bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: egene_temp_file_orthology_annotation_similarity_blast_database_966
164,496 sequences; 82,071,388 total letters
Query= Eace_0911_orf1
Length=110
Score E
Sequences producing significant alignments: (Bits) Value
pfa:MAL7P1.206 DNA mismatch repair protein, putative 70.9 9e-13
tgo:TGME49_061000 DNA mismatch repair protein, putative ; K087... 64.3 8e-11
pfa:PF14_0254 DNA mismatch repair protein Msh2p, putative; K08... 53.1 2e-07
ath:AT3G18524 MSH2; MSH2 (MUTS HOMOLOG 2); ATP binding / damag... 50.4 1e-06
tgo:TGME49_090640 DNA mismatch repair protein, putative (EC:3.... 50.1 2e-06
bbo:BBOV_I004430 19.m02191; DNA repair protein; K08737 DNA mis... 44.3 9e-05
sce:YCR092C MSH3; Mismatch repair protein, forms dimers with M... 43.1 2e-04
tpv:TP01_0185 DNA repair protein; K08737 DNA mismatch repair p... 42.7 3e-04
eco:b2733 mutS, ant, ECK2728, fdv, JW2703, plm; methyl-directe... 42.4 3e-04
hsa:4437 MSH3, DUP, MGC163306, MGC163308, MRP1; mutS homolog 3... 42.4 4e-04
ath:AT3G20475 MSH5; MSH5 (MUTS-HOMOLOGUE 5); ATP binding / dam... 42.0 5e-04
ath:AT4G02070 MSH6; MSH6 (MUTS HOMOLOG 6); damaged DNA binding... 40.4 0.001
ath:AT4G25540 MSH3; MSH3 (Arabidopsis homolog of DNA mismatch ... 40.0 0.002
sce:YOL090W MSH2, PMS5; Msh2p; K08735 DNA mismatch repair prot... 38.9 0.004
pfa:PFE0270c DNA repair protein, putative; K08737 DNA mismatch... 38.5 0.005
dre:406845 msh2, wu:fc06b02, wu:fc13e09, zgc:55333; mutS homol... 38.1 0.006
hsa:4439 MSH5, DKFZp434C1615, G7, MGC2939, MUTSH5, NG23; mutS ... 38.1 0.007
mmu:17686 Msh3, D13Em1, Rep-3, Rep3; mutS homolog 3 (E. coli);... 37.7 0.009
mmu:100046843 DNA mismatch repair protein Msh3-like 37.7 0.009
bbo:BBOV_I003810 19.m02277; DNA mismatch repair enzyme; K08735... 37.4 0.011
sce:YDR097C MSH6, PMS3; Msh6p; K08737 DNA mismatch repair prot... 37.4 0.011
cpv:cgd8_370 DNA repair protein ; K08737 DNA mismatch repair p... 36.6 0.019
dre:565400 novel protein similar to vertebrate mutS homolog 3 ... 36.6 0.020
sce:YDL154W MSH5; Msh5p; K08741 DNA mismatch repair protein MSH5 36.2 0.025
tpv:TP01_0456 DNA mismatch repair protein MSH2; K08735 DNA mis... 35.8 0.039
mmu:17687 Msh5, G7, Mut5; mutS homolog 5 (E. coli); K08741 DNA... 35.8 0.039
dre:570030 msh5; mutS homolog 5 (E. coli); K08741 DNA mismatch... 35.0 0.056
hsa:4436 MSH2, COCA1, FCC1, HNPCC, HNPCC1, LCFS2; mutS homolog... 34.7 0.075
mmu:17685 Msh2, AI788990; mutS homolog 2 (E. coli); K08735 DNA... 34.7 0.085
cpv:cgd8_3950 MutS like ABC ATpase involved in DNA repair ; K0... 33.9 0.12
ath:AT3G24495 MSH7; MSH7 (MUTS HOMOLOG 7); ATP binding / damag... 33.1 0.25
cpv:cgd8_3640 niemann-Pick type C1 disease protein/ patched li... 30.8 1.2
cel:H26D21.2 msh-2; MSH (MutS Homolog) family member (msh-2); ... 29.6 2.7
hsa:65267 WNK3, FLJ30437, FLJ42662, KIAA1566, PRKWNK3; WNK lys... 29.3 3.5
dre:559917 mutS homolog 4-like; K08740 DNA mismatch repair pro... 28.9 3.7
pfa:PFC0225c elongation factor (EF-TS), putative; K02357 elong... 28.9 4.0
tgo:TGME49_068390 hypothetical protein 28.9 4.2
dre:100148193 dnah6; dynein, axonemal, heavy chain 6 28.9
cel:Y47G6A.11 msh-6; MSH (MutS Homolog) family member (msh-6);... 28.9 4.8
dre:559325 lysosomal trafficking regulator-like 28.5 6.2
hsa:4438 MSH4; mutS homolog 4 (E. coli); K08740 DNA mismatch r... 28.1 6.6
mmu:71909 Haus5, 2310022K01Rik; HAUS augmin-like complex, subu... 27.7 8.2
sce:YHR114W BZZ1, LSB7; Bzz1p 27.7 8.7
dre:571240 transmembrane channel-like gene family 2-like 27.7 8.9
xla:380199 syap1, MGC53226; synapse associated protein 1, SAP4... 27.7 9.2
pfa:PF10_0224 dynein heavy chain, putative; K06025 [EC:3.6.4.2] 27.7 9.7
> pfa:MAL7P1.206 DNA mismatch repair protein, putative
Length=873
Score = 70.9 bits (172), Expect = 9e-13, Method: Composition-based stats.
