bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: egene_temp_file_orthology_annotation_similarity_blast_database_866
164,496 sequences; 82,071,388 total letters
Query= Eten_0344_orf3
Length=318
Score E
Sequences producing significant alignments: (Bits) Value
tgo:TGME49_095710 ubiquitin-transferase domain-containing prot... 538 2e-152
pfa:MAL8P1.23 ubiquitin-protein ligase 1, putative; K10592 E3 ... 455 9e-128
tpv:TP01_0229 ubiquitin-protein ligase 451 2e-126
bbo:BBOV_IV005150 23.m05795; HECT-domain (ubiquitin-transferas... 442 6e-124
cel:Y67D8C.5 eel-1; Enhancer of EfL-1 mutant phenotype family ... 355 2e-97
ath:AT1G55860 UPL1; UPL1 (UBIQUITIN-PROTEIN LIGASE 1); ubiquit... 334 2e-91
ath:AT1G70320 UPL2; UPL2 (UBIQUITIN-PROTEIN LIGASE 2); ubiquit... 332 9e-91
hsa:10075 HUWE1, ARF-BP1, HECTH9, HSPC272, Ib772, KIAA0312, LA... 329 8e-90
mmu:59026 Huwe1, 5430439H10Rik, AU041296, Arf-bp1, C430014N20R... 329 1e-89
sce:YDR457W TOM1; E3 ubiquitin ligase of the hect-domain class... 328 1e-89
dre:559439 huwe1, si:dkey-242a8.2; HECT, UBA and WWE domain co... 325 2e-88
xla:446912 hace1, MGC81769; HECT domain and ankyrin repeat con... 298 1e-80
dre:572430 HECT domain and ankyrin repeat containing, E3 ubiqu... 298 2e-80
sce:YER125W RSP5, MDP1, MUT2, NPI1, SMM1, UBY1; E3 ubiquitin l... 297 4e-80
hsa:57531 HACE1; HECT domain and ankyrin repeat containing, E3... 296 7e-80
mmu:209462 Hace1, 1700042J16Rik, A730034A22Rik, BC025474, KIAA... 295 1e-79
dre:100331274 itch; itchy E3 ubiquitin protein ligase homolog ... 288 2e-77
mmu:16396 Itch, 6720481N21Rik, 8030492O04Rik, A130065M08, AIP4... 287 3e-77
hsa:83737 ITCH, AIF4, AIP4, NAPP1, dJ468O1.1; itchy E3 ubiquit... 286 6e-77
hsa:11059 WWP1, AIP5, DKFZp434D2111, Tiul1, hSDRP1; WW domain ... 285 2e-76
mmu:107568 Wwp1, 8030445B08Rik, AIP5, SDRP1, Tiul1; WW domain ... 283 4e-76
mmu:66894 Wwp2, 1300010O06Rik, AA690238, AIP2, AW554328; WW do... 282 1e-75
hsa:11060 WWP2, AIP2, WWp2-like; WW domain containing E3 ubiqu... 280 4e-75
dre:564527 wwp2, id:ibd1121, wu:fo87e10, zgc:154036; WW domain... 278 2e-74
dre:619412 nedd4a; neural precursor cell expressed, developmen... 274 4e-73
dre:559634 nedd4l; neural precursor cell expressed, developmen... 272 1e-72
cel:Y65B4BR.4 wwp-1; WW domain Protein (E3 ubiquitin ligase) f... 270 8e-72
xla:399396 nedd4l, nedd4, nedd4-2; neural precursor cell expre... 266 5e-71
mmu:83814 Nedd4l, 1300012C07Rik, Nedd4-2, Nedd4b; neural precu... 266 8e-71
hsa:23327 NEDD4L, FLJ33870, KIAA0439, NEDD4-2, RSP5, hNedd4-2;... 266 9e-71
mmu:17999 Nedd4, AA959633, AL023035, AU019897, E430025J12Rik, ... 266 1e-70
hsa:4734 NEDD4, KIAA0093, MGC176705, NEDD4-1, RPF1; neural pre... 265 1e-70
xla:398372 smurf2, MGC130978; SMAD specific E3 ubiquitin prote... 261 2e-69
mmu:66313 Smurf2, 2810411E22Rik, AI558114, AI649275; SMAD spec... 261 2e-69
hsa:64750 SMURF2, DKFZp686F0270, MGC138150; SMAD specific E3 u... 258 2e-68
hsa:57154 SMURF1, KIAA1625; SMAD specific E3 ubiquitin protein... 258 2e-68
dre:563633 smurf2, wu:fb82a11, wu:fc41c02; SMAD specific E3 ub... 257 4e-68
mmu:75788 Smurf1, 4930431E10Rik, mKIAA1625; SMAD specific E3 u... 253 9e-67
xla:398131 smurf1; SMAD specific E3 ubiquitin protein ligase 1... 249 7e-66
dre:321695 wwp1, Smurf1, wu:fb30b12, zgc:66401; WW domain cont... 249 9e-66
hsa:57520 HECW2, DKFZp686M17164, NEDL2; HECT, C2 and WW domain... 242 1e-63
mmu:329152 Hecw2, A730039N16Rik, D030049F17Rik, Gm971, Nedl2, ... 241 3e-63
dre:100150269 HECT, C2 and WW domain containing E3 ubiquitin p... 240 4e-63
cel:Y92H12A.2 hypothetical protein; K10591 E3 ubiquitin-protei... 239 1e-62
hsa:23072 HECW1, KIAA0322, NEDL1; HECT, C2 and WW domain conta... 233 9e-61
dre:100334952 NEDD4-like ubiquitin-protein ligase 1-like 231 2e-60
mmu:94253 Hecw1, 9330116H24Rik, AV273951, E130207I19Rik, Nedl1... 231 3e-60
dre:563730 si:ch211-106n13.1; K12167 E3 ubiquitin-protein liga... 230 6e-60
tgo:TGME49_078940 ubiquitin--protein ligase, putative (EC:6.3.... 228 2e-59
tgo:TGME49_075630 ubiquitin-transferase domain-containing prot... 203 8e-52
> tgo:TGME49_095710 ubiquitin-transferase domain-containing protein
(EC:3.2.1.14 2.7.11.1 3.2.1.3 3.2.1.17); K10592 E3 ubiquitin-protein
ligase HUWE1 [EC:6.3.2.19]
Length=3125
Score = 538 bits (1385), Expect = 2e-152, Method: Composition-based stats.
Identities = 250/318 (78%), Positives = 286/318 (89%), Gaps = 1/318 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GGLTREWF LLARDMFNPNYALF REGAKSEFN PNPLS+INPEHL+YFKFIGR+IGK
Sbjct 2809 DAGGLTREWFSLLARDMFNPNYALFRREGAKSEFNHPNPLSSINPEHLHYFKFIGRIIGK 2868
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
ALFDG +L AYFCRSFYKHML ++C DAES+DP+LY+NL K+L+Y LEDL L +LTFS
Sbjct 2869 ALFDGQHLNAYFCRSFYKHMLGRRCVTADAESIDPTLYNNLLKMLQYSLEDLGL-ELTFS 2927
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
E DEFG H++ DL+P GR +PVTDANK LYVQL+CQRKI GGIQ+QLEAFLSGFHELIP
Sbjct 2928 TEVDEFGMHRIEDLIPNGRTIPVTDANKHLYVQLICQRKIVGGIQQQLEAFLSGFHELIP 2987
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
P+LISIFDDKELELLLSGLPT+N+ DL+ NT+YVN+LPT+Q I+WFWE+M E D Q+AA
Sbjct 2988 PALISIFDDKELELLLSGLPTVNLEDLKANTDYVNFLPTDQTIVWFWEVMNELDEQQRAA 3047
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKAIL 300
FLQFVTGTSRVP+GGF+ LVGMRGPQKFSIQ+AYGEN+LP+AHTCFNQLDLP Y+SK +L
Sbjct 3048 FLQFVTGTSRVPLGGFKFLVGMRGPQKFSIQRAYGENKLPTAHTCFNQLDLPGYSSKQLL 3107
Query 301 KKKLLLAITEGREGFGFV 318
KKKLLLAITEG+EGFGFV
Sbjct 3108 KKKLLLAITEGKEGFGFV 3125
> pfa:MAL8P1.23 ubiquitin-protein ligase 1, putative; K10592 E3
ubiquitin-protein ligase HUWE1 [EC:6.3.2.19]
Length=8591
Score = 455 bits (1171), Expect = 9e-128, Method: Composition-based stats.
Identities = 205/318 (64%), Positives = 257/318 (80%), Gaps = 1/318 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GGLTREW+ +LA+++FNPNYALF REG KSEFN PNPLS INP+HL++FKF+G+ I K
Sbjct 8275 DAGGLTREWYSILAKEIFNPNYALFCREGKKSEFNHPNPLSYINPDHLHFFKFVGKFIAK 8334
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
A++DG + AYFCRSFYKHML +K DAES+DP Y++L KI EY LEDL L ++ FS
Sbjct 8335 AIYDGQVIDAYFCRSFYKHMLGRKILPADAESVDPEFYNSLIKISEYKLEDLNL-EINFS 8393
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
E DEFGK KV DL+P GR++PVTD NK Y++L+C+ K+ I++QLEAF+ GF ELI
Sbjct 8394 TEIDEFGKTKVIDLIPNGRNIPVTDENKHKYIELLCELKVTNSIKEQLEAFMDGFKELIQ 8453
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
P LISIFDDKELELL+SG+PTI++ DL+EN EY NY I+W W++++EFD +KA+
Sbjct 8454 PKLISIFDDKELELLISGIPTIDLNDLKENVEYHNYTANSIQIIWLWDVLQEFDENKKAS 8513
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKAIL 300
FLQFVTGTSRVP+GGF+NL+GMRG QK I KAYGE+RLP+AHTCFNQLDLP Y+SK +L
Sbjct 8514 FLQFVTGTSRVPLGGFKNLMGMRGAQKMIIYKAYGEDRLPTAHTCFNQLDLPEYSSKELL 8573
Query 301 KKKLLLAITEGREGFGFV 318
K KL+ AI EG+EGFGF+
Sbjct 8574 KSKLIRAIMEGKEGFGFI 8591
> tpv:TP01_0229 ubiquitin-protein ligase
Length=4164
Score = 451 bits (1159), Expect = 2e-126, Method: Compositional matrix adjust.
Identities = 206/318 (64%), Positives = 252/318 (79%), Gaps = 1/318 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GGLTREW+ +L+++ FNPNYALFTREG K EFN PNPLSAINP+HL YFKFIGRVIGK
Sbjct 3848 DAGGLTREWYTILSKEFFNPNYALFTREGRKQEFNHPNPLSAINPDHLNYFKFIGRVIGK 3907
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
AL+DGH++ AYFCRSFYKHML + + DAES+DP Y+NL I LE L L +L FS
Sbjct 3908 ALYDGHHMEAYFCRSFYKHMLGSRITPCDAESVDPQFYNNLISIRNCSLEQLGL-ELYFS 3966
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
E DEFGK K+ DL+P GR++ VTD NK Y+QL+C+ K+ GI++QL+AF+ GF ELI
Sbjct 3967 TEIDEFGKVKIIDLVPNGRNILVTDENKHKYIQLLCRHKVTNGIKEQLDAFMQGFRELIA 4026
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
P LISIFDD+ELELL+SG+P I++ ++++N EY+NY I+W WEI+ EFD AA
Sbjct 4027 PELISIFDDRELELLISGIPIIDLENMKQNVEYINYTEDSLQIIWLWEILSEFDQSHLAA 4086
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKAIL 300
FLQFVTGTSRVPIGGF+NL+GMRGPQK SI K +G+NRLP+AHTCFNQLDLP Y K +L
Sbjct 4087 FLQFVTGTSRVPIGGFKNLMGMRGPQKISIHKTFGQNRLPTAHTCFNQLDLPCYPEKDML 4146
Query 301 KKKLLLAITEGREGFGFV 318
K KLL AI EG+EGFGF+
Sbjct 4147 KSKLLQAILEGKEGFGFM 4164
> bbo:BBOV_IV005150 23.m05795; HECT-domain (ubiquitin-transferase)
containing protein
Length=4221
Score = 442 bits (1138), Expect = 6e-124, Method: Compositional matrix adjust.
