bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: egene_temp_file_orthology_annotation_similarity_blast_database_866
164,496 sequences; 82,071,388 total letters
Query= Eten_0849_orf1
Length=147
Score E
Sequences producing significant alignments: (Bits) Value
tgo:TGME49_118680 3',5'--cyclic-nucleotide phosphodiesterase, ... 176 3e-44
tgo:TGME49_024840 cAMP phosphodiesterase, putative (EC:3.1.4.1... 152 4e-37
pfa:MAL13P1.118 3',5'-cyclic nucleotide phosphodiesterase (EC:... 143 2e-34
tgo:TGME49_041880 3', 5'-cyclic nucleotide phosphodiesterase, ... 139 2e-33
tgo:TGME49_110520 calcium/calmodulin-dependent 3', 5'-cyclic n... 137 9e-33
tgo:TGME49_002540 3',5'-cyclic nucleotide phosphodiesterase, p... 135 4e-32
cpv:cgd3_2320 cGMP phosphodiesterase A4 130 2e-30
tgo:TGME49_026770 cGMP-inhibited 3',5'-cyclic phosphodiesteras... 128 7e-30
tgo:TGME49_080410 3',5'-cyclic phosphodiesterase, putative (EC... 127 2e-29
tgo:TGME49_072650 calcium/calmodulin-dependent 3',5'-cyclic nu... 125 6e-29
tgo:TGME49_066920 phosphodiesterase, putative (EC:3.1.4.17) 117 2e-26
tpv:TP01_1200 hypothetical protein 110 2e-24
pfa:PFL0475w PDE1; cGMP-specific phosphodiesterase (EC:3.1.4.1... 108 4e-24
dre:564465 pde1a; phosphodiesterase 1A, calmodulin-dependent; ... 102 5e-22
mmu:18573 Pde1a, AI987702, AW125737, MGC116577; phosphodiester... 100 2e-21
hsa:5136 PDE1A, HCAM1, HSPDE1A, MGC26303; phosphodiesterase 1A... 99.8 3e-21
bbo:BBOV_IV010070 23.m06154; 3'5'-cyclic nucleotide phosphodie... 98.2 7e-21
bbo:BBOV_IV006510 23.m05980; 3'5'-cyclic nucleotide phosphodie... 97.8 1e-20
pfa:MAL13P1.119 calcium/calmodulin-dependent 3',5'-cyclic nucl... 95.9 4e-20
tgo:TGME49_057080 cAMP-specific 3',5'-cyclic phosphodiesterase... 95.5 5e-20
tpv:TP01_0664 3',5' cyclic nucleotide phosphodiesterase; K0112... 94.4 1e-19
mmu:18574 Pde1b, 63kDa, Pde1b1; phosphodiesterase 1B, Ca2+-cal... 93.6 2e-19
mmu:54611 Pde3a, A930022O17Rik, C87899; phosphodiesterase 3A, ... 93.2 2e-19
hsa:5139 PDE3A, CGI-PDE; phosphodiesterase 3A, cGMP-inhibited ... 92.4 5e-19
hsa:5153 PDE1B, PDE1B1, PDES1B; phosphodiesterase 1B, calmodul... 92.0 6e-19
dre:567051 si:dkey-48h7.2; K13296 cGMP-inhibited 3',5'-cyclic ... 91.7 8e-19
hsa:5140 PDE3B, HcGIP1, cGIPDE1; phosphodiesterase 3B, cGMP-in... 90.9 1e-18
tgo:TGME49_020420 3'5'-cyclic nucleotide phosphodiesterase, pu... 90.1 2e-18
xla:496104 pde3b; phosphodiesterase 3b, cGMP-inhibited; K13296... 89.7 3e-18
dre:563432 pde3b; phosphodiesterase 3B, cGMP-inhibited; K13296... 89.4 4e-18
mmu:18576 Pde3b, 9830102A01Rik, AI847709; phosphodiesterase 3B... 88.2 7e-18
hsa:5137 PDE1C, Hcam3; phosphodiesterase 1C, calmodulin-depend... 88.2 8e-18
mmu:18575 Pde1c; phosphodiesterase 1C (EC:3.1.4.17); K13755 ca... 88.2 9e-18
tgo:TGME49_057950 3'5'-cyclic nucleotide phosphodiesterase dom... 87.4 1e-17
dre:100151215 phosphodiesterase 7A-like (EC:3.1.4.17); K01120 ... 85.9 5e-17
cel:T04D3.3 pde-1; PhosphoDiEsterase family member (pde-1); K1... 83.2 3e-16
mmu:18583 Pde7a, AU015378, AW047537; phosphodiesterase 7A (EC:... 80.5 2e-15
hsa:5141 PDE4A, DPDE2, PDE4, PDE46; phosphodiesterase 4A, cAMP... 79.0 5e-15
mmu:18577 Pde4a, D9Ertd60e, Dpde2; phosphodiesterase 4A, cAMP ... 79.0 6e-15
cel:E01F3.1 pde-3; PhosphoDiEsterase family member (pde-3); K1... 79.0 6e-15
mmu:238871 Pde4d, 9630011N22Rik, Dpde3; phosphodiesterase 4D, ... 78.2 9e-15
xla:444562 pde4b, MGC83972; phosphodiesterase 4B, cAMP-specifi... 77.8 1e-14
mmu:18578 Pde4b, Dpde4, R74983, dunce; phosphodiesterase 4B, c... 77.4 1e-14
hsa:5142 PDE4B, DKFZp686F2182, DPDE4, MGC126529, PDE4B5, PDEIV... 77.4 1e-14
hsa:5144 PDE4D, DKFZp686M11213, DPDE3, FLJ97311, HSPDE4D, PDE4... 77.4 2e-14
dre:565706 cAMP-specific 3,5-cyclic phosphodiesterase 4B-like;... 77.0 2e-14
hsa:5143 PDE4C, DPDE1, MGC126222; phosphodiesterase 4C, cAMP-s... 77.0 2e-14
hsa:5150 PDE7A, HCP1, PDE7; phosphodiesterase 7A (EC:3.1.4.17)... 77.0 2e-14
dre:565259 pde4c, im:7160317, si:dkey-149i17.5; phosphodiester... 76.6 3e-14
dre:572061 pde4a; phosphodiesterase 4A, cAMP-specific; K01120 ... 76.6 3e-14
> tgo:TGME49_118680 3',5'--cyclic-nucleotide phosphodiesterase,
putative (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase
[EC:3.1.4.17]
Length=812
Score = 176 bits (445), Expect = 3e-44, Method: Compositional matrix adjust.
