bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: egene_temp_file_orthology_annotation_similarity_blast_database_966
164,496 sequences; 82,071,388 total letters
Query= Eace_1266_orf3
Length=855
Score E
Sequences producing significant alignments: (Bits) Value
tgo:TGME49_057010 insulysin, putative (EC:3.4.24.56); K01408 i... 1033 0.0
dre:561390 ide, MGC162603, zgc:162603; insulin-degrading enzym... 290 1e-77
mmu:15925 Ide, 1300012G03Rik, 4833415K22Rik, AA675336, AI50753... 287 1e-76
cpv:cgd1_1680 insulinase like protease, signal peptide ; K0140... 285 5e-76
sce:YLR389C STE23; Metalloprotease involved, with homolog Axl1... 281 1e-74
ath:AT2G41790 peptidase M16 family protein / insulinase family... 264 1e-69
cel:Y70C5C.1 hypothetical protein; K01408 insulysin [EC:3.4.24... 248 7e-65
cel:F44E7.4 hypothetical protein; K01408 insulysin [EC:3.4.24.56] 243 2e-63
dre:557565 nrd1, si:dkey-171o17.4; nardilysin (N-arginine diba... 242 6e-63
ath:AT1G06900 catalytic/ metal ion binding / metalloendopeptid... 241 9e-63
hsa:4898 NRD1, hNRD1, hNRD2; nardilysin (N-arginine dibasic co... 239 3e-62
cel:C02G6.2 hypothetical protein; K01408 insulysin [EC:3.4.24.56] 239 5e-62
mmu:230598 Nrd1, 2600011I06Rik, AI875733, MGC25477, NRD-C; nar... 238 6e-62
cpv:cgd2_930 peptidase'insulinase-like peptidase' ; K01408 ins... 236 4e-61
dre:565850 fk24c07; wu:fk24c07; K01411 nardilysin [EC:3.4.24.61] 231 8e-60
cel:C02G6.1 hypothetical protein; K01408 insulysin [EC:3.4.24.56] 230 2e-59
ath:AT3G57470 peptidase M16 family protein / insulinase family... 223 3e-57
cpv:cgd2_920 peptidase'insulinase-like peptidase' 206 2e-52
eco:b2821 ptrA, ECK2817, JW2789, ptr; protease III (EC:3.4.24.... 202 4e-51
tgo:TGME49_069890 M16 family peptidase, putative (EC:3.4.24.56) 201 1e-50
cel:C28F5.4 hypothetical protein; K01408 insulysin [EC:3.4.24.56] 197 2e-49
cpv:cgd3_4260 peptidase'insulinase like peptidase' ; K01408 in... 171 1e-41
cpv:cgd3_4270 peptidase'insulinase like peptidase' ; K01408 in... 162 5e-39
tgo:TGME49_044480 insulin-degrading enzyme, putative (EC:3.4.2... 136 4e-31
sce:YPR122W AXL1, FUS5, STE22; Axl1p (EC:3.4.24.-); K01422 [E... 133 4e-30
cpv:cgd2_4270 secreted insulinase-like peptidase 132 6e-30
cpv:cgd3_4240 insulinase like peptidase ; K01408 insulysin [EC... 125 6e-28
cpv:cgd6_5520 peptidase'insulinase like peptidase' ; K01408 in... 120 2e-26
cpv:cgd3_4170 secreted insulinase like peptidase 109 4e-23
tgo:TGME49_006510 peptidase M16 domain containing protein (EC:... 94.0 2e-18
cpv:cgd3_4180 secreted insulinase like peptidase 79.0 7e-14
cpv:cgd3_4280 secreted insulinase like peptidase, signal peptide 78.2 1e-13
ath:AT3G02090 MPPBETA; mitochondrial processing peptidase beta... 73.2 5e-12
cpv:cgd3_4210 secreted insulinase like peptidase, signal peptide 71.6 1e-11
eco:b1494 pqqL, ECK1488, JW1489, pqqE, pqqM, yddC; predicted p... 68.9 8e-11
hsa:3416 IDE, FLJ35968, INSULYSIN; insulin-degrading enzyme (E... 64.7 2e-09
cpv:cgd3_4250 secreted insulinase like peptidase, signal peptide 63.5 4e-09
tgo:TGME49_036210 mitochondrial-processing peptidase beta subu... 57.8 2e-07
cpv:cgd3_4200 secreted insulinase like peptidase, signal peptide 57.4 2e-07
ath:AT5G42390 metalloendopeptidase 57.4 3e-07
dre:503532 pmpcb, zgc:110738; peptidase (mitochondrial process... 56.2 5e-07
sce:YLR163C MAS1, MIF1; Mas1p (EC:3.4.24.64); K01412 mitochond... 55.8 6e-07
pfa:PF11_0226 petidase, M16 family 55.8 7e-07
hsa:9512 PMPCB, Beta-MPP, MPP11, MPPB, MPPP52, P-52; peptidase... 54.7 2e-06
mmu:73078 Pmpcb, 3110004O18Rik, MPP11, MPPB, MPPP52; peptidase... 54.3 2e-06
bbo:BBOV_II001130 18.m06083; hypothetical protein 53.9 3e-06
bbo:BBOV_IV001260 21.m02910; mitochondrial processing peptidas... 53.1 5e-06
cel:ZC410.2 mppb-1; Mitochondrial Processing Peptidase Beta fa... 52.4 7e-06
pfa:PFI1625c organelle processing peptidase, putative; K01412 ... 52.4 8e-06
tpv:TP01_0151 biquinol-cytochrome C reductase complex core pro... 52.4 8e-06
> tgo:TGME49_057010 insulysin, putative (EC:3.4.24.56); K01408
insulysin [EC:3.4.24.56]
Length=953
Score = 1033 bits (2671), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 466/843 (55%), Positives = 632/843 (74%), Gaps = 3/843 (0%)
Query 2 AIGALASDILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPG 61
A+G + ++LKP ADYRDF H+QL NGM +A+HHP++ E ++VA NTGSLYDPED+PG
Sbjct 15 AVGCVCGEVLKPGADYRDFHHFQLPNGMQCLAIHHPKTTEGAYSVAVNTGSLYDPEDLPG 74
Query 62 LAHFLEHMLFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRF 121
LAHFLEHMLFLGTSK+PEPESYD F+++ GG NNAYTDEEKTVFFN+V+D E+ALDRF
Sbjct 75 LAHFLEHMLFLGTSKHPEPESYDKFMSERGGQNNAYTDEEKTVFFNQVSDKYLEDALDRF 134
Query 122 AEFFKSPLFNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAKGPMSRFATGNAETLS 181
++FFKSPLFN +YEE+E +A+D+EHQKN+PND+ER W+TIRSLAKGP+SRFATGN ETL+
Sbjct 135 SQFFKSPLFNPEYEEREAHAVDSEHQKNVPNDEERTWFTIRSLAKGPLSRFATGNLETLN 194
Query 182 TYPKANGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLG 241
T PK GI++V RL+DFH KYYC SNM V +SPRSL EQE+L+R+ E +++G+ ++LG
Sbjct 195 TAPKRKGINVVSRLKDFHKKYYCASNMAVVIMSPRSLVEQETLLRKSFEDVTSGNPNFLG 254
Query 242 MVQCPGPMFDTVKPFDHTNSGKFIHLQSFSSQPSLWVAFGLPATLTSYKKQPTSVLTYLL 301
QCPG +D PFD +N+GKFIHLQS + SLWVAF LP T+TSYKKQPT +LTYL
Sbjct 255 FDQCPGVDYDRTPPFDLSNTGKFIHLQSVGGESSLWVAFSLPPTITSYKKQPTGILTYLF 314
Query 302 EYTGEGSLAKRLRLLGLADGISPAVDRNSISTLLGIKVDLTQKGAAHRGLVLQEIFSYIN 361
EY+G+GSL+KRLR +GLAD +S DR S+STL +KVDL KGA+ RG VL+E+FSYIN
Sbjct 315 EYSGDGSLSKRLRTMGLADEVSVVADRTSVSTLFAVKVDLASKGASERGAVLEEVFSYIN 374
Query 362 FLRDHGVGHDLVSTMAQQSHIDFHTTQPSSSIMDEAARLAHNLLTYEPYHVVAGDSLLID 421
L++ GV +S++++QS +DFHT+QP M+E ARLAHNLLTYEPYHV+AGDSLL+D
Sbjct 375 LLKNEGVDSKTISSISEQSLVDFHTSQPDPPAMNEVARLAHNLLTYEPYHVLAGDSLLVD 434
Query 422 ADPRLTNQLLQAMSPSKAIIAFSDPDFTSKVDNFETDPYYGVQFRVLDLPQHHAVAMAVL 481
D + NQLL M+ AIIAF+DP F D+F+ +P+YG+++++ +LP+ + +
Sbjct 435 PDAQFVNQLLDKMTSDHAIIAFADPQFKRNNDSFDVEPFYGIEYKITNLPKEQRRRLETV 494
Query 482 TASPNAFRMPPPLMHIPKASELKILPGLLGLTEPELISEQGGNAGTAVWWQGQGAFALPR 541
T SP A+++PP L H+P+ +L +LP L G++ PEL+ + + G AVWWQGQG +PR
Sbjct 495 TPSPGAYKIPPALKHVPRPEDLHLLPALGGMSIPELLGDSNTSGGHAVWWQGQGTLPVPR 554
Query 542 IAVQLNGSISKEKADVLSRTQGSLALAAIAEHLQEETVDFQNCGITHSLAFKGTGFHMTF 601
+ + + + ++ SRTQ +L +AA+AE L EETVD + CGI+HS+ G G + F
Sbjct 555 VHANIKARTQRSRTNMASRTQATLLMAALAEQLDEETVDLKQCGISHSVGVSGDGLLLAF 614
Query 602 EGYTQAQLGKVMAHVASLLSDPSMVEPERFERIKEKQIKLLADPATSMAFEHALEAAAIL 661
YT QL +VMA VAS + DP VE +RF+RIK++ I+ L D A+ +A+EHA+ AA++L
Sbjct 615 AAYTPKQLRQVMAVVASKIQDP-QVEQDRFDRIKQRMIEELEDSASQVAYEHAIAAASVL 673
Query 662 TRNDAFSRKDVLNALQQS--NYEDSIAKLSELKNIHVDAFVMGNIDRDQSLAMVEDFLEQ 719
RNDA SRKD+L L+ S + +++ +LK +H DAF+MGNID+ + ++V+ FL+
Sbjct 674 LRNDANSRKDLLRLLKSSSTSLNETLKTFRDLKAVHADAFIMGNIDKADANSVVQSFLQD 733
Query 720 AGFTPIAHDDAVASLAMEQKQTIEATLANPIKGDKDHASLVQFQLGIPSIEDRVNLAVLT 779
+GFT I DA SL ++Q+ IEA +ANPI D +HA++VQ+QLG+PSIE+RVNLAVL
Sbjct 734 SGFTQIPMKDAAQSLVVDQRAPIEALIANPIPKDVNHATVVQYQLGVPSIEERVNLAVLG 793
Query 780 QFLNRRIYDSLRTEAQLGYIAGAKESQAASTALLQCFVEGAKTHPDEVVKMIDEELTKAK 839
Q LNRR++D LRTE QLGYI GA+ +S L+C +EG++ HPDE+ +ID+EL K
Sbjct 794 QMLNRRLFDRLRTEEQLGYIVGARSYIDSSVESLRCVLEGSRKHPDEIADLIDKELWKMN 853
Query 840 EYL 842
++L
Sbjct 854 DHL 856
> dre:561390 ide, MGC162603, zgc:162603; insulin-degrading enzyme
(EC:3.4.24.56); K01408 insulysin [EC:3.4.24.56]
Length=978
Score = 290 bits (743), Expect = 1e-77, Method: Compositional matrix adjust.
Identities = 220/840 (26%), Positives = 384/840 (45%), Gaps = 51/840 (6%)
Query 2 AIGALASDILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPG 61
A+ + SDI++ D R++R + +NG+ AI + P ++++ A+ + GSL DPE++ G
Sbjct 5 AVKRVVSDIIRSPEDKREYRGLEFTNGLKAILISDPTTDKSSAALDVHMGSLSDPENISG 64
Query 62 LAHFLEHMLFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRF 121
LAHF EHMLFLGT KYP+ Y FL+++ G++NA+T E T ++ V+ + ALDRF
Sbjct 65 LAHFCEHMLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQGALDRF 124
Query 122 AEFFKSPLFNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLA--KGPMSRFATGNAET 179
A+FF PLF+ +++EVNA+D+EH+KN+ ND R + ++ K P S+F TGN T
Sbjct 125 AQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPKHPFSKFGTGNKLT 184
Query 180 LSTYPKANGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADW 239
L T P GID+ + L FHS YY + M + +LDE S++ + + +
Sbjct 185 LETRPSQQGIDIREELLKFHSTYYSSNLMGLCVLGRETLDELTSMVVKLFGEVENKNV-- 242
Query 240 LGMVQCPGPMFDTVKPFDHTNSGKFIHLQSFSSQPSLWVAFGLPATLTSYKKQPTSVLTY 299
P P F T PF + +F + +L+V F +P YK P L +
Sbjct 243 ------PVPEFPT-HPFQEEHLRQFYKVVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGH 295
Query 300 LLEYTGEGSLAKRLRLLGLADGISPAVDRNSISTLLG-IKVDLTQKGAAHRGLVLQEIFS 358
L+ + G GSL L+ G + + + + I VDLT++G H ++ +F
Sbjct 296 LIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIIFHMFQ 355
Query 359 YINFLRDHGVGHDLVSTMAQQSHIDFH---TTQPSSSIMDEAARLAHNLLTYEPY-HVVA 414
YI LR G + + + F +P A LL Y P ++A
Sbjct 356 YIQKLRTEGPQEWVFQECKDLNTVAFRFKDKERPRGYTSKVAG-----LLHYYPLEEILA 410
Query 415 GDSLLIDADPRLTNQLLQAMSPSKAIIAFSDPDFTSKVDNFETDPYYGVQFRVLDLPQHH 474
+ LL + P L +L + P +A F + D T+ +YG Q++
Sbjct 411 AEYLLEEFRPDLIEMVLDKLRPENVRVAVVSKSFEGQTDR--TEEWYGTQYK------QE 462
Query 475 AVAMAVLTASPNA-----FRMPPPLMHIPKASELKILPGLLGLTEPELISEQGGNAGTAV 529
A+ + NA F++P IP E+ L + P LI + A + V
Sbjct 463 AITDEAIKKWDNADLNGKFKLPMKNEFIPTNFEIYPLEK-DSPSAPTLIKD---TAMSKV 518
Query 530 WWQGQGAFALPRIAVQLNGSISKEKADVLSRTQGSLALAAIAEHLQEETVDFQNCGITHS 589
W++ F LP+ + D L L L + + L E + G+++
Sbjct 519 WFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYD 578
Query 590 LAFKGTGFHMTFEGYTQAQ---LGKVMAHVASLLSDPSMVEPERFERIKEKQIKLLADPA 646
L G +++ +GY Q L K++ +A+ ++ +RF+ IKE ++ L +
Sbjct 579 LQNTVYGMYLSVKGYNDKQHILLKKIIEKMATF-----EIDEKRFDIIKEAYMRSLNNFR 633
Query 647 TSMAFEHALEAAAILTRNDAFSRKDVLNALQQSNYEDSIAKLSE-LKNIHVDAFVMGNID 705
+HA+ +L A+++ ++ +AL A + + L +H++A + GNI
Sbjct 634 AEQPHQHAMYYLRLLMTEVAWTKDELRDALDDVTLPRLKAFIPQLLSRLHIEALLHGNIT 693
Query 706 RDQSLAMVE----DFLEQAGFTPIAHDDAVASLAMEQKQTIEATLANPIKGDKDHASLVQ 761
+ +L M++ +E A P+ + ++ + + +
Sbjct 694 KQSALEMMQMLEDTLIEHAHTKPLLPSQLIRYREVQVPDGGWYVYQQRNEVHNNCGIEIY 753
Query 762 FQLGIPSIEDRVNLAVLTQFLNRRIYDSLRTEAQLGYIAGAKESQAASTALLQCFVEGAK 821
+Q + + + + L + Q ++ +++LRT+ QLGYI + +A L+ ++ K
Sbjct 754 YQTDMQNTHENMLLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGVQGLRFIIQSEK 813
> mmu:15925 Ide, 1300012G03Rik, 4833415K22Rik, AA675336, AI507533;
insulin degrading enzyme (EC:3.4.24.56); K01408 insulysin
[EC:3.4.24.56]
Length=1019
Score = 287 bits (735), Expect = 1e-76, Method: Compositional matrix adjust.
Identities = 223/833 (26%), Positives = 383/833 (45%), Gaps = 37/833 (4%)
Query 2 AIGALASDILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPG 61
AI + I+K D R++R +L+NG+ + + P ++++ A+ + GSL DP ++PG
Sbjct 46 AIQRIEDQIVKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPG 105
Query 62 LAHFLEHMLFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRF 121
L+HF EHMLFLGT KYP+ Y FL+++ G++NA+T E T ++ V+ E ALDRF
Sbjct 106 LSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRF 165
Query 122 AEFFKSPLFNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLA--KGPMSRFATGNAET 179
A+FF PLF+ +++EVNA+D+EH+KN+ ND R + ++ K P S+F TGN T
Sbjct 166 AQFFLCPLFDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYT 225
Query 180 LSTYPKANGIDLVDRLRDFHSKYYCGSNMVAVTISPR-SLDEQESLIREKLEGISAGHAD 238
L T P GID+ + L FHS YY SN++A+ + R SLD+ +L+ + + +
Sbjct 226 LETRPNQEGIDVREELLKFHSTYY-SSNLMAICVLGRESLDDLTNLVVKLFSEVENKNV- 283
Query 239 WLGMVQCPGPMFDTVKPFDHTNSGKFIHLQSFSSQPSLWVAFGLPATLTSYKKQPTSVLT 298
P P F PF + + + +L+V F +P YK P L
Sbjct 284 -------PLPEFPE-HPFQEEHLRQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLG 335
Query 299 YLLEYTGEGSLAKRLRLLGLADGISPAVDRNSISTLLG-IKVDLTQKGAAHRGLVLQEIF 357
+L+ + G GSL L+ G + + + + I VDLT++G H ++ +F
Sbjct 336 HLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMF 395
Query 358 SYINFLRDHGVGHDLVSTMAQQSHIDFHTTQPSSSIMDEAARLAHNLLTYEPYHVVAGDS 417
YI LR G + + + F +++A L Y V+ +
Sbjct 396 QYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERP-RGYTSKIAGKLHYYPLNGVLTAEY 454
Query 418 LLIDADPRLTNQLLQAMSPSKAIIAFSDPDFTSKVDNFETDPYYGVQFRVLDLPQHHAVA 477
LL + P L + +L + P +A F K D T+ +YG Q++ +P+ +
Sbjct 455 LLEEFRPDLIDMVLDKLRPENVRVAIVSKSFEGKTD--RTEQWYGTQYKQEAIPED--II 510
Query 478 MAVLTASPNA-FRMPPPLMHIPKASELKILPGLLGLTEPELISEQGGNAGTAVWWQGQGA 536
A N F++P IP E+ L P LI + A + +W++
Sbjct 511 QKWQNADLNGKFKLPTKNEFIPTNFEILSLEK-DATPYPALIKD---TAMSKLWFKQDDK 566
Query 537 FALPRIAVQLNGSISKEKADVLSRTQGSLALAAIAEHLQEETVDFQNCGITHSLAFKGTG 596
F LP+ + D L L L + + L E + G+++ L G
Sbjct 567 FFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYG 626
Query 597 FHMTFEGYTQAQ---LGKVMAHVASLLSDPSMVEPERFERIKEKQIKLLADPATSMAFEH 653
+++ +GY Q L K+ +A+ ++ +RFE IKE ++ L + +H
Sbjct 627 MYLSVKGYNDKQPILLKKITEKMATF-----EIDKKRFEIIKEAYMRSLNNFRAEQPHQH 681
Query 654 ALEAAAILTRNDAFSRKDVLNALQQSNYEDSIAKLSE-LKNIHVDAFVMGNIDRDQSLA- 711
A+ +L A+++ ++ AL A + + L +H++A + GNI + +L
Sbjct 682 AMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGV 741
Query 712 --MVED-FLEQAGFTPIAHDDAVASLAMEQKQTIEATLANPIKGDKDHASLVQFQLGIPS 768
MVED +E A P+ V ++ + + + +Q + S
Sbjct 742 MQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQS 801
Query 769 IEDRVNLAVLTQFLNRRIYDSLRTEAQLGYIAGAKESQAASTALLQCFVEGAK 821
+ + L + Q ++ +++LRT+ QLGYI + +A L+ ++ K
Sbjct 802 TSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEK 854
> cpv:cgd1_1680 insulinase like protease, signal peptide ; K01408
insulysin [EC:3.4.24.56]
Length=1033
Score = 285 bits (729), Expect = 5e-76, Method: Compositional matrix adjust.
