score = 53.5 bits (127), Expect = 5e-07, Method: Compositional matrix adjust.
Identities = 55/207 (26%), Positives = 83/207 (40%), Gaps = 42/207 (20%)
Query 32 FAAGSSNTWVPSISCHVTSCA------------SGYIESVT------GR---------DS 64
F GSSN WVPSI C A S Y+++ T GR D+
Sbjct 109 FDTGSSNLWVPSIHCAFLDIACWLHRRYNSKKSSTYVQNGTEFSIQYGRGSLSGFISQDT 168
Query 65 LHLENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQHE-QGSSSLIHLLLEAGAIKR 123
++L + F V+QP F+ FDG+ G+ P + + + A + +
Sbjct 169 VNLAGLNVTGQQFAEAVKQPGIVFAVARFDGVLGMAYPAISVDRVTPVFDTAMAAKILPQ 228
Query 124 AMFS--IALPLSASSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDE 181
+FS I + GE+ GGF+ Y + RK + W + +DE
Sbjct 229 NIFSFYINRDPAGDVGGELMLGGFDQQYFNGDLHYVNV------TRKAY----WQIKMDE 278
Query 182 ATVG--VCTPQLPCTAVIDTGTSGIGG 206
VG + + C A++DTGTS I G
Sbjct 279 VQVGSTLTLCKSGCQAIVDTGTSMITG 305
> hsa:1509 CTSD, CLN10, CPSD, MGC2311; cathepsin D (EC:3.4.23.5);
K01379 cathepsin D [EC:3.4.23.5]
Length=412
Score = 51.2 bits (121), Expect = 3e-06, Method: Compositional matrix adjust.
Identities = 56/215 (26%), Positives = 85/215 (39%), Gaps = 55/215 (25%)
Query 32 FAAGSSNTWVPSISCHVTSCA------------SGYIESVTGRDSLHLENATLHDF---- 75
F GSSN WVPSI C + A S Y+++ T D +H + +L +
Sbjct 96 FDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFD-IHYGSGSLSGYLSQD 154
Query 76 -----------------------AFGFVVQQPEYPFSELPFDGIAGLGCPQHEQGSS-SL 111
FG +QP F FDGI G+ P+ + +
Sbjct 155 TVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPV 214
Query 112 IHLLLEAGAIKRAMFSIALPL--SASSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKK 169
L++ + + +FS L A GE+ GG + Y KG+ + L RK
Sbjct 215 FDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYY-KGSLS-----YLNVTRKA 268
Query 170 WELRLWDVLIDEATV--GVCTPQLPCTAVIDTGTS 202
+ W V +D+ V G+ + C A++DTGTS
Sbjct 269 Y----WQVHLDQVEVASGLTLCKEGCEAIVDTGTS 299
> mmu:13033 Ctsd, CD, CatD; cathepsin D (EC:3.4.23.5); K01379
cathepsin D [EC:3.4.23.5]
Length=410
Score = 51.2 bits (121), Expect = 3e-06, Method: Compositional matrix adjust.
Identities = 54/213 (25%), Positives = 80/213 (37%), Gaps = 53/213 (24%)
Query 32 FAAGSSNTWVPSISCHVTSCA------------SGYIESVTGRDSLHLENATLHDF---- 75
F GSSN WVPSI C + A S Y+++ T D +H + +L +
Sbjct 96 FDTGSSNLWVPSIHCKILDIACWVHHKYNSDKSSTYVKNGTSFD-IHYGSGSLSGYLSQD 154
Query 76 ---------------------AFGFVVQQPEYPFSELPFDGIAGLGCPQHEQGSS-SLIH 113
FG +QP F FDGI G+G P + +
Sbjct 155 TVSVPCKSDQSKARGIKVEKQIFGEATKQPGIVFVAAKFDGILGMGYPHISVNNVLPVFD 214
Query 114 LLLEAGAIKRAMFSIALPLS--ASSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWE 171
L++ + + +FS L GE+ GG + Y L RK +
Sbjct 215 NLMQQKLVDKNIFSFYLNRDPEGQPGGELMLGGTDSKYYH------GELSYLNVTRKAY- 267
Query 172 LRLWDVLIDEATVG--VCTPQLPCTAVIDTGTS 202
W V +D+ VG + + C A++DTGTS
Sbjct 268 ---WQVHMDQLEVGNELTLCKGGCEAIVDTGTS 297
> dre:405786 ren; renin (EC:3.4.23.15); K01380 renin [EC:3.4.23.15]
Length=395
Score = 49.3 bits (116), Expect = 9e-06, Method: Compositional matrix adjust.