Identities = 40/104 (38%), Positives = 63/104 (60%), Gaps = 5/104 (4%)
Query 2 EGVHNYHVRAAVCKKKRQVSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQ 61
+GV N HV A + +K+++SFLY++K+G+AD SYGV+VA A LP ++ +A S +L+
Sbjct 749 KGVINNHVGAKIDTEKKKISFLYEIKKGYADKSYGVYVAQIAQLPKSVIHKAFQKSKELE 808
Query 62 QESNNQKRKLQHLDQTEEENKTN-----NNTQDTLKKLRNIISE 100
N K + L QT ++N TN N + LK++ N+ E
Sbjct 809 SVENRHYFKKKLLTQTNQQNDTNHTSNYNKSISYLKEIFNVTHE 852
> tgo:TGME49_061000 DNA mismatch repair protein, putative ; K08735
DNA mismatch repair protein MSH2
Length=936
Score = 64.3 bits (155), Expect = 8e-11, Method: Composition-based stats.
Identities = 33/71 (46%), Positives = 46/71 (64%), Gaps = 1/71 (1%)
Query 1 VEGVHNYHVRAAVCKKKRQVSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQL 60
V GV N HV AAV ++ +Q++FLY ++ G D S+GVHVA FAGLP + RA S +L
Sbjct 747 VPGVSNLHVSAAVNRETQQLAFLYRLQSGCVDQSFGVHVAGFAGLPATVVERARQKSAEL 806
Query 61 QQ-ESNNQKRK 70
+ E Q+R+
Sbjct 807 EAVERGEQERR 817
> pfa:PF14_0254 DNA mismatch repair protein Msh2p, putative; K08735
DNA mismatch repair protein MSH2
Length=811
Score = 53.1 bits (126), Expect = 2e-07, Method: Composition-based stats.
Identities = 33/111 (29%), Positives = 58/111 (52%), Gaps = 3/111 (2%)
Query 2 EGVHNYHVRAAVCKKKRQVSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQ 61
EGV N HV + K+K+++ FLY++K+G ++ SYGV+VA A LP + +A +L+
Sbjct 686 EGVINRHVETTIDKEKKKICFLYEIKDGASNKSYGVNVAEIAKLPKEVIQKAYEKVEELE 745
Query 62 QESNNQ--KRKLQHLDQTEEENKTNNNTQDTLKKLRNIISEAFAAQTPQLF 110
N K KL ++D + ++ K+++ I F++ F
Sbjct 746 SAENKYYLKEKL-NIDTSASADENYKMKISNYMKIKDEIHYLFSSTNENEF 795
> ath:AT3G18524 MSH2; MSH2 (MUTS HOMOLOG 2); ATP binding / damaged
DNA binding / mismatched DNA binding / protein binding;
K08735 DNA mismatch repair protein MSH2
Length=937
Score = 50.4 bits (119), Expect = 1e-06, Method: Composition-based stats.
Identities = 30/85 (35%), Positives = 47/85 (55%), Gaps = 9/85 (10%)
Query 3 GVHNYHVRAAVCKKKRQVSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQQ 62
GV N+HV A + + R+++ LY V+ G D S+G+HVA FA P ++ + A + +L+
Sbjct 800 GVANFHVSAHIDTESRKLTMLYKVEPGACDQSFGIHVAEFANFPESVVALAREKAAELED 859
Query 63 ES------NNQ---KRKLQHLDQTE 78
S NN+ KRK + D E
Sbjct 860 FSPSSMIINNEESGKRKSREDDPDE 884
> tgo:TGME49_090640 DNA mismatch repair protein, putative (EC:3.2.1.3);
K08737 DNA mismatch repair protein MSH6
Length=1607
Score = 50.1 bits (118), Expect = 2e-06, Method: Composition-based stats.
Identities = 25/66 (37%), Positives = 42/66 (63%), Gaps = 0/66 (0%)
Query 4 VHNYHVRAAVCKKKRQVSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQQE 63
V N H++AA+ ++++ ++FLY + +G S+G+HVA AG+ P + A S +LQQE
Sbjct 1471 VVNVHMKAAINEEQQSLAFLYKLTKGVCPKSHGIHVARLAGIDPRILECAEEKSLRLQQE 1530
Query 64 SNNQKR 69
Q+R
Sbjct 1531 VVRQQR 1536
> bbo:BBOV_I004430 19.m02191; DNA repair protein; K08737 DNA mismatch
repair protein MSH6
Length=1313
Score = 44.3 bits (103), Expect = 9e-05, Method: Composition-based stats.