Identities = 181/623 (29%), Positives = 308/623 (49%), Gaps = 38/623 (6%)
Query 1 SAIGALASDILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVP 60
S+I +LKP+ D R +++ L NG+ A+ + S +AGF V GS +P
Sbjct 29 SSIWKSGYSVLKPKTDDRSYKNITLENGITALLIEDKFSEKAGFTVGIKVGSFNNPVYAL 88
Query 61 GLAHFLEHMLFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDR 120
GL H +EH+LFLGT KYP PESYD F+ Q+GG NNAYT EE+T++FN++ + EE LDR
Sbjct 89 GLFHLIEHVLFLGTKKYPAPESYDEFMAQHGGKNNAYTSEERTIYFNEIGEEYLEEGLDR 148
Query 121 FAEFFKSPLFNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAKGPMSRFATGNAETL 180
F+ FF PLF EKE++ I++EH KNIPN+ +R ++ +++ PMS+F TGN ETL
Sbjct 149 FSHFFIDPLFYENVIEKEIHIINSEHLKNIPNEFDRLFHMLKTHTNKPMSQFTTGNIETL 208
Query 181 STYPKANGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGI---SAGHA 237
P GI + L+ + KYYCG NM V S RSL +QE L+++ G+ + G
Sbjct 209 VDIPNKLGISIPRLLKKMYKKYYCGINMFIVLSSKRSLTDQEKLLQKYFSGVLIDNDGQC 268
Query 238 DWLGMVQCPGPMFDTVKPFDHTNSGKFIHLQSFSSQPSLWVAFGLPATLTSYKKQPTSVL 297
++ + + G + ++ D K IH++S + LW+ + PA L S KQP L
Sbjct 269 EFSSLKKEHGILNKSI--IDQKYLSKKIHVKSLGGRDLLWLIWSFPARLISPVKQPLIYL 326
Query 298 TYLLEYTGEGSLAKRLRLLGLADGISPAVDRNSISTLLGIKVDLTQKGAAHRGLVLQEIF 357
+Y+L + SL L+ + + + ++ +++LT +G ++ ++ I+
Sbjct 327 SYILNSKQKNSLFWFLQKNNYITNSNSVYENYTFGSIFIYQLELTSEGLKNQFEIIGLIY 386
Query 358 SYINFLRDHGVGHDLVSTMAQQSHIDF--HTTQPSSSIMDEAARLAHNLLTYEPYHVVAG 415
YIN L++ + + + +F +T SS M + + ++ Y + ++G
Sbjct 387 KYINKLKESKELLKVYQGIRSLTEREFITNTEMLESSPMHSTSEICSKMIQYGVHAALSG 446
Query 416 DSLLIDADPRLTNQLLQAMSPSKAIIAFSDP-DFTSKVDNFETDPYYGVQFRVLDLPQHH 474
D L+ D D L ++L A+SP + SD +F+ + F + V+ + D+P
Sbjct 447 DILIEDVDENLIYEILNAISPFDTLFLVSDEQEFSGTYEKF-----FHVKHAIEDIPIKT 501
Query 475 AVAMAVLTAS---PNAFRMPPPLMHIPKASELKILPGLLGLTEPELISEQGGNAGTAVWW 531
A + N ++P P P L+I+ + L+ P+ + N +WW
Sbjct 502 LNAWKKTKFNEREENEIKLPTPEKCSP--INLRIIQEVEDLSTPQRLDSMLAN----IWW 555
Query 532 QGQ-------GAFALPRIAVQLNGSISKEKADVLSRTQGSLALAAIAEHLQEETVDFQNC 584
G G L + + N I ++ G + + ++E+ + C
Sbjct 556 NGPVKKSHKIGIKILLKFPRRYNKGIE-------TQVWGEIITYILDTLIKEKIERYSEC 608
Query 585 GITHSLAFKGTGFHMTFE--GYT 605
G++ + + G ++ + GY+
Sbjct 609 GMSFYIEWDVEGILISIDTFGYS 631
Score = 76.6 bits (187), Expect = 4e-13, Method: Compositional matrix adjust.
Identities = 42/136 (30%), Positives = 73/136 (53%), Gaps = 0/136 (0%)
Query 696 VDAFVMGNIDRDQSLAMVEDFLEQAGFTPIAHDDAVASLAMEQKQTIEATLANPIKGDKD 755
+ A++ GNI +++SL ++E F+ + + ++ + + I+ L NP+ D +
Sbjct 761 IIAYLQGNISKNKSLYLIEKFVLNSKILSLNDKYSMKKKIHKLTRPIDIALINPVFEDIN 820
Query 756 HASLVQFQLGIPSIEDRVNLAVLTQFLNRRIYDSLRTEAQLGYIAGAKESQAASTALLQC 815
+ L +Q G+PS E++++L L + IYD+LRT QLGYI A +ST LL
Sbjct 821 NTVLAFYQFGVPSFEEKLHLMALQPIIQGYIYDNLRTNKQLGYIIFANIVPISSTRLLVV 880
Query 816 FVEGAKTHPDEVVKMI 831
VEG + E ++ I
Sbjct 881 GVEGDNNNSVEKIESI 896
> sce:YLR389C STE23; Metalloprotease involved, with homolog Axl1p,
in N-terminal processing of pro-A-factor to the mature
form; member of the insulin-degrading enzyme family (EC:3.4.24.-);
K01408 insulysin [EC:3.4.24.56]
Length=1027
Score = 281 bits (718), Expect = 1e-74, Method: Compositional matrix adjust.
Identities = 213/835 (25%), Positives = 398/835 (47%), Gaps = 50/835 (5%)
Query 9 DILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEH 68
D LKP+ D R +R +L N + A+ + P++++A ++ N G+ DP+++PGLAHF EH
Sbjct 63 DFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEH 122
Query 69 MLFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSP 128
+LF+G+ K+P+ Y S+L+++GG++NAYT + T +F +V ALDRF+ FF P
Sbjct 123 LLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCP 182
Query 129 LFNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSL--AKGPMSRFATGNAETLSTYPKA 186
LFN+ +KE+NA+++E++KN+ ND R + +SL K P +F+TGN ETL T PK
Sbjct 183 LFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKE 242
Query 187 NGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCP 246
NG+++ D L FH +Y +N++ + I L RE L+ +S D V
Sbjct 243 NGLNVRDELLKFHKNFY-SANLMKLCI----------LGREDLDTLSDWTYDLFKDVANN 291
Query 247 G---PMF-DTVKPFDHTNSGKFIHLQSFSSQPSLWVAFGLPATLTSYKKQPTSVLTYLLE 302
G P++ + + +H K I ++ L ++F +P ++ +P +L++L+
Sbjct 292 GREVPLYAEPIMQPEHLQ--KIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIG 349
Query 303 YTGEGSLAKRLRLLGLADGISPAVDRNSI-STLLGIKVDLTQKGAAHRGLVLQEIFSYIN 361
+ G GSL L+ LG A+ +S S + + +DLT G H V+ IF YI
Sbjct 350 HEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIE 409
Query 362 FLRDHGVGHDLVSTMAQQSHIDFHTTQ---PSSSIMDEAARLAHNLLTYEPYHVVAGDSL 418
L++ + + + S+ F Q PSS++ A L + Y P + L
Sbjct 410 MLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKD---YIPVSRILAMGL 466
Query 419 LIDADPRLTNQLLQAMSPSKAIIAFSDPDFTSKVDNFETDPYYGVQFRVLDLPQHHAVAM 478
L +P L Q A+ P + + + ++ + +YG ++V+D P M
Sbjct 467 LTKYEPDLLTQYTDALVPENSRVTL----ISRSLETDSAEKWYGTAYKVVDYPADLIKNM 522
Query 479 AVLTASPNAFRMPPPLMHIPKASELKILPGLLGLTEPELISEQGGNAGTAVWWQGQGAFA 538
+P A +P P + ++ + G+ L EP L+ + + +W++ F
Sbjct 523 KSPGLNP-ALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLL---SDDVSKLWYKKDDRFW 578
Query 539 LPRIAVQLNGSISKEKADVLSRTQGSLALAAIAEHLQEETVDFQNCGITHSLAFKGTGFH 598
PR + L+ + A +++ +L + L++ D + S G
Sbjct 579 QPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLA 638
Query 599 MTFEGYTQAQLGKVMAHVASLLSDPSMVEP--ERFERIKEKQIKLLADPATSMAFEHALE 656
+T G+ + K++ + L + EP +RFE +K+K I+ L + + +
Sbjct 639 ITASGFNE----KLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSN 694
Query 657 AAAILTRNDAFSRKDVLNALQQSNYEDSIAKLSEL-KNIHVDAFVMGNIDRDQSL---AM 712
+ ++S + L ++ +E I + + + ++ + + GNI +++L ++
Sbjct 695 YYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSL 754
Query 713 VEDFLEQAGFTPIAHDDAVASLAMEQKQTIEATLANPIKGDKDHASLVQF--QLGIPSIE 770
++ + ++ + S + + +T A +K ++ S +Q QL + S E
Sbjct 755 IKSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETA--LKDSQNVNSCIQHVTQLDVYS-E 811
Query 771 DRVNLA-VLTQFLNRRIYDSLRTEAQLGYIAGAKESQAASTALLQCFVEGAKTHP 824
D L+ + Q ++ +D+LRT+ QLGY+ + TA ++ ++ T P
Sbjct 812 DLSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTP 866
> ath:AT2G41790 peptidase M16 family protein / insulinase family
protein; K01408 insulysin [EC:3.4.24.56]
Length=970
Score = 264 bits (675), Expect = 1e-69, Method: Compositional matrix adjust.
Identities = 216/851 (25%), Positives = 382/851 (44%), Gaps = 72/851 (8%)
Query 9 DILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEH 68
+ILKP D R++R L N + + + P +++ +++ + GS DP+ + GLAHFLEH
Sbjct 14 EILKPRTDNREYRMIVLKNLLQVLLISDPDTDKCAASMSVSVGSFSDPQGLEGLAHFLEH 73
Query 69 MLFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSP 128
MLF + KYPE +SY ++T++GG+ NAYT E+T + V F+EALDRFA+FF P
Sbjct 74 MLFYASEKYPEEDSYSKYITEHGGSTNAYTASEETNYHFDVNADCFDEALDRFAQFFIKP 133
Query 129 LFNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAK--GPMSRFATGNAETLSTYPKA 186
L + +E+ A+D+E+QKN+ +D R + L+K P +F+TGN +TL P+A
Sbjct 134 LMSADATMREIKAVDSENQKNLLSDGWRIRQLQKHLSKEDHPYHKFSTGNMDTLHVRPQA 193
Query 187 NGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCP 246
G+D L F+ ++Y + M V SLD+ + L+ + I + + + P
Sbjct 194 KGVDTRSELIKFYEEHYSANIMHLVVYGKESLDKIQDLVERMFQEIQNTNK---VVPRFP 250
Query 247 GPMFDTVKPFDHTNSGKFIHLQSFSSQPSLWVAFGLPATLTSYKKQPTSVLTYLLEYTGE 306
G +P + + L V++ + ++ Y + P+ L +L+ + GE
Sbjct 251 G------QPCTADHLQILVKAIPIKQGHKLGVSWPVTPSIHHYDEAPSQYLGHLIGHEGE 304
Query 307 GSLAKRLRLLGLADGISPAVDRNSIS-TLLGIKVDLTQKGAAHRGLVLQEIFSYINFLRD 365
GSL L+ LG A G+S ++ + + +DLT G H +L +F+YI L+
Sbjct 305 GSLFHALKTLGWATGLSAGEGEWTLDYSFFKVSIDLTDAGHEHMQEILGLLFNYIQLLQQ 364
Query 366 HGVGHDLVSTMAQQSHIDFH---TTQPSSSIMDEAARLAHNLLTYEPYHVVAGDSLLIDA 422
GV + ++ FH P S I+D +A N+ Y + G SL
Sbjct 365 TGVCQWIFDELSAICETKFHYQDKIPPMSYIVD----IASNMQIYPTKDWLVGSSLPTKF 420
Query 423 DPRLTNQLLQAMSPSKAIIAFSDPDFTSKVDNFETDPYYGVQFRVLDLPQHHAVAMAVLT 482
+P + +++ +SPS I + F + D E P+Y + L+ + V +
Sbjct 421 NPAIVQKVVDELSPSNFRIFWESQKFEGQTDKAE--PWYNTAYS-LEKITSSTIQEWVQS 477
Query 483 ASPNAFRMPPPLMHIPKASELK------ILPGLLGLTEPELISEQGGNAGTAVWWQGQGA 536
A +P P + IP LK +P LL T + +W++
Sbjct 478 APDVHLHLPAPNVFIPTDLSLKDADDKETVPVLLRKT-----------PFSRLWYKPDTM 526
Query 537 FALPRIAVQLNG----SISKEKADVLSRTQGSLALAAIAEHLQEETVDFQNCGITHSLAF 592
F+ P+ V+++ ++S A VL+ L + ++L E Q G+ + ++
Sbjct 527 FSKPKAYVKMDFNCPLAVSSPDAAVLTDIFTRL----LMDYLNEYAYYAQVAGLYYGVSL 582
Query 593 KGTGFHMTFEGYT---QAQLGKVMAHVASLLSDPSMVEPERFERIKEKQIKLLADPATSM 649
GF +T GY + L V+ +A+ V+P+RF IKE K +
Sbjct 583 SDNGFELTLLGYNHKLRILLETVVGKIANF-----EVKPDRFAVIKETVTKEYQNYKFRQ 637
Query 650 AFEHALEAAAILTRNDAFSRKDVLNALQQSNYEDSIAKLSE--LKNIHVDAFVMGNIDRD 707
+ A+ +++ ++ + + L+ L ED +AK L ++ ++ GN++ +
Sbjct 638 PYHQAMYYCSLILQDQTWPWTEELDVLSHLEAED-VAKFVPMLLSRTFIECYIAGNVENN 696
Query 708 QSLAMVEDFLEQAGFT---PIAH--------DDAVASLAMEQKQTIEATLANPIKGDKDH 756
++ +MV+ +E F PI + V L K +NP D++
Sbjct 697 EAESMVKH-IEDVLFNDPKPICRPLFPSQHLTNRVVKLGEGMKYFYHQDGSNP--SDENS 753
Query 757 ASLVQFQLGIPSIEDRVNLAVLTQFLNRRIYDSLRTEAQLGYIAGAKESQAASTALLQCF 816
A + Q+ + L + + + LRT QLGYI + + +Q
Sbjct 754 ALVHYIQVHRDDFSMNIKLQLFGLVAKQATFHQLRTVEQLGYITALAQRNDSGIYGVQFI 813
Query 817 VEGAKTHPDEV 827
++ + P +
Sbjct 814 IQSSVKGPGHI 824
> cel:Y70C5C.1 hypothetical protein; K01408 insulysin [EC:3.4.24.56]
Length=985
Score = 248 bits (633), Expect = 7e-65, Method: Compositional matrix adjust.
Identities = 218/843 (25%), Positives = 375/843 (44%), Gaps = 47/843 (5%)
Query 10 ILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHM 69
ILK D R++R +L+NG+ + V P ++++ A+ N G L DP ++PGLAHF EHM
Sbjct 16 ILKGAQDEREYRGLELTNGIRVLLVSDPTTDKSAAALDVNVGHLMDPWELPGLAHFCEHM 75
Query 70 LFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPL 129
LFLGT+KYP Y FLT + G NA T + T +F +V ALDRF +FF SP
Sbjct 76 LFLGTAKYPSENEYFKFLTAHAGRANANTATDHTNYFFEVKPDQLPGALDRFVQFFLSPQ 135
Query 130 FNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAK--GPMSRFATGNAETLSTYPKAN 187
F E+EV A+D+EH N+ ND R RS AK +F TGN +TL +
Sbjct 136 FTESATEREVCAVDSEHSNNLNNDAWRFLQVHRSCAKPGHDYGKFGTGNKKTLLEDARKQ 195
Query 188 GIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCPG 247
GI+ D L FH K+Y + M I SLD ES L D + +
Sbjct 196 GIEPRDALLQFHKKWYSSNIMTCCIIGKESLDVLESY----LGTFEFAAIDNKKLERQIW 251
Query 248 PMFDTVKPFDHTNSGKFIHLQSFSSQPSLWVAFGLPATLTSYKKQPTSVLTYLLEYTGEG 307
F PF GK I + + ++F P + QP +++L+ + G G
Sbjct 252 KEF----PFGPEQLGKRIDVVPIKDTRQISISFPFPDLTGEFLSQPEHYISHLIGHEGHG 307
Query 308 SLAKRLRLLGLADGI-SPAVDRNSISTLLGIKVDLTQKGAAHRGLVLQEIFSYINFLRDH 366
SL L+ LG + S V + + + ++L+ +G H ++Q +F+YI ++
Sbjct 308 SLLSELKRLGWVVSLQSGYVVQAAGFGNFQVGIELSTEGLEHVDEIIQLMFNYIGMMQSS 367
Query 367 GVGHDLVSTMAQQSHIDFH---TTQPSSSIMDEAARLAHNLLTYEPY-HVVAGDSLLIDA 422
G + +A+ + F QP + AARL P+ HV++ LL +
Sbjct 368 GPKQWVHEELAELRAVTFRFKDKEQPMAMASCVAARLQRI-----PFKHVLSSPHLLTNY 422
Query 423 DPRLTNQLLQAMSPSKAIIAFSDPDFTSKVDNFETDPYYGVQFRVLDLPQHHAVAM-AVL 481
+P +LL + PS I F + N +P YG + +V + L
Sbjct 423 EPVRIKELLSMLIPSNMKIQVVSQKFKGQEGN-TNEPVYGTEIKVTRISSETMQKYEEAL 481
Query 482 TASPNAFRMPPPLMHIPKASELKILPG-LLGLTEPELISEQGGNAGTAVWWQGQGAFALP 540
S +A +P +I A++ P L+ P LI++ + + VW++ + +P
Sbjct 482 KTSHHALHLPEKNQYI--ATKFDQKPRELVKSDHPRLIND---DEWSRVWFKQDDEYKMP 536
Query 541 RIAVQLNGS---ISKE-KADVLSRTQGSLALAAIAEHLQEETVDFQNCGITHSLAFKGTG 596
+ +L + +S+ + +LSR L L +++ L EE+ + G+ + L G
Sbjct 537 KQETKLALTTPIVSQSPRMTLLSR----LWLRCLSDSLAEESYSAKVAGLNYELESSFFG 592
Query 597 FHMTFEGYTQAQLGKVMAHVASLLSDPSMVEPERFERIKEKQIKLLADPATSMAFEHALE 656
M GY + Q H+ L + ++ RF+ + + + L + A S + +
Sbjct 593 VQMRVSGYAEKQ-ALFSKHLTKRLFNFK-IDQTRFDVLFDSLKRDLTNHAFSQPYVLSQH 650
Query 657 AAAILTRNDAFSRKDVLNALQQSNYEDSIAKLSE--LKNIHVDAFVMGNIDRDQSLAMVE 714
+L + +S++ +L + ED + + + L+ H++ V GN +++ + +
Sbjct 651 YTELLVVDKEWSKQQLLAVCESVKLED-VQRFGKEMLQAFHLELLVYGNSTEKETIQLSK 709
Query 715 DFLE-----QAGFTPIAHDDAVASLAMEQKQTIEATLANPIKGDKDHASLVQFQLGIPSI 769
D ++ P+ ++ + ++ E + V +Q+G+ +
Sbjct 710 DLIDILKSAAPSSRPLFRNEHILRREIQLNNGDEYIYRHLQTTHDVGCVQVTYQIGVQNT 769
Query 770 EDRVNLAVLTQFLNRRIYDSLRTEAQLGYIAGAKESQAASTALLQCFVEGAKTHPDEVVK 829
D + ++ + +D+LRT+ LGYI + T LQ V+G K+ D V++
Sbjct 770 YDNAVIGLIKNLITEPAFDTLRTKESLGYIVWTRTHFNCGTVALQILVQGPKS-VDHVLE 828
Query 830 MID 832
I+
Sbjct 829 RIE 831
> cel:F44E7.4 hypothetical protein; K01408 insulysin [EC:3.4.24.56]
Length=1051
Score = 243 bits (621), Expect = 2e-63, Method: Compositional matrix adjust.
