bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schaffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: egene_temp_file_orthology_annotation_similarity_blast_database_866 164,496 sequences; 82,071,388 total letters Query= Eten_0849_orf1 Length=147 Score E Sequences producing significant alignments: (Bits) Value tgo:TGME49_118680 3',5'--cyclic-nucleotide phosphodiesterase, ... 176 3e-44 tgo:TGME49_024840 cAMP phosphodiesterase, putative (EC:3.1.4.1... 152 4e-37 pfa:MAL13P1.118 3',5'-cyclic nucleotide phosphodiesterase (EC:... 143 2e-34 tgo:TGME49_041880 3', 5'-cyclic nucleotide phosphodiesterase, ... 139 2e-33 tgo:TGME49_110520 calcium/calmodulin-dependent 3', 5'-cyclic n... 137 9e-33 tgo:TGME49_002540 3',5'-cyclic nucleotide phosphodiesterase, p... 135 4e-32 cpv:cgd3_2320 cGMP phosphodiesterase A4 130 2e-30 tgo:TGME49_026770 cGMP-inhibited 3',5'-cyclic phosphodiesteras... 128 7e-30 tgo:TGME49_080410 3',5'-cyclic phosphodiesterase, putative (EC... 127 2e-29 tgo:TGME49_072650 calcium/calmodulin-dependent 3',5'-cyclic nu... 125 6e-29 tgo:TGME49_066920 phosphodiesterase, putative (EC:3.1.4.17) 117 2e-26 tpv:TP01_1200 hypothetical protein 110 2e-24 pfa:PFL0475w PDE1; cGMP-specific phosphodiesterase (EC:3.1.4.1... 108 4e-24 dre:564465 pde1a; phosphodiesterase 1A, calmodulin-dependent; ... 102 5e-22 mmu:18573 Pde1a, AI987702, AW125737, MGC116577; phosphodiester... 100 2e-21 hsa:5136 PDE1A, HCAM1, HSPDE1A, MGC26303; phosphodiesterase 1A... 99.8 3e-21 bbo:BBOV_IV010070 23.m06154; 3'5'-cyclic nucleotide phosphodie... 98.2 7e-21 bbo:BBOV_IV006510 23.m05980; 3'5'-cyclic nucleotide phosphodie... 97.8 1e-20 pfa:MAL13P1.119 calcium/calmodulin-dependent 3',5'-cyclic nucl... 95.9 4e-20 tgo:TGME49_057080 cAMP-specific 3',5'-cyclic phosphodiesterase... 95.5 5e-20 tpv:TP01_0664 3',5' cyclic nucleotide phosphodiesterase; K0112... 94.4 1e-19 mmu:18574 Pde1b, 63kDa, Pde1b1; phosphodiesterase 1B, Ca2+-cal... 93.6 2e-19 mmu:54611 Pde3a, A930022O17Rik, C87899; phosphodiesterase 3A, ... 93.2 2e-19 hsa:5139 PDE3A, CGI-PDE; phosphodiesterase 3A, cGMP-inhibited ... 92.4 5e-19 hsa:5153 PDE1B, PDE1B1, PDES1B; phosphodiesterase 1B, calmodul... 92.0 6e-19 dre:567051 si:dkey-48h7.2; K13296 cGMP-inhibited 3',5'-cyclic ... 91.7 8e-19 hsa:5140 PDE3B, HcGIP1, cGIPDE1; phosphodiesterase 3B, cGMP-in... 90.9 1e-18 tgo:TGME49_020420 3'5'-cyclic nucleotide phosphodiesterase, pu... 90.1 2e-18 xla:496104 pde3b; phosphodiesterase 3b, cGMP-inhibited; K13296... 89.7 3e-18 dre:563432 pde3b; phosphodiesterase 3B, cGMP-inhibited; K13296... 89.4 4e-18 mmu:18576 Pde3b, 9830102A01Rik, AI847709; phosphodiesterase 3B... 88.2 7e-18 hsa:5137 PDE1C, Hcam3; phosphodiesterase 1C, calmodulin-depend... 88.2 8e-18 mmu:18575 Pde1c; phosphodiesterase 1C (EC:3.1.4.17); K13755 ca... 88.2 9e-18 tgo:TGME49_057950 3'5'-cyclic nucleotide phosphodiesterase dom... 87.4 1e-17 dre:100151215 phosphodiesterase 7A-like (EC:3.1.4.17); K01120 ... 85.9 5e-17 cel:T04D3.3 pde-1; PhosphoDiEsterase family member (pde-1); K1... 83.2 3e-16 mmu:18583 Pde7a, AU015378, AW047537; phosphodiesterase 7A (EC:... 80.5 2e-15 hsa:5141 PDE4A, DPDE2, PDE4, PDE46; phosphodiesterase 4A, cAMP... 79.0 5e-15 mmu:18577 Pde4a, D9Ertd60e, Dpde2; phosphodiesterase 4A, cAMP ... 79.0 6e-15 cel:E01F3.1 pde-3; PhosphoDiEsterase family member (pde-3); K1... 79.0 6e-15 mmu:238871 Pde4d, 9630011N22Rik, Dpde3; phosphodiesterase 4D, ... 78.2 9e-15 xla:444562 pde4b, MGC83972; phosphodiesterase 4B, cAMP-specifi... 77.8 1e-14 mmu:18578 Pde4b, Dpde4, R74983, dunce; phosphodiesterase 4B, c... 77.4 1e-14 hsa:5142 PDE4B, DKFZp686F2182, DPDE4, MGC126529, PDE4B5, PDEIV... 