Identities = 202/318 (63%), Positives = 251/318 (78%), Gaps = 1/318 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GGLTREWF +LA++MFNPNY LF REG K EFN PNPLS INP+HL +FKFIGRVIGK
Sbjct 3905 DAGGLTREWFNILAKEMFNPNYGLFRREGRKQEFNHPNPLSGINPDHLNFFKFIGRVIGK 3964
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
A+++G ++ AYFCRSFYKHML +K + DA+S+DP Y NL I LED+ L +L FS
Sbjct 3965 AVYEGQHIDAYFCRSFYKHMLCRKITPADAQSVDPQFYENLTSINNCRLEDMGL-ELFFS 4023
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
E DEFGK KV DL+P GR++PVTD NK Y++L+C+ K+ GI+ QL+AF+SGF ELI
Sbjct 4024 TEIDEFGKVKVIDLVPDGRNIPVTDENKQKYIELLCRHKVTNGIKDQLDAFMSGFQELIA 4083
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
P LISIFDDKELELL+SG+PTI++ DL+EN EYV Y I+W WE +E D AA
Sbjct 4084 PELISIFDDKELELLISGIPTIDLRDLRENVEYVGYTDHSDQIVWLWEFLEGLDQNNLAA 4143
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKAIL 300
FLQFVTGTSRVP+GGF+NL+GMRGPQ+ SI + +G++RLPSAHTCFNQLDLPAY S+ L
Sbjct 4144 FLQFVTGTSRVPLGGFKNLMGMRGPQRVSIHRTFGDDRLPSAHTCFNQLDLPAYPSREKL 4203
Query 301 KKKLLLAITEGREGFGFV 318
++K++ AI EG+EGFGF+
Sbjct 4204 QQKMMQAIVEGKEGFGFI 4221
> cel:Y67D8C.5 eel-1; Enhancer of EfL-1 mutant phenotype family
member (eel-1); K10592 E3 ubiquitin-protein ligase HUWE1 [EC:6.3.2.19]
Length=4177
Score = 355 bits (910), Expect = 2e-97, Method: Compositional matrix adjust.
Identities = 173/319 (54%), Positives = 223/319 (69%), Gaps = 2/319 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GGL REWF ++ R++FNPNYALF N S INPEHL YFKF+GR+I K
Sbjct 3860 DAGGLLREWFSVITREIFNPNYALFITAPGDMVTYMINKASYINPEHLDYFKFVGRLIAK 3919
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
++F+ YL YF R+FYKH+LN +D ES DP+ + +L +L+ P++DLAL DLTFS
Sbjct 3920 SVFEHKYLDCYFTRAFYKHILNLPVRYQDLESEDPAFFKSLDFLLQNPIDDLAL-DLTFS 3978
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
E +EFG V DL P GR + V DANK YV+L+CQ K+ G I+KQL+AFL+GF+E+IP
Sbjct 3979 TEVEEFGVRSVRDLKPNGRKIEVNDANKDEYVKLVCQMKMTGSIRKQLDAFLTGFYEIIP 4038
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
LIS+F+++ELELL+SGLPT+++ D+ NT+Y + T I WFW + F+ KA
Sbjct 4039 KDLISMFNEQELELLISGLPTVDIDDMAANTDYKGFQKTSTHIQWFWRALRSFEKEDKAK 4098
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQ-KAYGENRLPSAHTCFNQLDLPAYTSKAI 299
FLQFVTGTS+VP+ GF +L GM G QKFSI + G +RLP+AHTCFNQLDLP Y S
Sbjct 4099 FLQFVTGTSKVPLQGFASLEGMNGVQKFSIHMDSRGGDRLPAAHTCFNQLDLPQYESYEK 4158
Query 300 LKKKLLLAITEGREGFGFV 318
L++ LLLAI E EGFGF
Sbjct 4159 LRQSLLLAIRECTEGFGFA 4177
> ath:AT1G55860 UPL1; UPL1 (UBIQUITIN-PROTEIN LIGASE 1); ubiquitin-protein
ligase
Length=3891
Score = 334 bits (857), Expect = 2e-91, Method: Compositional matrix adjust.
Identities = 173/326 (53%), Positives = 218/326 (66%), Gaps = 11/326 (3%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GGLTREW+ LL+R +F+ LFT G + F QPNP S EHL YFKF+GR++ K
Sbjct 3569 DAGGLTREWYQLLSRVIFDKGALLFTTVGNDATF-QPNPNSVYQTEHLSYFKFVGRMVAK 3627
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
ALFDG L YF RSFYKH+L K + D E++DP Y NL+ +LE + D+ DLTFS
Sbjct 3628 ALFDGQLLDVYFTRSFYKHILGVKVTYHDIEAVDPDYYKNLKWLLENDVSDI--LDLTFS 3685
Query 121 VETDE-----FGKHKVND--LLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLS 173
++ DE + K +V D L PGGR++ VT+ K YV L+ + I+ Q+ AFL
Sbjct 3686 MDADEEKHILYEKTEVTDYELKPGGRNIRVTEETKHEYVDLVAGHILTNAIRPQINAFLE 3745
Query 174 GFHELIPPSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEF 233
GF+ELIP L+SIF+DKELELL+SGLP I+ DL+ NTEY +Y I WFWE+++ F
Sbjct 3746 GFNELIPRELVSIFNDKELELLISGLPEIDFDDLKANTEYTSYTAGSPVIHWFWEVVKAF 3805
Query 234 DTPQKAAFLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGE-NRLPSAHTCFNQLDLP 292
A FLQFVTGTS+VP+ GF+ L G+ GPQ+ I KAYG RLPSAHTCFNQLDLP
Sbjct 3806 SKEDMARFLQFVTGTSKVPLEGFKALQGISGPQRLQIHKAYGAPERLPSAHTCFNQLDLP 3865
Query 293 AYTSKAILKKKLLLAITEGREGFGFV 318
Y SK L+++LLLAI E EGFGF
Sbjct 3866 EYQSKEQLQERLLLAIHEASEGFGFA 3891
> ath:AT1G70320 UPL2; UPL2 (UBIQUITIN-PROTEIN LIGASE 2); ubiquitin-protein
ligase; K10592 E3 ubiquitin-protein ligase HUWE1
[EC:6.3.2.19]
Length=3658
Score = 332 bits (852), Expect = 9e-91, Method: Compositional matrix adjust.
Identities = 171/325 (52%), Positives = 217/325 (66%), Gaps = 11/325 (3%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GGLTREW+ LL+R +F+ LFT G + F QPNP S EHL YFKF+GR++ K
Sbjct 3336 DAGGLTREWYQLLSRVIFDKGALLFTTVGNDATF-QPNPNSVYQTEHLSYFKFVGRMVAK 3394
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
ALFDG L YF RSFYKH+L K + D E++DP Y NL+ +LE + D+ DLTFS
Sbjct 3395 ALFDGQLLDVYFTRSFYKHILGVKVTYHDIEAVDPDYYKNLKWLLENDVSDI--LDLTFS 3452
Query 121 VETDE-----FGKHKVND--LLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLS 173
++ DE + K +V D L PGGR++ VT+ K YV L+ + I+ Q+ AFL
Sbjct 3453 MDADEEKHILYEKTEVTDYELKPGGRNIRVTEETKHEYVDLVADHILTSAIRPQINAFLE 3512
Query 174 GFHELIPPSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEF 233
G +ELIP L+SIF+DKELELL+SGLP I+ DL+ NTEY +Y I WFWE+++ F
Sbjct 3513 GLNELIPRELVSIFNDKELELLISGLPEIDFDDLKANTEYTSYTVGSPVIRWFWEVVKAF 3572
Query 234 DTPQKAAFLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGE-NRLPSAHTCFNQLDLP 292
A FLQFVTGTS+VP+ GF+ L G+ GPQ+ I KAYG RLPSAHTCFNQLDLP
Sbjct 3573 SKEDMARFLQFVTGTSKVPLEGFKALQGISGPQRLQIHKAYGSPERLPSAHTCFNQLDLP 3632
Query 293 AYTSKAILKKKLLLAITEGREGFGF 317
Y SK ++++LLLAI E EGFGF
Sbjct 3633 EYQSKEQVQERLLLAIHEANEGFGF 3657
> hsa:10075 HUWE1, ARF-BP1, HECTH9, HSPC272, Ib772, KIAA0312,
LASU1, MULE, UREB1; HECT, UBA and WWE domain containing 1; K10592
E3 ubiquitin-protein ligase HUWE1 [EC:6.3.2.19]
Length=4374
Score = 329 bits (844), Expect = 8e-90, Method: Compositional matrix adjust.
Identities = 170/320 (53%), Positives = 208/320 (65%), Gaps = 4/320 (1%)
Query 1 DGGGLTREWFGLLARDMFNPNYALF-TREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIG 59
D GGL REW+ +++R+MFNP YALF T G + + NP S NP HL YFKF+GR++
Sbjct 4057 DAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTI-NPSSHCNPNHLSYFKFVGRIVA 4115
Query 60 KALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTF 119
KA++D L YF RSFYKH+L K D ES D Y L +LE + L DLTF
Sbjct 4116 KAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGY-DLTF 4174
Query 120 SVETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELI 179
S E EFG +V DL P G ++ VT+ NK YV L+CQ ++ G I+KQL AFL GF+E+I
Sbjct 4175 STEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEII 4234
Query 180 PPSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKA 239
P LISIF ++ELELL+SGLPTI++ DL+ NTEY Y I WFW + FD +A
Sbjct 4235 PKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRA 4294
Query 240 AFLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQK-AYGENRLPSAHTCFNQLDLPAYTSKA 298
FLQFVTGTS+VP+ GF L GM G QKF I + +RLPSAHTCFNQLDLPAY S
Sbjct 4295 KFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFE 4354
Query 299 ILKKKLLLAITEGREGFGFV 318
L+ LLLAI E EGFG
Sbjct 4355 KLRHMLLLAIQECSEGFGLA 4374
> mmu:59026 Huwe1, 5430439H10Rik, AU041296, Arf-bp1, C430014N20Rik,
C80292, Gm1718, Ib772, LASU1, Mule, Ureb1; HECT, UBA and
WWE domain containing 1; K10592 E3 ubiquitin-protein ligase
HUWE1 [EC:6.3.2.19]
Length=4378
Score = 329 bits (843), Expect = 1e-89, Method: Compositional matrix adjust.
Identities = 170/320 (53%), Positives = 208/320 (65%), Gaps = 4/320 (1%)
Query 1 DGGGLTREWFGLLARDMFNPNYALF-TREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIG 59
D GGL REW+ +++R+MFNP YALF T G + + NP S NP HL YFKF+GR++
Sbjct 4061 DAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTI-NPSSHCNPNHLSYFKFVGRIVA 4119
Query 60 KALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTF 119
KA++D L YF RSFYKH+L K D ES D Y L +LE + L DLTF
Sbjct 4120 KAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGY-DLTF 4178
Query 120 SVETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELI 179
S E EFG +V DL P G ++ VT+ NK YV L+CQ ++ G I+KQL AFL GF+E+I
Sbjct 4179 STEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEII 4238
Query 180 PPSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKA 239
P LISIF ++ELELL+SGLPTI++ DL+ NTEY Y I WFW + FD +A
Sbjct 4239 PKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRA 4298
Query 240 AFLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQK-AYGENRLPSAHTCFNQLDLPAYTSKA 298
FLQFVTGTS+VP+ GF L GM G QKF I + +RLPSAHTCFNQLDLPAY S
Sbjct 4299 KFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFE 4358
Query 299 ILKKKLLLAITEGREGFGFV 318
L+ LLLAI E EGFG
Sbjct 4359 KLRHMLLLAIQECSEGFGLA 4378
> sce:YDR457W TOM1; E3 ubiquitin ligase of the hect-domain class;
has a role in mRNA export from the nucleus and may regulate
transcriptional coactivators; involved in degradation of
excess histones (EC:6.3.2.-); K10592 E3 ubiquitin-protein ligase
HUWE1 [EC:6.3.2.19]
Length=3268
Score = 328 bits (842), Expect = 1e-89, Method: Compositional matrix adjust.