Identities = 54/206 (26%), Positives = 84/206 (40%), Gaps = 41/206 (19%)
Query 32 FAAGSSNTWVPSISCHVTSCASGYIESVTGRDSL-HLENATLHDFAF------GFVVQQ- 83
F GS+N WVPS SC A SL H+ N T + GF+ +
Sbjct 93 FDTGSANLWVPSHSCSPLYTACFTHNRYDASKSLTHIFNGTGFSIQYASGNVRGFLSEDV 152
Query 84 ------------------PEYPFSELPFDGIAGLGCPQHE-QGSSSLIHLLLEAGAIKRA 124
P PF FDG+ G+G P G + + ++ +K
Sbjct 153 VVVGGIPVVQVFAEATALPAIPFILAKFDGVLGMGYPNVAIDGITPVFDRIMSQHVLKEN 212
Query 125 MFSIALPLSASS--AGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDEA 182
+FS+ + GE+ GG +P+Y T + N +++ + W+V++
Sbjct 213 VFSVYYSRDPTHIPGGELVLGGTDPNY---HTGPFHYI----NTKEQGK---WEVIMKGV 262
Query 183 TVG--VCTPQLPCTAVIDTGTSGIGG 206
+VG + + CTAVIDTG+S I G
Sbjct 263 SVGADILFCKDGCTAVIDTGSSYITG 288
> pfa:PF14_0076 plasmepsin I; K06007 plasmepsin I [EC:3.4.23.38]
Length=452
Score = 49.3 bits (116), Expect = 1e-05, Method: Compositional matrix adjust.
Identities = 51/207 (24%), Positives = 80/207 (38%), Gaps = 49/207 (23%)
Query 30 YYFAAGSSNTWVPSISCHVTSC-------------------------ASGYIESVTGRDS 64
+ F GS+N WVPS C+ C SG + +D
Sbjct 154 FIFDTGSANLWVPSAQCNTIGCKTKNLYDSNKSKTYEKDGTKVEMNYVSGTVSGFFSKDI 213
Query 65 LHLENATLHDFAFGFVVQ------QPEYPFSELPFDGIAGLGCPQHEQGSSS-LIHLLLE 117
+ + N + F + F+ +P Y + FDGI GLG GS ++ L
Sbjct 214 VTIANLS---FPYKFIEVTDTNGFEPAYTLGQ--FDGIVGLGWKDLSIGSVDPVVVELKN 268
Query 118 AGAIKRAMFSIALPLSASSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDV 177
I++A+F+ LP G +T GG + + + + L N W++ L D+
Sbjct 269 QNKIEQAVFTFYLPFDDKHKGYLTIGGIEDRFYE---GQLTYEKL--NHDLYWQVDL-DL 322
Query 178 LIDEATVGVCTPQLPCTAVIDTGTSGI 204
TV TA++D+GTS I
Sbjct 323 HFGNLTVE------KATAIVDSGTSSI 343
> pfa:PF14_0075 plasmepsin IV
Length=449
Score = 47.8 bits (112), Expect = 3e-05, Method: Compositional matrix adjust.