77.4 1e-14 hsa:5144 PDE4D, DKFZp686M11213, DPDE3, FLJ97311, HSPDE4D, PDE4... 77.4 2e-14 dre:565706 cAMP-specific 3,5-cyclic phosphodiesterase 4B-like;... 77.0 2e-14 hsa:5143 PDE4C, DPDE1, MGC126222; phosphodiesterase 4C, cAMP-s... 77.0 2e-14 hsa:5150 PDE7A, HCP1, PDE7; phosphodiesterase 7A (EC:3.1.4.17)... 77.0 2e-14 dre:565259 pde4c, im:7160317, si:dkey-149i17.5; phosphodiester... 76.6 3e-14 dre:572061 pde4a; phosphodiesterase 4A, cAMP-specific; K01120 ... 76.6 3e-14 > tgo:TGME49_118680 3',5'--cyclic-nucleotide phosphodiesterase, putative (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=812 Score = 176 bits (445), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 77/141 (54%), Positives = 105/141 (74%), Gaps = 0/141 (0%) Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIG 66 E + VR+ +IDLILATDM+THF+FL+RFR R++ F+F + +D+WLA E+CIRASD+G Sbjct 470 EFKHVRANMIDLILATDMKTHFDFLSRFRNRRQAPGFNFHKVAEDQWLAAEICIRASDLG 529 Query 67 HGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRP 126 H + W QHFEW +R TEFYLQG+EE RLG +SPLCDR+ H +K Q GFL +VV+P Sbjct 530 HAMTEWDQHFEWASRVVTEFYLQGEEERRLGLHVSPLCDRDDHPSFSKCQHGFLGYVVKP 589 Query 127 LFAELQAIDDQKKPIAEMLKN 147 L AEL D ++ I ++++N Sbjct 590 LIAELGECDTLQRIIPQLMQN 610 > tgo:TGME49_024840 cAMP phosphodiesterase, putative (EC:3.1.4.17 1.1.99.3) Length=1324 Score = 152 bits (384), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 65/130 (50%), Positives = 89/130 (68%), Gaps = 0/130 (0%) Query 6 AEVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDI 65 + R +R +I+ ILATDM+ HFE L+RFR R S +F++ +N +DRW +C++ +DI Sbjct 839 SSFRYIRQYVIECILATDMKQHFESLSRFRIRRNSPEFNYVKNVEDRWFVARMCVKVADI 898 Query 66 GHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVR 125 GH + W QHFEW++R EFYLQGDEE +SPLCDR+ H+ +AKSQ GFL VV+ Sbjct 899 GHSCVPWNQHFEWSSRVVEEFYLQGDEERSRNMPVSPLCDRDKHADMAKSQGGFLEFVVK 958 Query 126 PLFAELQAID 135 PL E+ ID Sbjct 959 PLIKEIDEID 968 > pfa:MAL13P1.118 3',5'-cyclic nucleotide phosphodiesterase (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=1139 Score = 143 bits (361), Expect = 2e-34, Method: Composition-based stats. Identities = 61/132 (46%), Positives = 91/132 (68%), Gaps = 0/132 (0%) Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIG 66 + R +RS II+LIL+TDM+ HFE +++FR RE++ F + +N DD + ++ I+++DI Sbjct 943 DFRMMRSYIIELILSTDMKHHFEIISKFRIRRENEDFDYIKNSDDLLILTKMIIKSADIS 1002 Query 67 HGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRP 126 HG + W +H+ W R +EFY QGDEE + +SPLCDR H+++ KSQ+ FL+ VV P Sbjct 1003 HGSVSWSEHYCWCQRVLSEFYTQGDEELKNKMPLSPLCDRTKHNEVCKSQITFLKFVVMP 1062 Query 127 LFAELQAIDDQK 138 LF EL ID+ K Sbjct 1063 LFEELSHIDNNK 1074 > tgo:TGME49_041880 3', 5'-cyclic nucleotide phosphodiesterase, putative (EC:2.1.1.43 3.1.4.17) Length=1281 Score = 139 bits (351), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 62/125 (49%), Positives = 85/125 (68%), Gaps = 1/125 (0%) Query 11 VRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHGVL 70 VR+++IDLILATDM+ HFE +++FR R S F R NDDD W+ + +CI+ D+ HG+L Sbjct 964 VRNRMIDLILATDMKMHFEMVSKFRLRRNSPDFC-RTNDDDVWMLLRMCIKGGDLSHGLL 1022 Query 71 GWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLFAE 130 W H W+ RA +EFY QGD E GRTI+P+ DR H+ K Q GFLR ++ PL+ E Sbjct 1023 SWDSHVSWSYRAASEFYEQGDLELAQGRTITPMFDRRKHADFPKGQEGFLRFIIIPLYEE 1082 Query 131 LQAID 135 + A+D Sbjct 1083 IAAVD 1087 > tgo:TGME49_110520 calcium/calmodulin-dependent 3', 5'-cyclic nucleotide phosphodiesterase, putative (EC:3.4.21.69 3.1.4.17) Length=1531 Score = 137 bits (346), Expect = 9e-33, Method: Compositional matrix adjust. Identities = 66/146 (45%), Positives = 89/146 (60%), Gaps = 