Identities = 160/318 (50%), Positives = 220/318 (69%), Gaps = 3/318 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GG+TREW+ +L+R MFNP+YALF + PN S INPEHL +FKFIG +IGK
Sbjct 2952 DAGGVTREWYQVLSRQMFNPDYALFLPVPSDKTTFHPNRTSGINPEHLSFFKFIGMIIGK 3011
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
A+ D +L +F R YK++L + S++D ESLDP Y +L ILE + D+ + TFS
Sbjct 3012 AIRDQCFLDCHFSREVYKNILGRPVSLKDMESLDPDYYKSLVWILENDITDI--IEETFS 3069
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
VETD++G+HKV +L+ GG+ + VT+ANK YV+ + + K+ +++Q++ FL GF+ LI
Sbjct 3070 VETDDYGEHKVINLIEGGKDIIVTEANKQDYVKKVVEYKLQTSVKEQMDNFLVGFYALIS 3129
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
LI+IFD++ELELL+SGLP I+V D + NT YVNY T + + +FW + FD ++A
Sbjct 3130 KDLITIFDEQELELLISGLPDIDVDDWKNNTTYVNYTATCKEVSYFWRAVRSFDAEERAK 3189
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGEN-RLPSAHTCFNQLDLPAYTSKAI 299
LQFVTGTS+VP+ GF+ L G+ G KFSI + +G + RLPS+HTCFNQL+LP Y S
Sbjct 3190 LLQFVTGTSKVPLNGFKELSGVNGVCKFSIHRDFGSSERLPSSHTCFNQLNLPPYESYET 3249
Query 300 LKKKLLLAITEGREGFGF 317
L+ LLLAI EG EGFG
Sbjct 3250 LRGSLLLAINEGHEGFGL 3267
> dre:559439 huwe1, si:dkey-242a8.2; HECT, UBA and WWE domain
containing 1; K10592 E3 ubiquitin-protein ligase HUWE1 [EC:6.3.2.19]
Length=4360
Score = 325 bits (832), Expect = 2e-88, Method: Compositional matrix adjust.
Identities = 169/320 (52%), Positives = 208/320 (65%), Gaps = 4/320 (1%)
Query 1 DGGGLTREWFGLLARDMFNPNYALF-TREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIG 59
D GGL REW+ +++R+MFNP YALF T G + + NP S NP HL YFKF+GRV+
Sbjct 4043 DAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTI-NPSSHCNPNHLSYFKFVGRVVA 4101
Query 60 KALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTF 119
KA++D L YF RSFYKH+L K D ES D + L +LE + L +LTF
Sbjct 4102 KAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYPFFQGLVYLLENDVSTLGY-ELTF 4160
Query 120 SVETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELI 179
S E EFG +V DL G ++ VT+ NK YV L+CQ K+ G I+KQL AFL GF+E+I
Sbjct 4161 STEVQEFGVCEVRDLKANGANILVTEENKKEYVHLVCQMKMTGAIRKQLAAFLEGFYEII 4220
Query 180 PPSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKA 239
P LISIF ++ELELL+SGLPTI++ DL+ NTEY Y + I WFW + FD +A
Sbjct 4221 PKRLISIFTEQELELLISGLPTIDIDDLKANTEYHKYQSSSIQIQWFWRALRSFDQADRA 4280
Query 240 AFLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQK-AYGENRLPSAHTCFNQLDLPAYTSKA 298
FLQFVTGTS+VP+ GF L GM G QKF I + +RLPSAHTCFNQLDLPAY S
Sbjct 4281 KFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESYE 4340
Query 299 ILKKKLLLAITEGREGFGFV 318
L+ LLLAI E EGFG
Sbjct 4341 KLRHMLLLAIQECSEGFGLA 4360
> xla:446912 hace1, MGC81769; HECT domain and ankyrin repeat containing,
E3 ubiquitin protein ligase 1; K12166 E3 ubiquitin-protein
ligase HACE1 [EC:6.3.2.19]
Length=944
Score = 298 bits (764), Expect = 1e-80, Method: Compositional matrix adjust.
Identities = 155/316 (49%), Positives = 206/316 (65%), Gaps = 4/316 (1%)
Query 2 GGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGKA 61
G G+ REWF +L+ +M NP+YALFT+ + F QPN S++NP+HL YF+F G ++G A
Sbjct 628 GQGVVREWFDILSSEMINPDYALFTQSADGTTF-QPNSNSSVNPDHLNYFRFAGEILGLA 686
Query 62 LFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFSV 121
L+ + YF RSFYKH+L + +D S+DP NLQ IL+ + DL L +LTFSV
Sbjct 687 LYHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDNDISDLGL-ELTFSV 745
Query 122 ETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIPP 181
ETD FG + L PGG + VT NKA YVQL+ + ++ IQ Q+ FL GFH IPP
Sbjct 746 ETDVFGAMEEVPLKPGGASILVTQENKAEYVQLVTELRMTRAIQPQINGFLQGFHMFIPP 805
Query 182 SLISIFDDKELELLLSGLPTINVADLQENTEYVN-YLPTEQPILWFWEIMEEFDTPQKAA 240
SLI +FD+ ELELLLSG+P I+V D +NTEY + Y +Q I WFWE+++E ++
Sbjct 806 SLIQLFDEYELELLLSGMPEIDVNDWMKNTEYTSGYERDDQVIQWFWEVVQELTQEERVL 865
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQK-AYGENRLPSAHTCFNQLDLPAYTSKAI 299
LQFVTG+SRVP GGF ++G G Q F+I AY N LP++ TC N L LP Y SK I
Sbjct 866 LLQFVTGSSRVPHGGFAYIMGGSGLQNFTIAAVAYTANLLPTSSTCINMLKLPEYPSKEI 925
Query 300 LKKKLLLAITEGREGF 315
LK +LL+A+ G G+
Sbjct 926 LKDRLLVALHCGSYGY 941
> dre:572430 HECT domain and ankyrin repeat containing, E3 ubiquitin
protein ligase 1-like; K12166 E3 ubiquitin-protein ligase
HACE1 [EC:6.3.2.19]
Length=822
Score = 298 bits (763), Expect = 2e-80, Method: Compositional matrix adjust.
Identities = 151/316 (47%), Positives = 207/316 (65%), Gaps = 4/316 (1%)
Query 2 GGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGKA 61
G G+ REWF +L+ ++ NP+YALFT+ + F QPN S++NP+HL YF+F G+++G A
Sbjct 506 GQGVVREWFDILSNEIINPDYALFTQSADGTTF-QPNSNSSVNPDHLNYFRFAGQILGLA 564
Query 62 LFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFSV 121
L+ + YF RSFYKH+L S +D S+DP NLQ IL+ + DL L +LTFSV
Sbjct 565 LYHRQLVNIYFTRSFYKHILGIPVSYQDVSSIDPEYAKNLQWILDNDISDLGL-ELTFSV 623
Query 122 ETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIPP 181
ETD FG + L PGG + VT NK YVQL+ + ++ IQ Q+ AFL GFH IPP
Sbjct 624 ETDVFGTMEEVPLKPGGTTIQVTQDNKEEYVQLVTELRMTRAIQPQINAFLQGFHTFIPP 683
Query 182 SLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPIL-WFWEIMEEFDTPQKAA 240
SLI +FD+ ELELLLSG+P I+V D + NTEY + ++P++ WFWE++E ++
Sbjct 684 SLIQLFDEYELELLLSGMPEIDVMDWKRNTEYTSGYDLQEPVIQWFWEVVENLTQEERVL 743
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKA-YGENRLPSAHTCFNQLDLPAYTSKAI 299
LQFVTG+SRVP GGF L+G G QKF++ Y N LP++ TC N L LP Y SK +
Sbjct 744 LLQFVTGSSRVPHGGFAFLMGGSGLQKFTVAAVPYTSNLLPTSSTCINMLKLPEYPSKDV 803
Query 300 LKKKLLLAITEGREGF 315
L+ +LL+A+ G G+
Sbjct 804 LRDRLLVALHCGSYGY 819
> sce:YER125W RSP5, MDP1, MUT2, NPI1, SMM1, UBY1; E3 ubiquitin
ligase of the NEDD4 family; involved in regulating many cellular
processes, including MVB sorting, heat shock response,
transcription, and endocytosis; the human homolog is invovled
in Liddle syndrome (EC:6.3.2.-); K10591 E3 ubiquitin-protein
ligase NEDD4 [EC:6.3.2.19]
Length=809
Score = 297 bits (760), Expect = 4e-80, Method: Compositional matrix adjust.
Identities = 144/316 (45%), Positives = 212/316 (67%), Gaps = 3/316 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GG++RE+F LL+ +MFNP Y LF + Q NP S INPEHL YFKFIGRV+G
Sbjct 495 DYGGVSREFFFLLSHEMFNPFYCLFEYSAYDNYTIQINPNSGINPEHLNYFKFIGRVVGL 554
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
+F +L A+F + YK ML KK ++D E +D +Y++L +LE ++ + DLTFS
Sbjct 555 GVFHRRFLDAFFVGALYKMMLRKKVVLQDMEGVDAEVYNSLNWMLENSID--GVLDLTFS 612
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
+ + FG+ DL P GR++ VTD NK YV+L Q +I +Q+Q +AF+ GF+ELIP
Sbjct 613 ADDERFGEVVTVDLKPDGRNIEVTDGNKKEYVELYTQWRIVDRVQEQFKAFMDGFNELIP 672
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
L+++FD++ELELL+ G+ I++ D +++T+Y Y +++ I WFW+ + E+D Q+A
Sbjct 673 EDLVTVFDERELELLIGGIAEIDIEDWKKHTDYRGYQESDEVIQWFWKCVSEWDNEQRAR 732
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKAIL 300
LQF TGTSR+P+ GF++L G GP++F+I+KA +LP +HTCFN++DLP Y +
Sbjct 733 LLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKAGEVQQLPKSHTCFNRVDLPQYVDYDSM 792
Query 301 KKKLLLAITEGREGFG 316
K+KL LA+ E GFG
Sbjct 793 KQKLTLAVEETI-GFG 807
> hsa:57531 HACE1; HECT domain and ankyrin repeat containing,
E3 ubiquitin protein ligase 1; K12166 E3 ubiquitin-protein ligase
HACE1 [EC:6.3.2.19]
Length=909
Score = 296 bits (758), Expect = 7e-80, Method: Compositional matrix adjust.
Identities = 154/316 (48%), Positives = 207/316 (65%), Gaps = 4/316 (1%)
Query 2 GGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGKA 61
G G+ REWF +L+ ++ NP+YALFT+ + F QPN S +NP+HL YF+F G+++G A
Sbjct 593 GQGVVREWFDILSNEIVNPDYALFTQSADGTTF-QPNSNSYVNPDHLNYFRFAGQILGLA 651
Query 62 LFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFSV 121
L + YF RSFYKH+L + +D S+DP NLQ IL+ + DL L +LTFSV
Sbjct 652 LNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDNDISDLGL-ELTFSV 710
Query 122 ETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIPP 181
ETD FG + L PGG + VT NKA YVQL+ + ++ IQ Q+ AFL GFH IPP
Sbjct 711 ETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPP 770
Query 182 SLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPIL-WFWEIMEEFDTPQKAA 240
SLI +FD+ ELELLLSG+P I+V+D +NTEY + E P++ WFWE++E+ ++
Sbjct 771 SLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVL 830
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKA-YGENRLPSAHTCFNQLDLPAYTSKAI 299
LQFVTG+SRVP GGF N++G G Q F+I Y N LP++ TC N L LP Y SK I
Sbjct 831 LLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEI 890
Query 300 LKKKLLLAITEGREGF 315
LK +LL+A+ G G+
Sbjct 891 LKDRLLVALHCGSYGY 906
> mmu:209462 Hace1, 1700042J16Rik, A730034A22Rik, BC025474, KIAA1320;
HECT domain and ankyrin repeat containing, E3 ubiquitin
protein ligase 1; K12166 E3 ubiquitin-protein ligase HACE1
[EC:6.3.2.19]
Length=909
Score = 295 bits (755), Expect = 1e-79, Method: Compositional matrix adjust.