Identities = 53/205 (25%), Positives = 81/205 (39%), Gaps = 45/205 (21%)
Query 30 YYFAAGSSNTWVPSISCHVTSCA-------------------------SGYIESVTGRDS 64
+ F GS+N WVPS++C C+ SG + +D
Sbjct 152 FIFDTGSANLWVPSVNCDSIGCSTKHLYDASASKSYEKDGTKVEISYGSGTVRGYFSKDV 211
Query 65 LHLENATLHDFAFGFVVQ----QPEYPFSELPFDGIAGLGCPQHEQGS-SSLIHLLLEAG 119
+ L + +L + F V +P Y SE FDGI GLG GS ++ L +
Sbjct 212 ISLGDLSLP-YKFIEVTDADDLEPIYSGSE--FDGILGLGWKDLSIGSIDPVVVELKKQN 268
Query 120 AIKRAMFSIALPLSASSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLI 179
I A+F+ LP+ G +T GG + + + + L N W++ L
Sbjct 269 KIDNALFTFYLPVHDKHVGYLTIGGIESDFYE---GPLTYEKL--NHDLYWQIDL----- 318
Query 180 DEATVGVCTPQLPCTAVIDTGTSGI 204
+ G Q AV+D+GTS I
Sbjct 319 -DIHFGKYVMQ-KANAVVDSGTSTI 341
> cel:H22K11.1 asp-3; ASpartyl Protease family member (asp-3);
K01386 [EC:3.4.23.-]
Length=398
Score = 47.4 bits (111), Expect = 3e-05, Method: Compositional matrix adjust.
Identities = 55/211 (26%), Positives = 83/211 (39%), Gaps = 45/211 (21%)
Query 32 FAAGSSNTWVPSISC----------------HVTSC----ASGYIESVTGRDSLHLENAT 71
F GSSN WVP +C +SC AS I+ TG ++N
Sbjct 86 FDTGSSNLWVPCANCPFGDIACRMHNRFDCKKSSSCTATGASFEIQYGTGSMKGTVDNDV 145
Query 72 L---HDFAF--------GFVVQQPEYPFSELPFDGIAGLGCP--QHEQGSSSLIHLLLEA 118
+ HD + +P F FDGI G+G + S + + +
Sbjct 146 VCFGHDTTYCTDKNQGLACATSEPGITFVAAKFDGIFGMGWDTISVNKISQPMDQIFANS 205
Query 119 GAIKRAMFSIALPLSA---SSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLW 175
K +F+ L A ++ GEIT +P++ IAW PL+ W ++L
Sbjct 206 AICKNQLFAFWLSRDANDITNGGEITLCETDPNHY---VGNIAWEPLV--SEDYWRIKLA 260
Query 176 DVLIDEATVGVCTPQLPCTAVIDTGTSGIGG 206
V+ID G P +++DTGTS + G
Sbjct 261 SVVID----GTTYTSGPIDSIVDTGTSLLTG 287
> sce:YPL154C PEP4, PHO9, PRA1, yscA; Pep4p (EC:3.4.23.25); K01381
saccharopepsin [EC:3.4.23.25]
Length=405
Score = 46.6 bits (109), Expect = 6e-05, Method: Compositional matrix adjust.
Identities = 55/203 (27%), Positives = 78/203 (38%), Gaps = 46/203 (22%)
Query 35 GSSNTWVPSISCHVTSC-------------------------ASGYIESVTGRDSLHLEN 69
GSSN WVPS C +C +G +E +D+L + +
Sbjct 111 GSSNLWVPSNECGSLACFLHSKYDHEASSSYKANGTEFAIQYGTGSLEGYISQDTLSIGD 170
Query 70 ATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQHEQGS------SSLIHLLLEAGAIKR 123
T+ F +P F+ FDGI GLG +++ LL+ KR
Sbjct 171 LTIPKQDFAEATSEPGLTFAFGKFDGILGLGYDTISVDKVVPPFYNAIQQDLLDE---KR 227
Query 124 AMFSIA-LPLSASSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLIDEA 182
F + + GE TFGG + S K I W P+ R+K W+V +
Sbjct 228 FAFYLGDTSKDTENGGEATFGGIDES---KFKGDITWLPV----RRK---AYWEVKFEGI 277
Query 183 TVGVCTPQLPCT-AVIDTGTSGI 204
+G +L A IDTGTS I
Sbjct 278 GLGDEYAELESHGAAIDTGTSLI 300
> dre:100330180 cathepsin D-like
Length=163
Score = 46.2 bits (108), Expect = 7e-05, Method: Compositional matrix adjust.