Identities = 22/74 (29%), Positives = 40/74 (54%), Gaps = 0/74 (0%)
Query 8 HVRAAVCKKKRQVSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQQESNNQ 67
H+ A++ K++ ++FLY + G S+G+HVA AG+P +T A +S +
Sbjct 1222 HMAASLDDKEKSITFLYKLSLGLCPESHGIHVARLAGIPKHVTDMAEVVSRSYRASKRPI 1281
Query 68 KRKLQHLDQTEEEN 81
K LQ L + +++
Sbjct 1282 KSILQALLEAHKQD 1295
> sce:YCR092C MSH3; Mismatch repair protein, forms dimers with
Msh2p that mediate repair of insertion or deletion mutations
and removal of nonhomologous DNA ends, contains a PCNA (Pol30p)
binding motif required for genome stability; K08736 DNA
mismatch repair protein MSH3
Length=1018
Score = 43.1 bits (100), Expect = 2e-04, Method: Composition-based stats.
Identities = 34/96 (35%), Positives = 53/96 (55%), Gaps = 6/96 (6%)
Query 4 VHNYHVRAAVCKKKRQ----VSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQ 59
+ NYH+ +K + V FLY +K+G NSYG++VA A L + +RA +IS +
Sbjct 918 IRNYHMDYVEEQKTGEDWMSVIFLYKLKKGLTYNSYGMNVAKLARLDKDIINRAFSISEE 977
Query 60 LQQESNNQKRKLQHLDQTEEENKTNNNT-QDTLKKL 94
L++ES N+ L+ + K++N T D L KL
Sbjct 978 LRKESINED-ALKLFSSLKRILKSDNITATDKLAKL 1012
> tpv:TP01_0185 DNA repair protein; K08737 DNA mismatch repair
protein MSH6
Length=1160
Score = 42.7 bits (99), Expect = 3e-04, Method: Composition-based stats.
Identities = 29/101 (28%), Positives = 49/101 (48%), Gaps = 5/101 (4%)
Query 1 VEGVHNYHVRAAVCKKKRQVSFLYDVKEGHADNSYGVHVAAFAGLPP-----ALTSRAAA 55
+ V +H+ A V ++ R V FLY + G +S+G+HVA A +P A+ +R
Sbjct 1052 LSNVSMFHMAAKVDEETRSVEFLYKLVPGVCPDSHGMHVAKLARVPEHIIQNAMEARMRL 1111
Query 56 ISNQLQQESNNQKRKLQHLDQTEEENKTNNNTQDTLKKLRN 96
++++ E + KL + E NN D LK++ N
Sbjct 1112 YNSEVFGEGESASNKLLEILTEEILEAHYNNDNDKLKEIYN 1152
> eco:b2733 mutS, ant, ECK2728, fdv, JW2703, plm; methyl-directed
mismatch repair protein; K03555 DNA mismatch repair protein
MutS
Length=853
Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats.
Identities = 24/66 (36%), Positives = 38/66 (57%), Gaps = 2/66 (3%)
Query 1 VEGVHNYHVRAAVCKKKRQVSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQL 60
+EGV N H+ A + ++F++ V++G A SYG+ VAA AG+P + RA +L
Sbjct 739 MEGVANVHLDA--LEHGDTIAFMHSVQDGAASKSYGLAVAALAGVPKEVIKRARQKLREL 796
Query 61 QQESNN 66
+ S N
Sbjct 797 ESISPN 802
> hsa:4437 MSH3, DUP, MGC163306, MGC163308, MRP1; mutS homolog
3 (E. coli); K08736 DNA mismatch repair protein MSH3
Length=1137
Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust.
Identities = 23/70 (32%), Positives = 40/70 (57%), Gaps = 4/70 (5%)
Query 20 VSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQQESNNQKRKLQHLDQTEE 79
V+FLY + G A SYG++VA A +P + +AA S +L+ N ++++L++ +
Sbjct 1053 VTFLYQITRGIAARSYGLNVAKLADVPGEILKKAAHKSKELEGLINTKRKRLKYFAKLW- 1111
Query 80 ENKTNNNTQD 89
T +N QD
Sbjct 1112 ---TMHNAQD 1118
> ath:AT3G20475 MSH5; MSH5 (MUTS-HOMOLOGUE 5); ATP binding / damaged
DNA binding / mismatched DNA binding; K08741 DNA mismatch
repair protein MSH5
Length=807
Score = 42.0 bits (97), Expect = 5e-04, Method: Composition-based stats.