7/146 (4%) Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHG 68 R R II LILATD++ HFE ++RFR R S +F+F + ++D WL ++ + +DI H Sbjct 1316 RIARQNIITLILATDIKQHFETISRFRLRRNSPEFNFLKKEEDDWLVRKMIFKIADISHA 1375 Query 69 VLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLF 128 + W HF W+ + EFY QGD E RLG +SPLCDRE H ++ KSQV FL VV PL Sbjct 1376 TVAWDAHFFWSCKVNAEFYAQGDAEVRLGLPVSPLCDREKHFEMGKSQVAFLNFVVEPLL 1435 Query 129 AELQAIDDQKKPIA-------EMLKN 147 EL+AI+ P+ E+L N Sbjct 1436 RELEAIEALVLPLGTCPIISTELLPN 1461 > tgo:TGME49_002540 3',5'-cyclic nucleotide phosphodiesterase, putative (EC:3.1.4.17 1.6.99.5) Length=1670 Score = 135 bits (340), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 65/125 (52%), Positives = 86/125 (68%), Gaps = 1/125 (0%) Query 11 VRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHGVL 70 VRS IIDLILATDM+ HFE ++RFR R + F +++D W AV++ ++ +D+ H + Sbjct 1438 VRSLIIDLILATDMKNHFETVSRFRVRRNALDFDLS-SEEDFWFAVKIIMKCADLSHCSV 1496 Query 71 GWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLFAE 130 W QHF+W R + EFY QGDEE +SPLCDRE HS++AKSQ+GF+ V PLF E Sbjct 1497 PWSQHFQWCQRLSVEFYDQGDEEVARHLPMSPLCDREKHSEVAKSQLGFMSFVAVPLFEE 1556 Query 131 LQAID 135 L AID Sbjct 1557 LMAID 1561 > cpv:cgd3_2320 cGMP phosphodiesterase A4 Length=997 Score = 130 bits (326), Expect = 2e-30, Method: Composition-based stats. Identities = 64/142 (45%), Positives = 89/142 (62%), Gaps = 4/142 (2%) Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHG 68 +E R +I+LIL TDM HFE ++RFR R++ + + DR + C++A+DIGHG Sbjct 826 KEFRRIVIELILETDMHRHFECVSRFRVRRQAVDWDPYGDAQDRLMLARTCLKAADIGHG 885 Query 69 VLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLF 128 L W QH++W EF+LQGDEE L ISP+CDRE+ + + KSQVGFL V PLF Sbjct 886 ALKWNQHYKWCRSVVEEFFLQGDEEKALSLPISPICDRES-TDVPKSQVGFLNFVCLPLF 944 Query 129 AELQAID---DQKKPIAEMLKN 147 EL +D D ++ I +L+N Sbjct 945 QELCYVDVEGDVRRCIDRILEN 966 > tgo:TGME49_026770 cGMP-inhibited 3',5'-cyclic phosphodiesterase, putative (EC:3.1.4.17) Length=995 Score = 128 bits (321), Expect = 7e-30, Method: Compositional matrix adjust. Identities = 61/130 (46%), Positives = 82/130 (63%), Gaps = 1/130 (0%) Query 3 VVAAEVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRA 62 + AE R R +I+LILATDM HF ++ R RES F+F N++DRW+ +LC++ Sbjct 398 ITPAEYRYFRKHLIELILATDMSQHFSTISTVRVRRESRTFNFITNEEDRWMMKKLCMKI 457 Query 63 SDIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHS-QLAKSQVGFLR 121 DIGH L W QH++W+ R T EF LQGD E + G +SPLCDR +L KSQ F+ Sbjct 458 GDIGHAALDWDQHYKWSMRVTEEFLLQGDAELKAGLPVSPLCDRNAPEIELHKSQSSFIN 517 Query 122 HVVRPLFAEL 131 ++V PL EL Sbjct 518 YLVVPLINEL 527 > tgo:TGME49_080410 3',5'-cyclic phosphodiesterase, putative (EC:3.1.4.17 1.6.5.3); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=1085 Score = 127 bits (318), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 62/130 (47%), Positives = 84/130 (64%), Gaps = 1/130 (0%) Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHG 68 R R +I+LI++TDM+THFE + FR R+ ++F N DDR + + I+++DIGHG Sbjct 911 RSFRMTVIELIMSTDMKTHFEQIANFRVRRQKEEFDPINNYDDRQKVMSMIIKSADIGHG 970 Query 69 VLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHS-QLAKSQVGFLRHVVRPL 127 L W H W EFY QGDEE RLG +S LCDR+ H + KSQVGFL VV+PL Sbjct 971 TLPWADHERWCNLVVQEFYEQGDEEKRLGLPVSFLCDRDQHDREFFKSQVGFLDFVVKPL 1030 Query 128 FAELQAIDDQ 137 + EL+A++ Q Sbjct 1031 YEELKALETQ 1040 > tgo:TGME49_072650 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative (EC:3.1.4.17) Length=1320 Score = 125 bits (313), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 61/128 (47%), Positives = 80/128 (62%), Gaps = 0/128 (0%) Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIG 66 + R+VR K I+LIL+TDM HFEFL R RE+ F+F ++DR L + L I+ +D+G Sbjct 1159 QYRDVRKKAIELILSTDMSLHFEFLTRVAARRENPDFNFVDREEDRALVLSLAIKVADLG 1218 Query 67 HGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRP 126 H L W+ H W+AR EF QGDEE RLG +SPLCDR QLA+SQ F+ + P Sbjct 1219 HCALDWEAHTLWSARLKEEFLAQGDEELRLGLPVSPLCDRTQQGQLARSQANFIEFLFLP 1278 Query 127 LFAELQAI 134 L L A+ Sbjct 1279 LAQHLAAV 1286 > tgo:TGME49_066920 phosphodiesterase, putative (EC:3.1.4.17) Length=1065 Score = 117 bits (292), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 55/125 (44%), Positives = 78/125 (62%), Gaps = 0/125 (0%) Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIG 66 + R VRSK+I+ ILATDM+ HFE ++RFR +D F ++ DDRW +++ ++ +DI Sbjct 710 QFRFVRSKLIEAILATDMKQHFETISRFRLRTSADDFDVAKHVDDRWAVLKMFVKMADIS 769 Query 67 HGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRP 126 H L W HF + EFY QGDEE R G +S LCDR H+++ KSQ GF+ + +P Sbjct 770 HVALPWDMHFRLSCDIVEEFYQQGDEELRRGMPLSQLCDRSKHNEMPKSQEGFIEFLAKP 829 Query 127 LFAEL 131 L L Sbjct 830 LVGVL 834 > tpv:TP01_1200 hypothetical protein Length=840 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 56/128 (43%), Positives = 75/128 (58%), Gaps = 3/128 (2%) Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIG 66 E++ VR KII LIL+TD+ HF+ + +FR R S +FS D ++ I+ASDIG Sbjct 701 EMKIVRRKIIQLILSTDLEDHFQTITQFRVRRASREFSVEGEIDT---ICKMLIKASDIG 757 Query 67 HGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRP 126 + W+ EW+ R EFY QG EE LG I+PLCD H+ L K+Q GFL V P Sbjct 758 SSCMEWRLTLEWSQRLVQEFYTQGLEELSLGLPITPLCDPNKHNHLPKAQSGFLAIFVIP 817 Query 127 LFAELQAI 134 L+ E+ I Sbjct 818 LYTEIANI 825 > pfa:PFL0475w PDE1; cGMP-specific phosphodiesterase (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=954 Score = 108 bits (271), Expect = 4e-24, Method: Composition-based stats. Identities = 56/123 (45%), Positives = 73/123 (59%), Gaps = 1/123 (0%) Query 12 RSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHGVLG 71 + II IL+TDM+ HFE+++ FRT +E + ND W L ++ASDIGH L Sbjct 781 KKNIIKAILSTDMKNHFEYISDFRTSKEFIDYDNLSNDQ-IWQIFCLILKASDIGHSTLE 839 Query 72 WKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLFAEL 131 W +H EWT + EFYLQG E L S LCD T ++LA SQ+ FL+H+ PLF EL Sbjct 840 WNKHLEWTLKINEEFYLQGLLEKSLNIQNSFLCDINTMNKLALSQIDFLKHLCIPLFNEL 899 Query 132 QAI 134 I Sbjct 900 NYI 902 > dre:564465 pde1a; phosphodiesterase 1A, calmodulin-dependent; K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=625 Score = 102 bits (254), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 53/138 (38%), Positives = 87/138 (63%), Gaps = 9/138 (6%) Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHG 68 RE+R+ +I+++++TDM HF+ + +T+R S Q + D+ A+ L + A+DI H Sbjct 320 RELRTLVIEMVMSTDMSCHFQ---QIKTMRNSLQ---QPEGIDKAKALSLMLHAADISHP 373 Query 69 VLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLF 128 GWK H+ WT EF+ QGD+EA LG SPLCDR+ + +A+SQ+GF+ +V P F Sbjct 374 AKGWKLHYRWTQALMEEFFRQGDKEAELGLPFSPLCDRKA-TMIAQSQIGFIDFIVEPTF 432 Query 129 AELQAIDDQKKPIAEMLK 146 + L +D +K I+ +++ Sbjct 433 SVL--VDTTEKIISPLIE 448 > mmu:18573 Pde1a, AI987702, AW125737, MGC116577; phosphodiesterase 1A, calmodulin-dependent (EC:3.1.4.17); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=545 Score = 100 bits (248), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 51/123 (41%), Positives = 77/123 (62%), Gaps = 7/123 (5%) Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHG 68 R++R+ +I+++LATDM HF+ + + IR S Q + DR + L + A+DI H Sbjct 317 RDLRNLVIEMVLATDMSGHFQ---QIKNIRNSLQ---QPEGIDRAKTMSLILHAADISHP 370 Query 69 VLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLF 128 WK H+ WT EF+LQGD+EA LG SPLCDR++ + +A+SQ+GF+ +V P F Sbjct 371 AKTWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKS-TMVAQSQIGFIDFIVEPTF 429 Query 129 AEL 131 + L Sbjct 430 SLL 432 > hsa:5136 PDE1A, HCAM1, HSPDE1A, MGC26303; phosphodiesterase 1A, calmodulin-dependent (EC:3.1.4.17); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=535 Score = 99.8 bits (247), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 50/123 (40%), Positives = 77/123 (62%), Gaps = 7/123 (5%) Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHG 68 R++R+ +I+++L+TDM HF+ + + IR S Q + DR + L + A+DI H Sbjct 317 RDLRNLVIEMVLSTDMSGHFQ---QIKNIRNSLQ---QPEGIDRAKTMSLILHAADISHP 370 Query 69 VLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLF 128 WK H+ WT EF+LQGD+EA LG SPLCDR++ + +A+SQ+GF+ +V P F Sbjct 371 AKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKS-TMVAQSQIGFIDFIVEPTF 429 Query 129 AEL 131 + L Sbjct 430 SLL 432 > bbo:BBOV_IV010070 23.m06154; 3'5'-cyclic nucleotide phosphodiesterase (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=485 Score = 98.2 bits (243), Expect = 7e-21, Method: Composition-based stats. Identities = 49/135 (36%), Positives = 71/135 (52%), Gaps = 0/135 (0%) Query 11 VRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHGVL 70 +R +II L+LATDM THF +N + R S F + N +D W + L ++ +DIGH L Sbjct 310 IRKRIIQLVLATDMMTHFTHVNNVKERRLSGTFDYVNNPEDLWFCLVLLVKTADIGHNFL 369 Query 71 GWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLFAE 130 W +H WT EF++QGDEE L + DR + + SQ+GF + PL E Sbjct 370 PWCEHLPWTNALFDEFHMQGDEERLLSLPLLLFFDRTRSADIPDSQLGFFQGFTSPLIDE 429 Query 131 LQAIDDQKKPIAEML 145 L I+ + + L Sbjct 430 LTFINTNSTYLNDFL 444 > bbo:BBOV_IV006510 23.m05980; 3'5'-cyclic nucleotide phosphodiesterase (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=777 Score = 97.8 bits (242), Expect = 1e-20, Method: Composition-based stats. Identities = 56/141 (39%), Positives = 76/141 (53%), Gaps = 9/141 (6%) Query 11 VRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHGVL 70 VRS+II+ ILATD F +++F + D F+F + R L ++ ++A+D+ + Sbjct 595 VRSQIIEHILATDTVDQFHMISQFVLSCKRDDFTFEEYNS-RILTSKMLMKAADVAAPTM 653 Query 71 GWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLF-- 128 W EW +R EFY QG EE IS LCDR+ H Q AKSQ FLR VV PL+ Sbjct 654 QWANSLEWVSRLLGEFYAQGAEEVDYCIPISALCDRQHHEQSAKSQAAFLRIVVAPLYEA 713 Query 129 ------AELQAIDDQKKPIAE 143 E+ AI DQ + AE Sbjct 714 IASLGSPEIDAIMDQLEENAE 734 > pfa:MAL13P1.119 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1b (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=769 Score = 95.9 bits (237), Expect = 4e-20, Method: Composition-based stats. Identities = 45/126 (35%), Positives = 73/126 (57%), Gaps = 3/126 (2%) Query 11 VRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHGVL 70 +R +II+LILATDM H + L +FR + +N L +++ I+A+D+ H + Sbjct 588 LRQQIIELILATDMSKHIKILAQFRIKSIKIKSYIEKN---IILCLKMIIKAADLSHNCV 644 Query 71 GWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLFAE 130 W +H++W R EFY +GDE ++G I+PL DR H+ + Q FL+ +V PL Sbjct 645 DWSEHYQWVKRLVNEFYYEGDELFQMGYKINPLFDRNCHNNFIQIQRTFLKELVYPLIIS 704 Query 131 LQAIDD 136 L+ +D+ Sbjct 705 LKTLDN 710 > tgo:TGME49_057080 cAMP-specific 3',5'-cyclic phosphodiesterase, putative (EC:3.1.4.17) Length=1691 Score = 95.5 bits (236), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 52/134 (38%), Positives = 73/134 (54%), Gaps = 2/134 (1%) Query 4 VAAEVRE-VRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRA 62 +A EV + +R II LIL+TDM H +++R R ES F N+ DRWL + CI+A Sbjct 1440 LAKEVYQYMRQNIIGLILSTDMSKHISYVSRLRVRAESGNFDVN-NEGDRWLLFQGCIKA 1498 Query 63 SDIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRH 122 +D+ H W