Identities = 77/141 (54%), Positives = 105/141 (74%), Gaps = 0/141 (0%)
Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIG 66
E + VR+ +IDLILATDM+THF+FL+RFR R++ F+F + +D+WLA E+CIRASD+G
Sbjct 470 EFKHVRANMIDLILATDMKTHFDFLSRFRNRRQAPGFNFHKVAEDQWLAAEICIRASDLG 529
Query 67 HGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRP 126
H + W QHFEW +R TEFYLQG+EE RLG +SPLCDR+ H +K Q GFL +VV+P
Sbjct 530 HAMTEWDQHFEWASRVVTEFYLQGEEERRLGLHVSPLCDRDDHPSFSKCQHGFLGYVVKP 589
Query 127 LFAELQAIDDQKKPIAEMLKN 147
L AEL D ++ I ++++N
Sbjct 590 LIAELGECDTLQRIIPQLMQN 610
> tgo:TGME49_024840 cAMP phosphodiesterase, putative (EC:3.1.4.17
1.1.99.3)
Length=1324
Score = 152 bits (384), Expect = 4e-37, Method: Compositional matrix adjust.
Identities = 65/130 (50%), Positives = 89/130 (68%), Gaps = 0/130 (0%)
Query 6 AEVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDI 65
+ R +R +I+ ILATDM+ HFE L+RFR R S +F++ +N +DRW +C++ +DI
Sbjct 839 SSFRYIRQYVIECILATDMKQHFESLSRFRIRRNSPEFNYVKNVEDRWFVARMCVKVADI 898
Query 66 GHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVR 125
GH + W QHFEW++R EFYLQGDEE +SPLCDR+ H+ +AKSQ GFL VV+
Sbjct 899 GHSCVPWNQHFEWSSRVVEEFYLQGDEERSRNMPVSPLCDRDKHADMAKSQGGFLEFVVK 958
Query 126 PLFAELQAID 135
PL E+ ID
Sbjct 959 PLIKEIDEID 968
> pfa:MAL13P1.118 3',5'-cyclic nucleotide phosphodiesterase (EC:3.1.4.17);
K01120 3',5'-cyclic-nucleotide phosphodiesterase
[EC:3.1.4.17]
Length=1139
Score = 143 bits (361), Expect = 2e-34, Method: Composition-based stats.
Identities = 61/132 (46%), Positives = 91/132 (68%), Gaps = 0/132 (0%)
Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIG 66
+ R +RS II+LIL+TDM+ HFE +++FR RE++ F + +N DD + ++ I+++DI
Sbjct 943 DFRMMRSYIIELILSTDMKHHFEIISKFRIRRENEDFDYIKNSDDLLILTKMIIKSADIS 1002
Query 67 HGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRP 126
HG + W +H+ W R +EFY QGDEE + +SPLCDR H+++ KSQ+ FL+ VV P
Sbjct 1003 HGSVSWSEHYCWCQRVLSEFYTQGDEELKNKMPLSPLCDRTKHNEVCKSQITFLKFVVMP 1062
Query 127 LFAELQAIDDQK 138
LF EL ID+ K
Sbjct 1063 LFEELSHIDNNK 1074
> tgo:TGME49_041880 3', 5'-cyclic nucleotide phosphodiesterase,
putative (EC:2.1.1.43 3.1.4.17)
Length=1281
Score = 139 bits (351), Expect = 2e-33, Method: Compositional matrix adjust.
Identities = 62/125 (49%), Positives = 85/125 (68%), Gaps = 1/125 (0%)
Query 11 VRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHGVL 70
VR+++IDLILATDM+ HFE +++FR R S F R NDDD W+ + +CI+ D+ HG+L
Sbjct 964 VRNRMIDLILATDMKMHFEMVSKFRLRRNSPDFC-RTNDDDVWMLLRMCIKGGDLSHGLL 1022
Query 71 GWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLFAE 130
W H W+ RA +EFY QGD E GRTI+P+ DR H+ K Q GFLR ++ PL+ E
Sbjct 1023 SWDSHVSWSYRAASEFYEQGDLELAQGRTITPMFDRRKHADFPKGQEGFLRFIIIPLYEE 1082
Query 131 LQAID 135
+ A+D
Sbjct 1083 IAAVD 1087
> tgo:TGME49_110520 calcium/calmodulin-dependent 3', 5'-cyclic
nucleotide phosphodiesterase, putative (EC:3.4.21.69 3.1.4.17)
Length=1531
Score = 137 bits (346), Expect = 9e-33, Method: Compositional matrix adjust.
Identities = 66/146 (45%), Positives = 89/146 (60%), Gaps = 7/146 (4%)
Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHG 68
R R II LILATD++ HFE ++RFR R S +F+F + ++D WL ++ + +DI H
Sbjct 1316 RIARQNIITLILATDIKQHFETISRFRLRRNSPEFNFLKKEEDDWLVRKMIFKIADISHA 1375
Query 69 VLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLF 128
+ W HF W+ + EFY QGD E RLG +SPLCDRE H ++ KSQV FL VV PL
Sbjct 1376 TVAWDAHFFWSCKVNAEFYAQGDAEVRLGLPVSPLCDREKHFEMGKSQVAFLNFVVEPLL 1435
Query 129 AELQAIDDQKKPIA-------EMLKN 147
EL+AI+ P+ E+L N
Sbjct 1436 RELEAIEALVLPLGTCPIISTELLPN 1461
> tgo:TGME49_002540 3',5'-cyclic nucleotide phosphodiesterase,
putative (EC:3.1.4.17 1.6.99.5)
Length=1670
Score = 135 bits (340), Expect = 4e-32, Method: Compositional matrix adjust.
Identities = 65/125 (52%), Positives = 86/125 (68%), Gaps = 1/125 (0%)
Query 11 VRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHGVL 70
VRS IIDLILATDM+ HFE ++RFR R + F +++D W AV++ ++ +D+ H +
Sbjct 1438 VRSLIIDLILATDMKNHFETVSRFRVRRNALDFDLS-SEEDFWFAVKIIMKCADLSHCSV 1496
Query 71 GWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLFAE 130
W QHF+W R + EFY QGDEE +SPLCDRE HS++AKSQ+GF+ V PLF E
Sbjct 1497 PWSQHFQWCQRLSVEFYDQGDEEVARHLPMSPLCDREKHSEVAKSQLGFMSFVAVPLFEE 1556
Query 131 LQAID 135
L AID
Sbjct 1557 LMAID 1561
> cpv:cgd3_2320 cGMP phosphodiesterase A4
Length=997
Score = 130 bits (326), Expect = 2e-30, Method: Composition-based stats.
Identities = 64/142 (45%), Positives = 89/142 (62%), Gaps = 4/142 (2%)
Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHG 68
+E R +I+LIL TDM HFE ++RFR R++ + + DR + C++A+DIGHG
Sbjct 826 KEFRRIVIELILETDMHRHFECVSRFRVRRQAVDWDPYGDAQDRLMLARTCLKAADIGHG 885
Query 69 VLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLF 128
L W QH++W EF+LQGDEE L ISP+CDRE+ + + KSQVGFL V PLF
Sbjct 886 ALKWNQHYKWCRSVVEEFFLQGDEEKALSLPISPICDRES-TDVPKSQVGFLNFVCLPLF 944
Query 129 AELQAID---DQKKPIAEMLKN 147
EL +D D ++ I +L+N
Sbjct 945 QELCYVDVEGDVRRCIDRILEN 966
> tgo:TGME49_026770 cGMP-inhibited 3',5'-cyclic phosphodiesterase,
putative (EC:3.1.4.17)
Length=995
Score = 128 bits (321), Expect = 7e-30, Method: Compositional matrix adjust.