Identities = 154/316 (48%), Positives = 206/316 (65%), Gaps = 4/316 (1%)
Query 2 GGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGKA 61
G G+ REWF +L+ ++ NP+YALFT+ + F QPN S +NP+HL YF+F G+++G A
Sbjct 593 GQGVVREWFDILSNEIVNPDYALFTQSADGTTF-QPNSNSYVNPDHLNYFRFAGQILGLA 651
Query 62 LFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFSV 121
L + YF RSFYKH+L + +D S+DP NLQ IL+ + DL L +LTFSV
Sbjct 652 LNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDNDISDLGL-ELTFSV 710
Query 122 ETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIPP 181
ETD FG + L PGG + VT NKA YVQL+ + ++ IQ Q+ AFL GFH IPP
Sbjct 711 ETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPP 770
Query 182 SLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPIL-WFWEIMEEFDTPQKAA 240
SLI +FD+ ELELLLSG+P I+V D +NTEY + E P++ WFWE++E+ ++
Sbjct 771 SLIQLFDEYELELLLSGMPEIDVNDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVL 830
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKA-YGENRLPSAHTCFNQLDLPAYTSKAI 299
LQFVTG+SRVP GGF N++G G Q F+I Y N LP++ TC N L LP Y SK I
Sbjct 831 LLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEI 890
Query 300 LKKKLLLAITEGREGF 315
LK +LL+A+ G G+
Sbjct 891 LKDRLLVALHCGSYGY 906
> dre:100331274 itch; itchy E3 ubiquitin protein ligase homolog
(mouse)
Length=430
Score = 288 bits (736), Expect = 2e-77, Method: Compositional matrix adjust.
Identities = 142/316 (44%), Positives = 210/316 (66%), Gaps = 2/316 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GG+ REWF LL+ ++ NP Y LF G + Q NP S+INP+HL YFKFIGR I
Sbjct 115 DYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASSINPDHLKYFKFIGRFIAM 174
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
ALF G ++ F FYK +LNK +++D ES+DP Y++L I + +E+ L ++ FS
Sbjct 175 ALFHGKFIDTGFSLPFYKRILNKPLALKDLESIDPEFYNSLIWIKDNNIEECGL-EMFFS 233
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
V+ + G+ ++L P G ++ VT+ NK Y++L+ + +++ G+++Q +AFL GF++++P
Sbjct 234 VDKEILGEVTTHELKPDGGNIQVTEENKEEYIRLVAEWRLSRGVEEQTQAFLEGFNDVLP 293
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
+ FD KELE++L G+ I++ D Q N+ Y +Y + + I+WFW+ ++E D ++
Sbjct 294 QQYLQYFDAKELEVMLCGMQEIDLGDWQRNSIYRHYARSSKQIVWFWQFVKEMDNEKRMR 353
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKAIL 300
LQFVTGT R+P+GGF +L+G GPQKF I+K EN LP +HTCFN+LDLP Y S L
Sbjct 354 LLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQL 413
Query 301 KKKLLLAITEGREGFG 316
K+KLL AI E EGFG
Sbjct 414 KEKLLFAIEET-EGFG 428
> mmu:16396 Itch, 6720481N21Rik, 8030492O04Rik, A130065M08, AIP4,
C230047C07Rik, KIAA4011, mKIAA4011; itchy, E3 ubiquitin
protein ligase; K05632 atrophin-1 interacting protein 4 [EC:6.3.2.19]
Length=864
Score = 287 bits (735), Expect = 3e-77, Method: Compositional matrix adjust.
Identities = 143/316 (45%), Positives = 207/316 (65%), Gaps = 2/316 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GG+ REWF LL+ ++ NP Y LF G + Q NP S INP+HL YF+FIGR I
Sbjct 549 DYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAM 608
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
ALF G ++ F FYK +LNK ++D ES+DP Y++L + E +E+ L ++ FS
Sbjct 609 ALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECGL-EMYFS 667
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
V+ + G+ K +DL P G ++ VT+ NK Y++++ + +++ G+++Q +AF GF+E++P
Sbjct 668 VDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILP 727
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
+ FD KELE+LL G+ I++ D Q + Y +Y T + I+WFW+ ++E D ++
Sbjct 728 QQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYTRTSKQIMWFWQFVKEIDNEKRMR 787
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKAIL 300
LQFVTGT R+P+GGF +L+G GPQKF I+K EN LP +HTCFN+LDLP Y S L
Sbjct 788 LLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQL 847
Query 301 KKKLLLAITEGREGFG 316
K+KLL AI E EGFG
Sbjct 848 KEKLLFAIEE-TEGFG 862
> hsa:83737 ITCH, AIF4, AIP4, NAPP1, dJ468O1.1; itchy E3 ubiquitin
protein ligase homolog (mouse); K05632 atrophin-1 interacting
protein 4 [EC:6.3.2.19]
Length=862
Score = 286 bits (733), Expect = 6e-77, Method: Compositional matrix adjust.
Identities = 143/316 (45%), Positives = 207/316 (65%), Gaps = 2/316 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GG+ REWF LL+ ++ NP Y LF G + Q NP S INP+HL YF+FIGR I
Sbjct 547 DYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAM 606
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
ALF G ++ F FYK +LNK ++D ES+DP Y++L + E +E+ L ++ FS
Sbjct 607 ALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDL-EMYFS 665
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
V+ + G+ K +DL P G ++ VT+ NK Y++++ + +++ G+++Q +AF GF+E++P
Sbjct 666 VDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILP 725
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
+ FD KELE+LL G+ I++ D Q + Y +Y T + I+WFW+ ++E D ++
Sbjct 726 QQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMR 785
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKAIL 300
LQFVTGT R+P+GGF +L+G GPQKF I+K EN LP +HTCFN+LDLP Y S L
Sbjct 786 LLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQL 845
Query 301 KKKLLLAITEGREGFG 316
K+KLL AI E EGFG
Sbjct 846 KEKLLFAIEE-TEGFG 860
> hsa:11059 WWP1, AIP5, DKFZp434D2111, Tiul1, hSDRP1; WW domain
containing E3 ubiquitin protein ligase 1; K05633 atrophin-1
interacting protein 5 (WW domain containing E3 ubiquitin protein
ligase 1) [EC:6.3.2.19]
Length=922
Score = 285 bits (728), Expect = 2e-76, Method: Compositional matrix adjust.
Identities = 146/316 (46%), Positives = 204/316 (64%), Gaps = 2/316 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GGL REWF LL+ ++ NP Y LF G + Q NP S INP+HL YF FIGR I
Sbjct 607 DYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAM 666
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
ALF G ++ F FYK ML+KK +++D ES+D Y++L I + +E+ L ++ FS
Sbjct 667 ALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGL-EMYFS 725
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
V+ + GK +DL GG ++ VT+ NK Y+ LM + + + G+Q+Q +AFL GF+E++P
Sbjct 726 VDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVP 785
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
+ FD+KELE++L G+ +++AD Q NT Y +Y + I+WFW+ ++E D +
Sbjct 786 LQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMR 845
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKAIL 300
LQFVTGT R+P+GGF L+G GPQKF I+K + LP +HTCFN+LDLP Y S L
Sbjct 846 LLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQL 905
Query 301 KKKLLLAITEGREGFG 316
K+KLL AI E EGFG
Sbjct 906 KEKLLFAIEET-EGFG 920
> mmu:107568 Wwp1, 8030445B08Rik, AIP5, SDRP1, Tiul1; WW domain
containing E3 ubiquitin protein ligase 1; K05633 atrophin-1
interacting protein 5 (WW domain containing E3 ubiquitin protein
ligase 1) [EC:6.3.2.19]
Length=918
Score = 283 bits (725), Expect = 4e-76, Method: Compositional matrix adjust.
Identities = 146/316 (46%), Positives = 204/316 (64%), Gaps = 2/316 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GGL REWF LL+ ++ NP Y LF G + Q NP S INP+HL YF FIGR I
Sbjct 603 DYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAM 662
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
ALF G ++ F FYK ML+KK +++D ES+D Y++L I + +E+ L ++ FS
Sbjct 663 ALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGL-EMYFS 721
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
V+ + GK +DL GG ++ VT+ NK Y+ LM + + + G+Q+Q +AFL GF+E++P
Sbjct 722 VDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVP 781
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
+ FD+KELE++L G+ +++AD Q NT Y +Y + I+WFW+ ++E D +
Sbjct 782 LQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMR 841
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKAIL 300
LQFVTGT R+P+GGF L+G GPQKF I+K + LP +HTCFN+LDLP Y S L
Sbjct 842 LLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQL 901
Query 301 KKKLLLAITEGREGFG 316
K+KLL AI E EGFG
Sbjct 902 KEKLLFAIEET-EGFG 916
> mmu:66894 Wwp2, 1300010O06Rik, AA690238, AIP2, AW554328; WW
domain containing E3 ubiquitin protein ligase 2; K05630 atrophin-1
interacting protein 2 (WW domain containing E3 ubiquitin
protein ligase 2) [EC:6.3.2.19]
Length=870
Score = 282 bits (721), Expect = 1e-75, Method: Compositional matrix adjust.
Identities = 142/316 (44%), Positives = 203/316 (64%), Gaps = 2/316 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GG+ REWF LL+ ++ NP Y LF G + Q NP S+INP+HL YF+FIGR I
Sbjct 555 DYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAM 614
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
AL+ G ++ F FYK MLNK+ +++D ES+DP Y+++ I E LE+ L +L F
Sbjct 615 ALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGL-ELFFI 673
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
+ + GK ++L GG ++ VT+ NK Y+ L+ + G+++Q +AFL GF+E+ P
Sbjct 674 QDMEILGKVTTHELKEGGENIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAP 733
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
+ FD+KELEL+L G+ I+++D Q+N Y +Y + + I WFW++++E D ++
Sbjct 734 LEWLRYFDEKELELMLCGMQEIDMSDWQKNAIYRHYTKSSKQIQWFWQVVKEMDNEKRIR 793
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKAIL 300
LQFVTGT R+P+GGF L+G GPQKF I + E LP +HTCFN+LDLP Y S L
Sbjct 794 LLQFVTGTCRLPVGGFAELIGSNGPQKFCIDRVGKETWLPRSHTCFNRLDLPPYKSYEQL 853
Query 301 KKKLLLAITEGREGFG 316
K+KLL AI E EGFG
Sbjct 854 KEKLLYAIEE-TEGFG 868
> hsa:11060 WWP2, AIP2, WWp2-like; WW domain containing E3 ubiquitin
protein ligase 2; K05630 atrophin-1 interacting protein
2 (WW domain containing E3 ubiquitin protein ligase 2) [EC:6.3.2.19]
Length=870
Score = 280 bits (717), Expect = 4e-75, Method: Compositional matrix adjust.