H W EF+ QGDEE R G + + DR + +SQ F+ Sbjct 1499 ADLAHTATFWDNHKRWAECLCEEFFKQGDEERRQGMNVMDIFDRRQKDRFPQSQYRFIEL 1558 Query 123 VVRPLFAELQAIDD 136 VV PLF + +I+D Sbjct 1559 VVEPLFNSVCSIED 1572 > tpv:TP01_0664 3',5' cyclic nucleotide phosphodiesterase; K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=450 Score = 94.4 bits (233), Expect = 1e-19, Method: Composition-based stats. Identities = 53/134 (39%), Positives = 72/134 (53%), Gaps = 11/134 (8%) Query 11 VRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHGVL 70 +R +II LIL+TDM HF ++ + R +F + NDDD WL + LCI+A+DIGH L Sbjct 269 LRKRIIQLILSTDMINHFLHIDNVKEKRLQGKFDIK-NDDDFWLLLVLCIKAADIGHNFL 327 Query 71 GWKQHFEWTARATTEFYLQGDEEARLGRTISPLC--DRETHSQLAKSQVGFLRHVV---- 124 W H WT EFY QGDEE ++ISPL DR + Q+ F + Sbjct 328 PWADHLPWTQVLFEEFYKQGDEEKM--QSISPLMFFDRNESRNIPILQLQFFNTMTQLLI 385 Query 125 --RPLFAELQAIDD 136 +PL +EL D+ Sbjct 386 LSQPLLSELNYFDE 399 > mmu:18574 Pde1b, 63kDa, Pde1b1; phosphodiesterase 1B, Ca2+-calmodulin dependent (EC:3.1.4.17); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=535 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 51/138 (36%), Positives = 80/138 (57%), Gaps = 8/138 (5%) Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIG 66 E E+R+ +I+++LATDM HF+ + +T + R D + A+ L + A+DI Sbjct 318 EFAELRALVIEMVLATDMSCHFQQVKTMKTALQQ----LERIDKSK--ALSLLLHAADIS 371 Query 67 HGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRP 126 H W H WT EF+ QGD+EA LG SPLCDR T + +A+SQ+GF+ +V P Sbjct 372 HPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDR-TSTLVAQSQIGFIDFIVEP 430 Query 127 LFAELQAIDDQK-KPIAE 143 F+ L + ++ +P+A+ Sbjct 431 TFSVLTDVAEKSVQPLAD 448 > mmu:54611 Pde3a, A930022O17Rik, C87899; phosphodiesterase 3A, cGMP inhibited (EC:3.1.4.17); K13296 cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17] Length=1141 Score = 93.2 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 49/121 (40%), Positives = 67/121 (55%), Gaps = 1/121 (0%) Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIG 66 E + R +I+ ILATD++ HF+F+ +F D N++DR L ++CI+ +DI Sbjct 893 EFKHFRFLVIEAILATDLKKHFDFVAKFNAKVNDDVGIDWTNENDRLLVCQMCIKLADIN 952 Query 67 HGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRP 126 + H WT +EFY QGDEEA LG ISP DR QLA Q F+ H+V P Sbjct 953 GPAKCKELHLRWTEGIASEFYEQGDEEASLGLPISPFMDRSA-PQLANLQESFISHIVGP 1011 Query 127 L 127 L Sbjct 1012 L 1012 > hsa:5139 PDE3A, CGI-PDE; phosphodiesterase 3A, cGMP-inhibited (EC:3.1.4.17); K13296 cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17] Length=1141 Score = 92.4 bits (228), Expect = 5e-19, Method: Composition-based stats. Identities = 49/121 (40%), Positives = 67/121 (55%), Gaps = 1/121 (0%) Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIG 66 E + R +I+ ILATD++ HF+F+ +F D N++DR L ++CI+ +DI Sbjct 893 EFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADIN 952 Query 67 HGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRP 126 + H +WT EFY QGDEEA LG ISP DR QLA Q F+ H+V P Sbjct 953 GPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSA-PQLANLQESFISHIVGP 1011 Query 127 L 127 L Sbjct 1012 L 1012 > hsa:5153 PDE1B, PDE1B1, PDES1B; phosphodiesterase 1B, calmodulin-dependent (EC:3.1.4.17); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=536 Score = 92.0 bits (227), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 51/138 (36%), Positives = 80/138 (57%), Gaps = 8/138 (5%) Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIG 66 E E+R+ +I+++LATDM HF+ + +T + R D + A+ L + A+DI Sbjct 319 EFVELRALVIEMVLATDMSCHFQQVKTMKTALQQ----LERIDKPK--ALSLLLHAADIS 372 Query 67 HGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRP 126 H W H WT