Identities = 25/76 (32%), Positives = 39/76 (51%), Gaps = 3/76 (3%)
Query 19 QVSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQQESNNQKRKLQHLDQTE 78
++ FLY + G SYG+H A AG+P + RAA + + ESNN KL LD+
Sbjct 718 EIVFLYRLIPGQTLLSYGLHCALLAGVPEEVVKRAAIVLDAF--ESNNNVDKLS-LDKIS 774
Query 79 EENKTNNNTQDTLKKL 94
+++ + D +L
Sbjct 775 SQDQAFKDAVDKFAEL 790
> ath:AT4G02070 MSH6; MSH6 (MUTS HOMOLOG 6); damaged DNA binding;
K08737 DNA mismatch repair protein MSH6
Length=1324
Score = 40.4 bits (93), Expect = 0.001, Method: Composition-based stats.
Identities = 21/55 (38%), Positives = 28/55 (50%), Gaps = 0/55 (0%)
Query 19 QVSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQQESNNQKRKLQH 73
+V+FLY + G SYGV+VA AGLP + RA S + + RK H
Sbjct 1229 EVTFLYRLTPGACPKSYGVNVARLAGLPDYVLQRAVIKSQEFEALYGKNHRKTDH 1283
> ath:AT4G25540 MSH3; MSH3 (Arabidopsis homolog of DNA mismatch
repair protein MSH3); damaged DNA binding / mismatched DNA
binding / protein binding; K08736 DNA mismatch repair protein
MSH3
Length=1081
Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust.
Identities = 21/72 (29%), Positives = 36/72 (50%), Gaps = 6/72 (8%)
Query 4 VHNYHVRAAVCKKKR------QVSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAIS 57
V YHV +K + V++LY + G S+G VA A +PP+ RA +++
Sbjct 946 VGTYHVSYLTLQKDKGSYDHDDVTYLYKLVRGLCSRSFGFKVAQLAQIPPSCIRRAISMA 1005
Query 58 NQLQQESNNQKR 69
+L+ E ++R
Sbjct 1006 AKLEAEVRARER 1017
> sce:YOL090W MSH2, PMS5; Msh2p; K08735 DNA mismatch repair protein
MSH2
Length=964
Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust.
Identities = 31/108 (28%), Positives = 52/108 (48%), Gaps = 10/108 (9%)
Query 4 VHNYHVRAAVCKKKRQ-------VSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAI 56
V N HV A + K ++ ++ LY V+ G +D S+G+HVA P + A
Sbjct 816 VKNMHVVAHIEKNLKEQKHDDEDITLLYKVEPGISDQSFGIHVAEVVQFPEKIVKMAKRK 875
Query 57 SNQLQQ-ESNNQKRKLQHLDQTEEENKTNNNTQDTLKK-LRNIISEAF 102
+N+L ++NN+ K L +E N+ N + LK+ +R + E
Sbjct 876 ANELDDLKTNNEDLKKAKL-SLQEVNEGNIRLKALLKEWIRKVKEEGL 922
> pfa:PFE0270c DNA repair protein, putative; K08737 DNA mismatch
repair protein MSH6
Length=1350
Score = 38.5 bits (88), Expect = 0.005, Method: Composition-based stats.
Identities = 16/52 (30%), Positives = 30/52 (57%), Gaps = 0/52 (0%)
Query 2 EGVHNYHVRAAVCKKKRQVSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRA 53
+ + NYH+ ++ ++ ++ FLY +G S+G+H+A AGLP + A
Sbjct 1251 KNISNYHMSLSIDDEQEKIIFLYKFIKGVCPKSFGIHIAKLAGLPKEIIDLA 1302
> dre:406845 msh2, wu:fc06b02, wu:fc13e09, zgc:55333; mutS homolog
2 (E. coli); K08735 DNA mismatch repair protein MSH2
Length=936
Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust.
Identities = 19/46 (41%), Positives = 24/46 (52%), Gaps = 2/46 (4%)
Query 1 VEGVHNYHVRAAVCKKKRQVSFLYDVKEGHADNSYGVHVAAFAGLP 46
V V N HV A ++ LY VK+G D S+G+HVA A P
Sbjct 794 VPTVRNLHVTALTTDS--TLTMLYKVKKGVCDQSFGIHVAELASFP 837
> hsa:4439 MSH5, DKFZp434C1615, G7, MGC2939, MUTSH5, NG23; mutS
homolog 5 (E. coli); K08741 DNA mismatch repair protein MSH5
Length=834
Score = 38.1 bits (87), Expect = 0.007, Method: Composition-based stats.
Identities = 18/48 (37%), Positives = 26/48 (54%), Gaps = 0/48 (0%)
Query 14 CKKKRQVSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQ 61
C+ + F Y V EG A S+ H AA AGLP L +R +S+ ++
Sbjct 732 CEDGNDLVFFYQVCEGVAKASHASHTAAQAGLPDKLVARGKEVSDLIR 779
> mmu:17686 Msh3, D13Em1, Rep-3, Rep3; mutS homolog 3 (E. coli);
K08736 DNA mismatch repair protein MSH3
Length=1095
Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust.