Identities = 215/862 (24%), Positives = 375/862 (43%), Gaps = 63/862 (7%)
Query 10 ILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHM 69
I+K D R++R +L+NG+ + V P ++++ A+ G L DP ++PGLAHF EHM
Sbjct 75 IVKGAQDAREYRGLELTNGIRVLLVSDPTTDKSAAALDVKVGHLMDPWELPGLAHFCEHM 134
Query 70 LFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPL 129
LFLGT+KYP Y FL + G++NAYT + T + V ALDRF +FF SP
Sbjct 135 LFLGTAKYPSENEYSKFLAAHAGSSNAYTSSDHTNYHFDVKPDQLPGALDRFVQFFLSPQ 194
Query 130 FNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAK--GPMSRFATGNAETLSTYPKAN 187
F E+EV A+D+EH N+ ND R RS +K +F TGN +TL +
Sbjct 195 FTESATEREVCAVDSEHSNNLNNDLWRFLQVDRSRSKPGHDYGKFGTGNKQTLLEDARKK 254
Query 188 GIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCPG 247
GI+ D L FH K+Y M + L+ ES +LG ++
Sbjct 255 GIEPRDALLQFHKKWYSSDIMTCCIVGKEPLNVLES---------------YLGTLE--- 296
Query 248 PMFDTVK------------PFDHTNSGKFIHLQSFSSQPSLWVAFGLPATLTSYKKQPTS 295
FD ++ P+ K I + + ++F P + QP
Sbjct 297 --FDAIENKKVERKVWEEFPYGPDQLAKRIDVVPIKDTRLVSISFPFPDLNGEFLSQPGH 354
Query 296 VLTYLLEYTGEGSLAKRLRLLGLADGISPAVDRNSISTLLG---IKVDLTQKGAAHRGLV 352
+++L+ + G GSL L+ LG + D ++ + G + +DL+ +G H +
Sbjct 355 YISHLIGHEGPGSLLSELKRLGWVSSLQS--DSHTQAAGFGVYNVTMDLSTEGLEHVDEI 412
Query 353 LQEIFSYINFLRDHGVGHDLVSTMAQQSHIDFH---TTQPSSSIMDEAARLAHNLLTYEP 409
+Q +F+YI L+ G + +A+ S + F QP + ++ AA L Y P
Sbjct 413 IQLMFNYIGMLQSAGPKQWVHDELAELSAVKFRFKDKEQPMTMAINVAAS-----LQYIP 467
Query 410 Y-HVVAGDSLLIDADPRLTNQLLQAMSPSKAIIAFSDPDFTSKVDNFETDPYYGVQFRVL 468
+ H+++ LL +P +LL +SP+ + F + N +P YG + +V
Sbjct 468 FEHILSSRYLLTKYEPERIKELLSMLSPANMQVRVVSQKFKGQEGN-TNEPVYGTEMKVT 526
Query 469 DL-PQHHAVAMAVLTASPNAFRMPPPLMHIPKASELKILPGLLGLTEPELISEQGGNAGT 527
D+ P+ L S +A +P +I + K + P LIS+ G +
Sbjct 527 DISPETMKKYENALKTSHHALHLPEKNEYIATNFDQKPRESVKN-EHPRLISDDG---WS 582
Query 528 AVWWQGQGAFALPRIAVQLNGSISKEKADVLSRTQGSLALAAIAEHLQEETVDFQNCGIT 587
VW++ + +P+ +L + + SL L +++ L EET + G+
Sbjct 583 RVWFKQDDEYNMPKQETKLALTTPMVAQNPRMSLLSSLWLWCLSDTLAEETYNADLAGLK 642
Query 588 HSLAFKGTGFHMTFEGYTQAQLGKVMAHVASLLSDPSMVEPERFERIKEKQIKLLADPAT 647
L G M GY + Q H+A+ +++ ++ RF+ + E + L + A
Sbjct 643 CQLESSPFGVQMRVYGYDEKQ-ALFAKHLANRMTN-FKIDKTRFDVLFESLKRALTNHAF 700
Query 648 SMAFEHALEAAAILTRNDAFSRKDVLNALQQSNYEDSIAKLSE-LKNIHVDAFVMGNIDR 706
S + +L + +S++ +L ED E L+ H++ FV GN
Sbjct 701 SQPYLLTQHYNQLLIVDKVWSKEQLLAVCDSVTLEDVQGFAKEMLQAFHMELFVHGNSTE 760
Query 707 DQSLAMVEDFLE-----QAGFTPIAHDDAVASLAMEQKQTIEATLANPIKGDKDHASLVQ 761
+++ + ++ ++ P+ ++ ++ E + K V
Sbjct 761 KEAIQLSKELMDVLKSAAPNSRPLYRNEHNPRRELQLNNGDEYVYRHLQKTHDVGCVEVT 820
Query 762 FQLGIPSIEDRVNLAVLTQFLNRRIYDSLRTEAQLGYIAGAKESQAASTALLQCFVEGAK 821
+Q+G+ + D + ++ Q + +++LRT LGYI T L V+G K
Sbjct 821 YQIGVQNTYDNAVVGLIDQLIREPAFNTLRTNEALGYIVWTGSRLNCGTVALNVIVQGPK 880
Query 822 THPDEVVKMIDEELTKAKEYLA 843
+ D V++ I+ L ++ +A
Sbjct 881 S-VDHVLERIEVFLESVRKEIA 901
> dre:557565 nrd1, si:dkey-171o17.4; nardilysin (N-arginine dibasic
convertase) (EC:3.4.24.61)
Length=1061
Score = 242 bits (617), Expect = 6e-63, Method: Compositional matrix adjust.
Identities = 221/864 (25%), Positives = 375/864 (43%), Gaps = 102/864 (11%)
Query 4 GALASDILKPEADYRDFRHYQLSNGMHAIAV----------------------------- 34
A ++ I+K DY+ +R+ +LSNG+ A+ +
Sbjct 38 AADSNTIIKSPNDYKTYRYIELSNGLKALLISDVSSQSESCRESVDKEVEEEGDRGSASD 97
Query 35 ---HHPR-------SNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYD 84
H R ++ A+ + GS DP D+PGLAHFLEHM+F+G+ KYP +D
Sbjct 98 ISKHSERGKQSCRSEKQSAAALCISVGSFSDPADLPGLAHFLEHMVFMGSEKYPVENGFD 157
Query 85 SFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFNRQYEEKEVNAIDA 144
+FL ++GG++NA TD E+T+F V EALDR+A+FF PL ++EV A+D+
Sbjct 158 AFLKKHGGSDNASTDCERTIFQFDVQRKYLREALDRWAQFFICPLMIPDAVDREVEAVDS 217
Query 145 EHQKNIPNDDERAWYTIRSLAKG--PMSRFATGNAETLSTYPKANGIDLVDRLRDFHSKY 202
E+Q P D R SLAK PMS+F GNA+TL P+ I+ +RLRDF +Y
Sbjct 218 EYQMAQPLDSNRKEMLFGSLAKAGHPMSKFFWGNAQTLKQEPREKKINTYERLRDFWRRY 277
Query 203 YCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCPGPMF-DTVKPFDHTNS 261
Y M S +LD E +RE I G+ P F D PFD +
Sbjct 278 YSAQYMTLAVQSKETLDTLEEWVREIFVQIPNN-----GL---PKADFSDLQDPFDTPDF 329
Query 262 GKFIHLQSFSSQPSLWVAFGLPATLTSYKKQPTSVLTYLLEYTGEGS----LAKRLRLLG 317
K + +L +++ LP Y+ +P +++L+ + G GS L KR L
Sbjct 330 CKLYRVVPVQKVHALTISWALPPQAKHYRVKPLHYISWLIGHEGVGSVLSLLRKRCWALS 389
Query 318 LADGISPA-VDRNSISTLLGIKVDLTQKGAAHRGLVLQEIFSYINFLRDHGVGHDLVSTM 376
L G S + D+NS ++ I + L+ +G + V+ IF Y+ L+ G + +
Sbjct 390 LFGGNSESGFDQNSTYSIFSISITLSDEGLQNFLQVIHIIFQYLKMLQSVGPQQRIYEEI 449
Query 377 AQQSHIDFHTTQPSSSIMDEAARLAHNLLTYEPYHVVAGDSLLIDADPRLTNQLLQA--- 433
+ +FH + + I + A ++ N+ + H + GD L+ D +P ++ ++ A
Sbjct 450 QKIEANEFHYQEQTEPI-EFVANMSENMQLFPKEHFLCGDQLMFDFNPEASHCVISAALS 508
Query 434 -MSPSKAIIAFSDPDFTSKVDNFETDPYYGVQFRVLDLPQHHAVAMAVLTASPNAFRMPP 492
++P KA I P E ++G Q+ V D+PQ A F + P
Sbjct 509 LLTPGKANILLLSPQHDGLCPLKEK--WFGTQYSVEDIPQEFRDLWA------GDFPLHP 560
Query 493 PLMHIPKASELKILPGLLGLTEP-------ELISEQGGNAGTAVWWQGQGAFALPR--IA 543
L +P ++ L ++ ++I + G +W++ F +P+
Sbjct 561 EL-QLPAENKFIATDFTLRTSDCPDTDFPVKIIDNERGR----LWFRKDNKFKIPKAYAR 615
Query 544 VQLNGSISKEKADVLSRTQGSLALAAIAEHLQEETVDFQNCGITHSLAFKGTGFHMTFEG 603
QL +E L L + +A +L E D + + ++L G + +G
Sbjct 616 FQLLTPFIQESPKNL--VLFDLFVNIVAHNLAELAYDAEVAQLQYNLLPGDHGLFIRLKG 673
Query 604 YTQA---QLGKVMAHVASLLSDPSMVEPERFERIKEKQIKLLADPATSMAFEHALEAAAI 660
+ L ++ H+A + P + E++K+ +L P + + L+ I
Sbjct 674 FNHKLPLLLKLIVDHLADFSATPDVFN-MFIEQLKKTYYIILIRPE-RLGKDVRLQ---I 728
Query 661 LTRNDAFSRKDVLNALQQSNYEDSIAKLSELKN-----IHVDAFVMGNIDRDQSLAMVED 715
L + R V+ + + S+A L N + V+ V GN +S ++
Sbjct 729 LEHH----RWSVMQKYEAIMADPSVADLMTFANRFKAELFVEGLVQGNFTSAESKEFLQC 784
Query 716 FLEQAGFTPIAHDDAVASLAMEQKQTIEATLANPI-KGDKDHASLVQFQLGIPSIEDRVN 774
F+E+ + P + V +E QT + K D + V +Q G+ ++ +
Sbjct 785 FIEKLKYAPHPIEPPVLFRVVELPQTHHLCKVQSLNKADANSEVTVYYQTGLKNLREHTL 844
Query 775 LAVLTQFLNRRIYDSLRTEAQLGY 798
+ +L + +D LRT+ LGY
Sbjct 845 MELLVMHMEEPCFDFLRTKETLGY 868
> ath:AT1G06900 catalytic/ metal ion binding / metalloendopeptidase/
zinc ion binding; K01411 nardilysin [EC:3.4.24.61]
Length=1024
Score = 241 bits (615), Expect = 9e-63, Method: Compositional matrix adjust.
Identities = 202/787 (25%), Positives = 360/787 (45%), Gaps = 52/787 (6%)
Query 38 RSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYDSFLTQNGGANNAY 97
++ +A A+ + GS DP + GLAHFLEHMLF+G++++P+ YDS+L+++GG++NAY
Sbjct 103 QTKKAAAAMCVSMGSFLDPPEAQGLAHFLEHMLFMGSTEFPDENEYDSYLSKHGGSSNAY 162
Query 98 TDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFNRQYEEKEVNAIDAEHQKNIPNDDER- 156
T+ E T + +V + AL RF++FF +PL + E+EV A+D+E + + ND R
Sbjct 163 TEMEHTCYHFEVKREFLQGALKRFSQFFVAPLMKTEAMEREVLAVDSEFNQALQNDACRL 222
Query 157 AWYTIRSLAKG-PMSRFATGNAETLSTYPKANGIDLVDRLRDFHSKYYCGSNMVAVTISP 215
+ AKG P +RFA GN ++LS NG+DL + + + +YY G M V I
Sbjct 223 QQLQCYTSAKGHPFNRFAWGNKKSLSG-AMENGVDLRECIVKLYKEYYHGGLMKLVVIGG 281
Query 216 RSLDEQESLIREKLEGISAGHADWLGMVQCPGPMFDTVKPFDHTNSGKFIHLQSFSSQPS 275
SLD ES + E + G + ++ GP++ GK L++
Sbjct 282 ESLDMLESWVVELFGDVKNG-SKIRPTLEAEGPIW---------KGGKLYRLEAVKDVHI 331
Query 276 LWVAFGLPATLTSYKKQPTSVLTYLLEYTGEGSLAKRLRLLGLADGISPAV-----DRNS 330
L + + LP ++Y K+P L +LL + G GSL L+ G A +S V +R+S
Sbjct 332 LDLTWTLPPLRSAYVKKPEDYLAHLLGHEGRGSLHSFLKAKGWATSLSAGVGDDGINRSS 391
Query 331 ISTLLGIKVDLTQKGAAHRGLVLQEIFSYINFLRDHGVGHDLVSTMAQQSHIDFH--TTQ 388
++ + G+ + LT G ++ I+ Y+ LRD + + ++DF Q
Sbjct 392 LAYVFGMSIHLTDSGLEKIYDIIGYIYQYLKLLRDVSPQEWIFKELQDIGNMDFRFAEEQ 451
Query 389 PSSSIMDEAARLAHNLLTYEPYHVVAGDSLLIDADPRLTNQLLQAMSPSKAIIAFSDPDF 448
P+ D AA L+ N+L Y HV+ GD + DP+L L+ +P I
Sbjct 452 PAD---DYAAELSENMLAYPVEHVIYGDYVYQTWDPKLIEDLMGFFTPQNMRIDVVSKSI 508
Query 449 TSKVDNFETDPYYGVQFRVLDLPQHHAVAMAVLTASPNAFRMPPPLMHIPKASELKILPG 508
S + F+ +P++G + D+P + + + N+ +P IP ++ +
Sbjct 509 KS--EEFQQEPWFGSSYIEEDVPLSLMESWSNPSEVDNSLHLPSKNQFIPCDFSIRAINS 566
Query 509 LL---GLTEPELISEQGGNAGTAVWWQGQGAFALPRIAVQLNGSISKEKADVLSRTQGSL 565
+ + P I ++ W++ F +PR ++ A V + L
Sbjct 567 DVDPKSQSPPRCIIDE---PFMKFWYKLDETFKVPRANTYFRINLKGAYASVKNCLLTEL 623
Query 566 ALAAIAEHLQEETVDFQNCGITHSLAFKGTGFHMTFEGYTQ---AQLGKVMAHVASLLSD 622
+ + + L E + SL+ G + G+ + A L K++A S +
Sbjct 624 YINLLKDELNEIIYQASIAKLETSLSMYGDKLELKVYGFNEKIPALLSKILAIAKSFM-- 681
Query 623 PSMVEPERFERIKEKQIKLLADPATSMA-FEHALEAAAILTRNDAFSRKDVLNALQQSNY 681
P++ ERF+ IKE + + T+M H+ L + + L+ L +
Sbjct 682 PNL---ERFKVIKENMERGFRN--TNMKPLNHSTYLRLQLLCKRIYDSDEKLSVLNDLSL 736
Query 682 EDSIAKLSELKN-IHVDAFVMGNIDRDQSLAMVEDFLEQAGFTPI----AHDDAVASLAM 736
+D + + EL++ I ++A GN+ D+++ + F + P+ H + + M
Sbjct 737 DDLNSFIPELRSQIFIEALCHGNLSEDEAVNISNIFKDSLTVEPLPSKCRHGEQITCFPM 796
Query 737 EQKQTIEATLANPIKGDKDHASLVQFQLGIPSIEDRVNLAVLTQF---LNRRIYDSLRTE 793
K + + N K + + + +Q+ + AVL F + +++ LRT+
Sbjct 797 GAKLVRDVNVKN--KSETNSVVELYYQIEPEEAQSTRTKAVLDLFHEIIEEPLFNQLRTK 854
Query 794 AQLGYIA 800
QLGY+
Sbjct 855 EQLGYVV 861
> hsa:4898 NRD1, hNRD1, hNRD2; nardilysin (N-arginine dibasic
convertase) (EC:3.4.24.61); K01411 nardilysin [EC:3.4.24.61]
Length=1151
Score = 239 bits (611), Expect = 3e-62, Method: Compositional matrix adjust.
Identities = 210/777 (27%), Positives = 351/777 (45%), Gaps = 53/777 (6%)
Query 45 AVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTV 104
A+ GS DP+D+PGLAHFLEHM+F+G+ KYP+ +D+FL ++GG++NA TD E+TV
Sbjct 214 ALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTV 273
Query 105 FFNKVTDSAFEEALDRFAEFFKSPLFNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSL 164
F V F+EALDR+A+FF PL R ++EV A+D+E+Q P+D R SL
Sbjct 274 FQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSL 333
Query 165 AK--GPMSRFATGNAETLSTYPKANGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQE 222
A+ PM +F GNAETL P+ N ID RLR+F +YY M V S +LD E
Sbjct 334 ARPGHPMGKFFWGNAETLKHEPRKNNIDTHARLREFWMRYYSSHYMTLVVQSKETLDTLE 393
Query 223 SLIREKLEGISAGHADWLGMVQCPGPMFDTVK-PFDHTNSGKFIHLQSFSSQPSLWVAFG 281
+ E I G+ P P F + PFD K + +L + +
Sbjct 394 KWVTEIFSQIPNN-----GL---PRPNFGHLTDPFDTPAFNKLYRVVPIRKIHALTITWA 445
Query 282 LPATLTSYKKQPTSVLTYLLEYTGEGS----LAKRLRLLGLADGIS-PAVDRNSISTLLG 336
LP Y+ +P +++L+ + G+GS L K+ L L G ++NS ++
Sbjct 446 LPPQQQHYRVKPLHYISWLVGHEGKGSILSFLRKKCWALALFGGNGETGFEQNSTYSVFS 505
Query 337 IKVDLTQKGAAHRGLVLQEIFSYINFLRDHGVGHDLVSTMAQQSHIDFHTTQPSSSIMDE 396
I + LT +G H V +F Y+ L+ G + + + +FH Q + ++
Sbjct 506 ISITLTDEGYEHFYEVAYTVFQYLKMLQKLGPEKRIFEEIRKIEDNEFH-YQEQTDPVEY 564
Query 397 AARLAHNLLTYEPYHVVAGDSLLIDADPRLTNQLLQAMSPSKAIIAFSDPDFTSKVDNFE 456
+ N+ Y ++ GD LL + P + + L + P KA + K D E
Sbjct 565 VENMCENMQLYPLQDILTGDQLLFEYKPEVIGEALNQLVPQKANLVLLSGANEGKCDLKE 624
Query 457 TDPYYGVQFRVLDLPQHHAVAMAVLTASPNAFRMPPPLMHIPKASELKILPGLLGLT--- 513
++G Q+ + D+ + A L S F + P L H+P +E K + L
Sbjct 625 K--WFGTQYSIEDIEN----SWAELWNS--NFELNPDL-HLP--AENKYIATDFTLKAFD 673
Query 514 --EPELISEQGGNAGTAVWWQGQGAFALPRIAVQ---LNGSISKEKAD-VLSRTQGSLAL 567
E E + +W++ F +P+ ++ ++ I K A+ VL ++
Sbjct 674 CPETEYPVKIVNTPQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILT 733
Query 568 AAIAEHLQEETV---DFQNCGITHSLAFKGTGFHMTFEGYTQAQLGKVMAHVASLLSDPS 624
+AE E V +++ H L + GF+ Q ++ ++A S P+
Sbjct 734 HNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQL----IIDYLAEFNSTPA 789
Query 625 MVEPERFERIKEKQIKLLADPATSMAFEHALEAAAILTRNDAFSRKDVLNALQQS-NYED 683
+ E++K+ +L P T A + ++ +S D AL + E
Sbjct 790 VFTMIT-EQLKKTYFNILIKPETL-----AKDVRLLILEYARWSMIDKYQALMDGLSLES 843
Query 684 SIAKLSELKN-IHVDAFVMGNIDRDQSLAMVEDFLEQAGFTPIAHDDAVASLAMEQKQTI 742
++ + E K+ + V+ V GN+ +S+ ++ +++ F P+ + V +E
Sbjct 844 LLSFVKEFKSQLFVEGLVQGNVTSTESMDFLKYVVDKLNFKPLEQEMPVQFQVVELPSGH 903
Query 743 EATLANPI-KGDKDHASLVQFQLGIPSIEDRVNLAVLTQFLNRRIYDSLRTEAQLGY 798
+ KGD + V +Q G S+ + + +L + +D LRT+ LGY
Sbjct 904 HLCKVKALNKGDANSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGY 960
> cel:C02G6.2 hypothetical protein; K01408 insulysin [EC:3.4.24.56]
Length=816
Score = 239 bits (609), Expect = 5e-62, Method: Compositional matrix adjust.