Identities = 28/121 (23%), Positives = 55/121 (45%), Gaps = 3/121 (2%)
Query 32 FAAGSSNTWVPSISCHVTSCASGYIESVTGRDSLHLENATLHDFAFGFVVQQPEYPFSEL 91
+ G S+T+V + + SG + +D+ + + + FG ++QP F
Sbjct 21 YNGGKSSTYVKNGTQFAIQYGSGSLSGYLSQDTCTIGDIAVEKQIFGEAIKQPGVAFIAA 80
Query 92 PFDGIAGLGCPQHE-QGSSSLIHLLLEAGAIKRAMFSIALPLSASS--AGEITFGGFNPS 148
FDGI G+ P+ G + +++ +++ +FS L + + GE+ GG +P
Sbjct 81 KFDGILGMAYPRISVDGVPPVFDMMMSQKKVEKNVFSFYLNRNPDTQPGGELLLGGTDPK 140
Query 149 Y 149
Y
Sbjct 141 Y 141
> hsa:5225 PGC, FLJ99563, PEPC, PGII; progastricsin (pepsinogen
C) (EC:3.4.23.3); K01377 gastricsin [EC:3.4.23.3]
Length=315
Score = 45.8 bits (107), Expect = 1e-04, Method: Compositional matrix adjust.
Identities = 32/125 (25%), Positives = 52/125 (41%), Gaps = 26/125 (20%)
Query 32 FAAGSSNTWVPSISCHVTSC-------------------------ASGYIESVTGRDSLH 66
F GSSN WVPS+ C +C SG + G D+L
Sbjct 90 FDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLT 149
Query 67 LENATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQHE-QGSSSLIHLLLEAGAIKRAM 125
+++ + + FG +P F FDGI GL P +++ + +++ GA+ +
Sbjct 150 VQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPV 209
Query 126 FSIAL 130
FS+ L
Sbjct 210 FSVYL 214
> pfa:PF14_0077 plasmepsin II; K06008 plasmepsin II [EC:3.4.23.39]
Length=453
Score = 45.4 bits (106), Expect = 1e-04, Method: Compositional matrix adjust.
Identities = 49/206 (23%), Positives = 77/206 (37%), Gaps = 47/206 (22%)
Query 30 YYFAAGSSNTWVPSISCHVTSC-------------------------ASGYIESVTGRDS 64
+ GS+N WVPS+ C C SG + +D
Sbjct 155 FILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDL 214
Query 65 LHLENATLHDFAFGFVVQ----QPEYPFSELPFDGIAGLGCPQHEQGSSS-LIHLLLEAG 119
+ + N +L + F V+ +P Y S FDGI GLG GS ++ L
Sbjct 215 VTVGNLSL-PYKFIEVIDTNGFEPTYTAS--TFDGILGLGWKDLSIGSVDPIVVELKNQN 271
Query 120 AIKRAMFSIALPLSASSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRL-WDVL 178
I+ A+F+ LP+ G +T GG + + P +K L W +
Sbjct 272 KIENALFTFYLPVHDKHTGFLTIGGIEERFYEG-----------PLTYEKLNHDLYWQIT 320
Query 179 IDEATVGVCTPQLPCTAVIDTGTSGI 204
+D + + C ++D+GTS I
Sbjct 321 LDAHVGNIMLEKANC--IVDSGTSAI 344
> ath:AT4G22050 aspartyl protease family protein
Length=354
Score = 43.5 bits (101), Expect = 5e-04, Method: Compositional matrix adjust.