Identities = 18/53 (33%), Positives = 33/53 (62%), Gaps = 0/53 (0%)
Query 20 VSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQQESNNQKRKLQ 72
V+FLY + G A SYG++VA A +P + +AA S +L+ + ++++L+
Sbjct 1011 VTFLYQITRGIAARSYGLNVAKLADVPREVLQKAAHKSKELEGLVSLRRKRLE 1063
> mmu:100046843 DNA mismatch repair protein Msh3-like
Length=961
Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust.
Identities = 18/53 (33%), Positives = 33/53 (62%), Gaps = 0/53 (0%)
Query 20 VSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQQESNNQKRKLQ 72
V+FLY + G A SYG++VA A +P + +AA S +L+ + ++++L+
Sbjct 877 VTFLYQITRGIAARSYGLNVAKLADVPREVLQKAAHKSKELEGLVSLRRKRLE 929
> bbo:BBOV_I003810 19.m02277; DNA mismatch repair enzyme; K08735
DNA mismatch repair protein MSH2
Length=791
Score = 37.4 bits (85), Expect = 0.011, Method: Composition-based stats.
Identities = 25/93 (26%), Positives = 44/93 (47%), Gaps = 1/93 (1%)
Query 4 VHNYHVRAAVCKKKRQVSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQQE 63
V N +V A ++ +++ LY++K+G SY ++VA A P + + A +L+
Sbjct 696 VENKYVAAKYFEETKKMVLLYEIKDGVCKESYAINVADIALFPQEVIANAQVKLAELEHV 755
Query 64 SNNQKRKLQH-LDQTEEENKTNNNTQDTLKKLR 95
+ KL H L T NN + + KL+
Sbjct 756 DKDIDLKLLHQLTATSTYEDFRNNYPNLIAKLQ 788
> sce:YDR097C MSH6, PMS3; Msh6p; K08737 DNA mismatch repair protein
MSH6
Length=1242
Score = 37.4 bits (85), Expect = 0.011, Method: Composition-based stats.
Identities = 17/53 (32%), Positives = 30/53 (56%), Gaps = 0/53 (0%)
Query 18 RQVSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQQESNNQKRK 70
R V+FLY + EG ++ S+G+HVA+ G+ + A ++ L+ S K +
Sbjct 1124 RNVTFLYKMLEGQSEGSFGMHVASMCGISKEIIDNAQIAADNLEHTSRLVKER 1176
> cpv:cgd8_370 DNA repair protein ; K08737 DNA mismatch repair
protein MSH6
Length=1242
Score = 36.6 bits (83), Expect = 0.019, Method: Composition-based stats.
Identities = 15/58 (25%), Positives = 31/58 (53%), Gaps = 0/58 (0%)
Query 7 YHVRAAVCKKKRQVSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQQES 64
+H+ + + R ++FLY G SYG++VA AG+P + + A++ ++ +
Sbjct 1141 FHMDLKLNNETRSITFLYKFISGICPKSYGMNVAQLAGIPQEVVDNSVALAKDVESST 1198
> dre:565400 novel protein similar to vertebrate mutS homolog
3 (E. coli) (MSH3); K08736 DNA mismatch repair protein MSH3
Length=1083
Score = 36.6 bits (83), Expect = 0.020, Method: Composition-based stats.
Identities = 18/49 (36%), Positives = 31/49 (63%), Gaps = 0/49 (0%)
Query 20 VSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQQESNNQK 68
++FLY + EG A SYG++VA A +P ++ AA S +L+ N+++
Sbjct 1007 ITFLYQLIEGAAARSYGLNVARLAEIPESILRTAAFKSKELEALVNSRR 1055
> sce:YDL154W MSH5; Msh5p; K08741 DNA mismatch repair protein
MSH5
Length=901
Score = 36.2 bits (82), Expect = 0.025, Method: Composition-based stats.
Identities = 21/75 (28%), Positives = 39/75 (52%), Gaps = 3/75 (4%)
Query 20 VSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQQESNNQKRKLQHLDQTEE 79
++FL+ VKEG + S+G++ A GL + RA +S + + + + Q + TE+
Sbjct 805 ITFLFKVKEGISKQSFGIYCAKVCGLSRDIVERAEELSRMINRGDDVVQ---QCGNLTEK 861
Query 80 ENKTNNNTQDTLKKL 94
E + Q+ +KK
Sbjct 862 EMREFQKNQEIVKKF 876
> tpv:TP01_0456 DNA mismatch repair protein MSH2; K08735 DNA mismatch
repair protein MSH2
Length=790
Score = 35.8 bits (81), Expect = 0.039, Method: Composition-based stats.
Identities = 20/69 (28%), Positives = 35/69 (50%), Gaps = 0/69 (0%)
Query 3 GVHNYHVRAAVCKKKRQVSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQQ 62
GV N H+ A ++FLY VK+G S+G++VA A P + A +L++
Sbjct 698 GVVNKHLTAQFYDSINSMTFLYKVKDGVCKKSFGINVAIIAKFPQDVIESAQNKLKELER 757
Query 63 ESNNQKRKL 71
+ + ++ L
Sbjct 758 KYSPRRTDL 766
> mmu:17687 Msh5, G7, Mut5; mutS homolog 5 (E. coli); K08741 DNA
mismatch repair protein MSH5
Length=833
Score = 35.8 bits (81), Expect = 0.039, Method: Composition-based stats.