Identities = 210/828 (25%), Positives = 365/828 (44%), Gaps = 68/828 (8%)
Query 8 SDILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLE 67
+ I+K D R+ R +L+NG+ + V P ++++ ++A G L DP ++PGLAHF E
Sbjct 14 NSIVKGPQDERECRGLELTNGLRVLLVSDPTTDKSAVSLAVKAGHLMDPWELPGLAHFCE 73
Query 68 HMLFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKS 127
HMLFLGTSKYP + FL+ N G+ NA T+ + T + V ALDRF +FF
Sbjct 74 HMLFLGTSKYPLENEFTKFLSDNAGSYNACTEPDHTYYHFDVKPDQLYGALDRFVQFFLC 133
Query 128 PLFNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAK-GPMSR-FATGNAETLSTYPK 185
P F + E+EV A+D+EH N+ +D R RSL++ G +R F TGN +TL +
Sbjct 134 PQFTKSATEREVCAVDSEHLSNLNSDYWRILQVDRSLSRPGHDNRKFCTGNKKTLLEDAR 193
Query 186 ANGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIR----EKLEGISAGHADWLG 241
GI+ D L +F+ K+Y + M I SLD ES +R + ++ A W
Sbjct 194 KKGIEPRDALLEFYKKWYSSNIMTCCIIGKESLDVLESYLRTLEFDAIQNKKAESKVWAE 253
Query 242 MVQCPGPMFDTVKPFDHTNSGKFIHLQSFSSQPSLWVAFGLPATLTSYKKQPTSVLTYLL 301
P + K I + + + + F P Y QP + +L+
Sbjct 254 FQYGPDQL------------AKKIDVVPIKDKKLVSIIFPFPDLNNEYLSQPGHYIAHLI 301
Query 302 EYTGEGSLAKRLRLLGLADGISPAVDRNSISTLLG---IKVDLTQKGAAHRGLVLQEIFS 358
+ G GS++ L+ LG A + P + +I+ G + +DL+ +G H ++Q +F+
Sbjct 302 GHKGPGSISSELKRLGWASSLKP--ESKTIAAGFGYFNVTMDLSTEGLEHVDEIIQLMFN 359
Query 359 YINFLRDHGVGHDLVSTMAQQSHIDFHTTQPSSSIMDEAARLAHNLLTYEPY-HVVAGDS 417
YI L+ G + +A+ S I+F + + A ++A N L Y P+ H+++
Sbjct 360 YIGMLQSAGPQQWIHEELAELSAIEFR-FKDREPLTKNAIKVARN-LQYIPFEHILSSRY 417
Query 418 LLIDADPRLTNQLLQAMSPSKAIIAFSDPDFTSKVDNFETDPYYGVQFRVLDL-PQHHAV 476
LL +P +LL ++PS ++ F + N +P YG + +V D+ P+
Sbjct 418 LLTKYNPERIKELLSTLTPSNMLVRVVSKKFKEQEGN-TNEPVYGTEMKVTDISPEKMKK 476
Query 477 AMAVLTASPNAFRMPPPLMHIPKASELKILPGLLGLTEPELISEQGGNAGTAVWWQGQGA 536
L S +A +P +I + K + P LIS+ G + VW++
Sbjct 477 YENALKTSHHALHLPEKNEYIVTKFDQKPRESVKN-EHPRLISDDG---WSRVWFKQDDE 532
Query 537 FALPRIAVQLNGSISKEKADVLSRTQGSLALAAIAEHLQEETVDFQNCGITHSLAFKGTG 596
+ +P+ +L + + + SL L + + L EET + G+ L G
Sbjct 533 YNMPKQETKLAFTTPIVAQNPIMSLISSLWLWCLNDTLTEETYNAAIAGLKFQLESGHNG 592
Query 597 FH----------------MTFEGYTQAQLGKVMAHVASLLSDPSMVEPERFERIKEKQIK 640
H + GY + Q + H+ +++ ++ RF+ + E +
Sbjct 593 VHEQAGNWLDPERHASITLHVYGYDEKQ-PLFVKHLTKCMTN-FKIDRTRFDVVFESLKR 650
Query 641 LLADPATSMAFEHALEAAAILTRNDAFSRKDVLNALQQSNYEDSIAKLSEL-KNIHVDAF 699
L + A S + + +L +S++ +L + ED EL + H++ F
Sbjct 651 SLTNHAFSQPYMLSKYFNELLVVEKVWSKEQLLAVCDSATLEDVQGFSKELFQAFHLELF 710
Query 700 VMGNIDRDQSLAMVEDFLEQAGFTPIAHDDAVASLAMEQKQTIEATLANPIKGD------ 753
V GN +++ + + ++ A ++ E E L N GD
Sbjct 711 VHGNSTEKKAIQLSNELMD---ILKSAAPNSRLLYRNEHNPRREFQLNN---GDEYIYRH 764
Query 754 --KDH---ASLVQFQLGIPSIEDRVNLAVLTQFLNRRIYDSLRTEAQL 796
K H V F+ G+ + D +++Q + + + +LRT+ L
Sbjct 765 LQKTHDAGCVEVTFKFGVQNTYDNALAGLISQLIRQPAFSTLRTKESL 812
> mmu:230598 Nrd1, 2600011I06Rik, AI875733, MGC25477, NRD-C; nardilysin,
N-arginine dibasic convertase, NRD convertase 1 (EC:3.4.24.61);
K01411 nardilysin [EC:3.4.24.61]
Length=1161
Score = 238 bits (608), Expect = 6e-62, Method: Compositional matrix adjust.
Identities = 207/777 (26%), Positives = 348/777 (44%), Gaps = 53/777 (6%)
Query 45 AVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTV 104
A+ GS DP+D+PGLAHFLEHM+F+G+ KYP+ +D+FL ++GG++NA TD E+TV
Sbjct 225 ALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTV 284
Query 105 FFNKVTDSAFEEALDRFAEFFKSPLFNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSL 164
F V F+EALDR+A+FF PL R ++EV A+D+E+Q P+D R SL
Sbjct 285 FQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSL 344
Query 165 AK--GPMSRFATGNAETLSTYPKANGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQE 222
A+ PM +F GNAETL PK N ID RLR+F +YY M V S +LD E
Sbjct 345 ARPGHPMGKFFWGNAETLKHEPKKNNIDTHARLREFWMRYYSAHYMTLVVQSKETLDTLE 404
Query 223 SLIREKLEGISAGHADWLGMVQCPGPMFDTVK-PFDHTNSGKFIHLQSFSSQPSLWVAFG 281
+ E I G+ P P F + PFD K + +L + +
Sbjct 405 KWVTEIFSQIPNN-----GL---PKPNFSHLTDPFDTPAFNKLYRVVPIRKIHALTITWA 456
Query 282 LPATLTSYKKQPTSVLTYLLEYTGEGSLAKRLRLLGLADGI-----SPAVDRNSISTLLG 336
LP Y+ +P +++L+ + G+GS+ LR A + ++NS ++
Sbjct 457 LPPQQQHYRVKPLHYISWLVGHEGKGSILSYLRKKCWALALFGGNGETGFEQNSTYSVFS 516
Query 337 IKVDLTQKGAAHRGLVLQEIFSYINFLRDHGVGHDLVSTMAQQSHIDFHTTQPSSSIMDE 396
I + LT +G H V +F Y+ L+ G + + + +FH Q + ++
Sbjct 517 ISITLTDEGYEHFYEVAHTVFQYLKMLQKLGPEKRVFEEIQKIEDNEFH-YQEQTDPVEY 575
Query 397 AARLAHNLLTYEPYHVVAGDSLLIDADPRLTNQLLQAMSPSKAIIAFSDPDFTSKVDNFE 456
+ N+ Y + GD LL + P + + L + P KA + + D E
Sbjct 576 VENMCENMQLYPRQDFLTGDQLLFEYKPEVIAEALNQLVPQKANLVLLSGANEGRCDLKE 635
Query 457 TDPYYGVQFRVLDLPQHHAVAMAVLTASPNAFRMPPPLMHIPKASELKILPGLLGLT--- 513
++G Q+ + D+ + L S F + P L H+P +E K + L
Sbjct 636 K--WFGTQYSIEDIEN----SWTELWKS--NFDLNPDL-HLP--AENKYIATDFTLKAFD 684
Query 514 --EPELISEQGGNAGTAVWWQGQGAFALPRIAVQ---LNGSISKEKAD-VLSRTQGSLAL 567
E E ++ A +W++ F +P+ ++ ++ I K A+ VL ++
Sbjct 685 CPETEYPAKIVNTAQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILT 744
Query 568 AAIAEHLQEETV---DFQNCGITHSLAFKGTGFHMTFEGYTQAQLGKVMAHVASLLSDPS 624
+AE E V +++ H L + GF+ Q ++ ++ S P+
Sbjct 745 HNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQL----IIDYLTEFSSTPA 800
Query 625 MVEPERFERIKEKQIKLLADPATSMAFEHALEAAAILTRNDAFSRKDVLNALQQSNYEDS 684
+ E++K+ +L P T A + ++ +S D AL DS
Sbjct 801 VFTMIT-EQLKKTYFNILIKPETL-----AKDVRLLILEYSRWSMIDKYQALMDGLSLDS 854
Query 685 IAK-LSELKN-IHVDAFVMGNIDRDQSLAMVEDFLEQAGFTPIAHDDAVASLAMEQKQTI 742
+ + + K+ + V+ V GN+ +S+ ++ +++ F P+ + V +E
Sbjct 855 LLNFVKDFKSQLFVEGLVQGNVTSTESMDFLKYVVDKLNFAPLEREMPVQFQVVELPSGH 914
Query 743 EATLANPI-KGDKDHASLVQFQLGIPSIEDRVNLAVLTQFLNRRIYDSLRTEAQLGY 798
+ KGD + V +Q G S+ + + +L + +D LRT+ LGY
Sbjct 915 HLCKVRALNKGDANSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGY 971
> cpv:cgd2_930 peptidase'insulinase-like peptidase' ; K01408 insulysin
[EC:3.4.24.56]
Length=1013
Score = 236 bits (601), Expect = 4e-61, Method: Compositional matrix adjust.
Identities = 216/868 (24%), Positives = 389/868 (44%), Gaps = 89/868 (10%)
Query 1 SAIGALASDILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVP 60
+ + + ++I KP D +R L N + + V ++ +G +++ G DPE++
Sbjct 6 TNLKEIQNEITKPIYDDNKYRALVLKNNLRVLLVQDENTDISGASMSVFVGCQQDPEELN 65
Query 61 GLAHFLEHMLFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDR 120
GLAHFLEHMLFLG++++P P +D ++ NGG++NA+TD T +F ++ + +FE ALD
Sbjct 66 GLAHFLEHMLFLGSARHPNPSDFDDYMKLNGGSSNAFTDNLSTSYFFEIKNESFEHALDL 125
Query 121 FAEFFKSPLFNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAKG--PMSRFATGNAE 178
F+ FF PLF+ +Y ++EVNA+++EH KN+ +D ++ I S+A+ P+ +F TG+ E
Sbjct 126 FSAFFICPLFDTKYVDREVNAVNSEHNKNLLSDLWIRYHVISSIARNGHPLRKFGTGSIE 185
Query 179 TLSTYPKANGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGI---SAG 235
TL P+ GIDL+ L++FH+KYY +NM +S LDE ES + I +
Sbjct 186 TLKYEPEKKGIDLIAELKNFHNKYYSSNNMFLTLVSNCDLDELESYAIKYFSEIVDKNIA 245
Query 236 HADWLGMVQCPGPMFDTVKPFDHTNSGKFIHLQSFSSQPSLWVAFGLPATLTSYKKQPTS 295
D+ G Q P ++ + +++ + + F +P K P
Sbjct 246 RVDYFGEFQKERPYLSIMESPEDGALESMVYVIPNKDEKKVSFNFQIPDLRKFRKGLPEM 305
Query 296 VLTYLLEYTGEGSLAKRLRLLGLADGISPAVDRNSISTLLGIKVDLTQKGAAHRGLVLQE 355
T +L + G GSL LR G +S ++ + L I + LT+KGA V++
Sbjct 306 YFTNILGHEGPGSLTSALRRNGWCLALSSGLNEMYSANLFEIIITLTEKGAREVLSVIEY 365
Query 356 IFSYINFLRDHGVGHDLVSTMAQQSHIDF-HTTQPS--SSIMDEAARLAHNLLTYEPYHV 412
+++N + + + ++VS + + S + F + +PS +I + LA NL +
Sbjct 366 TLNFVNLVIKNEIDMEVVSDLEKLSQLVFDYRNRPSLDETISNNVFALA-NLPPLKELLT 424
Query 413 VAGDSLLIDADPRLTNQLLQAMSPSKAIIAFSDPDFTSKV------DNFETDPYYGVQFR 466
+D D L Q P I S P+ + + D D +Y + +
Sbjct 425 FGNRVEKMDVDA--VKYLKQYFDPKNMFILLSIPENKALIEDERLKDKLIYDRHYNINYL 482
Query 467 VLDL-PQHHAVA--MAVLTASPNAFRMPPPLMHIPKASELKILPGLLGLTEPELISEQGG 523
L+ P+ + +++ AS +MP +IP+ +L G P ++ G
Sbjct 483 KLEFGPEIKEIISNISLSNASRFGLKMPTKNNYIPENFDLMNTYGGNMQAFPTILEIPGN 542
Query 524 NAGTAV--WWQGQGAFALPR-IAVQLNGSISKEKADVLS-RTQGSLALAA-IAEHLQEET 578
+ V +++ F P + S SK ++L T SL L+ +AE T
Sbjct 543 SFSDRVVAYYKPDTNFQTPHGFSQFFFFSSSKVTCELLVLDTLTSLTLSKFVAEEAYNAT 602
Query 579 V---DFQNCGITHSLAFKGTGFHMTFEGYTQAQLGKVMAHVASLLSDPSMVEPERFERIK 635
+ D++ G ++L +T G+ H S+VE +
Sbjct 603 IANLDYKISG-GYNLRNSMNCLSITISGFNDKM------HTLLKFLIKSLVE---LKNDG 652
Query 636 EKQIKLLADPATSMAFEHALEAAAILTRNDAF----------------------SRKDVL 673
+KQ+ FE ALE + + RN F S++++L
Sbjct 653 KKQL-------YKSFFEDALEESRLSVRNSLFNPDILAHLTSYNFREFYSVYTPSKEEIL 705
Query 674 NALQQSNYEDSIAKLSE-LKNIHVDAFVMGNIDRDQSLAMVE-----DFLEQAGFTPIAH 727
+ L + YE +S + + +GN++++Q+ +VE + L
Sbjct 706 SILSTTTYERLCDHISTFFSQCLIKSITVGNLNKEQARELVETVTIKELLSSEQLNS-KM 764
Query 728 DDAVASLAMEQKQTIEA-------------TLANPIKGDKDHASLVQFQLGIPSIEDRVN 774
+ + ++ ++ IE+ ++ NP+ DK+ + + +G ++ + V
Sbjct 765 EKTIIRNCIDLEKAIESDPEIKSNRIILSKSVINPM--DKNGSVIYSIDMGEYNLRNYVL 822
Query 775 LAVLTQFLNRRIYDSLRTEAQLGYIAGA 802
L +L+++L+ Y LRT QLGYI A
Sbjct 823 LELLSKYLDSNCYLELRTNQQLGYIVHA 850
> dre:565850 fk24c07; wu:fk24c07; K01411 nardilysin [EC:3.4.24.61]
Length=1091
Score = 231 bits (590), Expect = 8e-60, Method: Compositional matrix adjust.
Identities = 202/785 (25%), Positives = 347/785 (44%), Gaps = 69/785 (8%)
Query 45 AVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTV 104
A+ GS DP D+PGLAHFLEHM+F+G+ KYP +D+FL ++GG++NA TD E+T+
Sbjct 149 ALCIGVGSFSDPNDLPGLAHFLEHMVFMGSEKYPSENGFDAFLKKHGGSDNASTDCERTI 208
Query 105 FFNKVTDSAFEEALDRFAEFFKSPLFNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSL 164
F V F+EALDR+A+FF PL ++EV A+D+E+Q P+D R SL
Sbjct 209 FQFDVQRKRFKEALDRWAQFFICPLMIEDAIDREVEAVDSEYQLAKPSDSHRKEMLFGSL 268
Query 165 AK--GPMSRFATGNAETLSTYPKANGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQE 222
AK PMS+F GNA+TL T PK I++ RLR+F ++Y M S SLD E
Sbjct 269 AKPDHPMSKFCWGNAQTLKTEPKEKNINVYKRLREFWKRHYSAHYMTLAVQSKESLDTLE 328
Query 223 SLIREKLEGISAGHADWLGMVQCPGPMF-DTVKPFDHTNSGKFIHLQSFSSQPSLWVAFG 281
+RE + G ++ P F D + PF+ K + +L + +
Sbjct 329 EWVREIFSQVPNN-----GQLK---PDFSDKLNPFETPAFNKLYRVVPVRKVHALTITWA 380
Query 282 LPATLTSYKKQPTSVLTYLLEYTGEGSLAKRLR----LLGLADGIS-PAVDRNSISTLLG 336
LP Y+ +P + +L+ + G GS+ LR L L G S D+N+ ++
Sbjct 381 LPPQEKHYRVKPLHYIAWLIGHEGTGSILSMLRRKCWALALFGGNSETGFDQNTTYSIFS 440
Query 337 IKVDLTQKGAAHRGLVLQEIFSYINFLRDHGVGHDLVSTMAQQSHIDFHTTQPSSSIMDE 396
I + LT +G + V +F Y+ L+ G + + + +FH + + I +
Sbjct 441 ISITLTDEGFQNFYEVAHLVFQYLKMLQTLGPQQRIYEEIQKIEANEFHYQEQTDPI-EY 499
Query 397 AARLAHNLLTYEPYHVVAGDSLLIDADPRLTNQLLQAMSPSKAIIAFSDPDFTSKVDNFE 456
+ N+ + + GD L+ + P + + L ++P KA + P+ + E
Sbjct 500 VEDICENMQLFPKEDFLTGDQLMFEFKPEVISAALNLLTPEKANLLLLSPEHEGQCPLRE 559
Query 457 TDPYYGVQFRVLDLPQHHAVAMAVLTASPNAFRMPPPLMHIPKASELKILPGLLGLT--- 513
++G Q+ D+ QH A F + P L H+P +E K + L
Sbjct 560 K--WFGTQYSTEDIEQHWREIWA------KDFDLNPSL-HLP--AENKFIATDFALKTSD 608
Query 514 --EPELISEQGGNAGTAVWWQGQGAFALPRIAVQ---LNGSISKE-KADVLSRTQGSLAL 567
+ E N +W++ F +P+ V+ ++ + K K VL ++ +
Sbjct 609 CPDTEYPVRIMNNDRGCLWYKKDNKFKIPKAYVRFHLISPVVQKSPKNLVLFDLFVNILV 668
Query 568 AAIAEHLQEETV---DFQNCGITHSLAFKGTGFHMTFEGYTQAQLGKVMAHVASLLSDPS 624
+AE E V +++ H L K GF+ +L + + L+D S
Sbjct 669 HNLAEPAYEADVAQLEYKLVAGEHGLVIKVKGFN--------HKLPLLFNLIVDYLADFS 720
Query 625 MVEPERF----ERIKEKQIKLLADP------ATSMAFEHALEAAAILTRNDAFSRKDVLN 674
P+ F E++K+ +L P + EH+ + + + A VL+
Sbjct 721 AA-PDVFSMFAEQLKKTYFNILIKPEKLGKDVRLLILEHS--RWSTIQKYQA-----VLD 772
Query 675 ALQQSNYEDSIAKLSELKNIHVDAFVMGNIDRDQSLAMVEDFLEQAGFTPIAHDDAVASL 734
L + ++ ++ + + GN+ +S+ ++ E+ F ++ + V
Sbjct 773 GLSVDELMEFVSGFK--SELYAEGLLQGNVTSTESMGFLQYVTEKLQFKKLSVEVPVLFR 830
Query 735 AMEQKQTIEATLANPI-KGDKDHASLVQFQLGIPSIEDRVNLAVLTQFLNRRIYDSLRTE 793
+E Q + KGD + V +Q G ++ + + +L + +D LRT+
Sbjct 831 VVELPQKHHLCKVKSLNKGDANSEVTVYYQSGPKNLREHTLMELLVMHMEEPCFDFLRTK 890
Query 794 AQLGY 798
LGY
Sbjct 891 ETLGY 895
> cel:C02G6.1 hypothetical protein; K01408 insulysin [EC:3.4.24.56]
Length=980
Score = 230 bits (586), Expect = 2e-59, Method: Compositional matrix adjust.
Identities = 217/846 (25%), Positives = 363/846 (42%), Gaps = 83/846 (9%)
Query 10 ILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHM 69
I+K D R++R +L+NG+ + V P ++++ A+ G L DP ++PGLAHF EHM
Sbjct 16 IVKGAQDDREYRGLELTNGIRVLLVSDPTTDKSAAALDVKVGHLMDPWELPGLAHFCEHM 75
Query 70 LFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPL 129
LFLGT+KYP Y FLT N G NA T + T + V ALDRF +FF SP
Sbjct 76 LFLGTAKYPTENEYSKFLTDNAGHRNAVTASDHTNYHFDVKPDQLRGALDRFVQFFLSPQ 135
Query 130 FNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAK--GPMSRFATGNAETLSTYPKAN 187
F E+EV A+D+EH N+ ND R RSL+K ++F TGN +TL +
Sbjct 136 FTESATEREVCAVDSEHSNNLNNDLWRLSQVDRSLSKPGHDYAKFGTGNKKTLLEEARKK 195
Query 188 GIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCPG 247
G++ D L F+ K+Y + M I SLD +S ++ LE
Sbjct 196 GVEPRDALLQFYKKWYSSNIMTCCIIGKESLDVLQSHLK-TLE----------------- 237
Query 248 PMFDTVKPFDHTNSGKFIHLQSFSSQPSLWVAFGLPATLTSYKKQPTSVLTYLLEYTGEG 307
FDT++ K + + ++ P +G P L K+ +L+ + G G
Sbjct 238 --FDTIE-------NKKVERKVWNENP-----YG-PEQLG--KRIDRKFFAHLIRHKGPG 280
Query 308 SLAKRLRLLGLADGISPAVDRNSIST---LLGIKVDLTQKGAAHRGLVLQEIFSYINFLR 364
SL L+ LG + + D N+I+ +L + +DL+ G + ++Q + +YI L+
Sbjct 281 SLLVELKRLGWVNSLKS--DSNTIAAGFGILNVTMDLSTGGLENVDEIIQLMLNYIGMLK 338
Query 365 DHGVGHDLVSTMAQQSHIDFH---TTQPSSSIMDEAARLAHNLLTYEPY-HVVAGDSLLI 420
G + +A S + F QP ++ AA L Y P H+++ LL
Sbjct 339 SFGPQQWIHDELADLSDVKFRFKDKEQPMKMAINIAASLQ-----YIPIEHILSSRYLLT 393
Query 421 DADPRLTNQLLQAMSPSKAIIAFSDPDFTSKVDNFETDPYYGVQFRVLDL-PQHHAVAMA 479
+P +LL ++PS ++ F + N +P YG + +V D+ P+
Sbjct 394 KYEPERIKELLSTLTPSNMLVRVVSQKFKEQEGN-TNEPVYGTEMKVTDISPEKMKKYEN 452
Query 480 VLTASPNAFRMPPPLMHIPKASELKILPGLLGLTE-PELISEQGGNAGTAVWWQGQGAFA 538
L S +A +P +I A+ P E P+LIS+ G + VW++ +
Sbjct 453 ALKTSHHALHLPEKNEYI--ATNFGQKPRESVKNEHPKLISDDG---WSRVWFKQDDEYN 507
Query 539 LPRIAVQL---------NGSISKEKA-------DVLSRTQGSLALAAIAEHLQEETVDFQ 582
+P+ + N IS + D+LS + ALA + + Q
Sbjct 508 MPKQETKFALTTPIVSQNPRISLISSLWLWCFCDILSEETYNAALAGLGCQFELSPFGVQ 567
Query 583 NCGITHSLAFKGTGFHMTFEGYTQAQLGKVMAHVASLLSDPSMVEPERFERIKEKQIKLL 642
A + + GY + Q + H+ S + + ++ RFE + E + L
Sbjct 568 KQSTDGREAERHASLTLHVYGYDEKQ-PLFVKHLTSCMIN-FKIDRTRFEVLFESLKRTL 625
Query 643 ADPATSMAFEHALEAAAILTRNDAFSRKDVLNALQQSNYEDSIAKLSE-LKNIHVDAFVM 701
+ A S + +L + +S++ +L E+ E L+ H++ FV
Sbjct 626 TNHAFSQPYLLTQHYNQLLIVDKVWSKEQLLAVCDSVTLENVQGFAREMLQAFHMELFVH 685
Query 702 GNIDRDQSLAMVE---DFLEQAG--FTPIAHDDAVASLAMEQKQTIEATLANPIKGDKDH 756
GN +++ + + D L+ A P+ ++ + E + K
Sbjct 686 GNSTEKEAIQLSKELMDILKSAAPNSRPLYRNEHNPRREFQLNNGDEYIYRHLQKTHDAG 745
Query 757 ASLVQFQLGIPSIEDRVNLAVLTQFLNRRIYDSLRTEAQLGYIAGAKESQAASTALLQCF 816
V +Q+G+ + D + ++ Q + ++D+LRT LGYI L F
Sbjct 746 CVEVTYQIGVQNKYDNAVVGLIDQLIKEPVFDTLRTNEALGYIVWTGCRFNCGAVALNIF 805
Query 817 VEGAKT 822
V+G K+
Sbjct 806 VQGPKS 811
> ath:AT3G57470 peptidase M16 family protein / insulinase family
protein; K01408 insulysin [EC:3.4.24.56]
Length=891
Score = 223 bits (567), Expect = 3e-57, Method: Compositional matrix adjust.