Identities = 61/130 (46%), Positives = 82/130 (63%), Gaps = 1/130 (0%)
Query 3 VVAAEVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRA 62
+ AE R R +I+LILATDM HF ++ R RES F+F N++DRW+ +LC++
Sbjct 398 ITPAEYRYFRKHLIELILATDMSQHFSTISTVRVRRESRTFNFITNEEDRWMMKKLCMKI 457
Query 63 SDIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHS-QLAKSQVGFLR 121
DIGH L W QH++W+ R T EF LQGD E + G +SPLCDR +L KSQ F+
Sbjct 458 GDIGHAALDWDQHYKWSMRVTEEFLLQGDAELKAGLPVSPLCDRNAPEIELHKSQSSFIN 517
Query 122 HVVRPLFAEL 131
++V PL EL
Sbjct 518 YLVVPLINEL 527
> tgo:TGME49_080410 3',5'-cyclic phosphodiesterase, putative (EC:3.1.4.17
1.6.5.3); K01120 3',5'-cyclic-nucleotide phosphodiesterase
[EC:3.1.4.17]
Length=1085
Score = 127 bits (318), Expect = 2e-29, Method: Compositional matrix adjust.
Identities = 62/130 (47%), Positives = 84/130 (64%), Gaps = 1/130 (0%)
Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHG 68
R R +I+LI++TDM+THFE + FR R+ ++F N DDR + + I+++DIGHG
Sbjct 911 RSFRMTVIELIMSTDMKTHFEQIANFRVRRQKEEFDPINNYDDRQKVMSMIIKSADIGHG 970
Query 69 VLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHS-QLAKSQVGFLRHVVRPL 127
L W H W EFY QGDEE RLG +S LCDR+ H + KSQVGFL VV+PL
Sbjct 971 TLPWADHERWCNLVVQEFYEQGDEEKRLGLPVSFLCDRDQHDREFFKSQVGFLDFVVKPL 1030
Query 128 FAELQAIDDQ 137
+ EL+A++ Q
Sbjct 1031 YEELKALETQ 1040
> tgo:TGME49_072650 calcium/calmodulin-dependent 3',5'-cyclic
nucleotide phosphodiesterase, putative (EC:3.1.4.17)
Length=1320
Score = 125 bits (313), Expect = 6e-29, Method: Compositional matrix adjust.
Identities = 61/128 (47%), Positives = 80/128 (62%), Gaps = 0/128 (0%)
Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIG 66
+ R+VR K I+LIL+TDM HFEFL R RE+ F+F ++DR L + L I+ +D+G
Sbjct 1159 QYRDVRKKAIELILSTDMSLHFEFLTRVAARRENPDFNFVDREEDRALVLSLAIKVADLG 1218
Query 67 HGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRP 126
H L W+ H W+AR EF QGDEE RLG +SPLCDR QLA+SQ F+ + P
Sbjct 1219 HCALDWEAHTLWSARLKEEFLAQGDEELRLGLPVSPLCDRTQQGQLARSQANFIEFLFLP 1278
Query 127 LFAELQAI 134
L L A+
Sbjct 1279 LAQHLAAV 1286
> tgo:TGME49_066920 phosphodiesterase, putative (EC:3.1.4.17)
Length=1065
Score = 117 bits (292), Expect = 2e-26, Method: Compositional matrix adjust.
Identities = 55/125 (44%), Positives = 78/125 (62%), Gaps = 0/125 (0%)
Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIG 66
+ R VRSK+I+ ILATDM+ HFE ++RFR +D F ++ DDRW +++ ++ +DI
Sbjct 710 QFRFVRSKLIEAILATDMKQHFETISRFRLRTSADDFDVAKHVDDRWAVLKMFVKMADIS 769
Query 67 HGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRP 126
H L W HF + EFY QGDEE R G +S LCDR H+++ KSQ GF+ + +P
Sbjct 770 HVALPWDMHFRLSCDIVEEFYQQGDEELRRGMPLSQLCDRSKHNEMPKSQEGFIEFLAKP 829
Query 127 LFAEL 131
L L
Sbjct 830 LVGVL 834
> tpv:TP01_1200 hypothetical protein
Length=840
Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats.
Identities = 56/128 (43%), Positives = 75/128 (58%), Gaps = 3/128 (2%)
Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIG 66
E++ VR KII LIL+TD+ HF+ + +FR R S +FS D ++ I+ASDIG
Sbjct 701 EMKIVRRKIIQLILSTDLEDHFQTITQFRVRRASREFSVEGEIDT---ICKMLIKASDIG 757
Query 67 HGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRP 126
+ W+ EW+ R EFY QG EE LG I+PLCD H+ L K+Q GFL V P
Sbjct 758 SSCMEWRLTLEWSQRLVQEFYTQGLEELSLGLPITPLCDPNKHNHLPKAQSGFLAIFVIP 817
Query 127 LFAELQAI 134
L+ E+ I
Sbjct 818 LYTEIANI 825
> pfa:PFL0475w PDE1; cGMP-specific phosphodiesterase (EC:3.1.4.17);
K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17]
Length=954
Score = 108 bits (271), Expect = 4e-24, Method: Composition-based stats.
Identities = 56/123 (45%), Positives = 73/123 (59%), Gaps = 1/123 (0%)
Query 12 RSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHGVLG 71
+ II IL+TDM+ HFE+++ FRT +E + ND W L ++ASDIGH L
Sbjct 781 KKNIIKAILSTDMKNHFEYISDFRTSKEFIDYDNLSNDQ-IWQIFCLILKASDIGHSTLE 839
Query 72 WKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLFAEL 131
W +H EWT + EFYLQG E L S LCD T ++LA SQ+ FL+H+ PLF EL
Sbjct 840 WNKHLEWTLKINEEFYLQGLLEKSLNIQNSFLCDINTMNKLALSQIDFLKHLCIPLFNEL 899
Query 132 QAI 134
I
Sbjct 900 NYI 902
> dre:564465 pde1a; phosphodiesterase 1A, calmodulin-dependent;
K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide
phosphodiesterase [EC:3.1.4.17]
Length=625
Score = 102 bits (254), Expect = 5e-22, Method: Compositional matrix adjust.
Identities = 53/138 (38%), Positives = 87/138 (63%), Gaps = 9/138 (6%)
Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHG 68
RE+R+ +I+++++TDM HF+ + +T+R S Q + D+ A+ L + A+DI H
Sbjct 320 RELRTLVIEMVMSTDMSCHFQ---QIKTMRNSLQ---QPEGIDKAKALSLMLHAADISHP 373
Query 69 VLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLF 128
GWK H+ WT EF+ QGD+EA LG SPLCDR+ + +A+SQ+GF+ +V P F
Sbjct 374 AKGWKLHYRWTQALMEEFFRQGDKEAELGLPFSPLCDRKA-TMIAQSQIGFIDFIVEPTF 432
Query 129 AELQAIDDQKKPIAEMLK 146
+ L +D +K I+ +++
Sbjct 433 SVL--VDTTEKIISPLIE 448
> mmu:18573 Pde1a, AI987702, AW125737, MGC116577; phosphodiesterase
1A, calmodulin-dependent (EC:3.1.4.17); K13755 calcium/calmodulin-dependent
3',5'-cyclic nucleotide phosphodiesterase
[EC:3.1.4.17]
Length=545
Score = 100 bits (248), Expect = 2e-21, Method: Compositional matrix adjust.