Identities = 142/316 (44%), Positives = 202/316 (63%), Gaps = 2/316 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GG+ REWF LL+ ++ NP Y LF G + Q NP S+INP+HL YF+FIGR I
Sbjct 555 DYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAM 614
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
AL+ G ++ F FYK MLNK+ +++D ES+DP Y+++ I E LE+ L +L F
Sbjct 615 ALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGL-ELYFI 673
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
+ + GK ++L GG + VT+ NK Y+ L+ + G+++Q +AFL GF+E+ P
Sbjct 674 QDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAP 733
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
+ FD+KELEL+L G+ I+++D Q++T Y +Y + I WFW++++E D ++
Sbjct 734 LEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIR 793
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKAIL 300
LQFVTGT R+P+GGF L+G GPQKF I K E LP +HTCFN+LDLP Y S L
Sbjct 794 LLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQL 853
Query 301 KKKLLLAITEGREGFG 316
++KLL AI E EGFG
Sbjct 854 REKLLYAIEE-TEGFG 868
> dre:564527 wwp2, id:ibd1121, wu:fo87e10, zgc:154036; WW domain
containing E3 ubiquitin protein ligase 2; K05630 atrophin-1
interacting protein 2 (WW domain containing E3 ubiquitin
protein ligase 2) [EC:6.3.2.19]
Length=866
Score = 278 bits (711), Expect = 2e-74, Method: Compositional matrix adjust.
Identities = 140/316 (44%), Positives = 200/316 (63%), Gaps = 2/316 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GG+ REWF LL+ ++ NP Y LF G + Q NP S+INP+HL YF+FIGR I
Sbjct 551 DYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAM 610
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
AL+ G ++ F FYK MLNKK +++D ES+DP Y+++ + E LE+ + +L F+
Sbjct 611 ALYHGKFIDTGFTLPFYKRMLNKKPTLKDLESIDPEFYNSIMWVKENDLEECGV-ELYFA 669
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
+ + GK + L G + VT NK Y+ L+ + G+++Q +AFL GF+E++P
Sbjct 670 QDMEILGKVTTHQLKDDGENELVTQDNKEEYIGLLTDWRFTRGVEEQTKAFLDGFNEVVP 729
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
+ FD+KELEL+L G+ I++ D Q+NT Y +Y + I WFW++++E D ++
Sbjct 730 LEWLRYFDEKELELMLCGMQEIDLNDWQKNTIYRHYTKNSKQIHWFWQVVKEMDNEKRIR 789
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKAIL 300
LQFVTGT R+P+GGF L+G GPQKF I K E LP +HTCFN+LDLP Y + L
Sbjct 790 LLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKNLEQL 849
Query 301 KKKLLLAITEGREGFG 316
++KLL AI E EGFG
Sbjct 850 REKLLFAIEE-TEGFG 864
> dre:619412 nedd4a; neural precursor cell expressed, developmentally
down-regulated 4a; K10591 E3 ubiquitin-protein ligase
NEDD4 [EC:6.3.2.19]
Length=910
Score = 274 bits (700), Expect = 4e-73, Method: Compositional matrix adjust.
Identities = 148/320 (46%), Positives = 202/320 (63%), Gaps = 6/320 (1%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAI-NPEHLYYFKFIGRVIG 59
D GG+ REWF L++++MFNP Y LF + Q NP S + N +HL YFKFIGRV G
Sbjct 594 DYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAG 653
Query 60 KALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTF 119
A++ G L A+F R FYK ML K +++D ES+D +++L+ ILE DL DL F
Sbjct 654 MAVYHGKLLDAFFIRPFYKMMLQKPITLQDMESVDSEYFNSLRWILENDPTDL---DLRF 710
Query 120 SVETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELI 179
+++ + FG+ ++L PGG + V D NK Y+ L+ Q + IQ+Q+ AF GF+ELI
Sbjct 711 TIDEELFGQTHQHELKPGGADIVVNDTNKKEYIHLVMQWRFVDRIQRQMTAFKEGFYELI 770
Query 180 PPSLISIFDDKELELLLSGLPTINVADLQENTEYVN-YLPTEQPILWFWEIMEEFDTPQK 238
P LI IFD+ ELELL+ GL ++V D +ENT+Y N Y P I+WFW+ + D ++
Sbjct 771 PQDLIKIFDENELELLMCGLGDVDVNDWRENTKYKNGYNPNHPAIIWFWKTVLLMDAEKR 830
Query 239 AAFLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKA 298
LQFVTGTSRVP+ GF L G GPQ F+I++ +LP AHTCFN+LDLP S
Sbjct 831 IRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGTREKLPRAHTCFNRLDLPPXESFE 890
Query 299 ILKKKLLLAITEGREGFGFV 318
L++KL +AI E +GF V
Sbjct 891 ELREKLHMAI-ENAQGFDGV 909
> dre:559634 nedd4l; neural precursor cell expressed, developmentally
down-regulated 4-like; K13305 E3 ubiquitin-protein ligase
NEDD4-like [EC:6.3.2.19]
Length=994
Score = 272 bits (695), Expect = 1e-72, Method: Compositional matrix adjust.
Identities = 147/317 (46%), Positives = 198/317 (62%), Gaps = 6/317 (1%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAI-NPEHLYYFKFIGRVIG 59
D GG+ REWF LL+++MFNP Y LF + Q NP S + N +HL YFKFIGRV G
Sbjct 678 DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAG 737
Query 60 KALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTF 119
A++ G L +F R FYK ML K+ ++ D ES+D Y++L+ ILE D DL F
Sbjct 738 MAVYHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLRF 794
Query 120 SVETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELI 179
++ D FG+ DL P G + VT+ NK Y+ L+ Q + +QKQ+ AFL GF ELI
Sbjct 795 CIDEDNFGQTYQVDLKPSGSDMVVTNDNKKEYIDLVIQWRFVNRVQKQMNAFLEGFTELI 854
Query 180 PPSLISIFDDKELELLLSGLPTINVADLQENTEYVN-YLPTEQPILWFWEIMEEFDTPQK 238
P LI IFD+ ELELL+ GL ++V D +++T Y N Y P I WFW+ + D ++
Sbjct 855 PIDLIKIFDENELELLMCGLGDVDVNDWRQHTVYKNGYCPNHPVIQWFWKAVLLMDAEKR 914
Query 239 AAFLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKA 298
LQFVTGTSRVP+ GF L G GPQ F+I++ ++LP AHTCFN+LDLP Y +
Sbjct 915 IRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGTPDKLPRAHTCFNRLDLPMYETFE 974
Query 299 ILKKKLLLAITEGREGF 315
L++KLL+A+ E +GF
Sbjct 975 DLREKLLMAV-ENAQGF 990
> cel:Y65B4BR.4 wwp-1; WW domain Protein (E3 ubiquitin ligase)
family member (wwp-1); K05633 atrophin-1 interacting protein
5 (WW domain containing E3 ubiquitin protein ligase 1) [EC:6.3.2.19]
Length=794
Score = 270 bits (689), Expect = 8e-72, Method: Compositional matrix adjust.
Identities = 135/316 (42%), Positives = 198/316 (62%), Gaps = 2/316 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GG+ REWF LL+ ++ NP Y LF G + Q NP S +NP+HL YF++IGR I
Sbjct 479 DYGGVAREWFFLLSHEVLNPMYCLFMYAGNNNYSLQINPASFVNPDHLKYFEYIGRFIAM 538
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
ALF G ++ + F FYK MLNKK ++D E +D +Y++L I + +++ + +L F
Sbjct 539 ALFHGKFIYSGFTMPFYKKMLNKKIVLKDIEQVDSEIYNSLMWIKDNNIDECDM-ELYFV 597
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
+ + G+ K +L GG + VT+ NK Y++L+ + + G+++Q +AF +GF+ + P
Sbjct 598 ADYELLGELKTYELKEGGTEIAVTEENKLEYIELLVEWRFNRGVEQQTKAFFTGFNSVFP 657
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
+ FD++ELELLL G+ ++V D Q NT Y +Y P + + WFW+ + D ++A
Sbjct 658 LEWMQYFDERELELLLCGMQDVDVDDWQRNTVYRHYAPQSKQVTWFWQWVRSLDQEKRAR 717
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKAIL 300
LQFVTGT RVP+GGF L+G GPQ F I++ EN LP +HTCFN+LDLP Y S L
Sbjct 718 LLQFVTGTCRVPVGGFSELMGSTGPQLFCIERVGKENWLPRSHTCFNRLDLPPYRSYDQL 777
Query 301 KKKLLLAITEGREGFG 316
+KL +AI E EGFG
Sbjct 778 VEKLSMAI-EMTEGFG 792
> xla:399396 nedd4l, nedd4, nedd4-2; neural precursor cell expressed,
developmentally down-regulated 4-like; K13305 E3 ubiquitin-protein
ligase NEDD4-like [EC:6.3.2.19]
Length=971
Score = 266 bits (681), Expect = 5e-71, Method: Compositional matrix adjust.
Identities = 144/317 (45%), Positives = 197/317 (62%), Gaps = 6/317 (1%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAI-NPEHLYYFKFIGRVIG 59
D GG+ REWF LL+++MFNP Y LF + Q NP S + N +HL YF FIGR+ G
Sbjct 655 DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRIAG 714
Query 60 KALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTF 119
A+F G L +F R FYK ML K+ +++D ES+D Y++L+ ILE D DL F
Sbjct 715 LAVFHGKLLDGFFIRPFYKMMLGKQITLKDMESVDSEYYNSLKWILE---NDPTELDLMF 771
Query 120 SVETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELI 179
++ + FG+ DL P G + VT+ NK Y+ L+ Q + +QKQ+ AFL GF ELI
Sbjct 772 CIDEENFGQTYQVDLKPNGSEMVVTNDNKREYIDLVIQWRFVNRVQKQMNAFLEGFTELI 831
Query 180 PPSLISIFDDKELELLLSGLPTINVADLQENTEYVN-YLPTEQPILWFWEIMEEFDTPQK 238
LI IFD+ ELELL+ GL ++V D +++T Y N Y P + WFW+ + D ++
Sbjct 832 AIDLIKIFDENELELLMCGLGDVDVNDWRQHTLYKNGYCPNHPAVQWFWKAVLLMDAEKR 891
Query 239 AAFLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKA 298
LQFVTGTSRVP+ GF L G GPQ F+I++ ++LP AHTCFN+LDLP Y S
Sbjct 892 IRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPDKLPRAHTCFNRLDLPPYDSFE 951
Query 299 ILKKKLLLAITEGREGF 315
L++KLL+A+ E +GF
Sbjct 952 DLREKLLMAV-ENAQGF 967
> mmu:83814 Nedd4l, 1300012C07Rik, Nedd4-2, Nedd4b; neural precursor
cell expressed, developmentally down-regulated gene 4-like;
K13305 E3 ubiquitin-protein ligase NEDD4-like [EC:6.3.2.19]
Length=976
Score = 266 bits (680), Expect = 8e-71, Method: Compositional matrix adjust.
Identities = 144/317 (45%), Positives = 196/317 (61%), Gaps = 6/317 (1%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAI-NPEHLYYFKFIGRVIG 59
D GG+ REWF LL+++MFNP Y LF + Q NP S + N +HL YF FIGRV G
Sbjct 660 DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAG 719
Query 60 KALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTF 119
A+F G L +F R FYK ML K+ ++ D ES+D Y++L+ ILE D DL F
Sbjct 720 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMF 776
Query 120 SVETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELI 179
++ + FG+ DL P G + VT+ NK Y+ L+ Q + +QKQ+ AFL GF EL+
Sbjct 777 CIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELL 836
Query 180 PPSLISIFDDKELELLLSGLPTINVADLQENTEYVN-YLPTEQPILWFWEIMEEFDTPQK 238
P LI IFD+ ELELL+ GL ++V D ++++ Y N Y P I WFW+ + D ++
Sbjct 837 PIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKR 896
Query 239 AAFLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKA 298
LQFVTGTSRVP+ GF L G GPQ F+I++ +LP AHTCFN+LDLP Y +
Sbjct 897 IRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFE 956
Query 299 ILKKKLLLAITEGREGF 315
L++KLL+A+ E +GF
Sbjct 957 DLREKLLMAV-ENAQGF 972
> hsa:23327 NEDD4L, FLJ33870, KIAA0439, NEDD4-2, RSP5, hNedd4-2;
neural precursor cell expressed, developmentally down-regulated
4-like (EC:6.3.2.-); K13305 E3 ubiquitin-protein ligase
NEDD4-like [EC:6.3.2.19]
Length=854
Score = 266 bits (679), Expect = 9e-71, Method: Compositional matrix adjust.