Identities = 193/788 (24%), Positives = 345/788 (43%), Gaps = 66/788 (8%)
Query 69 MLFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSP 128
MLF + KYPE +SY ++T++GG+ NAYT E T + + +F EALDRFA+FF P
Sbjct 1 MLFYASEKYPEEDSYSKYITEHGGSTNAYTSSEDTNYHFDINTDSFYEALDRFAQFFIQP 60
Query 129 LFNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAK--GPMSRFATGNAETLSTYPKA 186
L + +E+ A+D+EHQ N+ +D R + L++ P +F+TGN +TL P+
Sbjct 61 LMSTDATMREIKAVDSEHQNNLLSDSWRMAQLQKHLSREDHPYHKFSTGNMDTLHVRPEE 120
Query 187 NGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCP 246
NG+D L F+ ++Y + M V +LD+ + L+ +GI + G+ + P
Sbjct 121 NGVDTRSELIKFYDEHYSANIMHLVVYGKENLDKTQGLVEALFQGIRNTNQ---GIPRFP 177
Query 247 GPMFDTVKPFDHTNSGKFIHLQSFSSQPSLWVAFGLPATLTSYKKQPTSVLTYLLEYTGE 306
G +P + + L V++ + +++ Y++ P L L+ + GE
Sbjct 178 G------QPCTLDHLQVLVKAVPIMQGHELSVSWPVTPSISHYEEAPCRYLGDLIGHEGE 231
Query 307 GSLAKRLRLLGLADGI-SPAVDRNSISTLLGIKVDLTQKGAAHRGLVLQEIFSYINFLRD 365
GSL L++LG A G+ + D + + + +DLT G H +L +F YI L+
Sbjct 232 GSLFHALKILGWATGLYAGEADWSMEYSFFNVSIDLTDAGHEHMQDILGLLFEYIKVLQQ 291
Query 366 HGVGHDLVSTMAQQSHIDFHTTQPSSSIMDEAARLAHNLLTYEPYHVVAGDSLLIDADPR 425
GV + ++ +FH Q + A ++ N+ Y H + G SL +P
Sbjct 292 SGVSQWIFDELSAICEAEFH-YQAKIDPISYAVDISSNMKIYPTKHWLVGSSLPSKFNPA 350
Query 426 LTNQLLQAMSPSKAIIAFSDPDFTSKVDNFETDPYYGVQFRVLDLPQHHAVAMAVLTASP 485
+ ++L +SP+ I + F + D E P+Y + + + + + + +A
Sbjct 351 IVQKVLDELSPNNVRIFWESNKFEGQTDKVE--PWYNTAYSLEKITK-FTIQEWMQSAPD 407
Query 486 NAFRMPPPLMHIPKASELK------ILPGLLGLTEPELISEQGGNAGTAVWWQGQGAFAL 539
+P P + IP LK I P LL T + + +W++ F
Sbjct 408 VNLLLPTPNVFIPTDFSLKDLKDKDIFPVLLRKT-----------SYSRLWYKPDTKFFK 456
Query 540 PRIAVQLNG----SISKEKADVLSRTQGSLALAAIAEHLQEETVDFQNCGITHSLAFKGT 595
P+ V+++ ++S A VLS + + + ++L E Q G+ + L+
Sbjct 457 PKAYVKMDFNCPLAVSSPDAAVLS----DIFVWLLVDYLNEYAYYAQAAGLDYGLSLSDN 512
Query 596 GFHMTFEGYT---QAQLGKVMAHVASLLSDPSMVEPERFERIKEKQIKLLADPATSMAFE 652
GF ++ G+ + L V+ +A V+P+RF IKE K + E
Sbjct 513 GFELSLAGFNHKLRILLEAVIQKIAKF-----EVKPDRFSVIKETVTKAYQNNKFQQPHE 567
Query 653 HALEAAAILTRNDAFSRKDVLNALQQSNYEDSIAKLSE--LKNIHVDAFVMGNIDRDQSL 710
A +++ ++ + + L+AL ED +A L V+ ++ GN+++D++
Sbjct 568 QATNYCSLVLQDQIWPWTEELDALSHLEAED-LANFVPMLLSRTFVECYIAGNVEKDEAE 626
Query 711 AMVEDFLEQAGFT---PIAH--------DDAVASLAMEQKQTIEATLANPIKGDKDHASL 759
+MV+ +E FT PI + V L K +N D++ A +
Sbjct 627 SMVKH-IEDVLFTDSKPICRPLFPSQFLTNRVTELGTGMKHFYYQEGSN--SSDENSALV 683
Query 760 VQFQLGIPSIEDRVNLAVLTQFLNRRIYDSLRTEAQLGYIAGAKESQAASTALLQCFVEG 819
Q+ L + + + LRT QLGYI S + +Q ++
Sbjct 684 HYIQVHKDEFSMNSKLQLFELIAKQDTFHQLRTIEQLGYITSLSLSNDSGVYGVQFIIQS 743
Query 820 AKTHPDEV 827
+ P +
Sbjct 744 SVKGPGHI 751
> cpv:cgd2_920 peptidase'insulinase-like peptidase'
Length=1028
Score = 206 bits (525), Expect = 2e-52, Method: Compositional matrix adjust.
Identities = 204/892 (22%), Positives = 384/892 (43%), Gaps = 75/892 (8%)
Query 9 DILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEH 68
DI+ PE + R +R +L NG+ A V + +G + G++Y P+++ GLAHFLEH
Sbjct 16 DIVLPECEDRKYRALELKNGLTAFLVSDKETKTSGCCLTVYIGAMYSPKNLNGLAHFLEH 75
Query 69 MLFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSP 128
MLF GT KYP + Y F+ +GG + T T ++ ++ ++AF EALDRF+ FF P
Sbjct 76 MLFCGTKKYPNVDEYQKFIASHGGKRHGSTTRSTTTYYFEIKNNAFNEALDRFSSFFTEP 135
Query 129 LFNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAKG--PMSRFATGNAETLSTYPKA 186
LF + EKEV+AI+ E +D+ ++ + L+ P++ F TGN ETL PK
Sbjct 136 LFCKDMTEKEVSAIENEFHLKYHSDERVRFHLLGQLSNKSHPLNCFTTGNKETLEFKPKK 195
Query 187 NGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCP 246
GI+L L F+S YY + M + LD E E I + +
Sbjct 196 LGINLHSELLKFYSSYYSSNIMSIILYGKEDLDTLEKYTIEYFSKIPNHQVNCFDYTK-- 253
Query 247 GPMFDTVKPFDH-TNSGKFIHLQSFSSQPSLWVAFGLPATLTSYKKQPTSVLTYLLEYTG 305
+F + P+ T+ GK I L + + L + F LP + + ++ + G
Sbjct 254 --IFMEIPPYTRETSIGKIIKLIPYETDKRLKIYFPLPPLDKYNDSCAPAYIANIIGHKG 311
Query 306 EGSLAKRLRLLGLADGISPAVDRNSISTLLGIKVDLTQKGAAHRGLVLQEIFSYINFLRD 365
EG ++ LR LA G S A+ L V LT +G + G VL+ IF+++ +
Sbjct 312 EGGISSILRAKKLATGASFAITNEDPCALAQFGVVLTDEGYNNIGQVLEIIFNFLVLFKA 371
Query 366 HGVGHDLVSTMAQQSHIDFHTTQPSSSIMDEAARLAHNLLTYEPYHVVAGDSLLIDA--- 422
V +LV + F T QP SI D + A L + + ++
Sbjct 372 TPVIPELVDEFIGITRAGF-TYQPKFSIRDLFSLPAKYLKYKCKFEEILSSGFVVKKFSQ 430
Query 423 DPRLTNQLLQAMSPSKAIIAFS----DPDFTSKVDNFETDPYYGVQFRVLDLPQ------ 472
D + +L+ +S I S + ++ +NF + YYG ++ + +L +
Sbjct 431 DDVFS--ILEYLSNDNFFILLSSQAIEEEYKKNQENFIVEHYYGTKYSISELDEDLLSII 488
Query 473 -----HHAVAMAVLTASPNAFRMPPPLMHIPK---ASELKILPGLLGLTEPELISEQGGN 524
A+ + ++ PN F + P+ ++ +P LL E + QG
Sbjct 489 NSSSPEKALKLGLILPKPNQFVSTDFSILNPQKVCVNDYLRIPELLNFDE---LKAQGNT 545
Query 525 AG-------TAVWWQGQGAFALPRIAVQL------------NGS---ISKEKADVLSRTQ 562
+W++ F P + + N S +S +++ +
Sbjct 546 DSYNIHSHPLNIWFKPDSTFNSPHSLINMRLVAERILEFKENSSFEKLSNFSNELVFQVF 605
Query 563 GSLALAAIAEHLQEETVDFQNCGITHSLAFKGTGFHMTFEGYTQA-QLGKVMAHVASLLS 621
G + + + E + D +++++ F +G+ + +L +++ + L
Sbjct 606 GEILNEVMYRSMHELSSDILAASLSYTINFNSRTNVFVLQGFGLSHKLNYLISIMFEKLY 665
Query 622 DPSMVEPERFERI----KEKQIKLLADPATSMAFEHALEAAAILTRNDAFSRKDVLNALQ 677
+ V E I K+ + K++ TS++ E E+ + F+R++ LN L+
Sbjct 666 HGTEVRKYYDEAILIISKDWKNKIIKPNLTSLSLECISESLSPF----FFNRQEKLNVLE 721
Query 678 QSNYEDSIA-KLSELKNIHVDAFVMGNIDRDQSLAM-VEDFLEQAGF-TPIAHDDAVASL 734
+E + + L N ++ +MGN + + ++ + F + ++ +
Sbjct 722 SFTFELFCSIRQHFLSNCRLEGLIMGNFSEPNAKCISIQHWKNLINFQNSVKNEVKSCGI 781
Query 735 AMEQ------KQTIEATLANPIKGDKDHASLVQFQLGIPSIEDRVNLAVLTQFLNRRIYD 788
+EQ K+ I P DK+ ++ F LG ++ +V ++ F++ +
Sbjct 782 KVEQFSIVNLKKDIYTLNYIPNSSDKNGCWMLSFFLGEYNLRKQVLCDLILPFVSSEAFA 841
Query 789 SLRTEAQLGYIAGAKESQAASTALLQCFVEGAK-THPDEVVKMIDEELTKAK 839
LRT QL Y+ A + ++ ++ +++ ++ T+ + ++++ + K K
Sbjct 842 DLRTNQQLAYVVRATQIFSSPAIIIGYYLQSSEYTNALTLERLLEFHINKTK 893
> eco:b2821 ptrA, ECK2817, JW2789, ptr; protease III (EC:3.4.24.55);
K01407 protease III [EC:3.4.24.55]
Length=962
Score = 202 bits (515), Expect = 4e-51, Method: Compositional matrix adjust.
Identities = 223/806 (27%), Positives = 347/806 (43%), Gaps = 57/806 (7%)
Query 10 ILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHM 69
I K + D R ++ +L NGM + V P++ ++ A+ GSL DPE GLAH+LEHM
Sbjct 34 IRKSDKDNRQYQAIRLDNGMVVLLVSDPQAVKSLSALVVPVGSLEDPEAYQGLAHYLEHM 93
Query 70 LFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPL 129
+G+ KYP+ +S +L +GG++NA T +T F+ +V + A A+DR A+ PL
Sbjct 94 SLMGSKKYPQADSLAEYLKMHGGSHNASTAPYRTAFYLEVENDALPGAVDRLADAIAEPL 153
Query 130 FNRQYEEKEVNAIDAEHQKNIPNDDER-AWYTIRSLAKG-PMSRFATGNAETLSTYPKAN 187
+++Y E+E NA++AE D R A + ++ P S+F+ GN ETLS P
Sbjct 154 LDKKYAERERNAVNAELTMARTRDGMRMAQVSAETINPAHPGSKFSGGNLETLSDKP--- 210
Query 188 GIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMV---Q 244
G + L+DFH KYY + M AV S + L E ++ AD G V +
Sbjct 211 GNPVQQALKDFHEKYYSANLMKAVIYSNKPLPE-----------LAKMAADTFGRVPNKE 259
Query 245 CPGPMFDTVKPFDHTNSGKFIHLQSFSSQPSLWVAFGLPATLTSYKKQPTSVLTYLLEYT 304
P TV G IH + L V F + ++ + ++TYL+
Sbjct 260 SKKPEI-TVPVVTDAQKGIIIHYVPALPRKVLRVEFRIDNNSAKFRSKTDELITYLIGNR 318
Query 305 GEGSLAKRLRLLGLADGISPAVDR--NSISTLLGIKVDLTQKGAAHRGLVLQEIFSYINF 362
G+L+ L+ GL +GIS D N S +L I LT KG A+R V+ IFSY+N
Sbjct 319 SPGTLSDWLQKQGLVEGISANSDPIVNGNSGVLAISASLTDKGLANRDQVVAAIFSYLNL 378
Query 363 LRDHGVGHDLVSTMAQQSHIDFHTTQPS-SSIMDEAARLAHNLLTYEPYHVVAGDSLLID 421
LR+ G+ +A IDF PS + MD LA ++ H + ++
Sbjct 379 LREKGIDKQYFDELANVLDIDFRY--PSITRDMDYVEWLADTMIRVPVEHTLDAVNIADR 436
Query 422 ADPRLTNQLLQAMSPSKAIIAFSDPDFTSKVDNFETDPYYGVQFRVLDLPQHHAVAMAVL 481
D + + L M+P A I + P + D Y V D A
Sbjct 437 YDAKAVKERLAMMTPQNARIWYISPKEPHNKTAYFVDAPYQV-----DKISAQTFADWQK 491
Query 482 TASPNAFRMPPPLMHIPKASELKILPGLLGLTEPELISEQGGNAGTAVWWQGQGAFAL-P 540
A+ A +P +IP + ++ PELI ++ + V + FA P
Sbjct 492 KAADIALSLPELNPYIP--DDFSLIKSEKKYDHPELIVDE---SNLRVVYAPSRYFASEP 546
Query 541 RIAVQLNGSISKEKADVLSRTQGSLALAAIAEHLQEETVDFQNC--GITHSLAFKGTGFH 598
+ V L + KA +R Q AL L + + Q GI+ S G
Sbjct 547 KADVSL--ILRNPKAMDSARNQVMFALNDYLAGLALDQLSNQASVGGISFSTN-ANNGLM 603
Query 599 MTFEGYTQAQLGKVMAHVASLLSDPSMVEPERFERIKEKQIKLLADPATSMAFEHALEAA 658
+ GYTQ A + S ++ E+ K +++ AFE A+ A
Sbjct 604 VNANGYTQRLPQLFQALLEGYFS--YTATEDQLEQAKSWYNQMMDSAEKGKAFEQAIMPA 661
Query 659 AILTRNDAFSRKDVLNALQQSNYEDSIAKLSELKNIHVDAF-VMGNIDRDQSLAMVEDFL 717
+L++ FSR + L ++ +A LK+ F V+GN+ Q+ + D
Sbjct 662 QMLSQVPYFSRDERRKILPSITLKEVLAYRDALKSGARPEFMVIGNMTEAQATTLARDVQ 721
Query 718 EQAGFTP---IAHDDAVASLAMEQKQTIEATLANPIKGDKDHASL--VQFQLGIPSIEDR 772
+Q G + D V +++KQ++ A G+ ++L V G
Sbjct 722 KQLGADGSEWCRNKDVV----VDKKQSVIFEKA----GNSTDSALAAVFVPTGYDEYTSS 773
Query 773 VNLAVLTQFLNRRIYDSLRTEAQLGY 798
++L Q + Y+ LRTE QLGY
Sbjct 774 AYSSLLGQIVQPWFYNQLRTEEQLGY 799
> tgo:TGME49_069890 M16 family peptidase, putative (EC:3.4.24.56)
Length=941
Score = 201 bits (511), Expect = 1e-50, Method: Compositional matrix adjust.
Identities = 135/453 (29%), Positives = 211/453 (46%), Gaps = 13/453 (2%)
Query 10 ILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHM 69
+ KP D R++R+ +L N + A+ V P +EA ++ GS+ DP +PGLAHF EHM
Sbjct 25 VRKPRNDSRNYRYIELPNELRALLVSDPECDEAAASMRVGVGSMSDPPKIPGLAHFTEHM 84
Query 70 LFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPL 129
LF G+ ++P + F+ +GG NA+T + TVF + E LDR A+ F +PL
Sbjct 85 LFQGSKRFPGTHDFFDFVHNHGGYTNAFTSKFSTVFSFSIGPGFLEPGLDRLADLFSAPL 144
Query 130 FNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAK-GPMSRFATGNAETLSTYPKANG 188
+ KEVNA+ +E+ ++ +D R + IR AK GP S F GN E+L K G
Sbjct 145 LKSENLLKEVNAVHSEYIIDLTDDGRRKHHLIRQTAKGGPFSNFTVGNLESLMERTKQQG 204
Query 189 IDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCPGP 248
ID V +R+FH+K+Y + M + SLD ES +R+ + G +C
Sbjct 205 IDPVKAMREFHNKWYSSNLMTLAVVGRESLDVLESHVRKHFGNVPNGRVTPPVFEECS-- 262
Query 249 MFDTVKPFDHTNSGKFIHLQSFSSQPSLWVAFGLPATLTSYKKQPTSVLTYLLEYTGEGS 308
+ P D G + + F LP +++ +P ++ +LE+ G S
Sbjct 263 --EAFIPLDPNELGTETLVVPEADLHDATFVFYLPPQAKNWRSKPLQFISEMLEHEGPTS 320
Query 309 LAKRLRLLGLADGISPAVDRNSISTLLGIKVDLTQKGAAHRGLVLQEIFSYINFLRDHGV 368
L+ +L+ GL + + T+L + V LT+ G + V + + FLR+ GV
Sbjct 321 LSSKLKREGLITSLVTDYWSPELCTVLQVNVRLTEGGRSKES-VYKIGHALFTFLRNLGV 379
Query 369 GHD---LVSTMAQQSHIDF-HTTQPSSSIMDEAARLAHNLLTYEPYHVVAGDSLLIDADP 424
V+ MA+ + F P + R L Y P V+AGD L+ DP
Sbjct 380 SRPERWRVTEMAKIRQLGFAFADMPDPYAL--TVRAVEGLNYYTPEEVIAGDRLIYHFDP 437
Query 425 RLTNQLLQA-MSPSKAIIAFSDPDFTSKVDNFE 456
+ Q +Q + P + D + VD E
Sbjct 438 DIIQQYVQKFLVPDNVRLFIFDKKLAADVDREE 470
> cel:C28F5.4 hypothetical protein; K01408 insulysin [EC:3.4.24.56]
Length=856
Score = 197 bits (501), Expect = 2e-49, Method: Compositional matrix adjust.