Identities = 16/48 (33%), Positives = 26/48 (54%), Gaps = 0/48 (0%)
Query 14 CKKKRQVSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQ 61
C+ + F Y + +G A S+ H AA AGLP L +R +S+ ++
Sbjct 731 CEDGEDLVFFYQLCQGVASASHASHTAAQAGLPDPLIARGKEVSDLIR 778
> dre:570030 msh5; mutS homolog 5 (E. coli); K08741 DNA mismatch
repair protein MSH5
Length=793
Score = 35.0 bits (79), Expect = 0.056, Method: Composition-based stats.
Identities = 18/64 (28%), Positives = 32/64 (50%), Gaps = 2/64 (3%)
Query 19 QVSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQQESNNQKRKLQHLDQTE 78
++ FLY VK G +S ++A AG+P L R +S+ + + RK++ E
Sbjct 696 ELVFLYQVKNGICQSSCAANIATLAGIPDDLVRRGVEVSDLYR--TGRTIRKMERPSADE 753
Query 79 EENK 82
+ N+
Sbjct 754 QNNR 757
> hsa:4436 MSH2, COCA1, FCC1, HNPCC, HNPCC1, LCFS2; mutS homolog
2, colon cancer, nonpolyposis type 1 (E. coli); K08735 DNA
mismatch repair protein MSH2
Length=934
Score = 34.7 bits (78), Expect = 0.075, Method: Compositional matrix adjust.
Identities = 18/46 (39%), Positives = 26/46 (56%), Gaps = 2/46 (4%)
Query 1 VEGVHNYHVRAAVCKKKRQVSFLYDVKEGHADNSYGVHVAAFAGLP 46
+ V+N HV A + ++ LY VK+G D S+G+HVA A P
Sbjct 794 IPTVNNLHVTAL--TTEETLTMLYQVKKGVCDQSFGIHVAELANFP 837
> mmu:17685 Msh2, AI788990; mutS homolog 2 (E. coli); K08735 DNA
mismatch repair protein MSH2
Length=935
Score = 34.7 bits (78), Expect = 0.085, Method: Compositional matrix adjust.
Identities = 18/43 (41%), Positives = 25/43 (58%), Gaps = 2/43 (4%)
Query 4 VHNYHVRAAVCKKKRQVSFLYDVKEGHADNSYGVHVAAFAGLP 46
V+N HV A + ++ LY VK+G D S+G+HVA A P
Sbjct 797 VNNLHVTAL--TTEETLTMLYQVKKGVCDQSFGIHVAELANFP 837
> cpv:cgd8_3950 MutS like ABC ATpase involved in DNA repair ;
K08735 DNA mismatch repair protein MSH2
Length=848
Score = 33.9 bits (76), Expect = 0.12, Method: Composition-based stats.
Identities = 20/59 (33%), Positives = 28/59 (47%), Gaps = 9/59 (15%)
Query 20 VSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQ---------QESNNQKR 69
+ FLY V++G D S GV VA +GLP R+ + +L Q N+KR
Sbjct 738 LKFLYKVEKGFTDKSLGVDVAELSGLPSETVKRSREKAEELTLVEQVYVDPQSCQNKKR 796
> ath:AT3G24495 MSH7; MSH7 (MUTS HOMOLOG 7); ATP binding / damaged
DNA binding / mismatched DNA binding
Length=1109
Score = 33.1 bits (74), Expect = 0.25, Method: Composition-based stats.
Identities = 20/76 (26%), Positives = 37/76 (48%), Gaps = 6/76 (7%)
Query 22 FLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQQESNNQKRKLQHLDQTEEEN 81
FLY + EG SYG+ VA AG+P + A+ + +++ ++ +E +
Sbjct 1007 FLYRLTEGACPESYGLQVALMAGIPNQVVETASGAAQAMKRSIG------ENFKSSELRS 1060
Query 82 KTNNNTQDTLKKLRNI 97
+ ++ +D LK L I
Sbjct 1061 EFSSLHEDWLKSLVGI 1076
> cpv:cgd8_3640 niemann-Pick type C1 disease protein/ patched
like cholesterol transporter of the SecD family, 12 transmembrane
domain
Length=1465
Score = 30.8 bits (68), Expect = 1.2, Method: Composition-based stats.
Identities = 21/49 (42%), Positives = 29/49 (59%), Gaps = 3/49 (6%)
Query 39 VAAFAGL--PPALTSRAAAISNQLQQESNNQKRKLQHLDQTEEENKTNN 85
V+A AG+ PA+ S A N ++ NN+KR+ Q LD T E K+NN
Sbjct 1416 VSATAGIMIAPAILSIALDFGNFIRDYYNNRKRQ-QELDDTILEIKSNN 1463
> cel:H26D21.2 msh-2; MSH (MutS Homolog) family member (msh-2);
K08735 DNA mismatch repair protein MSH2
Length=849
Score = 29.6 bits (65), Expect = 2.7, Method: Composition-based stats.