Identities = 145/320 (45%), Positives = 197/320 (61%), Gaps = 6/320 (1%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAI-NPEHLYYFKFIGRVIG 59
D GG+ REWF LL+++MFNP Y LF + Q NP S + N +HL YF FIGRV G
Sbjct 538 DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAG 597
Query 60 KALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTF 119
A+F G L +F R FYK ML K+ ++ D ES+D Y++L+ ILE D DL F
Sbjct 598 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMF 654
Query 120 SVETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELI 179
++ + FG+ DL P G + VT+ NK Y+ L+ Q + +QKQ+ AFL GF EL+
Sbjct 655 CIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELL 714
Query 180 PPSLISIFDDKELELLLSGLPTINVADLQENTEYVN-YLPTEQPILWFWEIMEEFDTPQK 238
P LI IFD+ ELELL+ GL ++V D ++++ Y N Y P I WFW+ + D ++
Sbjct 715 PIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKR 774
Query 239 AAFLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKA 298
LQFVTGTSRVP+ GF L G GPQ F+I++ +LP AHTCFN+LDLP Y +
Sbjct 775 IRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFE 834
Query 299 ILKKKLLLAITEGREGFGFV 318
L++KLL+A+ E +GF V
Sbjct 835 DLREKLLMAV-ENAQGFEGV 853
> mmu:17999 Nedd4, AA959633, AL023035, AU019897, E430025J12Rik,
Nedd4-1, Nedd4a, mKIAA0093; neural precursor cell expressed,
developmentally down-regulated 4; K10591 E3 ubiquitin-protein
ligase NEDD4 [EC:6.3.2.19]
Length=887
Score = 266 bits (679), Expect = 1e-70, Method: Compositional matrix adjust.
Identities = 147/320 (45%), Positives = 197/320 (61%), Gaps = 6/320 (1%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAI-NPEHLYYFKFIGRVIG 59
D GG+ REWF L++++MFNP Y LF + Q NP S + N +HL YFKFIGRV G
Sbjct 571 DYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAG 630
Query 60 KALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTF 119
A++ G L +F R FYK ML K ++ D ES+D YS+L+ ILE D DL F
Sbjct 631 MAVYHGKLLDGFFIRPFYKMMLQKLITLHDMESVDSEYYSSLRWILE---NDPTELDLRF 687
Query 120 SVETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELI 179
++ + FG+ ++L GG + VT+ NK Y+ L+ Q + IQKQ+ AF GF ELI
Sbjct 688 IIDEELFGQTHQHELKTGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELI 747
Query 180 PPSLISIFDDKELELLLSGLPTINVADLQENTEYVN-YLPTEQPILWFWEIMEEFDTPQK 238
P LI IFD+ ELELL+ GL ++V D +E+T+Y N Y Q I WFW+ + D+ ++
Sbjct 748 PQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSMNHQVIHWFWKAVWMMDSEKR 807
Query 239 AAFLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKA 298
LQFVTGTSRVP+ GF L G GPQ F++++ ++LP AHTCFN+LDLP Y S
Sbjct 808 IRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPDKLPRAHTCFNRLDLPPYESFD 867
Query 299 ILKKKLLLAITEGREGFGFV 318
L KL +AI E +GF V
Sbjct 868 ELWDKLQMAI-ENTQGFDGV 886
> hsa:4734 NEDD4, KIAA0093, MGC176705, NEDD4-1, RPF1; neural precursor
cell expressed, developmentally down-regulated 4 (EC:6.3.2.-);
K10591 E3 ubiquitin-protein ligase NEDD4 [EC:6.3.2.19]
Length=900
Score = 265 bits (678), Expect = 1e-70, Method: Compositional matrix adjust.
Identities = 146/320 (45%), Positives = 197/320 (61%), Gaps = 6/320 (1%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAI-NPEHLYYFKFIGRVIG 59
D GG+ REWF L++++MFNP Y LF + Q NP S + N +HL YFKFIGRV G
Sbjct 584 DYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAG 643
Query 60 KALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTF 119
A++ G L +F R FYK ML+K ++ D ES+D Y++L+ ILE D DL F
Sbjct 644 MAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILE---NDPTELDLRF 700
Query 120 SVETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELI 179
++ + FG+ ++L GG + VT+ NK Y+ L+ Q + IQKQ+ AF GF ELI
Sbjct 701 IIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELI 760
Query 180 PPSLISIFDDKELELLLSGLPTINVADLQENTEYVN-YLPTEQPILWFWEIMEEFDTPQK 238
P LI IFD+ ELELL+ GL ++V D +E+T+Y N Y Q I WFW+ + D+ ++
Sbjct 761 PQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKR 820
Query 239 AAFLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKA 298
LQFVTGTSRVP+ GF L G GPQ F++++ +LP AHTCFN+LDLP Y S
Sbjct 821 IRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFE 880
Query 299 ILKKKLLLAITEGREGFGFV 318
L KL +AI E +GF V
Sbjct 881 ELWDKLQMAI-ENTQGFDGV 899
> xla:398372 smurf2, MGC130978; SMAD specific E3 ubiquitin protein
ligase 2 (EC:6.3.2.-); K04678 E3 ubiquitin ligase SMURF1/2
[EC:6.3.2.19]
Length=751
Score = 261 bits (668), Expect = 2e-69, Method: Compositional matrix adjust.
Identities = 137/311 (44%), Positives = 190/311 (61%), Gaps = 3/311 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GG+ REW LL+ DM NP Y LF Q NP SA+NPEHL YF F+GR++G
Sbjct 436 DYGGVAREWLYLLSHDMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGM 495
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
A+F GHY+ F FYK +L K ++ D ES+DP L+++L ILE + + D TF
Sbjct 496 AVFHGHYIDGGFTLPFYKQLLGKPITLDDMESVDPDLHNSLVWILENDI--TGVLDHTFC 553
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
VE + +G+ ++L P G+ +PVT+ K YV+L + GI+ Q A GF+E+IP
Sbjct 554 VEHNAYGELIQHELKPSGKSIPVTEDTKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIP 613
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
L+ FD+KELEL++ GL I+V+D + NT + + WFW+ +E FD ++A
Sbjct 614 QHLLKAFDEKELELIICGLGKIDVSDWKSNTRLKHCTTDSNIVKWFWKAVESFDEERRAR 673
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSI-QKAYGENRLPSAHTCFNQLDLPAYTSKAI 299
LQFVTG+SRVP+ GF+ L G GP+ F+I Q N LP AHTCFN++D+P Y +
Sbjct 674 LLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDASTNNLPKAHTCFNRIDIPPYETYEK 733
Query 300 LKKKLLLAITE 310
L +KLL AI E
Sbjct 734 LYEKLLTAIEE 744
> mmu:66313 Smurf2, 2810411E22Rik, AI558114, AI649275; SMAD specific
E3 ubiquitin protein ligase 2; K04678 E3 ubiquitin ligase
SMURF1/2 [EC:6.3.2.19]
Length=748
Score = 261 bits (667), Expect = 2e-69, Method: Compositional matrix adjust.
Identities = 137/311 (44%), Positives = 191/311 (61%), Gaps = 3/311 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GG+ REW LL+ +M NP Y LF Q NP SA+NPEHL YF F+GR++G
Sbjct 433 DYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGM 492
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
A+F GHY+ F FYK +L K ++ D E +DP L+++L ILE + + D TF
Sbjct 493 AVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDI--TGVLDHTFC 550
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
VE + +G+ ++L P G+ +PVT+ NK YV+L + GI+ Q A GF+E+IP
Sbjct 551 VEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIP 610
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
L+ FD+KELEL++ GL I+V+D + NT + P + WFW+ +E FD ++A
Sbjct 611 QHLLKTFDEKELELIICGLGKIDVSDWKVNTRLKHCTPDSNVVKWFWKAVEFFDEERRAR 670
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYG-ENRLPSAHTCFNQLDLPAYTSKAI 299
LQFVTG+SRVP+ GF+ L G GP+ F+I + N LP AHTCFN++D+P Y S
Sbjct 671 LLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEK 730
Query 300 LKKKLLLAITE 310
L +KLL AI E
Sbjct 731 LYEKLLTAIEE 741
> hsa:64750 SMURF2, DKFZp686F0270, MGC138150; SMAD specific E3
ubiquitin protein ligase 2; K04678 E3 ubiquitin ligase SMURF1/2
[EC:6.3.2.19]
Length=748
Score = 258 bits (659), Expect = 2e-68, Method: Compositional matrix adjust.
Identities = 136/311 (43%), Positives = 189/311 (60%), Gaps = 3/311 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GG+ REW LL+ +M NP Y LF Q NP SA+NPEHL YF F+GR++G
Sbjct 433 DYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGM 492
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
A+F GHY+ F FYK +L K ++ D E +DP L+++L ILE + + D TF
Sbjct 493 AVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDI--TGVLDHTFC 550
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
VE + +G+ ++L P G+ +PV + NK YV+L + GI+ Q A GF+E+IP
Sbjct 551 VEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIP 610
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
L+ FD+KELEL++ GL I+V D + NT + P + WFW+ +E FD ++A
Sbjct 611 QHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDEERRAR 670
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYG-ENRLPSAHTCFNQLDLPAYTSKAI 299
LQFVTG+SRVP+ GF+ L G GP+ F+I + N LP AHTCFN++D+P Y S
Sbjct 671 LLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEK 730
Query 300 LKKKLLLAITE 310
L +KLL AI E
Sbjct 731 LYEKLLTAIEE 741
> hsa:57154 SMURF1, KIAA1625; SMAD specific E3 ubiquitin protein
ligase 1; K04678 E3 ubiquitin ligase SMURF1/2 [EC:6.3.2.19]
Length=728
Score = 258 bits (658), Expect = 2e-68, Method: Compositional matrix adjust.
Identities = 138/312 (44%), Positives = 189/312 (60%), Gaps = 5/312 (1%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GG+ REW LL +M NP Y LF Q NP S+INP+HL YF F+GR++G
Sbjct 413 DYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGL 472
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
A+F GHY+ F FYK +L K + D ES+DP L+ +L ILE + + D TF
Sbjct 473 AVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDI--TPVLDHTFC 530
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
VE + FG+ ++L P GR+VPVT+ NK YV+L + GI+ Q A GF+ELIP
Sbjct 531 VEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIP 590
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
L+ FD KELEL++ GL I++ D + NT + + + WFW+ +E FD ++A
Sbjct 591 QHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRAR 650
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQ--KAYGENRLPSAHTCFNQLDLPAYTSKA 298
LQFVTG++RVP+ GF+ L G GP+ F+I A +N LP AHTCFN++D+P Y S
Sbjct 651 LLQFVTGSTRVPLQGFKALQGAAGPRLFTIHLIDANTDN-LPKAHTCFNRIDIPPYESYE 709
Query 299 ILKKKLLLAITE 310
L +KLL A+ E
Sbjct 710 KLYEKLLTAVEE 721
> dre:563633 smurf2, wu:fb82a11, wu:fc41c02; SMAD specific E3
ubiquitin protein ligase 2 (EC:6.3.2.-); K04678 E3 ubiquitin
ligase SMURF1/2 [EC:6.3.2.19]
Length=765
Score = 257 bits (657), Expect = 4e-68, Method: Compositional matrix adjust.