Identities = 216/865 (24%), Positives = 347/865 (40%), Gaps = 145/865 (16%)
Query 10 ILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHM 69
I+K D + +R +L+NG+ + V ++ + A+ G L DP ++PGLAHF EHM
Sbjct 17 IVKGSQDTKKYRGLELTNGLRVLLVSDSKTRVSAVALDVKVGHLMDPWELPGLAHFCEHM 76
Query 70 LFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPL 129
LFLGT+KYP Y +L N G +NAYTD + T + +V ALDRFA+FF P
Sbjct 77 LFLGTAKYPSEREYFKYLAANNGDSNAYTDTDHTNYSFEVRSEKLYGALDRFAQFFLDPQ 136
Query 130 FNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAK--GPMSRFATGNAETLSTYPKAN 187
F E+EV A++ E+ + D R RSL+K S+FA GN +TL P+
Sbjct 137 FTESATEREVCAVNCEYLDKVNEDFWRCLQVERSLSKPGHDYSKFAIGNKKTLLEDPRTK 196
Query 188 GIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCPG 247
GI+ D L DF+ +Y M + SLD ES +LG +
Sbjct 197 GIEPRDVLLDFYKNWYSSDIMTCCIVGKESLDVLES---------------YLGSFK--- 238
Query 248 PMFDTVK------------PFDHTNSGKFIHLQSFSSQPSLWVAFGLPATLTSYKKQPTS 295
FD +K PF K I + + + + F P + QP
Sbjct 239 --FDAIKNTRKERKIWKDSPFGPDQLAKRIEIVPIQNTGQVSIKFPFPDLNGEFLSQPGD 296
Query 296 VLTYLLEYTGEGSLAKRLRLLGLADGISPAVDRNSISTLLGI---KVDLTQKGAAHRGLV 352
+ +L+ + G GSL L+ LG IS D ++I++ G+ +DL+ +G H V
Sbjct 297 YIAHLIGHEGPGSLLSELKRLGWV--ISLEADNHTIASGFGVFSVTMDLSTEGLEHVDDV 354
Query 353 LQEIFSYINFLRDHGVGHDLVSTMAQQSHIDFHTTQPSSSIMDEAARL-AHNLLTYEPYH 411
+Q +F++I FL+ G P I DE A L A + + H
Sbjct 355 IQLVFNFIGFLKSSG---------------------PQKWIHDELAELNAVDFRFDDVKH 393
Query 412 VVAGDSLLIDA-DPRLTNQLLQAMSPSKAIIAFSDPDFTSKVDNFETDPYYGVQFRVLDL 470
+ S+L + P++ NFET
Sbjct 394 TMEKASILAECLHPKIRK-------------------------NFET------------- 415
Query 471 PQHHAVAMAVLTASPNAFRMPPPLMHIPKASELKIL-PGLLGLTEPELISEQGGNAGTAV 529
L S +AF +P +IP + K P G P LISE + V
Sbjct 416 ---------ALKTSHHAFNLPEKNEYIPSKFDQKPREPVKSGY--PRLISE---DEWIQV 461
Query 530 WWQGQGAFALPRIAVQLNGSISKEKADVLSRTQGSLALAAIAEHLQEETVDFQNCGITHS 589
W++ + P+ + + V +++ +A ++ + + EET + + G+
Sbjct 462 WFKQDNEYNSPKQGIMFALTTPL----VAKKSKNVVAFKSL-DTIIEETYNARLAGLECQ 516
Query 590 LAFKGTGFHMTFEGYTQAQ------LGKVMAH--VASLLSDPSMVEPERFERIKEKQIKL 641
+G + GY + Q L MA+ V L D S FE +K +
Sbjct 517 FESSSSGVQIRVFGYDEKQSLFAKHLVNRMANFQVNRLCFDIS------FESLK----RT 566
Query 642 LADPATSMAFEHALEAAAILTRNDAFSRKDVLNALQQSNYEDSIA-KLSELKNIHVDAFV 700
L + A S + + +L ++ +S++ +L ED + L+ H++ FV
Sbjct 567 LTNHAFSQPHDLSAHFIDLLVVDNIWSKEQLLAVCDSVTLEDVHGFAIKMLQAFHMELFV 626
Query 701 MGNIDRDQSLAM---VEDFLEQAG--FTPIAHDDAVASLAMEQKQTIEATLANPIKGDKD 755
GN +L + + D L+ P+ D+ ++ E + K
Sbjct 627 HGNSTEKDTLQLSKELSDILKSVAPNSRPLKRDEHNPHRELQLINGHEHVYRHFQKTHDV 686
Query 756 HASLVQFQLGIPSIEDRVNLAVLTQFLNRRIYDSLRTEAQLGYIAGAKESQAASTALLQC 815
V FQ+G+ S + +L + + Y LRT LGY + L
Sbjct 687 GCVEVAFQIGVQSTYNNSVNKLLNELIKNPAYTILRTNEALGYNVSTESRLNDGNVYLHV 746
Query 816 FVEGAKTHPDEVVKMIDEELTKAKE 840
V+G ++ D V++ I+ L A+E
Sbjct 747 IVQGPES-ADHVLERIEVFLESARE 770
> cpv:cgd3_4260 peptidase'insulinase like peptidase' ; K01408
insulysin [EC:3.4.24.56]
Length=1172
Score = 171 bits (432), Expect = 1e-41, Method: Compositional matrix adjust.
Identities = 123/444 (27%), Positives = 208/444 (46%), Gaps = 12/444 (2%)
Query 11 LKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHML 70
+KP + FR+ +L N + V H + + +A GS +P+ PGLAH+LEH+L
Sbjct 61 IKPAKSDKQFRYIKLKNELEVFLVSHNDTKVSSANIAVKVGSYMEPDSFPGLAHYLEHLL 120
Query 71 FLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLF 130
F+ T KYPE + ++ ++ + G NAYT++ T + + S+FE AL F+EFFKSPLF
Sbjct 121 FINTEKYPELDGFNKLISLHNGYTNAYTEDTSTSYLFSIDSSSFEAALSMFSEFFKSPLF 180
Query 131 NRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLA--KGPMSRFATGNAETLSTYPKANG 188
+ Y EKE+ +I+ E + R + L+ + RF+ GN ETL T P++ G
Sbjct 181 DENYVEKELMSIENEFNFRKDSLFFRFNHVTHELSDKRSLFGRFSYGNIETLKTIPESQG 240
Query 189 IDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCPGP 248
I+L D + F+ K Y + MV S +LDE + I + L + P
Sbjct 241 INLRDEVIKFYQKEYSSNRMVLALASNHTLDELTQFAYKYFSNIENKN---LPVNSIKTP 297
Query 249 MFD-TVKPFDHTNSGKFIHLQSFSSQPSLWVAFGLPATLTSYK-KQPTSVLTYLLEYTGE 306
+ + + PF+ T + + +++ L + F + + +K K T + L+ +
Sbjct 298 IQNGNLNPFN-TMINQLVVIETLDDSRILKLIFPMKEYMVQHKNKVRTMYIDKLISFDRP 356
Query 307 GSLAKRLRLLGLADGIS-PAVDRNSISTLLGIKVDLTQKGAAHRGLVLQEIFSYINFLRD 365
GSL L+ L + +D N T I +LT G + G +L FS I F +
Sbjct 357 GSLGHHLKSKKLILNMDFSIIDDNLGFTNAVIGFELTIDGEKNIGYILLSFFSVIKFASN 416
Query 366 HGVGHDLVSTMAQQSHIDFHTTQPSSSIMDEAARLAHNLLTYE--PYHVVAGDSLLIDAD 423
+ ++ I F P+S+ D++ + + +E P V+ D + + D
Sbjct 417 NEFSKEIYDEWKNLIDISFKYEDPTST-SDQSEEIVTYYIKHECKPEDVLYSDYYMDEFD 475
Query 424 PRLTNQLLQAMSPSKAIIAFSDPD 447
P + ++ ++P II PD
Sbjct 476 PNIYKEINSQLTPENLIITLERPD 499
> cpv:cgd3_4270 peptidase'insulinase like peptidase' ; K01408
insulysin [EC:3.4.24.56]
Length=1176
Score = 162 bits (410), Expect = 5e-39, Method: Compositional matrix adjust.
Identities = 120/444 (27%), Positives = 201/444 (45%), Gaps = 12/444 (2%)
Query 11 LKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHML 70
+KP + FR+ +L N + V H + + + GS +P+ PGLAH+LEH+L
Sbjct 65 IKPAKSDKQFRYIKLKNELEVFLVSHNDTKVSSANIVVKVGSYMEPDSFPGLAHYLEHLL 124
Query 71 FLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLF 130
F+ T KYPE + ++ F+ + G Y+ K + + FE AL F+EFFKSPLF
Sbjct 125 FINTEKYPEFDGFNEFVLLHNGNFETYSLRSKARYRFNIDSPFFEVALSMFSEFFKSPLF 184
Query 131 NRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLA--KGPMSRFATGNAETLSTYPKANG 188
+ Y EKE+ +ID E + R + L+ + RF+ GN ETL T P++ G
Sbjct 185 DENYAEKELMSIDDEFNLCKYSKSTRFLLVMGELSDKRSFFGRFSYGNIETLKTIPESQG 244
Query 189 IDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCPGP 248
I+L D + F+ K Y + MV S +LDE + I + L + P
Sbjct 245 INLRDEVIKFYQKEYSSNRMVLALASNHTLDELTQFAYKYFSNIENKN---LPVNSIKTP 301
Query 249 MFD-TVKPFDHTNSGKFIHLQSFSSQPSLWVAFGLPATLTSY-KKQPTSVLTYLLEYTGE 306
+ + + PF+ T + + +++ L + F + + + K T + L+ +
Sbjct 302 IQNGNLNPFN-TMINQLVVIETLDDSRILKLIFPMKEYMVQHNNKARTLYIDKLISFDRP 360
Query 307 GSLAKRLRLLGLA-DGISPAVDRNSISTLLGIKVDLTQKGAAHRGLVLQEIFSYINFLRD 365
GSL L+ L D +D + T I +LT G + G +L FS I F +
Sbjct 361 GSLGHHLKSKKLILDVYFSLIDDDLGFTNAVIGFELTIDGEKNIGYILLSFFSAIKFASN 420
Query 366 HGVGHDLVSTMAQQSHIDFHTTQPSSSIMDEAARLAHNLLTYE--PYHVVAGDSLLIDAD 423
+ ++ + +I F P+S+ D+ + + YE P V+ D + + D
Sbjct 421 NEFSKEIYDEWRKLLYISFKYEDPTST-FDQCKEIVTYYIQYECKPEDVLYSDYYMDEFD 479
Query 424 PRLTNQLLQAMSPSKAIIAFSDPD 447
P + ++ ++P II PD
Sbjct 480 PNIYKEINSQLTPENLIITLERPD 503
> tgo:TGME49_044480 insulin-degrading enzyme, putative (EC:3.4.24.56)
Length=299
Score = 136 bits (343), Expect = 4e-31, Method: Compositional matrix adjust.
Identities = 91/303 (30%), Positives = 146/303 (48%), Gaps = 25/303 (8%)
Query 9 DILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEH 68
DI KP+ + R +R +L N + V P ++ A A+ N GS +DP V GLAHF EH
Sbjct 8 DIDKPKTNKRSYRFVKLPNHLSVWLVSDPAADLASAALDINVGSYFDPPPVEGLAHFCEH 67
Query 69 MLFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSP 128
MLFLGT K+P+ Y +F+ Q+GG NAYT+ T + F+ FF +P
Sbjct 68 MLFLGTEKFPDETEYSNFIKQHGGCTNAYTEHTHTNY--------------HFS-FFIAP 112
Query 129 LFNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAK--GPMSRFATGNAETLSTYPKA 186
L E+E+NA+D++ + + ND R W + LA P +RF+ GN +L PKA
Sbjct 113 LSTEIAAERELNAVDSKFRLRLVNDFIRRWQLLHKLANPDHPFNRFSCGNQVSLQEVPKA 172
Query 187 NGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADW---LGMV 243
G D+ L FH +Y + M V + SLD + ++ + I +V
Sbjct 173 LGADVRHELLAFHKTWYSANIMTLVGLGTDSLDCLQGMVEKYFGTIKDKQVPVRPSRAIV 232
Query 244 QCPGPMFDTVKPFDHTNSGKFIHLQSFSSQPSLWVAFGLPATLTSYKKQPTSVLTYLLEY 303
P+F H + + +++ Q + F LP + +++ + + L++L +
Sbjct 233 DPSVPVFRR-----HEDLQQVVYIVPIKDQREIHFEFVLPPQIDAWRTKHSRCLSHLAGH 287
Query 304 TGE 306
G+
Sbjct 288 EGK 290
> sce:YPR122W AXL1, FUS5, STE22; Axl1p (EC:3.4.24.-); K01422
[EC:3.4.99.-]
Length=1208
Score = 133 bits (334), Expect = 4e-30, Method: Compositional matrix adjust.
Identities = 77/229 (33%), Positives = 119/229 (51%), Gaps = 9/229 (3%)
Query 18 RDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLF-LGTSK 76
R + +L NG+ A+ + P + ++ TGS DP+D+ GLAH EHM+ G+ K
Sbjct 22 RTHKVCKLPNGILALIISDPTDTSSSCSLTVCTGSHNDPKDIAGLAHLCEHMILSAGSKK 81
Query 77 YPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDS------AFEEALDRFAEFFKSPLF 130
YP+P + + + +N G+ NA+T E+T F+ ++ ++ FE LD FA FFK PLF
Sbjct 82 YPDPGLFHTLIAKNNGSQNAFTTGEQTTFYFELPNTQNNGEFTFESILDVFASFFKEPLF 141
Query 131 NRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAK--GPMSRFATGNAETLSTYPKANG 188
N KE+ AI +EH+ NI + + ++ R LA P SRF+TGN +LS+ P+
Sbjct 142 NPLLISKEIYAIQSEHEGNISSTTKIFYHAARILANPDHPFSRFSTGNIHSLSSIPQLKK 201
Query 189 IDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHA 237
I L L + + G N+ P+S++ L K I A
Sbjct 202 IKLKSSLNTYFENNFFGENITLCIRGPQSVNILTKLALSKFGDIKPKSA 250
> cpv:cgd2_4270 secreted insulinase-like peptidase
Length=1257
Score = 132 bits (332), Expect = 6e-30, Method: Compositional matrix adjust.
Identities = 70/214 (32%), Positives = 114/214 (53%), Gaps = 3/214 (1%)
Query 21 RHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEP 80
+ Y S G+ + V E+ F+ G DP+++ GLAH +EH++FLG+ + P P
Sbjct 94 KAYTTSKGLKTLLVSDNTMLESAFSFGIGCGYYQDPDNLAGLAHLMEHVVFLGSQENPNP 153
Query 81 ESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFNRQYEEKEVN 140
+D FL + GGA NAYT + T+F+ E + F + +P+ + + E++
Sbjct 154 VGWDEFLLKKGGAANAYTSADTTIFYVLSPPRELESVMSYFTKMLVNPVIDERSSVSEID 213
Query 141 AIDAEHQKNIPNDDERAWYTIRSLA--KGPMSRFATGNAETLSTYPKANGIDLVDRLRDF 198
A++ EH+KNIPN LA + P +F TGN ETL K N I+L D L+++
Sbjct 214 AVNQEHEKNIPNKVRAMIELAMYLAPEECPARKFGTGNKETLYINSKKNNINLKDALKEY 273
Query 199 HSKYYCGSNMVAVTISPRSLDEQESLIREKLEGI 232
H+ Y N V + P+S +E+ I +K++G+
Sbjct 274 HTNCYTSDNASIVIMGPQS-NEELVKIADKIDGL 306
Score = 75.9 bits (185), Expect = 7e-13, Method: Compositional matrix adjust.
Identities = 99/451 (21%), Positives = 196/451 (43%), Gaps = 60/451 (13%)
Query 397 AARLAHNLLTY--EPYHVVAG--DSLLIDADPRLTN-------QLLQAMSPSK-AIIAFS 444
A++ A +LL + EP ++ + ++ D L+N + ++ + PSK II S
Sbjct 537 ASQAAESLLIFPDEPEMALSAFVKPVSMNKDSELSNGQITALKEFVKHLEPSKMKIIKLS 596
Query 445 DPDFTSKVDNFETDPYYGVQFRVLDLPQHHAVAMAVLTASPNAFRMPPPLMHIPKASEL- 503
D +S NF +PY ++++ L S N + L K EL
Sbjct 597 DSLNSSSEHNFRFEPY----------KTEYSISKISLENSENTSKTIEALKSTNKIGELL 646
Query 504 KILPGLLGLT-------------EPELISEQGGNA----------GTAVWWQGQGAFALP 540
+PG L + E E+ + GN G ++W+G +P
Sbjct 647 TCVPGDLSIISFSEDKCPGYKSFEKEIQERKIGNELQPCPILEEEGLRIFWKGP-IHTVP 705
Query 541 RIAVQLNGSISKEKADVLSRTQGSLALAAIAEHLQEETVD-----FQNCGITHSLAFKGT 595
I + L + + DV + + SL +A + LQ +D F+ CG+ +++
Sbjct 706 TINLTLVQRLPNK--DVSNNVRVSL-IANLHAQLQNSKMDYILSSFKLCGLEADISYSRG 762
Query 596 GFHMTFEGYTQAQLGKVMAHVAS-LLSDPSMVEPERFERIKEKQIKLLADPATSMAFEHA 654
F + + Y+ + ++ +++ L+S+ + FE + + + MA++ A
Sbjct 763 RFVINVQSYS-SNFEDIIEKLSNYLVSESRLPTKTEFETALTNLKSEILNLSDLMAYDVA 821
Query 655 LEAAAILTRNDAFSRKDVLNALQQS--NYEDSIAKLSELKNI-HVDAFVMGNIDRDQSLA 711
+ A + ++ +SR + +LQ++ +++ I K+ ++ ++ + DA ++GNI ++S+
Sbjct 822 TDVAQSVYLSNYYSRLQLRESLQKTEITFDEYIEKIKDIFSVGYFDALIVGNIGYEKSIK 881
Query 712 MVEDFLEQAGFTPIAHDDAVASLAMEQKQTIEATLANPIKGDKDHASLVQFQLGIPSIED 771
+V + I + +A+ + I NPI DK++A + F + D
Sbjct 882 LVSRMVGSLVTKKIPYSNAIHDGILNVSGDIHIKANNPISSDKNNAVVAHFLTPPVDLID 941
Query 772 RVNLAVLTQFLNRRIYDSLRTEAQLGYIAGA 802
+ + + LN YD+LRTE Q GY+A A
Sbjct 942 VSIYSSIGEILNSPFYDTLRTEWQDGYVAFA 972
> cpv:cgd3_4240 insulinase like peptidase ; K01408 insulysin [EC:3.4.24.56]
Length=1113
Score = 125 bits (315), Expect = 6e-28, Method: Compositional matrix adjust.
Identities = 106/407 (26%), Positives = 181/407 (44%), Gaps = 36/407 (8%)
Query 8 SDILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLE 67
S+ +KP+ + +L G+ + + + GS + ++ GLAHFLE
Sbjct 20 SEFIKPKESSFKCKFERLKTGLEVFLISSEKLTSTSVNLVVKVGSANEGSEIDGLAHFLE 79
Query 68 HMLFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKS 127
H +FLGT K+P + F+ GGA NA TD T + + + E AL+RF EFFKS
Sbjct 80 HSVFLGTEKFPGQNEFGKFVRTYGGATNASTDILMTHYSFFIPNQFLEPALERFCEFFKS 139
Query 128 PLFNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAKGP--MSRFATGNAETLSTYPK 185
PLF+ +Y + E+N ++ E N + ++ +A S+F GN++TL P+
Sbjct 140 PLFSEEYLQNEINIVENEFLSKTNNFYTLLEHVLKQIADETHIYSKFFYGNSKTLKKIPE 199
Query 186 ANGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQC 245
NGI L +R F +YY NMV +S S+ E L IS + + + C
Sbjct 200 KNGISLRERTIRFFEEYYGSKNMVLFILSNISIQE--------LSKISYKY--FSNVRSC 249
Query 246 ----PGP----MFDTVKPFDHTNSGKFIHLQSFSSQPSLWVAFGLPATLTSYKKQPTSVL 297
P P +F + + IHL +SQ L + F LP + + L
Sbjct 250 SRLSPKPESLSLFPELPYLGISKKLVKIHLNINASQ--LMLMFSLPKKEYGLSRIFSQYL 307
Query 298 TYLL-EYTGEGSLAKRLRLLGLADGISPAVDRNSISTLLGIK-----VDLTQKGAAHRGL 351
++ L +GEG L ++ + + N + LG + LT++G +
Sbjct 308 SFFLCPKSGEGLLNDIIQ-----KNLCHKISLNETYSQLGFSYITFYLFLTKEGVFNIRE 362
Query 352 VLQEIFSYINFLRDHGVGHDLVSTMAQQSHIDF---HTTQPSSSIMD 395
++ +FS ++ + + + +A + +++F T PS I++
Sbjct 363 IILSLFSAFQIIKKTELIDEYIQRIANKDYLNFLKIEDTLPSIQILE 409
> cpv:cgd6_5520 peptidase'insulinase like peptidase' ; K01408
insulysin [EC:3.4.24.56]
Length=570
Score = 120 bits (302), Expect = 2e-26, Method: Compositional matrix adjust.