EF+ QGD+EA LG SPLCDR T + +A+SQ+GF+ +V P Sbjct 373 HPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDR-TSTLVAQSQIGFIDFIVEP 431 Query 127 LFAELQAIDDQK-KPIAE 143 F+ L + ++ +P+A+ Sbjct 432 TFSVLTDVAEKSVQPLAD 449 > dre:567051 si:dkey-48h7.2; K13296 cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17] Length=1117 Score = 91.7 bits (226), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 54/126 (42%), Positives = 72/126 (57%), Gaps = 5/126 (3%) Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFR--RNDDDRWLAVELCIRASD 64 E + R +I+ ILATD++ HF+FL F D S N++DR L ++CI+ +D Sbjct 819 EFKRFRFLVIEAILATDLKKHFDFLAEFNAKVGDDGCSGIDWTNENDRLLVCQMCIKLAD 878 Query 65 IGHGVLGWKQ-HFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123 I +G L K H +WT EFY QGDEE+ LG ISP DR QLAK Q F+ H+ Sbjct 879 I-NGPLKCKDLHLQWTEGIVNEFYEQGDEESSLGLPISPFMDRSA-PQLAKLQESFITHI 936 Query 124 VRPLFA 129 V PL + Sbjct 937 VGPLCS 942 > hsa:5140 PDE3B, HcGIP1, cGIPDE1; phosphodiesterase 3B, cGMP-inhibited (EC:3.1.4.17); K13296 cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17] Length=1112 Score = 90.9 bits (224), Expect = 1e-18, Method: Composition-based stats. Identities = 52/124 (41%), Positives = 70/124 (56%), Gaps = 5/124 (4%) Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFR---RNDDDRWLAVELCIRAS 63 E + R +I+ ILATD++ HF+FL F + +D S N++DR L ++CI+ + Sbjct 878 EFKRFRFLVIEAILATDLKKHFDFLAEFNA-KANDVNSNGIEWSNENDRLLVCQVCIKLA 936 Query 64 DIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123 DI H +WT EFY QGDEEA LG ISP DR + QLAK Q F+ H+ Sbjct 937 DINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRSS-PQLAKLQESFITHI 995 Query 124 VRPL 127 V PL Sbjct 996 VGPL 999 > tgo:TGME49_020420 3'5'-cyclic nucleotide phosphodiesterase, putative (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=466 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 53/165 (32%), Positives = 80/165 (48%), Gaps = 34/165 (20%) Query 4 VAAEVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQF-----------SFRRND--- 49 + + +++ R II+L+L TD+ HF+F+ RFR R F SF +N Sbjct 289 LCSMIQDFRKLIIELVLETDILFHFDFIGRFRLRRPMSPFFKLLGERGANPSFGQNPVSL 348 Query 50 -------------------DDRWLAVELCIRASDIGHGVLGWKQHFEWTARATTEFYLQG 90 D L + CIR++D+GH + W+QH+ ++ TEF+ QG Sbjct 349 LSSPSRTATDVEATSKEEAQDLTLLAKACIRSADVGHAAVEWRQHYFYSKAVQTEFFNQG 408 Query 91 DEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLFAELQAID 135 E RL ISP CD + + K Q GF+ ++ RPLF EL I+ Sbjct 409 KAEKRLRLRISPCCD-PVSTDVPKCQDGFISYISRPLFEELALIN 452 > xla:496104 pde3b; phosphodiesterase 3b, cGMP-inhibited; K13296 cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17] Length=985 Score = 89.7 bits (221), Expect = 3e-18, Method: Composition-based stats. Identities = 48/123 (39%), Positives = 69/123 (56%), Gaps = 3/123 (2%) Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRT-IRESDQFSFR-RNDDDRWLAVELCIRASD 64 + + R +I+ ILATD++ HF+FL F + + + N++DR L ++CI+ +D Sbjct 747 QFKRFRFLVIEAILATDLKKHFDFLAEFNAKVNDVNGLGIDWSNENDRLLVCQVCIKLAD 806 Query 65 IGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVV 124 I + H +WT EFY QGDEE+ LG ISP DR QLAK Q F+ H+V Sbjct 807 INGPAKTRELHLKWTEGIVNEFYEQGDEESSLGLPISPFMDRSA-PQLAKLQESFITHIV 865 Query 125 RPL 127 PL Sbjct 866 GPL 868 > dre:563432 pde3b; phosphodiesterase 3B, cGMP-inhibited; K13296 cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17] Length=1107 Score = 89.4 bits (220), Expect = 4e-18, Method: Composition-based stats. Identities = 49/123 (39%), Positives = 68/123 (55%), Gaps = 3/123 (2%) Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRT-IRESDQFSFR-RNDDDRWLAVELCIRASD 64 E + R +I+ ILATD++ HF+FL F + + + + N++DR L ++CI+ +D