Identities = 135/311 (43%), Positives = 187/311 (60%), Gaps = 3/311 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GG+ REW LL+ +M NP Y LF Q NP SA+NPEHL YF F+GR++G
Sbjct 450 DYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGM 509
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
A+F GHY+ F FYK +L K ++ D ES+DP L+++L IL+ + + D TF
Sbjct 510 AVFHGHYIDGGFTLPFYKQLLGKPITLDDMESVDPDLHNSLVWILDNDI--TGVLDHTFC 567
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
VE + +G+ ++L P G+ +PVT K YV+L + GI+ Q A GF+E+IP
Sbjct 568 VEHNAYGEIIQHELKPNGKSIPVTQDTKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIP 627
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
L+ FD+KELEL++ GL I++ D + NT + P + WFW +E +D ++A
Sbjct 628 QHLLKAFDEKELELIVCGLGKIDINDWKSNTRLKHCTPDSNIVKWFWRAVESYDEERRAR 687
Query 241 FLQFVTGTSRVPIGGFRNLVGMRGPQKFSI-QKAYGENRLPSAHTCFNQLDLPAYTSKAI 299
LQFVTG+SRVP+ GF+ L G GP+ F+I Q N LP AHTCFN++D+P Y S
Sbjct 688 LLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDASTNNLPKAHTCFNRIDIPPYESYDK 747
Query 300 LKKKLLLAITE 310
L KLL AI E
Sbjct 748 LYDKLLTAIEE 758
> mmu:75788 Smurf1, 4930431E10Rik, mKIAA1625; SMAD specific E3
ubiquitin protein ligase 1; K04678 E3 ubiquitin ligase SMURF1/2
[EC:6.3.2.19]
Length=731
Score = 253 bits (645), Expect = 9e-67, Method: Compositional matrix adjust.
Identities = 138/315 (43%), Positives = 189/315 (60%), Gaps = 8/315 (2%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GG+ REW LL +M NP Y LF Q NP S+INP+HL YF F+GR++G
Sbjct 413 DYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVGRIMGL 472
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
A+F GHY+ F FYK +L K + D ES+DP L+ +L ILE + + D TF
Sbjct 473 AVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDI--TPVLDHTFC 530
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
VE + FG+ ++L P GR+VPVT+ NK YV+L + GI+ Q A GF+ELIP
Sbjct 531 VEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIP 590
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
L+ FD KELEL++ GL I++ D + NT + + + WFW+ +E FD ++A
Sbjct 591 QHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRAR 650
Query 241 FLQFVTGTSRVPIGGFRNL---VGMRGPQKFSIQ--KAYGENRLPSAHTCFNQLDLPAYT 295
LQFVTG++RVP+ GF+ L G GP+ F+I A +N LP AHTCFN++D+P Y
Sbjct 651 LLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDN-LPKAHTCFNRIDIPPYE 709
Query 296 SKAILKKKLLLAITE 310
S L +KLL A+ E
Sbjct 710 SYEKLYEKLLTAVEE 724
> xla:398131 smurf1; SMAD specific E3 ubiquitin protein ligase
1; K04678 E3 ubiquitin ligase SMURF1/2 [EC:6.3.2.19]
Length=731
Score = 249 bits (637), Expect = 7e-66, Method: Compositional matrix adjust.
Identities = 135/315 (42%), Positives = 190/315 (60%), Gaps = 8/315 (2%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GG+ REW LL +M NP Y LF Q NP S+INP+HL YF F+GR++G
Sbjct 413 DYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVGRIMGL 472
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
A+F GHY+ F FYK +L K + D ES+DP L+ +L ILE + ++ D TF
Sbjct 473 AVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDI--TSVLDHTFC 530
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
VE + FG+ ++L P G+++ VT+ NK YV+L + GI+ Q A GF+ELIP
Sbjct 531 VEHNAFGRLLQHELKPNGKNLQVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIP 590
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
L+ F+ KELEL++ GL I+++D + NT + L + WFW+ +E FD ++A
Sbjct 591 QHLLKPFEQKELELIIGGLDKIDISDWKANTRLKHCLANSNIVQWFWQAVESFDEERRAR 650
Query 241 FLQFVTGTSRVPIGGFRNL---VGMRGPQKFSIQ--KAYGENRLPSAHTCFNQLDLPAYT 295
LQFVTG++RVP+ GF+ L G GP+ F+I A +N LP AHTCFN++D+P Y
Sbjct 651 LLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDN-LPKAHTCFNRIDIPPYE 709
Query 296 SKAILKKKLLLAITE 310
S L +KLL A+ E
Sbjct 710 SYEKLYEKLLTAVEE 724
> dre:321695 wwp1, Smurf1, wu:fb30b12, zgc:66401; WW domain containing
E3 ubiquitin protein ligase 1; K04678 E3 ubiquitin
ligase SMURF1/2 [EC:6.3.2.19]
Length=731
Score = 249 bits (636), Expect = 9e-66, Method: Compositional matrix adjust.
Identities = 135/315 (42%), Positives = 190/315 (60%), Gaps = 8/315 (2%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GG+ REW LL +M NP Y LF Q NP S+INP+HL YF F+GR++G
Sbjct 413 DYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVGRIMGL 472
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
A+F GHY+ F FYK +L K + D E++DP L+ +L ILE + ++ D TF
Sbjct 473 AVFHGHYINGGFTLPFYKQLLGKPIQLCDLETVDPELHKSLVWILENDI--TSVLDHTFC 530
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
VE + FGK ++L P G+++PVT+ NK YV+L + GI+ Q A GF+ELIP
Sbjct 531 VEHNAFGKFLQHELKPNGKNIPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIP 590
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVNYLPTEQPILWFWEIMEEFDTPQKAA 240
L+ FD+KELEL++ GL I++ D + NT + + + WFW+ +E FD ++
Sbjct 591 QHLLKPFDNKELELIIGGLGKIDLNDWKANTRLKHCVADSNIVKWFWQAVESFDEERRGR 650
Query 241 FLQFVTGTSRVPIGGFRNL---VGMRGPQKFSIQ--KAYGENRLPSAHTCFNQLDLPAYT 295
LQFVTG++RVP+ GF+ L G GP+ F+I A +N LP AHTCFN++D+P Y
Sbjct 651 LLQFVTGSTRVPLQGFKALQGSTGSAGPRLFTIHLIDANTDN-LPKAHTCFNRIDIPPYE 709
Query 296 SKAILKKKLLLAITE 310
S L +KLL A+ E
Sbjct 710 SYEKLYEKLLTAVEE 724
> hsa:57520 HECW2, DKFZp686M17164, NEDL2; HECT, C2 and WW domain
containing E3 ubiquitin protein ligase 2; K12168 E3 ubiquitin-protein
ligase HECW2 [EC:6.3.2.19]
Length=1572
Score = 242 bits (618), Expect = 1e-63, Method: Compositional matrix adjust.
Identities = 126/311 (40%), Positives = 191/311 (61%), Gaps = 3/311 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D G +RE+F L++R++FNP Y LF + Q +P+SA H +F+F GR++G
Sbjct 1257 DYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGL 1316
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
AL + L A+F R FYK +L C + D E LD + +LQ + + + D+ DLTF+
Sbjct 1317 ALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDI--LDLTFT 1374
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
V + FG+ +L PGG ++PVT+ NK Y++ M + +I G+ +Q E+ + GF+E++
Sbjct 1375 VNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVD 1434
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVN-YLPTEQPILWFWEIMEEFDTPQKA 239
L+S+FD +ELEL+++G I+++D + NTEY Y I WFW +E F+ Q+
Sbjct 1435 ARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRL 1494
Query 240 AFLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKAI 299
LQFVTGTS +P GF +L G GP++F ++K LP AHTCFN+LDLP Y S ++
Sbjct 1495 RLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSM 1554
Query 300 LKKKLLLAITE 310
L +KLL A+ E
Sbjct 1555 LYEKLLTAVEE 1565
> mmu:329152 Hecw2, A730039N16Rik, D030049F17Rik, Gm971, Nedl2,
mKIAA1301; HECT, C2 and WW domain containing E3 ubiquitin
protein ligase 2; K12168 E3 ubiquitin-protein ligase HECW2 [EC:6.3.2.19]
Length=1578
Score = 241 bits (615), Expect = 3e-63, Method: Compositional matrix adjust.
Identities = 126/311 (40%), Positives = 190/311 (61%), Gaps = 3/311 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D G +RE+F L++R++FNP Y LF + Q +P+SA H +F+F GR++G
Sbjct 1263 DYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGL 1322
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
AL + L A+F R FYK +L C + D E LD + +LQ + + + D+ DLTF+
Sbjct 1323 ALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDI--LDLTFT 1380
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
V + FG+ +L PGG ++PVT+ NK Y++ M + +I G+ +Q E+ + GF+E++
Sbjct 1381 VNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVD 1440
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVN-YLPTEQPILWFWEIMEEFDTPQKA 239
L+S+FD +ELEL+++G I++ D + NTEY Y I WFW +E F+ Q+
Sbjct 1441 ARLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRL 1500
Query 240 AFLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKAI 299
LQFVTGTS +P GF +L G GP++F ++K LP AHTCFN+LDLP Y S ++
Sbjct 1501 RLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSM 1560
Query 300 LKKKLLLAITE 310
L +KLL A+ E
Sbjct 1561 LYEKLLTAVEE 1571
> dre:100150269 HECT, C2 and WW domain containing E3 ubiquitin
protein ligase 2-like; K12168 E3 ubiquitin-protein ligase HECW2
[EC:6.3.2.19]
Length=1474
Score = 240 bits (613), Expect = 4e-63, Method: Compositional matrix adjust.
Identities = 124/311 (39%), Positives = 190/311 (61%), Gaps = 3/311 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D G +RE+F L++R++FNP Y LF + Q +P+SA H +F+F GR++G
Sbjct 1159 DYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGL 1218
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
AL + L A+F R FYK +L C + D E LD + +LQ + + +ED+ DLTF+
Sbjct 1219 ALIHQYLLDAFFTRPFYKGLLRIPCDLSDLEFLDEEFHQSLQWMKDNDIEDM--LDLTFT 1276
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
V + FG+ +L PGG + V+D NK Y++ M + +I G+ +Q E+ + GF+E++
Sbjct 1277 VNEEVFGQITERELKPGGSGIAVSDKNKKEYIERMVKWRIERGVAQQTESLVRGFYEVVD 1336
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVN-YLPTEQPILWFWEIMEEFDTPQKA 239
L+S+FD +ELEL+++G I+++D + NTEY Y I WFW +E F+ Q+
Sbjct 1337 VRLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRL 1396
Query 240 AFLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKAI 299
LQFVTGTS +P GF +L G GP++F ++K LP AHTCFN+LDLP Y S ++
Sbjct 1397 RLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKVTSLPRAHTCFNRLDLPPYPSFSM 1456
Query 300 LKKKLLLAITE 310
L +K++ A+ E
Sbjct 1457 LYEKMVTAVEE 1467
> cel:Y92H12A.2 hypothetical protein; K10591 E3 ubiquitin-protein
ligase NEDD4 [EC:6.3.2.19]
Length=724
Score = 239 bits (610), Expect = 1e-62, Method: Compositional matrix adjust.
Identities = 141/320 (44%), Positives = 188/320 (58%), Gaps = 29/320 (9%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLS-AINPEHLYYFKFIGRVIG 59
D GG+TREWF LL+ +FNP Y LF + Q NP S A NPEHL YF FIGR+IG
Sbjct 431 DYGGVTREWFFLLSHQIFNPYYGLFEYSATDNYTLQINPHSEACNPEHLSYFHFIGRIIG 490
Query 60 KALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTF 119
A++ G L A+F R FYK ML KK ++ D ES+D Y++L + + DL +LTF
Sbjct 491 MAIYHGKLLDAFFIRPFYKMMLGKKITLFDMESVDNEYYNSLIYVKDNDPADL---ELTF 547
Query 120 SVETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELI 179
S++ FG+ + +L+P G +VPVT+ NK Y++ ++
Sbjct 548 SLDDSIFGETQNIELIPNGANVPVTEDNKEEYIEA-----------------------VV 584
Query 180 PPSLISIFDDKELELLLSGLPTINVADLQENTEYVN-YLPTEQPILWFWEIMEEFDTPQK 238
P +L+ +FD ELELL+ GL I+V D + NT Y Y P+ Q + FW+ + FD +
Sbjct 585 PSNLLRLFDANELELLMCGLQKIDVKDWKANTIYKGGYGPSSQVVHNFWKCILSFDNEMR 644
Query 239 AAFLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKA 298
A LQFV+GTSRVP+ GFR L G G QKF+I++ + LP AHTCFN+LDLP YT+
Sbjct 645 ARVLQFVSGTSRVPMNGFRELYGSNGLQKFTIERWGSADMLPRAHTCFNRLDLPPYTTFK 704
Query 299 ILKKKLLLAITEGREGFGFV 318
LK KLL AI E E F V
Sbjct 705 ELKSKLLTAI-ENSEIFSGV 723
> hsa:23072 HECW1, KIAA0322, NEDL1; HECT, C2 and WW domain containing
E3 ubiquitin protein ligase 1; K12167 E3 ubiquitin-protein
ligase HECW1 [EC:6.3.2.19]
Length=1606
Score = 233 bits (593), Expect = 9e-61, Method: Compositional matrix adjust.