Identities = 49/204 (24%), Positives = 88/204 (43%), Gaps = 40/204 (19%)
Query 32 FAAGSSNTWVPS----------ISCHVTSCASGYIESVT------GRDSL----HLENAT 71
F GSS+ WVPS + +++S + + E+ T G+ SL ++ T
Sbjct 63 FDTGSSSLWVPSENWLAKTENPRNRYISSASRTFKENGTKAELKYGKGSLTGFLSVDTVT 122
Query 72 L-------HDFAFGFVVQQPEYPFSELPFDGIAGLGCPQHEQGSSSLIHLLLEAGAIKRA 124
+ F G E+ F ++PFDGI GL +S+ H ++ G I +
Sbjct 123 VGGISITSQTFIEGVKTPYKEF-FKKMPFDGILGLRFTDPLNFGTSVWHSMVFQGKIAKN 181
Query 125 MFSIALPLSASS----AGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVLID 180
+FSI L ++S GE+ FGG P++ + + P + + ++ +
Sbjct 182 VFSIWLRRFSNSGEINGGEVVFGGIIPAHFSGDHTYVD----VEGPGNFFAMS--NIWVG 235
Query 181 EATVGVCTPQLPCTAVIDTGTSGI 204
+C+ C A++D+G+S I
Sbjct 236 GKNTNICSSG--CKAIVDSGSSNI 257
> tpv:TP01_0692 pepsinogen; K06002 pepsin A [EC:3.4.23.1]
Length=377
Score = 42.7 bits (99), Expect = 0.001, Method: Compositional matrix adjust.
Identities = 42/195 (21%), Positives = 78/195 (40%), Gaps = 38/195 (19%)
Query 34 AGSSNTWVPSISCHVTSCA-------------------------SGYIESVTGRDSLHLE 68
GS+NTWV S C+ +C+ +G I+ V G D++ +
Sbjct 159 TGSTNTWVISEQCNSITCSGVPTFNSRKSSTFSPVNEGLRIRFGTGTIKGVLGIDNVTIG 218
Query 69 NATLHDFAFGFVVQQPEYPFSELPFDGIAGLGCPQHEQGSSSLIHLLLEAGAIKRAMFSI 128
T+ FG V ++ F + F GI GLG P+ + ++ +FS+
Sbjct 219 QDTIEKQIFGLVNEESSNVFKVIKFQGIIGLGFPKLAFDHHTSLYDNYSKQINADLIFSL 278
Query 129 ALPLSASSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRK-KWELRLWDVLIDEATVGVC 187
++ + GG + + + +LP R+ WE++L+++ + V +C
Sbjct 279 YF---SNQYSYVMIGGVDERFY------VGDLYMLPVVREYYWEIKLYELWV--GNVKLC 327
Query 188 TPQLPCTAVIDTGTS 202
+ D+GTS
Sbjct 328 CDD-ESYVIFDSGTS 341
> tgo:TGME49_046550 eukaryotic aspartyl protease, putative (EC:3.4.23.1);
K06002 pepsin A [EC:3.4.23.1]
Length=643
Score = 41.6 bits (96), Expect = 0.002, Method: Compositional matrix adjust.
Identities = 46/204 (22%), Positives = 74/204 (36%), Gaps = 40/204 (19%)
Query 32 FAAGSSNTWVPSISCHVTSC---------------------------ASGYIESVTGRDS 64
F GS+N WV C +C +G IE TG D
Sbjct 298 FDTGSTNLWVVGSKCTDDTCTKVTRFDPSASKTFRAANPPVHLDITFGTGRIEGSTGIDD 357
Query 65 LHLENATLHDFAFGFVVQQPEYP-----FSELPFDGIAGLGCPQHEQ-GSSSLIHLLLEA 118
+ + +FG V + + F + F+GI GL P+ G+ + ++
Sbjct 358 FTVGPFLVKGQSFGLVESEGGHNMHGNIFKTINFEGIVGLAFPEMSSTGTVPIYDNIISQ 417
Query 119 GAIKRAMFSIALPLSASSAGEITFGGFNPSYVQKGTAAIAWFPLLPNPRKKWELRLWDVL 178
G +K F+ + S + FGG +P + + A I FP+ WE L +
Sbjct 418 GTLKENEFAFYM-AKGSQVSALFFGGVDPRFYE---APIHMFPV--TREHYWETSLDAIY 471
Query 179 IDEATVGVCTPQLPCTAVIDTGTS 202
I + C ++D+GTS
Sbjct 472 IGDKKF-CCEEGTKNYVILDSGTS 494
Lambda K H
0.319 0.135 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 6382561284
Database: egene_temp_file_orthology_annotation_similarity_blast_database_966
Posted date: Sep 16, 2011 8:45 PM
Number of letters in database: 82,071,388
Number of sequences in database: 164,496
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40