Identities = 18/64 (28%), Positives = 33/64 (51%), Gaps = 4/64 (6%)
Query 16 KKRQVSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQQ----ESNNQKRKL 71
+ ++ LY V EG A S+G+ VA G+ + ++AA + L++ +S +K L
Sbjct 776 ENNEIHMLYKVFEGVAQCSFGLQVAKMVGIDENVINKAAQLLEGLEKKLVIDSKKKKELL 835
Query 72 QHLD 75
+ D
Sbjct 836 ESAD 839
> hsa:65267 WNK3, FLJ30437, FLJ42662, KIAA1566, PRKWNK3; WNK lysine
deficient protein kinase 3 (EC:2.7.11.1); K08867 WNK lysine
deficient protein kinase [EC:2.7.11.1]
Length=1743
Score = 29.3 bits (64), Expect = 3.5, Method: Compositional matrix adjust.
Identities = 17/45 (37%), Positives = 24/45 (53%), Gaps = 0/45 (0%)
Query 55 AISNQLQQESNNQKRKLQHLDQTEEENKTNNNTQDTLKKLRNIIS 99
A+ N L + S NQ ++ QH +TE NK + NT T+ IS
Sbjct 1604 AVGNSLIKPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWIS 1648
> dre:559917 mutS homolog 4-like; K08740 DNA mismatch repair protein
MSH4
Length=931
Score = 28.9 bits (63), Expect = 3.7, Method: Compositional matrix adjust.
Identities = 14/57 (24%), Positives = 30/57 (52%), Gaps = 2/57 (3%)
Query 8 HVRAAVCKKKRQVSFLYDVKEGHADN-SYGVHVAAFAGLPPALTSRAAAISNQLQQE 63
H+R + +R V + Y + GH++ +YG+ A LP + A +++++ Q+
Sbjct 808 HIRTGDGRAER-VVYTYQLSRGHSEERNYGIRAAEMTNLPLDIIQEAKTVADKINQK 863
> pfa:PFC0225c elongation factor (EF-TS), putative; K02357 elongation
factor Ts
Length=390
Score = 28.9 bits (63), Expect = 4.0, Method: Composition-based stats.
Identities = 26/88 (29%), Positives = 37/88 (42%), Gaps = 2/88 (2%)
Query 13 VCKKKRQVSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQQESNNQKRKLQ 72
V + K V F+Y + DN V AG N L +NN ++
Sbjct 135 VARNKMFVQFVYSLLNVTLDNDLSVGNCKNAGDNKNSEDGYTTSGNILS--NNNIMDEIL 192
Query 73 HLDQTEEENKTNNNTQDTLKKLRNIISE 100
L +EENK+N+ ++ L LRNI E
Sbjct 193 SLPYVDEENKSNSTMREQLNYLRNIFRE 220
> tgo:TGME49_068390 hypothetical protein
Length=359
Score = 28.9 bits (63), Expect = 4.2, Method: Compositional matrix adjust.
Identities = 23/67 (34%), Positives = 34/67 (50%), Gaps = 8/67 (11%)
Query 48 ALTSRAAAI-------SNQLQQESNNQKRKLQHLDQTEEENKTNNNTQDTLKKLRNIISE 100
+L+SRAAA NQ + ES R + D+TE E++ NN +T K+ R +
Sbjct 91 SLSSRAAAGRTALHLNENQTRGESGT-PRACESQDETEAESQANNEETETEKRDRQVEQA 149
Query 101 AFAAQTP 107
A A+ P
Sbjct 150 AAASHLP 156
> dre:100148193 dnah6; dynein, axonemal, heavy chain 6
Length=4163
Score = 28.9 bits (63), Expect = 4.3, Method: Composition-based stats.
Identities = 20/82 (24%), Positives = 38/82 (46%), Gaps = 2/82 (2%)
Query 15 KKKRQVSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQLQQESNNQKRKLQHL 74
K+ VS +Y + E ++ + +A +A LPP +T+ I + + + + QHL
Sbjct 758 KETVTVSEMYKLIECYSVPTPPEDIAVYATLPPCITAVRNTIDKAVGERDSYVDKFCQHL 817
Query 75 DQTEEENKTNNNTQDTLKKLRN 96
Q + + NN Q+ + N
Sbjct 818 QQ--DIGQLNNTVQEVKAEAEN 837
> cel:Y47G6A.11 msh-6; MSH (MutS Homolog) family member (msh-6);
K08737 DNA mismatch repair protein MSH6
Length=1186
Score = 28.9 bits (63), Expect = 4.8, Method: Composition-based stats.