Identities = 126/311 (40%), Positives = 186/311 (59%), Gaps = 3/311 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D G +RE+F LL++++FNP Y LF + Q +P+SA HL +F+F GR++G
Sbjct 1291 DYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGL 1350
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
AL + L A+F R FYK +L C + D E LD + +LQ + + + D+ DLTF+
Sbjct 1351 ALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDI--LDLTFT 1408
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
V + FG+ +L GG + VT+ NK Y++ M + ++ G+ +Q EA + GF+E++
Sbjct 1409 VNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVD 1468
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVN-YLPTEQPILWFWEIMEEFDTPQKA 239
L+S+FD +ELEL+++G I++ D + NTEY Y I WFW +E F+ Q+
Sbjct 1469 SRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRL 1528
Query 240 AFLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKAI 299
LQFVTGTS VP GF L G G ++F I+K LP AHTCFN+LDLP Y S ++
Sbjct 1529 RLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSM 1588
Query 300 LKKKLLLAITE 310
L +KLL A+ E
Sbjct 1589 LYEKLLTAVEE 1599
> dre:100334952 NEDD4-like ubiquitin-protein ligase 1-like
Length=1304
Score = 231 bits (589), Expect = 2e-60, Method: Compositional matrix adjust.
Identities = 124/311 (39%), Positives = 186/311 (59%), Gaps = 3/311 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D G +RE+F LL++++FNP Y LF + Q +P+SA HL +F+F GR++G
Sbjct 989 DYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGL 1048
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
AL + L A+F R FYK +L + D E LD + +LQ + + + D+ DLTF+
Sbjct 1049 ALIHQYLLDAFFTRPFYKALLRLVTDLSDLEYLDEEFHQSLQWMKDNDITDIL--DLTFT 1106
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
V + FG+ +L GG ++ VT+ NK Y++ M + ++ G+ +Q EA + GF+E++
Sbjct 1107 VNEEVFGQVTERELKSGGSNIQVTEKNKKDYIERMARWRVERGVMQQAEALVRGFYEVVD 1166
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVN-YLPTEQPILWFWEIMEEFDTPQKA 239
L+S+FD +ELEL+++G I+++D + NTEY Y + WFW +E F+ Q+
Sbjct 1167 SRLVSVFDARELELVIAGTAEIDLSDWRSNTEYRGGYHDGHMVMRWFWAAVERFNNEQRL 1226
Query 240 AFLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKAI 299
LQFVTGTS VP GF L G G ++F I+K LP AHTCFN+LDLP Y S +
Sbjct 1227 RLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKVTSLPRAHTCFNRLDLPPYPSYTM 1286
Query 300 LKKKLLLAITE 310
L +KLL A+ E
Sbjct 1287 LYEKLLTAVEE 1297
> mmu:94253 Hecw1, 9330116H24Rik, AV273951, E130207I19Rik, Nedl1;
HECT, C2 and WW domain containing E3 ubiquitin protein ligase
1; K12167 E3 ubiquitin-protein ligase HECW1 [EC:6.3.2.19]
Length=1604
Score = 231 bits (589), Expect = 3e-60, Method: Compositional matrix adjust.
Identities = 126/311 (40%), Positives = 186/311 (59%), Gaps = 3/311 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D G +RE+F LL++++FNP Y LF + Q +P+SA +L +F+F GR++G
Sbjct 1289 DYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENYLEWFRFSGRILGL 1348
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
AL + L A+F R FYK +L C + D E LD + +LQ + + + D+ DLTF+
Sbjct 1349 ALIHQYLLDAFFTRPFYKGLLKLPCDLSDLEYLDEEFHQSLQWMKDNNITDI--LDLTFT 1406
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
V + FG+ +L GG + VT+ NK Y++ M + ++ G+ +Q EA L GF+E++
Sbjct 1407 VNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALLRGFYEVVD 1466
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVN-YLPTEQPILWFWEIMEEFDTPQKA 239
L+S+FD +ELEL+++G I++ D + NTEY Y I WFW +E F+ Q+
Sbjct 1467 SRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRL 1526
Query 240 AFLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKAI 299
LQFVTGTS VP GF L G G ++F I+K LP AHTCFN+LDLP Y S ++
Sbjct 1527 RLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSM 1586
Query 300 LKKKLLLAITE 310
L +KLL A+ E
Sbjct 1587 LYEKLLTAVEE 1597
> dre:563730 si:ch211-106n13.1; K12167 E3 ubiquitin-protein ligase
HECW1 [EC:6.3.2.19]
Length=1552
Score = 230 bits (586), Expect = 6e-60, Method: Compositional matrix adjust.
Identities = 126/311 (40%), Positives = 186/311 (59%), Gaps = 3/311 (0%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D G +RE+F LL++++FNP Y LF + Q +P+SA HL +F+F GR++G
Sbjct 1237 DYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGL 1296
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
AL + L A+F R FYK +L + D E LD + +LQ + E + D+ DLTF+
Sbjct 1297 ALIHQYLLDAFFTRPFYKALLRLPTDLSDLEYLDEEFHQSLQWMKENDITDVL--DLTFT 1354
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
V + FG+ +L GG +V VT+ NK Y++ M + ++ G+ +Q +A + GF+E++
Sbjct 1355 VNEEVFGQVTERELKSGGTNVQVTEKNKKEYIERMVKWRVERGVVQQTQALVRGFYEVVD 1414
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYVN-YLPTEQPILWFWEIMEEFDTPQKA 239
L+S+FD +ELEL+++G I++ D + NTEY Y I WFW +E F+ Q+
Sbjct 1415 SRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHIVIRWFWGAVERFNNEQRL 1474
Query 240 AFLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPAYTSKAI 299
LQFVTGTS VP GF L G G ++F I+K LP AHTCFN+LDLP Y S +
Sbjct 1475 RLLQFVTGTSSVPYEGFTALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYTM 1534
Query 300 LKKKLLLAITE 310
L +KLL+A+ E
Sbjct 1535 LYEKLLIAVEE 1545
> tgo:TGME49_078940 ubiquitin--protein ligase, putative (EC:6.3.2.-)
Length=1288
Score = 228 bits (581), Expect = 2e-59, Method: Composition-based stats.
Identities = 128/325 (39%), Positives = 190/325 (58%), Gaps = 11/325 (3%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNPLSAINPEHLYYFKFIGRVIGK 60
D GG TRE+F L+++ + +PN LF + NP SA+N HL +F+F+G ++GK
Sbjct 963 DAGGPTREFFTLISQKILDPNAGLFQFCDVDEIAYRINPNSAVNEHHLEFFRFVGLILGK 1022
Query 61 ALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYPLEDLALTDLTFS 120
ALFD + A FCR KH+L + +D E D ++ +LQ I +P++ + D +F+
Sbjct 1023 ALFDKQMIGAPFCRPLLKHLLQRDGGFQDLEFFDSQVHRSLQWIRAHPID--GVLDTSFT 1080
Query 121 VETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGFHELIP 180
V D FG+ KV L GG VTDANK Y+ L+ + K+ ++ QL A GF ++P
Sbjct 1081 VTEDFFGETKVIPLKEGGEFERVTDANKEEYISLIARHKLVYSVRDQLRALQEGFWSVVP 1140
Query 181 PSLISIFDDKELELLLSGLPTINVADLQENTEYV-NYLPTEQPILWFWEIMEE-FDTPQK 238
L+ IFDD+EL+LLL+G ++V D + NT+Y Y ++ I WFW+++ F+ ++
Sbjct 1141 LCLLRIFDDRELDLLLNGQNRVDVDDWKRNTQYSGGYCESDPIIQWFWDVVGNIFNDEER 1200
Query 239 AAFLQFVTGTSRVPIGGFRNLVGMRGP-QKFSIQ-----KAYGENRLPSAHTCFNQLDLP 292
LQF TGTSRVP GFR L RG +F++Q + LP AHTCFN++DLP
Sbjct 1201 GRLLQFCTGTSRVPAEGFRVLESNRGQLARFTLQPIERIPGHSPALLPRAHTCFNRVDLP 1260
Query 293 AYTSKAILKKKLLLAI-TEGREGFG 316
Y+S+ L + L +AI + GFG
Sbjct 1261 KYSSREELLRYLRMAIEVDHLTGFG 1285
> tgo:TGME49_075630 ubiquitin-transferase domain-containing protein
; K10589 ubiquitin-protein ligase E3 C [EC:6.3.2.19]
Length=647
Score = 203 bits (516), Expect = 8e-52, Method: Compositional matrix adjust.
Identities = 119/324 (36%), Positives = 186/324 (57%), Gaps = 20/324 (6%)
Query 1 DGGGLTREWFGLLARDMFNPNYALFTREGAKSEFNQPNP---LSAINPEHLYYFKFIGRV 57
DGGGL +E+ LL+R +F+P+Y LF S + PNP L+ +P LY +G+V
Sbjct 336 DGGGLFKEFLVLLSRKVFDPDYGLFKASSDNSLY--PNPSVHLAHTHPTALY--NALGKV 391
Query 58 IGKALFDGHYLPAYFCRSFYKHMLNKKCSMRDAESLDPSLYSNLQKILEYP--LEDLALT 115
+GKA+++ + R F +L + + D ++LDP ++ NL + Y +++LAL+
Sbjct 392 VGKAIYEKILIEPQLNRVFLNLLLGRPNQVDDVQALDPVVHKNLLFLKHYTDNVQNLALS 451
Query 116 DLTFSVETDEFGKHKVNDLLPGGRHVPVTDANKALYVQLMCQRKIAGGIQKQLEAFLSGF 175
FS +FG ++ DL+P GR +PVT+ +K Y+Q + K I KQ +AFL+G
Sbjct 452 ---FSATLGDFGSNEEEDLIPNGRTIPVTNDSKLRYIQAVAHFKCTKQIAKQTQAFLNGL 508
Query 176 HELIPPSLISIFDDKELELLLSGLPT-INVADLQENTEYVNYLPTEQP-ILWFWEIMEEF 233
++IP + +F EL+LL+SG P +VADL+ + + P I W W+ +EE
Sbjct 509 SQVIPLKWLKMFSPAELQLLISGSPLGFDVADLRAHANFTGGFEASSPTICWLWDTLEEM 568
Query 234 DTPQKAAFLQFVTGTSRVPIGGFRNLVGMRGPQKFSIQKAYGENRLPSAHTCFNQLDLPA 293
+ +++ FL FVT SR P+ GFRNL F++ + +RLP++ TC N L LP
Sbjct 569 SSEERSKFLMFVTSCSRPPLLGFRNL-----HPSFTVHRVPERHRLPTSSTCVNLLKLPP 623
Query 294 YTSKAILKKKLLLAITEGREGFGF 317
Y SK +L+++L+ AI EG EGFG
Sbjct 624 YESKEVLRERLMEAI-EGAEGFGL 646
Lambda K H
0.322 0.140 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 13111454216
Database: egene_temp_file_orthology_annotation_similarity_blast_database_866
Posted date: Sep 17, 2011 2:57 PM
Number of letters in database: 82,071,388
Number of sequences in database: 164,496
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40