Identities = 51/123 (41%), Positives = 77/123 (62%), Gaps = 7/123 (5%)
Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHG 68
R++R+ +I+++LATDM HF+ + + IR S Q + DR + L + A+DI H
Sbjct 317 RDLRNLVIEMVLATDMSGHFQ---QIKNIRNSLQ---QPEGIDRAKTMSLILHAADISHP 370
Query 69 VLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLF 128
WK H+ WT EF+LQGD+EA LG SPLCDR++ + +A+SQ+GF+ +V P F
Sbjct 371 AKTWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKS-TMVAQSQIGFIDFIVEPTF 429
Query 129 AEL 131
+ L
Sbjct 430 SLL 432
> hsa:5136 PDE1A, HCAM1, HSPDE1A, MGC26303; phosphodiesterase
1A, calmodulin-dependent (EC:3.1.4.17); K13755 calcium/calmodulin-dependent
3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17]
Length=535
Score = 99.8 bits (247), Expect = 3e-21, Method: Compositional matrix adjust.
Identities = 50/123 (40%), Positives = 77/123 (62%), Gaps = 7/123 (5%)
Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHG 68
R++R+ +I+++L+TDM HF+ + + IR S Q + DR + L + A+DI H
Sbjct 317 RDLRNLVIEMVLSTDMSGHFQ---QIKNIRNSLQ---QPEGIDRAKTMSLILHAADISHP 370
Query 69 VLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLF 128
WK H+ WT EF+LQGD+EA LG SPLCDR++ + +A+SQ+GF+ +V P F
Sbjct 371 AKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKS-TMVAQSQIGFIDFIVEPTF 429
Query 129 AEL 131
+ L
Sbjct 430 SLL 432
> bbo:BBOV_IV010070 23.m06154; 3'5'-cyclic nucleotide phosphodiesterase
(EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase
[EC:3.1.4.17]
Length=485
Score = 98.2 bits (243), Expect = 7e-21, Method: Composition-based stats.
Identities = 49/135 (36%), Positives = 71/135 (52%), Gaps = 0/135 (0%)
Query 11 VRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHGVL 70
+R +II L+LATDM THF +N + R S F + N +D W + L ++ +DIGH L
Sbjct 310 IRKRIIQLVLATDMMTHFTHVNNVKERRLSGTFDYVNNPEDLWFCLVLLVKTADIGHNFL 369
Query 71 GWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLFAE 130
W +H WT EF++QGDEE L + DR + + SQ+GF + PL E
Sbjct 370 PWCEHLPWTNALFDEFHMQGDEERLLSLPLLLFFDRTRSADIPDSQLGFFQGFTSPLIDE 429
Query 131 LQAIDDQKKPIAEML 145
L I+ + + L
Sbjct 430 LTFINTNSTYLNDFL 444
> bbo:BBOV_IV006510 23.m05980; 3'5'-cyclic nucleotide phosphodiesterase
(EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase
[EC:3.1.4.17]
Length=777
Score = 97.8 bits (242), Expect = 1e-20, Method: Composition-based stats.
Identities = 56/141 (39%), Positives = 76/141 (53%), Gaps = 9/141 (6%)
Query 11 VRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHGVL 70
VRS+II+ ILATD F +++F + D F+F + R L ++ ++A+D+ +
Sbjct 595 VRSQIIEHILATDTVDQFHMISQFVLSCKRDDFTFEEYNS-RILTSKMLMKAADVAAPTM 653
Query 71 GWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLF-- 128
W EW +R EFY QG EE IS LCDR+ H Q AKSQ FLR VV PL+
Sbjct 654 QWANSLEWVSRLLGEFYAQGAEEVDYCIPISALCDRQHHEQSAKSQAAFLRIVVAPLYEA 713
Query 129 ------AELQAIDDQKKPIAE 143
E+ AI DQ + AE
Sbjct 714 IASLGSPEIDAIMDQLEENAE 734
> pfa:MAL13P1.119 calcium/calmodulin-dependent 3',5'-cyclic nucleotide
phosphodiesterase 1b (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide
phosphodiesterase [EC:3.1.4.17]
Length=769
Score = 95.9 bits (237), Expect = 4e-20, Method: Composition-based stats.
Identities = 45/126 (35%), Positives = 73/126 (57%), Gaps = 3/126 (2%)
Query 11 VRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHGVL 70
+R +II+LILATDM H + L +FR + +N L +++ I+A+D+ H +
Sbjct 588 LRQQIIELILATDMSKHIKILAQFRIKSIKIKSYIEKN---IILCLKMIIKAADLSHNCV 644
Query 71 GWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLFAE 130
W +H++W R EFY +GDE ++G I+PL DR H+ + Q FL+ +V PL
Sbjct 645 DWSEHYQWVKRLVNEFYYEGDELFQMGYKINPLFDRNCHNNFIQIQRTFLKELVYPLIIS 704
Query 131 LQAIDD 136
L+ +D+
Sbjct 705 LKTLDN 710
> tgo:TGME49_057080 cAMP-specific 3',5'-cyclic phosphodiesterase,
putative (EC:3.1.4.17)
Length=1691
Score = 95.5 bits (236), Expect = 5e-20, Method: Compositional matrix adjust.
Identities = 52/134 (38%), Positives = 73/134 (54%), Gaps = 2/134 (1%)
Query 4 VAAEVRE-VRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRA 62
+A EV + +R II LIL+TDM H +++R R ES F N+ DRWL + CI+A
Sbjct 1440 LAKEVYQYMRQNIIGLILSTDMSKHISYVSRLRVRAESGNFDVN-NEGDRWLLFQGCIKA 1498
Query 63 SDIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRH 122
+D+ H W H W EF+ QGDEE R G + + DR + +SQ F+
Sbjct 1499 ADLAHTATFWDNHKRWAECLCEEFFKQGDEERRQGMNVMDIFDRRQKDRFPQSQYRFIEL 1558
Query 123 VVRPLFAELQAIDD 136
VV PLF + +I+D
Sbjct 1559 VVEPLFNSVCSIED 1572
> tpv:TP01_0664 3',5' cyclic nucleotide phosphodiesterase; K01120
3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17]
Length=450
Score = 94.4 bits (233), Expect = 1e-19, Method: Composition-based stats.