Identities = 111/454 (24%), Positives = 199/454 (43%), Gaps = 40/454 (8%)
Query 20 FRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPE 79
+R +L+N + + P + G + GS DPE +PGLAH L+ LF+ T KYPE
Sbjct 64 YRFIKLNNELDVFLISRPGKHTYG-TLHIQVGSHNDPEYIPGLAHLLKQSLFINTKKYPE 122
Query 80 PESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFNRQYEEKEV 139
+ F+ + G +A+TD E T ++ K+ + EEALDRF++ F PLF+ + EKE+
Sbjct 123 IYGFYKFIHLHFGETSAFTDLEYTRYYFKINSNVIEEALDRFSQSFIDPLFDEHFIEKEI 182
Query 140 NAIDAEHQKNIPNDDERAWYTIRSLAKGPMSRFATGNAETLSTYPKANGIDLVDRLRDFH 199
I+ H+ +I E ++ + + K ++ N ET P ID+ + + F+
Sbjct 183 --ININHENDIYKKQE--YFNLSIIRK--LTNNNNNNNETFKLEPILKEIDIRNEIIRFY 236
Query 200 SKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCPGPMFDTVKPFDHT 259
Y + M+ V S +S+DE L ++ + + Q P FD F+HT
Sbjct 237 QNEYSSNKMILVLTSNKSIDE--------LTNLAIKYFSKIQNKQLPLKSFDEEIIFNHT 288
Query 260 N-----SGKFIHLQSFSSQPSLWVAFGLPATLTSYKK-----QPTSVLTYLLEYTGEGSL 309
N K I +S + + + L +K + + L L
Sbjct 289 NPYEYLKKKIIFAESIHKKNLITLYLPFETKLNGNEKLIIIYIIMKYINHNLNSNKFQYL 348
Query 310 AKRLRLLGLADGISPAVDRNSIS-TLLGIKVDLTQKGAAHRGLVLQEIFSYINFLRDH-- 366
K+L L + I I L I ++LT G + +L+EI+S I +++++
Sbjct 349 NKKL----LINDIKCHFYTQEIQFNLFKIYIELTINGIKNIEYILKEIYSAIIYIKENIS 404
Query 367 --GVGHDLVSTMAQQSHIDFHTTQPSSSIMDEAARLAHNLLTYEPYHVVAGDSLLIDADP 424
+ D + +Q + ++ P++ I+D+ + L+ P +V+ + +
Sbjct 405 FEQILQDYNHSQNEQYY-NYVDDSPNNQIIDKY--FNYKLM---PKYVIINNIETNQINE 458
Query 425 RLTNQLLQAMSPSKAIIAFSDPDFTSKVDNFETD 458
N +L + P +I + F D+FE +
Sbjct 459 NTINSILSEIEPENMLILINTNKFNKLFDHFENN 492
> cpv:cgd3_4170 secreted insulinase like peptidase
Length=1289
Score = 109 bits (273), Expect = 4e-23, Method: Compositional matrix adjust.
Identities = 94/446 (21%), Positives = 195/446 (43%), Gaps = 19/446 (4%)
Query 11 LKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHML 70
+K D +R+ +L NG+ A V + ++ A+ + G LYDP + GL++ +++ L
Sbjct 59 IKSRVDKAKYRYIKLKNGLKAFLVSKEDAEKSEVAILVDVGFLYDPPKIIGLSNLVQYSL 118
Query 71 FLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLF 130
L + +YP + +F+ G E+ TV+ + E++ RF+ +F SPL
Sbjct 119 LLASYQYPNINEFHNFIKLLNGRMYLDLHEKSTVYSFTIGTEYLSESIFRFSSYFHSPLL 178
Query 131 NRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAK---GPMSRFAT---GNAETLSTYP 184
N K + I ++ + N+ ++ R + + G ++F T GN TL P
Sbjct 179 NNDTINKAMLTIFSQLNRMKRNE----FWAKREIEREIIGLNAKFDTFYYGNKNTLLNNP 234
Query 185 KANGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQ 244
+ ++ +++R + SK+Y +NM + LD+ E + + I ++ +V+
Sbjct 235 HLSEGEIYEKVRHYFSKFYSPNNMKLAIVGREPLDKLEKYVIQNFAHIK---SNGFNIVR 291
Query 245 CPGPMFDTVKPFDHTNSGKFIHLQSFSSQ--PSLWVAFGLPATLTSYKKQPTSVLTYLLE 302
V PF S + ++ F ++ + F + + ++K+ PT + YLL+
Sbjct 292 IDDSYKYIVNPFIRI-SKNIVTIRRFKKTGINTINLRFPIEIQVVNWKRIPTMYIKYLLD 350
Query 303 YTGEGSLAKRLRLLGLADGISPAVDRNSISTLLGIKVDLTQKGAAHRGLVLQEIFSYINF 362
+G L K L+ +G+++ I V + L I +DL H +++ + S + +
Sbjct 351 GNYKGILRKYLKSIGISNPIKVGVVNYEGFSTLDISIDLYNSQLRHSWNLVKAVISAVKY 410
Query 363 LRDHGVGHDLVSTMAQQSHIDFHTTQPSSSIMDEAARLAHNLLTY--EPYHVVAGDSLLI 420
+ + V +V + I F+ + + D A + + Y +P ++ D ++
Sbjct 411 IIELPVSERIVEEAKNVADIIFNYRETEFT-RDLAYNIVYKASKYRIKPQEIIYADEVME 469
Query 421 DADPRLTNQLLQAMSPSKAIIAFSDP 446
D + ++ + I F P
Sbjct 470 IVDISFIKAFISSIKIDQVSIFFFTP 495
> tgo:TGME49_006510 peptidase M16 domain containing protein (EC:4.1.1.70
3.4.24.13 3.4.24.56 3.4.21.10 3.4.24.35 3.2.1.91)
Length=2435
Score = 94.0 bits (232), Expect = 2e-18, Method: Compositional matrix adjust.
Identities = 73/233 (31%), Positives = 106/233 (45%), Gaps = 25/233 (10%)
Query 10 ILKPEADYRDFRHYQLSN-GMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEH 68
+ KP D + + + + +A+ FAV+ G +DP +PG+AH LEH
Sbjct 204 VRKPPRDTSAYSVFSVPALKLEGVAIADQEEAVGSFAVSVGCGFFHDPPAIPGVAHQLEH 263
Query 69 MLFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKV-TDSAFEEALDRFAEFFKS 127
++FLG S+D F++Q GG +NA+T E T FF TD+ E F
Sbjct 264 LIFLGAEGEEAATSWDEFVSQRGGTHNAHTTAELTTFFVAAPTDTLPELLDRLLLHLFHP 323
Query 128 PLFNRQYEEKEVNAIDAEHQKNIPNDD----ERAWYTIRSLAKGPMS------------- 170
L Q+ EV A+ EH+KN P+ E A SLA S
Sbjct 324 LLAAEQF-ASEVMAVQFEHEKNQPDVARVLLELAMAVTPSLASPASSATQDEVPTSFYRP 382
Query 171 ----RFATGNAETLSTYPKANGIDLVDRLRDFHSKYYCGSNM-VAVTISPRSL 218
+F TG+ +TL P G+D++ LR+FH K Y NM +AV + RS+
Sbjct 383 EVARKFGTGDFDTLCKTPLEQGLDVLKALREFHGKCYKPENMTIAVRMGRRSV 435
Score = 85.1 bits (209), Expect = 1e-15, Method: Compositional matrix adjust.
Identities = 73/320 (22%), Positives = 143/320 (44%), Gaps = 6/320 (1%)
Query 528 AVWWQGQGAFALPRIAVQLNGSISKEKADVLSRTQGSLALAAIAEHLQEETVDFQNCGIT 587
+V+W+ F P + +S E A + G + E + FQ CG+
Sbjct 960 SVFWKNAEPFNKPIVRGYFKLRVSAEDATAQNTLYGKIFATLAGERARTALASFQGCGVD 1019
Query 588 HSLAFKGTGFHMTFEGYTQAQLGKVMAHVASLLSDPS-MVEPERFERIKEKQIKLLADPA 646
++F + + +++ V+A + +L + V+ F +I L+D +
Sbjct 1020 LLMSFTNGALVLEIQAFSEL-FAPVLARLIEVLKESQDNVKQSDFNKIFNTLKVQLSDFS 1078
Query 647 TSMAFEHALEAAAILTRNDAFSRKDVLNALQ--QSNYEDSIAKLSE-LKNIHVDAFVMGN 703
T FE AL+ A + R + FS+ D+ +A+ S +ED L + L +D F+MG+
Sbjct 1079 TVTPFELALDVALSVVRRNRFSQLDLRSAVTDASSQFEDFKVFLEKVLTKNALDVFIMGD 1138
Query 704 IDRDQSLAMVEDFLEQAGFTPIAHDDAVASLAMEQKQTIEATLANPIKGDKDHASLVQFQ 763
ID +++ + EDF P+ ++ S + IE +NPI D +A + +
Sbjct 1139 IDYEEARKLAEDFRAALSKQPLPFSESAGSEILNLADDIEIRFSNPIPEDATNAYVSLYV 1198
Query 764 L-GIPSIEDRVNLAVLTQFLNRRIYDSLRTEAQLGYIAGAKESQAASTALLQCFVEGAKT 822
P + + V +++ + ++ +D++RT GY+A A + L V+G++
Sbjct 1199 THPPPDMMEMVVYSLIGEVISSPFFDTIRTHWMDGYVAAAAVREVPPAMTLATIVQGSQR 1258
Query 823 HPDEVVKMIDEELTKAKEYL 842
PDE+ + + L + +E +
Sbjct 1259 KPDELERHVCAFLAEMEENI 1278
Score = 40.8 bits (94), Expect = 0.024, Method: Compositional matrix adjust.
Identities = 53/200 (26%), Positives = 84/200 (42%), Gaps = 29/200 (14%)
Query 292 QPTSVLTYLLEYTGEGSLAKRLRLLGLADGISPAVDRNSISTLLGIKVDLTQKGAAHRGL 351
QPT++L YLLEY GE +L RL+ GL S + + +LT +G
Sbjct 639 QPTALLEYLLEYPGEAALLNRLKAQGLIADAEYVDYTTSQKAFVALLFELTDEGEEKFED 698
Query 352 VLQEIFSYINFLRDHGVGH---DLVSTMAQQSHIDFHTTQPS---SSIMDEAARLAHNLL 405
V+ +Y LR D A+ ++ + P S+++ A +LA +L
Sbjct 699 VVSATLAYAEQLRTSVTETYILDFFDEFARVANRSWTYKDPEDAVSAVIAAAEKLA--VL 756
Query 406 TYEPYHVVAGD---------SLLIDADPRLTNQLLQAMSPSKAIIAFSDPDFTSK----- 451
P V+AG +LL+D + + L++ ++A P+ T++
Sbjct 757 PQRPDMVIAGGEFVSLPGDRTLLVD----VLKEELESFGRARASAIVVLPEDTARGSAEV 812
Query 452 VDNFETDPYYGVQFRVLDLP 471
V F YGVQF V LP
Sbjct 813 VHAFRP---YGVQFSVSALP 829
> cpv:cgd3_4180 secreted insulinase like peptidase
Length=1215
Score = 79.0 bits (193), Expect = 7e-14, Method: Compositional matrix adjust.
Identities = 94/456 (20%), Positives = 184/456 (40%), Gaps = 29/456 (6%)
Query 7 ASDILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFL 66
+S +K + D ++ +L N M V + + ++ GS+ DPED+PGL +
Sbjct 69 SSSFIKSKIDGSTYKFMKLQNQMSVFLVSNNNFEYSIITLSVGVGSVMDPEDLPGLVSLV 128
Query 67 EHMLFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFK 126
+ L LGT ++ + ++ +F+ G + E +VF KV LDR ++ +
Sbjct 129 QESLCLGTYRFFDHSNFCNFIISINGEIDMEVYERNSVFTIKVGSQYISTVLDRLSDMIR 188
Query 127 SPLFNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIR--SLAKGPMSRFATGNAETLSTYP 184
+P F + + + + N + IR SL R +++
Sbjct 189 NPSFPEKLFFAKTKEYSGTFESLLNNSEFLFQCVIRDISLDDHIFKRLNVLTDKSIKEAR 248
Query 185 KANGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQ 244
+ + I+L++++++F+ + Y S M V S ++ KL + + +
Sbjct 249 EISEINLLEQVKNFYYQQYSSSIMTLVVASKHTI--------AKLSNEVVLNFSLVKNLN 300
Query 245 CPGPM-FDTVKPFDHTN---SGKFIHLQSFSSQPSLWVAFGLPATLTSYKKQPTSVLTYL 300
P+ FD K H + G I++++ S L + F + + P+S L YL
Sbjct 301 ISNPLPFDLAKIVRHPHLGVVGNAIYVKAHSIN-ELILEFPIDYQEVLWDSSPSSYLEYL 359
Query 301 LEYTGEGSLAKRLRLLGLADGISPAVD--RNSISTLLGIKVDLTQKGAAHRGLVLQEIFS 358
L+ E SL+ L G + + R S S+ I+ LT KG ++Q F
Sbjct 360 LKDNSEKSLSNFLIKKGWISKMDAVTNSHRYSFSS-FEIRFLLTSKGIDKIKSIIQTTFI 418
Query 359 YINFLRDHGVGHDLVSTMAQ------QSHIDFHTTQPSSSIMDEAARLAHNLLTYEPYHV 412
+ ++ V ++++ + Q + D Q S I+D + ++ P V
Sbjct 419 ALEHIKSSPVNQEILAEIKQILKYKFDYYFDVSPRQISKQIID-----SFDIKGCSPEEV 473
Query 413 VAGDSLLIDADPRLTNQLLQAMSPSKAIIAFSDPDF 448
+ +L+ D+ + L +S ++ DF
Sbjct 474 LIAGNLIRDSSFEEISAFLNKISIENLLVFVKLTDF 509
> cpv:cgd3_4280 secreted insulinase like peptidase, signal peptide
Length=1244
Score = 78.2 bits (191), Expect = 1e-13, Method: Compositional matrix adjust.
Identities = 96/447 (21%), Positives = 187/447 (41%), Gaps = 32/447 (7%)
Query 12 KPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGF-AVAANTGSLYDPEDVPGLAHFLEHML 70
KP R++R+ +LSN + V+ ++ E F ++ + G DPE++PGL+ +L + L
Sbjct 105 KPIGCTREYRYLRLSNSLKVFMVY-DKTTEISFGSMNLDFGFASDPENIPGLSRYLLYTL 163
Query 71 FLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLF 130
G+ K + + ++ + A + + F + + FE AL FA F +
Sbjct 164 LFGSLKKKFTRQFALLIKKHKCSYRASISRDNSRFDFDILSNEFEIALKIFANMFINLNT 223
Query 131 NRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAKGPMSRFATGNAE---TLSTYPKAN 187
N E+ I A+ N+ N+ + + + + S T N+ L Y + +
Sbjct 224 NDNIHEE----IFAKLVNNLANNINFDSFRLSDILQEISSPTKTDNSSYDWNLLEYMQLH 279
Query 188 GIDLVDR---LRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQ 244
+D LR+F ++YY M +S ++LDEQ S++R+ I G ++ + ++
Sbjct 280 HLDKFKSKRLLREFFNQYYRADRMTLTILSNKTLDEQTSIVRKYFNKIRRGDSNIITRLR 339
Query 245 CPG-----PMFDTVKPFDHTNSGKFIHLQSFSSQPSLWVAFGL-PATLTSYKKQPTSVLT 298
P P++D++ GK + S L + F L + +P +
Sbjct 340 LPESGIKHPLYDSI--------GKILVFNSPRRSSLLKLIFPLNNISKIKLSSKPMFFFS 391
Query 299 YLLEYTGEGSLAKRLRLLGLADGISPAVDRNSISTLLGIKVDLTQKGAAHRGL--VLQEI 356
+ +GSL L + + NSI + +D+ + + ++Q I
Sbjct 392 MYISSKRKGSLYYYFYKHELVTEMKIYLS-NSIFGYYSLIIDINLQNLGELSIIHIIQGI 450
Query 357 FSYINFLRDHGVGHDLVSTMAQQSHIDFHTTQPSSSIMDEAARL--AHNLLTYEPYHVVA 414
FS +R+ +L + A+ + +S I DE + A N+L P V++
Sbjct 451 FSVFEMMRNSKPKLELYN-QAKTLKMKRFKHSANSFIYDECKNIQDAFNILKCPPEKVLS 509
Query 415 GDSLLIDADPRLTNQLLQAMSPSKAII 441
S+ + + L ++L + P +I
Sbjct 510 ARSIYTEYNLELHYKILSNLKPGNMLI 536
> ath:AT3G02090 MPPBETA; mitochondrial processing peptidase beta
subunit, putative; K01412 mitochondrial processing peptidase
[EC:3.4.24.64]
Length=531
Score = 73.2 bits (178), Expect = 5e-12, Method: Compositional matrix adjust.
Identities = 53/191 (27%), Positives = 88/191 (46%), Gaps = 10/191 (5%)
Query 21 RHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEP 80
R L NG+ + + A V + GS ++ ++ G AHFLEHM+F GT +
Sbjct 98 RVTTLPNGLRVATESNLSAKTATVGVWIDAGSRFESDETNGTAHFLEHMIFKGTDRR-TV 156
Query 81 ESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFNRQYEEKEVN 140
+ + + GG NAYT E+T ++ KV DS +ALD A+ ++ F Q +E +
Sbjct 157 RALEEEIEDIGGHLNAYTSREQTTYYAKVLDSNVNQALDVLADILQNSKFEEQRINRERD 216
Query 141 AIDAEHQKNIPNDDERAWYTIRSLA--KGPMSRFATGNAETLSTYPKANGIDLVDRLRDF 198
I E Q+ DE + + A P+ R G A+ + + + + L+++
Sbjct 217 VILREMQEVEGQTDEVVLDHLHATAFQYTPLGRTILGPAQNVKSITRED-------LQNY 269
Query 199 HSKYYCGSNMV 209
+Y S MV
Sbjct 270 IKTHYTASRMV 280
> cpv:cgd3_4210 secreted insulinase like peptidase, signal peptide
Length=1254
Score = 71.6 bits (174), Expect = 1e-11, Method: Compositional matrix adjust.
Identities = 81/387 (20%), Positives = 155/387 (40%), Gaps = 31/387 (8%)
Query 9 DILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEH 68
D +K D + +L N + V S + + GS +P+ PGLA L
Sbjct 86 DFIKSVKDSNKYSFIRLKNDIQVFLVSQRSSLFSSITLGVRVGSSMEPKKFPGLATLLSE 145
Query 69 MLFLGTSKYPE---PESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFF 125
+LF K P+ YD F++ N G T + + F EAL +F +
Sbjct 146 LLFYDW-KRPDVGRETPYDLFISSNSGIFKTKVAPFLTEYHLSIKHEYFSEALIKFCSYL 204
Query 126 KSPLFNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLA-KGPMSR-FATGNAETLSTY 183
KS R + + + A+ ++ + + + ++ L+ +G ++ F GN + L
Sbjct 205 KSFSPKRIHLDPAMEALQSDFEALMGMSSIKLKQILKELSVEGHVNHGFHMGNMKRLMAN 264
Query 184 PKANGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMV 243
+ L+ L F+ YY + M +S +S+DE LEG++ D
Sbjct 265 IDFDTEALLFELIKFYGSYYSSNLMTISIVSDKSIDE--------LEGLARTFFD----- 311
Query 244 QCPGPMFDTVKPFDHTN---------SGKFIHLQSFSSQPSLWVAFGLPATLTSYKKQPT 294
+ P + PFD +N + K I ++S V F +P +K +P
Sbjct 312 EIPNQSKQLITPFDLSNEIIHPYIDLNNKVIQVKSAEENTYFTVIFPIPHQSPLWKYKPA 371
Query 295 SVLTYLLEYTGEGSLAKRLRLLGLADGISPA--VDRNSISTLLGIKVDLTQKGAAHRGLV 352
+++ SL L+ +G+ G+ V+ N S + I+ L KG +
Sbjct 372 EYISFFFTDYSNKSLYSYLKGIGIILGLETMIEVNDNGFSNFI-IRFKLNSKGEKAIVKI 430
Query 353 LQEIFSYINFLRDHGVGHDLVSTMAQQ 379
L+ S++ +++ + +++ + ++
Sbjct 431 LEITLSFLKLIKEVSISETIINQIRKK 457
> eco:b1494 pqqL, ECK1488, JW1489, pqqE, pqqM, yddC; predicted
peptidase; K07263 zinc protease [EC:3.4.24.-]
Length=931
Score = 68.9 bits (167), Expect = 8e-11, Method: Compositional matrix adjust.
Identities = 65/235 (27%), Positives = 112/235 (47%), Gaps = 40/235 (17%)
Query 24 QLSNGM-HAIAVH-HPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEP- 80
QL NG+ + I H HP+ ++ + +TGSL + ++ G+AHF+EHM+F GT +P
Sbjct 39 QLDNGLRYMIYPHAHPK-DQVNLWLQIHTGSLQEEDNELGVAHFVEHMMFNGTKTWPGNK 97
Query 81 --ESYDSFLTQNGGANNAYTDEEKTVF---FNKVTDSAFEEALDRFAEFFKSPLFNRQYE 135
E+++S + G NAYT ++TV+ ++ + F+E+ + F E
Sbjct 98 VIETFESMGLRFGRDVNAYTSYDETVYQVSLPTTQKQNLQQVMAIFSEWSNAATF----E 153
Query 136 EKEVNAIDAEHQKNIPNDDERA-----WYTIRSLAKGPMSRFATGNAETLSTYPKANGID 190
+ EV+A ++ + ++ RA W T S A+ P F N L P I
Sbjct 154 KLEVDA-----ERGVITEEWRAHQDAKWRT--SQARRP---FLLANTRNLDREP----IG 199
Query 191 LVD--------RLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHA 237
L+D +LR F+ ++Y +NM + + E +LI++ L + A A
Sbjct 200 LMDTVATVTPAQLRQFYQRWYQPNNMTFIVVGDIDSKEALALIKDNLSKLPANKA 254
> hsa:3416 IDE, FLJ35968, INSULYSIN; insulin-degrading enzyme
(EC:3.4.24.56); K01408 insulysin [EC:3.4.24.56]
Length=464
Score = 64.7 bits (156), Expect = 2e-09, Method: Compositional matrix adjust.