Identities = 17/59 (28%), Positives = 29/59 (49%), Gaps = 6/59 (10%)
Query 8 HVRAAVCKKKRQ------VSFLYDVKEGHADNSYGVHVAAFAGLPPALTSRAAAISNQL 60
H++ V K+ + V+FLY+++ G SYG + A AG+ + A SN+
Sbjct 1094 HMKCVVDKENNEDPTMEDVTFLYELESGICPKSYGFYAAKLAGIDHQVVRNAYLESNKF 1152
> dre:559325 lysosomal trafficking regulator-like
Length=2563
Score = 28.5 bits (62), Expect = 6.2, Method: Composition-based stats.
Identities = 15/49 (30%), Positives = 26/49 (53%), Gaps = 0/49 (0%)
Query 39 VAAFAGLPPALTSRAAAISNQLQQESNNQKRKLQHLDQTEEENKTNNNT 87
+A GL A R+ + ++ +ES +Q ++L +EE KT+N T
Sbjct 1503 IARVKGLVKAPLKRSRSTADGADEESQDQLQELLESGAMDEEQKTDNTT 1551
> hsa:4438 MSH4; mutS homolog 4 (E. coli); K08740 DNA mismatch
repair protein MSH4
Length=936
Score = 28.1 bits (61), Expect = 6.6, Method: Composition-based stats.
Identities = 13/63 (20%), Positives = 32/63 (50%), Gaps = 1/63 (1%)
Query 15 KKKRQVSFLYDVKEG-HADNSYGVHVAAFAGLPPALTSRAAAISNQLQQESNNQKRKLQH 73
+ K + + Y + +G + +YG+ A + LPP++ A I+ Q+ ++ +R
Sbjct 822 RNKEAILYTYKLSKGLTEEKNYGLKAAEVSSLPPSIVLDAKEITTQITRQILQNQRSTPE 881
Query 74 LDQ 76
+++
Sbjct 882 MER 884
> mmu:71909 Haus5, 2310022K01Rik; HAUS augmin-like complex, subunit
5
Length=619
Score = 27.7 bits (60), Expect = 8.2, Method: Compositional matrix adjust.
Identities = 14/34 (41%), Positives = 20/34 (58%), Gaps = 1/34 (2%)
Query 76 QTEEENKTNNNTQDTLKKLRNIISEAFAAQTPQL 109
Q +E + N N TLKKL N++ +A Q P+L
Sbjct 555 QVSQEKEQNENVGQTLKKLSNLLKQAL-EQIPEL 587
> sce:YHR114W BZZ1, LSB7; Bzz1p
Length=633
Score = 27.7 bits (60), Expect = 8.7, Method: Compositional matrix adjust.
Identities = 19/58 (32%), Positives = 32/58 (55%), Gaps = 6/58 (10%)
Query 58 NQLQQESNNQKRKLQHLDQTEEENKTNNNT------QDTLKKLRNIISEAFAAQTPQL 109
N LQ ++ N+ KL L++ + E KTN + DTLK+ N++S + +T +L
Sbjct 326 NSLQDKTQNELSKLSTLNKIKHEMKTNEDNINATKFYDTLKEYLNVVSPFTSHETLKL 383
> dre:571240 transmembrane channel-like gene family 2-like
Length=761
Score = 27.7 bits (60), Expect = 8.9, Method: Composition-based stats.
Identities = 12/39 (30%), Positives = 24/39 (61%), Gaps = 2/39 (5%)
Query 62 QESNNQKRKLQHLDQTEEENKTNN--NTQDTLKKLRNII 98
+ SNN+ +K + + EE+N+ NN +T +K L +++
Sbjct 639 KNSNNELKKKMQMARDEEKNRRNNKDSTNQVMKDLEDLL 677
> xla:380199 syap1, MGC53226; synapse associated protein 1, SAP47
homolog (Drosophila)
Length=364
Score = 27.7 bits (60), Expect = 9.2, Method: Composition-based stats.
Identities = 13/44 (29%), Positives = 27/44 (61%), Gaps = 0/44 (0%)
Query 57 SNQLQQESNNQKRKLQHLDQTEEENKTNNNTQDTLKKLRNIISE 100
++ L QE ++ + LD+ EE +K T+D +K+L++++ E
Sbjct 295 ASNLNQEDFRKEMEQLILDKKEEVDKAEEETEDWIKELQDVVQE 338
> pfa:PF10_0224 dynein heavy chain, putative; K06025 [EC:3.6.4.2]
Length=5687
Score = 27.7 bits (60), Expect = 9.7, Method: Composition-based stats.
Identities = 12/49 (24%), Positives = 29/49 (59%), Gaps = 0/49 (0%)
Query 52 RAAAISNQLQQESNNQKRKLQHLDQTEEENKTNNNTQDTLKKLRNIISE 100
+ + ++LQ+ +NN+ + + LDQ E + K ++ + L++ N ++E
Sbjct 4283 KVKPLMDKLQEATNNKNKAQEKLDQLENKVKELTDSVEKLRRKMNEVNE 4331
Lambda K H
0.312 0.125 0.345
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 2067351240
Database: egene_temp_file_orthology_annotation_similarity_blast_database_966
Posted date: Sep 16, 2011 8:45 PM
Number of letters in database: 82,071,388
Number of sequences in database: 164,496
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40