Identities = 53/134 (39%), Positives = 72/134 (53%), Gaps = 11/134 (8%)
Query 11 VRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHGVL 70
+R +II LIL+TDM HF ++ + R +F + NDDD WL + LCI+A+DIGH L
Sbjct 269 LRKRIIQLILSTDMINHFLHIDNVKEKRLQGKFDIK-NDDDFWLLLVLCIKAADIGHNFL 327
Query 71 GWKQHFEWTARATTEFYLQGDEEARLGRTISPLC--DRETHSQLAKSQVGFLRHVV---- 124
W H WT EFY QGDEE ++ISPL DR + Q+ F +
Sbjct 328 PWADHLPWTQVLFEEFYKQGDEEKM--QSISPLMFFDRNESRNIPILQLQFFNTMTQLLI 385
Query 125 --RPLFAELQAIDD 136
+PL +EL D+
Sbjct 386 LSQPLLSELNYFDE 399
> mmu:18574 Pde1b, 63kDa, Pde1b1; phosphodiesterase 1B, Ca2+-calmodulin
dependent (EC:3.1.4.17); K13755 calcium/calmodulin-dependent
3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17]
Length=535
Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust.
Identities = 51/138 (36%), Positives = 80/138 (57%), Gaps = 8/138 (5%)
Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIG 66
E E+R+ +I+++LATDM HF+ + +T + R D + A+ L + A+DI
Sbjct 318 EFAELRALVIEMVLATDMSCHFQQVKTMKTALQQ----LERIDKSK--ALSLLLHAADIS 371
Query 67 HGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRP 126
H W H WT EF+ QGD+EA LG SPLCDR T + +A+SQ+GF+ +V P
Sbjct 372 HPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDR-TSTLVAQSQIGFIDFIVEP 430
Query 127 LFAELQAIDDQK-KPIAE 143
F+ L + ++ +P+A+
Sbjct 431 TFSVLTDVAEKSVQPLAD 448
> mmu:54611 Pde3a, A930022O17Rik, C87899; phosphodiesterase 3A,
cGMP inhibited (EC:3.1.4.17); K13296 cGMP-inhibited 3',5'-cyclic
phosphodiesterase [EC:3.1.4.17]
Length=1141
Score = 93.2 bits (230), Expect = 2e-19, Method: Composition-based stats.
Identities = 49/121 (40%), Positives = 67/121 (55%), Gaps = 1/121 (0%)
Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIG 66
E + R +I+ ILATD++ HF+F+ +F D N++DR L ++CI+ +DI
Sbjct 893 EFKHFRFLVIEAILATDLKKHFDFVAKFNAKVNDDVGIDWTNENDRLLVCQMCIKLADIN 952
Query 67 HGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRP 126
+ H WT +EFY QGDEEA LG ISP DR QLA Q F+ H+V P
Sbjct 953 GPAKCKELHLRWTEGIASEFYEQGDEEASLGLPISPFMDRSA-PQLANLQESFISHIVGP 1011
Query 127 L 127
L
Sbjct 1012 L 1012
> hsa:5139 PDE3A, CGI-PDE; phosphodiesterase 3A, cGMP-inhibited
(EC:3.1.4.17); K13296 cGMP-inhibited 3',5'-cyclic phosphodiesterase
[EC:3.1.4.17]
Length=1141
Score = 92.4 bits (228), Expect = 5e-19, Method: Composition-based stats.
Identities = 49/121 (40%), Positives = 67/121 (55%), Gaps = 1/121 (0%)
Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIG 66
E + R +I+ ILATD++ HF+F+ +F D N++DR L ++CI+ +DI
Sbjct 893 EFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADIN 952
Query 67 HGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRP 126
+ H +WT EFY QGDEEA LG ISP DR QLA Q F+ H+V P
Sbjct 953 GPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSA-PQLANLQESFISHIVGP 1011
Query 127 L 127
L
Sbjct 1012 L 1012
> hsa:5153 PDE1B, PDE1B1, PDES1B; phosphodiesterase 1B, calmodulin-dependent
(EC:3.1.4.17); K13755 calcium/calmodulin-dependent
3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17]
Length=536
Score = 92.0 bits (227), Expect = 6e-19, Method: Compositional matrix adjust.
Identities = 51/138 (36%), Positives = 80/138 (57%), Gaps = 8/138 (5%)
Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIG 66
E E+R+ +I+++LATDM HF+ + +T + R D + A+ L + A+DI
Sbjct 319 EFVELRALVIEMVLATDMSCHFQQVKTMKTALQQ----LERIDKPK--ALSLLLHAADIS 372
Query 67 HGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRP 126
H W H WT EF+ QGD+EA LG SPLCDR T + +A+SQ+GF+ +V P
Sbjct 373 HPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDR-TSTLVAQSQIGFIDFIVEP 431
Query 127 LFAELQAIDDQK-KPIAE 143
F+ L + ++ +P+A+
Sbjct 432 TFSVLTDVAEKSVQPLAD 449
> dre:567051 si:dkey-48h7.2; K13296 cGMP-inhibited 3',5'-cyclic
phosphodiesterase [EC:3.1.4.17]
Length=1117
Score = 91.7 bits (226), Expect = 8e-19, Method: Compositional matrix adjust.
Identities = 54/126 (42%), Positives = 72/126 (57%), Gaps = 5/126 (3%)
Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFR--RNDDDRWLAVELCIRASD 64
E + R +I+ ILATD++ HF+FL F D S N++DR L ++CI+ +D
Sbjct 819 EFKRFRFLVIEAILATDLKKHFDFLAEFNAKVGDDGCSGIDWTNENDRLLVCQMCIKLAD 878
Query 65 IGHGVLGWKQ-HFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123
I +G L K H +WT EFY QGDEE+ LG ISP DR QLAK Q F+ H+
Sbjct 879 I-NGPLKCKDLHLQWTEGIVNEFYEQGDEESSLGLPISPFMDRSA-PQLAKLQESFITHI 936
Query 124 VRPLFA 129
V PL +
Sbjct 937 VGPLCS 942
> hsa:5140 PDE3B, HcGIP1, cGIPDE1; phosphodiesterase 3B, cGMP-inhibited
(EC:3.1.4.17); K13296 cGMP-inhibited 3',5'-cyclic
phosphodiesterase [EC:3.1.4.17]
Length=1112
Score = 90.9 bits (224), Expect = 1e-18, Method: Composition-based stats.
Identities = 52/124 (41%), Positives = 70/124 (56%), Gaps = 5/124 (4%)
Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFR---RNDDDRWLAVELCIRAS 63
E + R +I+ ILATD++ HF+FL F + +D S N++DR L ++CI+ +
Sbjct 878 EFKRFRFLVIEAILATDLKKHFDFLAEFNA-KANDVNSNGIEWSNENDRLLVCQVCIKLA 936
Query 64 DIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123
DI H +WT EFY QGDEEA LG ISP DR + QLAK Q F+ H+
Sbjct 937 DINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRSS-PQLAKLQESFITHI 995
Query 124 VRPL 127
V PL
Sbjct 996 VGPL 999
> tgo:TGME49_020420 3'5'-cyclic nucleotide phosphodiesterase,
putative (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase
[EC:3.1.4.17]
Length=466
Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust.