Identities = 63/303 (20%), Positives = 128/303 (42%), Gaps = 13/303 (4%)
Query 527 TAVWWQGQGAFALPRIAVQLNGSISKEKADVLSRTQGSLALAAIAEHLQEETVDFQNCGI 586
+ +W++ F LP+ + D L L L + + L E + G+
Sbjct 2 SKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGL 61
Query 587 THSLAFKGTGFHMTFEGYTQAQ---LGKVMAHVASLLSDPSMVEPERFERIKEKQIKLLA 643
++ L G +++ +GY Q L K++ +A+ ++ +RFE IKE ++ L
Sbjct 62 SYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATF-----EIDEKRFEIIKEAYMRSLN 116
Query 644 DPATSMAFEHALEAAAILTRNDAFSRKDVLNALQQSNYEDSIAKLSEL-KNIHVDAFVMG 702
+ +HA+ +L A+++ ++ AL A + +L +H++A + G
Sbjct 117 NFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHG 176
Query 703 NIDRDQSLA---MVED-FLEQAGFTPIAHDDAVASLAMEQKQTIEATLANPIKGDKDHAS 758
NI + +L MVED +E A P+ V ++ + +
Sbjct 177 NITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGI 236
Query 759 LVQFQLGIPSIEDRVNLAVLTQFLNRRIYDSLRTEAQLGYIAGAKESQAASTALLQCFVE 818
+ +Q + S + + L + Q ++ +++LRT+ QLGYI + +A L+ ++
Sbjct 237 EIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQ 296
Query 819 GAK 821
K
Sbjct 297 SEK 299
> cpv:cgd3_4250 secreted insulinase like peptidase, signal peptide
Length=1198
Score = 63.5 bits (153), Expect = 4e-09, Method: Compositional matrix adjust.
Identities = 91/445 (20%), Positives = 185/445 (41%), Gaps = 24/445 (5%)
Query 11 LKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHML 70
+KP +D + F+ +L+N + I P +E ++ GS++DP ++ GL +L +++
Sbjct 74 MKPISD-QSFKLLKLNNDIEVILNSAPNVDECTASILNRVGSMHDPSNLHGLGFYLMNIM 132
Query 71 FLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLF 130
++ YD F N + + ++F E L +E KSP+F
Sbjct 133 LSASNSDVGSGLYD-FCIDNSLSLSYQIYSTYSLFHVTTPMVLLENVLKLVSEMLKSPVF 191
Query 131 NRQYEEKEVNAIDAEHQKNIPNDDERAWYT--IRSLAKGPMSRFATGNAETLSTYPKANG 188
+ EK +N + E++ + N + T + S K +R G+ +TL T P++
Sbjct 192 TDEVMEKALNIL--ENKTTLDNHSYNIFSTNLVLSDPKSIFTRDRFGSRDTLKTIPQSKK 249
Query 189 IDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCPGP 248
ID+ L F ++ Y + ++ + + L+ + GI + +
Sbjct 250 IDVKQSLIKFFNEQYSSNRLMLSLKCNLPIQVMQDLVAKYFNGIINKNLPINTQYKSINN 309
Query 249 MFDTVKPFDHTNSGKFIHLQSFSSQPSLWVAFGLPATLTSYKKQ-PTSVLTYLLEYTGEG 307
+ + P ++ GK ++ S+Q +L + F L L Y K P + + EG
Sbjct 310 L--IINPLSYS-VGKIMYRIDESNQ-TLMLLFPLKNYLQPYMKSGPIFFINNYICANKEG 365
Query 308 SLAKRLRLLGLADGISPAVDRNSISTLLGIK--VDLTQKGAAHRGLVLQEIFSYINFLRD 365
+L + L+ ++ V N +S I+ +LT G + +++ F IN ++D
Sbjct 366 TLMRFLKQKNYIKNMNCHVS-NDMSGFSNIQFSFNLTNNGLFNVQNIIRAFFLSINKIKD 424
Query 366 HGVGHDLVSTMAQ------QSHIDFHTTQPSSSIMDEAARLAHNLLTYEPYHVVAGDSLL 419
+ ++ + Q +S + S SI++ + + ++ G +
Sbjct 425 LKLDINIYNKTNQNILKEIKSSNKYFANLNSLSILNNYFKFNSSSFK----SIILGVNEF 480
Query 420 IDADPRLTNQLLQAMSPSKAIIAFS 444
+ D L Q+L ++P II F+
Sbjct 481 SNFDLNLHRQILMEINPQNMIIIFN 505
> tgo:TGME49_036210 mitochondrial-processing peptidase beta subunit,
putative (EC:3.4.24.64); K01412 mitochondrial processing
peptidase [EC:3.4.24.64]
Length=524
Score = 57.8 bits (138), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 38/117 (32%), Positives = 57/117 (48%), Gaps = 7/117 (5%)
Query 25 LSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYD 84
L NG+ P A V ++GS YD ++ G AHFLEHM F GT + +
Sbjct 74 LPNGIRVATQRLPFHQTATVGVWIDSGSRYDTKETNGAAHFLEHMTFKGTKRRSRIQLEQ 133
Query 85 SFLTQNGGAN-NAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFNRQYEEKEVN 140
+N GA+ NAYT E+TV++ K AF++ + + + L N +E+ V
Sbjct 134 EI--ENMGAHLNAYTSREQTVYYAK----AFKKDIPQCVDILSDILLNSTIDEEAVQ 184
> cpv:cgd3_4200 secreted insulinase like peptidase, signal peptide
Length=1286
Score = 57.4 bits (137), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 73/352 (20%), Positives = 136/352 (38%), Gaps = 19/352 (5%)
Query 15 ADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGT 74
D +R+ +L NG+ V + + ++ GS +DP+ + G+++ + LF
Sbjct 159 GDENKYRYIKLDNGLKVFLVSNSLLYTSSLSLGIEVGSAHDPKGIDGVSYLITQELFKKE 218
Query 75 SKYPEPESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFNRQY 134
+ L N G N +++ T++ + F ++ F +
Sbjct 219 QNVTSDTDFRKLLDDNNGYFNVESNKFSTIYSYNIKSKYFMSSVSAFRKRLDKTKITWSS 278
Query 135 EEKEVNAID--AEHQKNIPNDDERAWYTIRSLAKGPMSRFATGNAETLSTYPKANGIDLV 192
++ ++ + E K + + E S + RF G ETL P N + +
Sbjct 279 LDESISQVTELTEIFKRVDSLQELQLKRELSNSSHAFHRFPYGTNETLREIPSKNNLSVH 338
Query 193 DRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLE-----GISAGH-ADWLGMVQCP 246
+ F KYY MV + SL+ E L+R + G++ G ++ G V P
Sbjct 339 EEAIRFKKKYYSPHLMVLSIATSLSLETVEELVRNEFSDLFSTGVTPGKPEEFSGNVTHP 398
Query 247 GPMFDTVKPFDHTNSGKFIHLQSFSSQPSLWVAFGLPATLTSYKKQPTSVLTYLLEYTGE 306
+DT+ GKFI ++S + + + + F +P +K + S + Y L
Sbjct 399 ---YDTL-------IGKFIEVKSRTPEAYITMEFPIPNQSKLWKYKLGSYVKYFLTQRFH 448
Query 307 GSLAKRLRLLGLADGIS-PAVDRNSISTLLGIKVDLTQKGAAHRGLVLQEIF 357
++ LG I V+ ++ + L IK L V+Q IF
Sbjct 449 DGFLDKMTNLGWVREIEVDIVNHDTGFSNLVIKAILVDSDRDKLVRVIQAIF 500
> ath:AT5G42390 metalloendopeptidase
Length=1265
Score = 57.4 bits (137), Expect = 3e-07, Method: Compositional matrix adjust.
Identities = 62/229 (27%), Positives = 91/229 (39%), Gaps = 50/229 (21%)
Query 9 DILKPEADYRDFRHY--------------QLSNGMHAIAVHH---PRSNEAGFAVAANTG 51
D+L PE D + + QL NG+ + + + P EA V + G
Sbjct 170 DLLPPEIDSAELEAFLGCELPSHPKLHRGQLKNGLRYLILPNKVPPNRFEAHMEV--HVG 227
Query 52 SLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYDSFLTQNGGANNAYTDEEKTVFF----- 106
S+ + ED G+AH +EH+ FLG+ K + L G +NAYTD TVF
Sbjct 228 SIDEEEDEQGIAHMIEHVAFLGSKKREK-------LLGTGARSNAYTDFHHTVFHIHSPT 280
Query 107 --NKVTDSAFEEALDRFAEFFKSPLFNRQYEEKEVNAIDAEHQK------NIPNDDERAW 158
D F LD E P F EKE AI +E Q + +
Sbjct 281 HTKDSEDDLFPSVLDALNEIAFHPKFLSSRVEKERRAILSELQMMNTIEYRVDCQLLQHL 340
Query 159 YTIRSLAKGPMSRFATGNAETLSTYPKANGIDLVDRLRDFHSKYYCGSN 207
++ L + RF G E + + VD++R FH ++Y +N
Sbjct 341 HSENKLGR----RFPIGLEEQIKKWD-------VDKIRKFHERWYFPAN 378
> dre:503532 pmpcb, zgc:110738; peptidase (mitochondrial processing)
beta (EC:3.4.24.64); K01412 mitochondrial processing
peptidase [EC:3.4.24.64]
Length=470
Score = 56.2 bits (134), Expect = 5e-07, Method: Compositional matrix adjust.
Identities = 42/147 (28%), Positives = 69/147 (46%), Gaps = 5/147 (3%)
Query 49 NTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYDSFLTQNGGAN-NAYTDEEKTVFFN 107
+ GS Y+ E G AHFLEHM F GT K + + +N GA+ NAYT E+TV++
Sbjct 72 DAGSRYENEHNNGTAHFLEHMAFKGTRKRSQLDL--ELEIENMGAHLNAYTSREQTVYYA 129
Query 108 KVTDSAFEEALDRFAEFFKSPLFNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLA-- 165
K A++ A+ ++ E+E I E Q+ N E + + + A
Sbjct 130 KAFSKDLPRAVEILADIIQNSTLGEAEIERERGVILREMQEVETNLQEVVFDYLHATAYQ 189
Query 166 KGPMSRFATGNAETLSTYPKANGIDLV 192
+ P+ R G E + T + + ++ +
Sbjct 190 ETPLGRTILGPTENIKTINRGDLVEYI 216
> sce:YLR163C MAS1, MIF1; Mas1p (EC:3.4.24.64); K01412 mitochondrial
processing peptidase [EC:3.4.24.64]
Length=462
Score = 55.8 bits (133), Expect = 6e-07, Method: Compositional matrix adjust.
Identities = 45/191 (23%), Positives = 82/191 (42%), Gaps = 10/191 (5%)
Query 21 RHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEP 80
R +L NG+ + P ++ A + + GS + G AHFLEH+ F GT +
Sbjct 27 RTSKLPNGLTIATEYIPNTSSATVGIFVDAGSRAENVKNNGTAHFLEHLAFKGTQNRSQ- 85
Query 81 ESYDSFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFNRQYEEKEVN 140
+ + + G NAYT E TV++ K +A+D ++ + + E+E +
Sbjct 86 QGIELEIENIGSHLNAYTSRENTVYYAKSLQEDIPKAVDILSDILTKSVLDNSAIERERD 145
Query 141 AIDAEHQKNIPNDDERAWYTIRSLA--KGPMSRFATGNAETLSTYPKANGIDLVDRLRDF 198
I E ++ DE + + + P+ R G + + + + + L+D+
Sbjct 146 VIIRESEEVDKMYDEVVFDHLHEITYKDQPLGRTILGPIKNIKSITRTD-------LKDY 198
Query 199 HSKYYCGSNMV 209
+K Y G MV
Sbjct 199 ITKNYKGDRMV 209
> pfa:PF11_0226 petidase, M16 family
Length=2024
Score = 55.8 bits (133), Expect = 7e-07, Method: Compositional matrix adjust.
Identities = 62/263 (23%), Positives = 110/263 (41%), Gaps = 31/263 (11%)
Query 7 ASDILKPEADYRDFRHYQL-SNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHF 65
S + K E D+ ++ +++L SN + + + + S + GF+++ N G D ++PG+++
Sbjct 665 KSTLKKGENDWNEYEYFKLKSNELKVLGIINKYSPKGGFSISVNCGGYDDFREIPGISNL 724
Query 66 LEHMLFLGTSKYPEPESYDSFLTQNG---GANNAYTDEEKTVFFNKVTDSAFEEALDRFA 122
L H +F Y + + L++ G NN+ E T ++ L F+
Sbjct 725 LRHAIF-----YKSEKRITTLLSELGKYSSENNSRIGESFTTYYAIGKSENIYNILTLFS 779
Query 123 EFFKSPLFNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAKG-PMSR-FATGNAETL 180
+ PLF+ + E EV I+ ++ + N+ I S+ F GN TL
Sbjct 780 QNLFYPLFDEDFIENEVREINNKYIS-MENNSLNCLKIISQFITDLKYSKFFFHGNYITL 838
Query 181 STYPKANGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWL 240
NG+++ L +FH K Y NM A+TI L G D
Sbjct 839 CNNVLKNGLNIKKLLYNFHKKCYQPKNM-ALTI---------------LLGKKGNSHDNY 882
Query 241 GMVQCPG---PMFDTVKPFDHTN 260
M +F+ +K +D+ N
Sbjct 883 NMNDIENFVIDIFEKIKNYDYVN 905
> hsa:9512 PMPCB, Beta-MPP, MPP11, MPPB, MPPP52, P-52; peptidase
(mitochondrial processing) beta (EC:3.4.24.64); K01412 mitochondrial
processing peptidase [EC:3.4.24.64]
Length=489
Score = 54.7 bits (130), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 50/175 (28%), Positives = 77/175 (44%), Gaps = 12/175 (6%)
Query 49 NTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYDSFLTQNGGAN-NAYTDEEKTVFFN 107
+ GS Y+ E G AHFLEHM F GT K + + +N GA+ NAYT E+TV++
Sbjct 86 DAGSRYENEKNNGTAHFLEHMAFKGTKKRSQLDL--ELEIENMGAHLNAYTSREQTVYYA 143
Query 108 KVTDSAFEEALDRFAEFFKSPLFNRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLA-- 165
K A++ A+ ++ E+E I E Q+ N E + + + A
Sbjct 144 KAFSKDLPRAVEILADIIQNSTLGEAEIERERGVILREMQEVETNLQEVVFDYLHATAYQ 203
Query 166 KGPMSRFATGNAETLSTYPKANGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDE 220
+ R G E + + + DLV D+ + +Y G +V S DE
Sbjct 204 NTALGRTILGPTENIKSISRK---DLV----DYITTHYKGPRIVLAAAGGVSHDE 251
> mmu:73078 Pmpcb, 3110004O18Rik, MPP11, MPPB, MPPP52; peptidase
(mitochondrial processing) beta (EC:3.4.24.64); K01412 mitochondrial
processing peptidase [EC:3.4.24.64]
Length=489
Score = 54.3 bits (129), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 52/188 (27%), Positives = 83/188 (44%), Gaps = 13/188 (6%)
Query 25 LSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYD 84
L NG+ +A + + + + GS Y+ E G AHFLEHM F GT K + +
Sbjct 63 LENGLR-VASENSGLSTCTVGLWIDAGSRYENEKNNGTAHFLEHMAFKGTKKRSQLDL-- 119
Query 85 SFLTQNGGAN-NAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFNRQYEEKEVNAID 143
+N GA+ NAYT E+TV++ K A++ A+ ++ E+E I
Sbjct 120 ELEIENMGAHLNAYTSREQTVYYAKAFSRDLPRAVEILADIIQNSTLGEAEIERERGVIL 179
Query 144 AEHQKNIPNDDERAWYTIRSLA--KGPMSRFATGNAETLSTYPKANGIDLVDRLRDFHSK 201
E Q+ N E + + + A + R G E + + N DLV D+ +
Sbjct 180 REMQEVETNLQEVVFDYLHATAYQNTALGRTILGPTENIKSI---NRKDLV----DYITT 232
Query 202 YYCGSNMV 209
+Y G +V
Sbjct 233 HYKGPRIV 240
> bbo:BBOV_II001130 18.m06083; hypothetical protein
Length=1138
Score = 53.9 bits (128), Expect = 3e-06, Method: Compositional matrix adjust.
Identities = 57/200 (28%), Positives = 92/200 (46%), Gaps = 31/200 (15%)
Query 24 QLSNGMHAIAV---HHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEP 80
+L NG+ + +H + EA V + + D + G+AHF EH+ ++G+ K
Sbjct 4 RLPNGLEYTVLPNSNHGQRFEAYLEVLSGSADELDHQR--GIAHFCEHVTYMGSRK---- 57
Query 81 ESYDSFLTQNGGANNAYTDEEKTVFFNKVTDS---------AFEEALDRFAEFFKSPL-F 130
D L ++ NA+TD TVF+ + + E ALD A+ ++P F
Sbjct 58 --RDCLLGRD-VRTNAFTDFHHTVFYTSCPSAIEGCYSKQDSLERALDALADVVEAPTQF 114
Query 131 NRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSL-AKGPMS-RFATGNAETLSTYPKANG 188
+ EKE AI +E + + + T+ +L A+ +S RF G+ E L TY N
Sbjct 115 SVSRVEKERQAILSEARIINTLEYRKNCATVEALHAENRLSRRFPIGDLEKLQTYSVQN- 173
Query 189 IDLVDRLRDFHSKYYCGSNM 208
L D+HS +Y SN+
Sbjct 174 ------LVDYHSVHYRPSNL 187
> bbo:BBOV_IV001260 21.m02910; mitochondrial processing peptidase
beta subunit; K01412 mitochondrial processing peptidase
[EC:3.4.24.64]
Length=514
Score = 53.1 bits (126), Expect = 5e-06, Method: Compositional matrix adjust.
Identities = 34/124 (27%), Positives = 58/124 (46%), Gaps = 2/124 (1%)
Query 25 LSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYD 84
L NG+ +V P N V ++GS ++ ++ G AHFLEHM+F GT E +
Sbjct 71 LKNGLRVASVWMP-GNSTTVGVWIDSGSRFETKETNGAAHFLEHMIFKGTKNRSRLE-LE 128
Query 85 SFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFNRQYEEKEVNAIDA 144
+ Q G NAYT E+T ++ + + + ++ ++ L E E + I
Sbjct 129 EEIEQKGAHLNAYTAREQTGYYARCFNKDVPWCTELLSDILQNSLIEPSQMEAEKHVILR 188
Query 145 EHQK 148
E ++
Sbjct 189 EMEE 192
> cel:ZC410.2 mppb-1; Mitochondrial Processing Peptidase Beta
family member (mppb-1); K01412 mitochondrial processing peptidase
[EC:3.4.24.64]
Length=458
Score = 52.4 bits (124), Expect = 7e-06, Method: Compositional matrix adjust.
Identities = 39/118 (33%), Positives = 53/118 (44%), Gaps = 8/118 (6%)
Query 25 LSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYD 84
L NG +A + + A V + GS Y+ E G AHFLEHM F GT +
Sbjct 35 LPNGFR-VATENTGGSTATIGVFIDAGSRYENEKNNGTAHFLEHMAFKGTPR--RTRMGL 91
Query 85 SFLTQNGGAN-NAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFNRQYEEKEVNA 141
+N GA+ NAYT E T ++ K F E LD+ + L N K++ A
Sbjct 92 ELEVENIGAHLNAYTSRESTTYYAK----CFTEKLDQSVDILSDILLNSSLATKDIEA 145
> pfa:PFI1625c organelle processing peptidase, putative; K01412
mitochondrial processing peptidase [EC:3.4.24.64]
Length=484
Score = 52.4 bits (124), Expect = 8e-06, Method: Compositional matrix adjust.
Identities = 44/177 (24%), Positives = 81/177 (45%), Gaps = 6/177 (3%)
Query 21 RHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEP 80
R +LSN + +A H + ++GS Y+ + G+AHFLEHM+F GT K
Sbjct 43 RVTELSNKL-KVATVHTNCEIPTIGLWISSGSKYENKKNNGVAHFLEHMIFKGTKKRNRI 101
Query 81 ESYDSFLTQNGGAN-NAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFNRQYEEKEV 139
+ +N GA+ NAYT E+T ++ K + + ++ ++ + +F+ E E
Sbjct 102 QLEKEI--ENMGAHLNAYTAREQTGYYCKCFKNDIKWCIELLSDILSNSIFDDNLIELEK 159
Query 140 NAIDAEHQKNIPNDDERAWYTIRSLA--KGPMSRFATGNAETLSTYPKANGIDLVDR 194
+ I E ++ DE + + A P+ G E + + + ID +++
Sbjct 160 HVILREMEEVEKCKDEVIFDKLHMTAFRDHPLGFTILGPEENIKNMKRKDIIDYINK 216
> tpv:TP01_0151 biquinol-cytochrome C reductase complex core protein
I (EC:1.10.2.2); K01412 mitochondrial processing peptidase
[EC:3.4.24.64]
Length=518
Score = 52.4 bits (124), Expect = 8e-06, Method: Compositional matrix adjust.
Identities = 35/131 (26%), Positives = 63/131 (48%), Gaps = 2/131 (1%)
Query 25 LSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYD 84
L NG+ V P S+ + V ++GS ++ + G AHFLEHM+F GT K +
Sbjct 77 LKNGLRVATVWMPGSS-STVGVWIDSGSRFETPETNGSAHFLEHMIFKGT-KSRSRHQLE 134
Query 85 SFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFNRQYEEKEVNAIDA 144
+ G NAYT E+T ++ + ++ + ++ ++ L + + E E + I
Sbjct 135 EQIEHKGAHLNAYTSREQTAYYARCFNNDIPWCTELLSDILQNSLIDPDHMENEKHVILR 194
Query 145 EHQKNIPNDDE 155
E ++ + DE
Sbjct 195 EMEEVEKSHDE 205
Lambda K H
0.317 0.132 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 45630851048
Database: egene_temp_file_orthology_annotation_similarity_blast_database_966
Posted date: Sep 16, 2011 8:45 PM
Number of letters in database: 82,071,388
Number of sequences in database: 164,496
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40