Identities = 53/165 (32%), Positives = 80/165 (48%), Gaps = 34/165 (20%)
Query 4 VAAEVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQF-----------SFRRND--- 49
+ + +++ R II+L+L TD+ HF+F+ RFR R F SF +N
Sbjct 289 LCSMIQDFRKLIIELVLETDILFHFDFIGRFRLRRPMSPFFKLLGERGANPSFGQNPVSL 348
Query 50 -------------------DDRWLAVELCIRASDIGHGVLGWKQHFEWTARATTEFYLQG 90
D L + CIR++D+GH + W+QH+ ++ TEF+ QG
Sbjct 349 LSSPSRTATDVEATSKEEAQDLTLLAKACIRSADVGHAAVEWRQHYFYSKAVQTEFFNQG 408
Query 91 DEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLFAELQAID 135
E RL ISP CD + + K Q GF+ ++ RPLF EL I+
Sbjct 409 KAEKRLRLRISPCCD-PVSTDVPKCQDGFISYISRPLFEELALIN 452
> xla:496104 pde3b; phosphodiesterase 3b, cGMP-inhibited; K13296
cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17]
Length=985
Score = 89.7 bits (221), Expect = 3e-18, Method: Composition-based stats.
Identities = 48/123 (39%), Positives = 69/123 (56%), Gaps = 3/123 (2%)
Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRT-IRESDQFSFR-RNDDDRWLAVELCIRASD 64
+ + R +I+ ILATD++ HF+FL F + + + N++DR L ++CI+ +D
Sbjct 747 QFKRFRFLVIEAILATDLKKHFDFLAEFNAKVNDVNGLGIDWSNENDRLLVCQVCIKLAD 806
Query 65 IGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVV 124
I + H +WT EFY QGDEE+ LG ISP DR QLAK Q F+ H+V
Sbjct 807 INGPAKTRELHLKWTEGIVNEFYEQGDEESSLGLPISPFMDRSA-PQLAKLQESFITHIV 865
Query 125 RPL 127
PL
Sbjct 866 GPL 868
> dre:563432 pde3b; phosphodiesterase 3B, cGMP-inhibited; K13296
cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17]
Length=1107
Score = 89.4 bits (220), Expect = 4e-18, Method: Composition-based stats.
Identities = 49/123 (39%), Positives = 68/123 (55%), Gaps = 3/123 (2%)
Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRT-IRESDQFSFR-RNDDDRWLAVELCIRASD 64
E + R +I+ ILATD++ HF+FL F + + + + N++DR L ++CI+ +D
Sbjct 867 EFKRFRFLVIEAILATDLKKHFDFLAEFNSKVNDVNSPGIDWTNENDRLLVCQVCIKLAD 926
Query 65 IGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVV 124
I H +WT EFY QGDEE LG ISP DR QLAK Q F+ H+V
Sbjct 927 INGPAKDRSLHLKWTEGIVNEFYEQGDEEGTLGLPISPFMDRSA-PQLAKLQESFITHIV 985
Query 125 RPL 127
PL
Sbjct 986 GPL 988
> mmu:18576 Pde3b, 9830102A01Rik, AI847709; phosphodiesterase
3B, cGMP-inhibited (EC:3.1.4.17); K13296 cGMP-inhibited 3',5'-cyclic
phosphodiesterase [EC:3.1.4.17]
Length=1099
Score = 88.2 bits (217), Expect = 7e-18, Method: Composition-based stats.
Identities = 51/124 (41%), Positives = 69/124 (55%), Gaps = 5/124 (4%)
Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFR---RNDDDRWLAVELCIRAS 63
E + R +I+ ILATD++ HF+FL F + +D S +++DR L ++CI+ +
Sbjct 854 EFKRFRFLVIEAILATDLKKHFDFLAEFNA-KANDVNSNGIEWSSENDRLLVCQVCIKLA 912
Query 64 DIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123
DI H WT EFY QGDEEA LG ISP DR + QLAK Q F+ H+
Sbjct 913 DINGPAKDRDLHLRWTEGIVNEFYEQGDEEATLGLPISPFMDRSS-PQLAKLQESFITHI 971
Query 124 VRPL 127
V PL
Sbjct 972 VGPL 975
> hsa:5137 PDE1C, Hcam3; phosphodiesterase 1C, calmodulin-dependent
70kDa (EC:3.1.4.17); K13755 calcium/calmodulin-dependent
3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17]
Length=634
Score = 88.2 bits (217), Expect = 8e-18, Method: Compositional matrix adjust.
Identities = 45/123 (36%), Positives = 69/123 (56%), Gaps = 7/123 (5%)
Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHG 68
RE R+ +I++++ATDM HF+ + +T + + ++ A+ L + +DI H
Sbjct 327 REFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAI------EKPKALSLMLHTADISHP 380
Query 69 VLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLF 128
W H WT EF+ QGD EA LG SPLCDR++ + +A+SQVGF+ +V P F
Sbjct 381 AKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKS-TMVAQSQVGFIDFIVEPTF 439
Query 129 AEL 131
L
Sbjct 440 TVL 442
> mmu:18575 Pde1c; phosphodiesterase 1C (EC:3.1.4.17); K13755
calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase
[EC:3.1.4.17]
Length=631
Score = 88.2 bits (217), Expect = 9e-18, Method: Compositional matrix adjust.
Identities = 45/123 (36%), Positives = 69/123 (56%), Gaps = 7/123 (5%)
Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHG 68
RE R+ +I++++ATDM HF+ + +T + + ++ A+ L + +DI H
Sbjct 327 REFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAI------EKPKALSLMLHTADISHP 380
Query 69 VLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLF 128
W H WT EF+ QGD EA LG SPLCDR++ + +A+SQVGF+ +V P F
Sbjct 381 AKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKS-TMVAQSQVGFIDFIVEPTF 439
Query 129 AEL 131
L
Sbjct 440 TVL 442
> tgo:TGME49_057950 3'5'-cyclic nucleotide phosphodiesterase domain-containing
protein (EC:3.1.4.17)
Length=587
Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust.
Identities = 44/114 (38%), Positives = 67/114 (58%), Gaps = 1/114 (0%)
Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHG 68
R R ++I+LI+ TDM HF L F+ R++ N++DR + +++ ++A+DIGH
Sbjct 283 RNFRKEVIELIVHTDMTKHFSLLALFKVKRQTGGLDIVNNEEDRSMLLKMLLKAADIGHA 342
Query 69 VLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETH-SQLAKSQVGFLR 121
+ HF + EF+ QGDEE + G ISPLCDR+ Q+ SQ GFL+
Sbjct 343 TKAFDFHFFLSCCLIEEFHRQGDEEKKRGMVISPLCDRQQELRQIFSSQAGFLQ 396
> dre:100151215 phosphodiesterase 7A-like (EC:3.1.4.17); K01120
3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17]
Length=490
Score = 85.9 bits (211), Expect = 5e-17, Method: Compositional matrix adjust.
Identities = 46/136 (33%), Positives = 77/136 (56%), Gaps = 2/136 (1%)
Query 3 VVAAEVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRA 62
+ A + + ++ LILATD+ E+L+RFRT + + + N R +++ ++
Sbjct 304 LPAEDSLSIERQLGSLILATDISRQNEYLSRFRTHLDENDLNLG-NASHRHFVLQMALKC 362
Query 63 SDIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRH 122
+DI + W+ +W+ + T EF+ QGD E +L ISPLCD E ++ +A Q+GF+ +
Sbjct 363 ADICNPCRPWELSKQWSEKVTEEFFHQGDIEKKLKLEISPLCDSEANT-IASVQIGFMTY 421
Query 123 VVRPLFAELQAIDDQK 138
VV PLFAE D +
Sbjct 422 VVEPLFAEWARFSDTR 437
> cel:T04D3.3 pde-1; PhosphoDiEsterase family member (pde-1);
K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide
phosphodiesterase [EC:3.1.4.17]
Length=664
Score = 83.2 bits (204), Expect = 3e-16, Method: Composition-based stats.
Identities = 45/120 (37%), Positives = 66/120 (55%), Gaps = 7/120 (5%)
Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIG 66
E +E+R+ +I+++LATDM THF + +++ + D+ A+ L + A DI
Sbjct 429 EYKELRNMVIEIVLATDMSTHFMQIKTMKSMLSLPE------GIDKNKALCLIVHACDIS 482
Query 67 HGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRP 126
H W H WT EF+ QGD EA +G SPLCDR T +A SQ+GF+ +V P
Sbjct 483 HPAKPWNLHERWTEGVLEEFFRQGDLEASMGLPYSPLCDRHT-VHVADSQIGFIDFIVEP 541
> mmu:18583 Pde7a, AU015378, AW047537; phosphodiesterase 7A (EC:3.1.4.17);
K01120 3',5'-cyclic-nucleotide phosphodiesterase
[EC:3.1.4.17]
Length=482
Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust.
Identities = 45/131 (34%), Positives = 76/131 (58%), Gaps = 4/131 (3%)
Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDD-DRWLAVELCIRASDIGH 67
+E+ ++I LILATD+ E+L+ FR+ D+ +D R L +++ ++ +DI +
Sbjct 308 QEMEAQIGALILATDISRQNEYLSLFRS--HLDKGDLHLDDGRHRHLVLQMALKCADICN 365
Query 68 GVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPL 127
W+ +W+ + T EF+ QGD E + +SPLCDR+T S +A Q+GF+ ++V PL
Sbjct 366 PCRNWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRQTES-IANIQIGFMTYLVEPL 424
Query 128 FAELQAIDDQK 138
F E D +
Sbjct 425 FTEWARFSDTR 435
> hsa:5141 PDE4A, DPDE2, PDE4, PDE46; phosphodiesterase 4A, cAMP-specific
(EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase
[EC:3.1.4.17]
Length=886
Score = 79.0 bits (193), Expect = 5e-15, Method: Compositional matrix adjust.
Identities = 42/125 (33%), Positives = 68/125 (54%), Gaps = 6/125 (4%)
Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFS-----FRRNDDDRWLAVELCIRAS 63
+ +R +ID++LATDM H L +T+ E+ + + N DR + + +
Sbjct 531 QSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA 590
Query 64 DIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123
D+ + + + +WT R EF+ QGD E G ISP+CD+ T S + KSQVGF+ ++
Sbjct 591 DLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTAS-VEKSQVGFIDYI 649
Query 124 VRPLF 128
V PL+
Sbjct 650 VHPLW 654
> mmu:18577 Pde4a, D9Ertd60e, Dpde2; phosphodiesterase 4A, cAMP
specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase
[EC:3.1.4.17]
Length=610
Score = 79.0 bits (193), Expect = 6e-15, Method: Compositional matrix adjust.
Identities = 42/125 (33%), Positives = 68/125 (54%), Gaps = 6/125 (4%)
Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFS-----FRRNDDDRWLAVELCIRAS 63
+ +R +ID++LATDM H L +T+ E+ + + N DR + + +
Sbjct 283 QSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA 342
Query 64 DIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123
D+ + + + +WT R EF+ QGD E G ISP+CD+ T S + KSQVGF+ ++
Sbjct 343 DLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTAS-VEKSQVGFIDYI 401
Query 124 VRPLF 128
V PL+
Sbjct 402 VHPLW 406
> cel:E01F3.1 pde-3; PhosphoDiEsterase family member (pde-3);
K13296 cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17]
Length=578
Score = 79.0 bits (193), Expect = 6e-15, Method: Composition-based stats.
Identities = 48/123 (39%), Positives = 69/123 (56%), Gaps = 6/123 (4%)
Query 6 AEVREVRSKIIDLILATDMRTHFEFLNRF-RTIRESDQFSFRRNDDDRWLAVELCIRASD 64
AE++ R +++ ILATD++ HFE + F + E D + + DR L +L I+ +D
Sbjct 376 AEMKRFRYLVLEYILATDLKQHFEIIMTFTERLTEIDV----QVETDRLLIGKLLIKMAD 431
Query 65 IGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVV 124
I + H +WT R EFY QGD+E R G I+P DR +Q+AK Q F+ HVV
Sbjct 432 INSPTKPYGLHRQWTDRICEEFYEQGDDERRRGLPITPYMDR-GDAQVAKLQDSFIAHVV 490
Query 125 RPL 127
PL
Sbjct 491 SPL 493
> mmu:238871 Pde4d, 9630011N22Rik, Dpde3; phosphodiesterase 4D,
cAMP specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide
phosphodiesterase [EC:3.1.4.17]
Length=747
Score = 78.2 bits (191), Expect = 9e-15, Method: Compositional matrix adjust.
Identities = 41/125 (32%), Positives = 68/125 (54%), Gaps = 6/125 (4%)
Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFS-----FRRNDDDRWLAVELCIRAS 63
+ +R +ID++LATDM H L +T+ E+ + + N DR ++ + +
Sbjct 499 QSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCA 558
Query 64 DIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123
D+ + + + +WT R EF+ QGD E G ISP+CD+ S + KSQVGF+ ++
Sbjct 559 DLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNAS-VEKSQVGFIDYI 617
Query 124 VRPLF 128
V PL+
Sbjct 618 VHPLW 622
> xla:444562 pde4b, MGC83972; phosphodiesterase 4B, cAMP-specific;
K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17]
Length=721
Score = 77.8 bits (190), Expect = 1e-14, Method: Composition-based stats.
Identities = 43/125 (34%), Positives = 68/125 (54%), Gaps = 6/125 (4%)
Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFS-----FRRNDDDRWLAVELCIRAS 63
+ +R +IDL+LATDM H L +T+ E+ + + N DR + + +
Sbjct 490 QSLRKMVIDLVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCA 549
Query 64 DIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123
D+ + + + +WT R EF+ QGD E G ISP+CD+ T S + KSQVGF+ ++
Sbjct 550 DLSNPTKSLELYRQWTDRIMEEFFQQGDRERERGMEISPMCDKHTAS-VEKSQVGFIDYI 608
Query 124 VRPLF 128
V PL+
Sbjct 609 VHPLW 613
> mmu:18578 Pde4b, Dpde4, R74983, dunce; phosphodiesterase 4B,
cAMP specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide
phosphodiesterase [EC:3.1.4.17]
Length=564
Score = 77.4 bits (189), Expect = 1e-14, Method: Composition-based stats.
Identities = 42/125 (33%), Positives = 69/125 (55%), Gaps = 6/125 (4%)
Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFS-----FRRNDDDRWLAVELCIRAS 63
+ +R +ID++LATDM H L +T+ E+ + + N DR + + +
Sbjct 332 QTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCA 391
Query 64 DIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123
D+ + + + +WT R EF+ QGD+E G ISP+CD+ T S + KSQVGF+ ++
Sbjct 392 DLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTAS-VEKSQVGFIDYI 450
Query 124 VRPLF 128
V PL+
Sbjct 451 VHPLW 455
> hsa:5142 PDE4B, DKFZp686F2182, DPDE4, MGC126529, PDE4B5, PDEIVB;
phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17); K01120
3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17]
Length=564
Score = 77.4 bits (189), Expect = 1e-14, Method: Composition-based stats.
Identities = 42/125 (33%), Positives = 69/125 (55%), Gaps = 6/125 (4%)
Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFS-----FRRNDDDRWLAVELCIRAS 63
+ +R +ID++LATDM H L +T+ E+ + + N DR + + +
Sbjct 332 QTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCA 391
Query 64 DIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123
D+ + + + +WT R EF+ QGD+E G ISP+CD+ T S + KSQVGF+ ++
Sbjct 392 DLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTAS-VEKSQVGFIDYI 450
Query 124 VRPLF 128
V PL+
Sbjct 451 VHPLW 455
> hsa:5144 PDE4D, DKFZp686M11213, DPDE3, FLJ97311, HSPDE4D, PDE4DN2,
STRK1; phosphodiesterase 4D, cAMP-specific (EC:3.1.4.17);
K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17]
Length=809
Score = 77.4 bits (189), Expect = 2e-14, Method: Compositional matrix adjust.
Identities = 41/125 (32%), Positives = 68/125 (54%), Gaps = 6/125 (4%)
Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFS-----FRRNDDDRWLAVELCIRAS 63
+ +R +ID++LATDM H L +T+ E+ + + N DR ++ + +
Sbjct 560 QSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCA 619
Query 64 DIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123
D+ + + + +WT R EF+ QGD E G ISP+CD+ S + KSQVGF+ ++
Sbjct 620 DLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNAS-VEKSQVGFIDYI 678
Query 124 VRPLF 128
V PL+
Sbjct 679 VHPLW 683
> dre:565706 cAMP-specific 3,5-cyclic phosphodiesterase 4B-like;
K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17]
Length=713
Score = 77.0 bits (188), Expect = 2e-14, Method: Composition-based stats.
Identities = 42/123 (34%), Positives = 67/123 (54%), Gaps = 6/123 (4%)
Query 11 VRSKIIDLILATDMRTHFEFLNRFRTIRESDQFS-----FRRNDDDRWLAVELCIRASDI 65
+R +ID++LATDM H L +T+ E+ + + N DR + + +D+
Sbjct 484 LRRMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADL 543
Query 66 GHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVR 125
+ + + +WT R EF+ QGD E G ISP+CD+ T S + KSQVGF+ ++V
Sbjct 544 SNPTKSLELYRQWTDRIMEEFFHQGDRERERGMEISPMCDKHTAS-VEKSQVGFIDYIVH 602
Query 126 PLF 128
PL+
Sbjct 603 PLW 605
> hsa:5143 PDE4C, DPDE1, MGC126222; phosphodiesterase 4C, cAMP-specific
(EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase
[EC:3.1.4.17]
Length=712
Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust.
Identities = 41/123 (33%), Positives = 66/123 (53%), Gaps = 6/123 (4%)
Query 11 VRSKIIDLILATDMRTHFEFLNRFRTIRESDQFS-----FRRNDDDRWLAVELCIRASDI 65
+R +ID++LATDM H L +T+ E+ + + N DR ++ + +D+
Sbjct 488 LRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADL 547
Query 66 GHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVR 125
+ + +WT R EF+ QGD E G ISP+CD+ T S + KSQVGF+ ++
Sbjct 548 SNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTAS-VEKSQVGFIDYIAH 606
Query 126 PLF 128
PL+
Sbjct 607 PLW 609
> hsa:5150 PDE7A, HCP1, PDE7; phosphodiesterase 7A (EC:3.1.4.17);
K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17]
Length=456
Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust.
Identities = 41/122 (33%), Positives = 71/122 (58%), Gaps = 2/122 (1%)
Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHG 68
+++ ++I LILATD+ E+L+ FR+ + + R L +++ ++ +DI +
Sbjct 282 QQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLE-DTRHRHLVLQMALKCADICNP 340
Query 69 VLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLF 128
W+ +W+ + T EF+ QGD E + +SPLCDR T S +A Q+GF+ ++V PLF
Sbjct 341 CRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTES-IANIQIGFMTYLVEPLF 399
Query 129 AE 130
E
Sbjct 400 TE 401
> dre:565259 pde4c, im:7160317, si:dkey-149i17.5; phosphodiesterase
4C, cAMP-specific (phosphodiesterase E1 dunce homolog,
Drosophila)
Length=672
Score = 76.6 bits (187), Expect = 3e-14, Method: Composition-based stats.
Identities = 41/125 (32%), Positives = 68/125 (54%), Gaps = 6/125 (4%)
Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFS-----FRRNDDDRWLAVELCIRAS 63
+ +R +ID++LATDM H L +T+ E+ + + N DR ++ + +
Sbjct 472 QSLRKMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNMVHCA 531
Query 64 DIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123
D+ + + + +WT R EF+ QGD E G ISP+CD+ S + KSQVGF+ ++
Sbjct 532 DLSNPTKPLELYRQWTDRIMVEFFTQGDRERDKGMEISPMCDKHNAS-IEKSQVGFIDYI 590
Query 124 VRPLF 128
V PL+
Sbjct 591 VHPLW 595
> dre:572061 pde4a; phosphodiesterase 4A, cAMP-specific; K01120
3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17]
Length=736
Score = 76.6 bits (187), Expect = 3e-14, Method: Compositional matrix adjust.
Identities = 41/125 (32%), Positives = 69/125 (55%), Gaps = 6/125 (4%)
Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFS-----FRRNDDDRWLAVELCIRAS 63
+ +R +ID++LATDM H L +T+ E+ + + + +DR + + +
Sbjct 490 QSLRKLVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLMLDHYNDRIQVLRNMVHCA 549
Query 64 DIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123
D+ + + +WT R EF+ QGD+E G ISP+CD+ T S + KSQVGF+ ++
Sbjct 550 DLSNPTKPLAVYRQWTERIMEEFFQQGDKERERGMEISPMCDKHTAS-VEKSQVGFIDYI 608
Query 124 VRPLF 128
V PL+
Sbjct 609 VHPLW 613
Lambda K H
0.325 0.137 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 2938175820
Database: egene_temp_file_orthology_annotation_similarity_blast_database_866
Posted date: Sep 17, 2011 2:57 PM
Number of letters in database: 82,071,388
Number of sequences in database: 164,496
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40