Sbjct 867 EFKRFRFLVIEAILATDLKKHFDFLAEFNSKVNDVNSPGIDWTNENDRLLVCQVCIKLAD 926 Query 65 IGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVV 124 I H +WT EFY QGDEE LG ISP DR QLAK Q F+ H+V Sbjct 927 INGPAKDRSLHLKWTEGIVNEFYEQGDEEGTLGLPISPFMDRSA-PQLAKLQESFITHIV 985 Query 125 RPL 127 PL Sbjct 986 GPL 988 > mmu:18576 Pde3b, 9830102A01Rik, AI847709; phosphodiesterase 3B, cGMP-inhibited (EC:3.1.4.17); K13296 cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17] Length=1099 Score = 88.2 bits (217), Expect = 7e-18, Method: Composition-based stats. Identities = 51/124 (41%), Positives = 69/124 (55%), Gaps = 5/124 (4%) Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFR---RNDDDRWLAVELCIRAS 63 E + R +I+ ILATD++ HF+FL F + +D S +++DR L ++CI+ + Sbjct 854 EFKRFRFLVIEAILATDLKKHFDFLAEFNA-KANDVNSNGIEWSSENDRLLVCQVCIKLA 912 Query 64 DIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123 DI H WT EFY QGDEEA LG ISP DR + QLAK Q F+ H+ Sbjct 913 DINGPAKDRDLHLRWTEGIVNEFYEQGDEEATLGLPISPFMDRSS-PQLAKLQESFITHI 971 Query 124 VRPL 127 V PL Sbjct 972 VGPL 975 > hsa:5137 PDE1C, Hcam3; phosphodiesterase 1C, calmodulin-dependent 70kDa (EC:3.1.4.17); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=634 Score = 88.2 bits (217), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 45/123 (36%), Positives = 69/123 (56%), Gaps = 7/123 (5%) Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHG 68 RE R+ +I++++ATDM HF+ + +T + + ++ A+ L + +DI H Sbjct 327 REFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAI------EKPKALSLMLHTADISHP 380 Query 69 VLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLF 128 W H WT EF+ QGD EA LG SPLCDR++ + +A+SQVGF+ +V P F Sbjct 381 AKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKS-TMVAQSQVGFIDFIVEPTF 439 Query 129 AEL 131 L Sbjct 440 TVL 442 > mmu:18575 Pde1c; phosphodiesterase 1C (EC:3.1.4.17); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=631 Score = 88.2 bits (217), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 45/123 (36%), Positives = 69/123 (56%), Gaps = 7/123 (5%) Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHG 68 RE R+ +I++++ATDM HF+ + +T + + ++ A+ L + +DI H Sbjct 327 REFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAI------EKPKALSLMLHTADISHP 380 Query 69 VLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLF 128 W H WT EF+ QGD EA LG SPLCDR++ + +A+SQVGF+ +V P F Sbjct 381 AKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKS-TMVAQSQVGFIDFIVEPTF 439 Query 129 AEL 131 L Sbjct 440 TVL 442 > tgo:TGME49_057950 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein (EC:3.1.4.17) Length=587 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 44/114 (38%), Positives = 67/114 (58%), Gaps = 1/114 (0%) Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHG 68 R R ++I+LI+ TDM HF L F+ R++ N++DR + +++ ++A+DIGH Sbjct 283 RNFRKEVIELIVHTDMTKHFSLLALFKVKRQTGGLDIVNNEEDRSMLLKMLLKAADIGHA 342 Query 69 VLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETH-SQLAKSQVGFLR 121 + HF + EF+ QGDEE + G ISPLCDR+ Q+ SQ GFL+ Sbjct 343 TKAFDFHFFLSCCLIEEFHRQGDEEKKRGMVISPLCDRQQELRQIFSSQAGFLQ 396 > dre:100151215 phosphodiesterase 7A-like (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=490 Score = 85.9 bits (211), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 46/136 (33%), Positives = 77/136 (56%), Gaps = 2/136 (1%) Query 3 VVAAEVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRA 62 + A + + ++ LILATD+ E+L+RFRT + + + N R +++ ++ Sbjct 304 LPAEDSLSIERQLGSLILATDISRQNEYLSRFRTHLDENDLNLG-NASHRHFVLQMALKC 362 Query 63 SDIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRH 122 +DI + W+ +W+ + T EF+ QGD E +L ISPLCD E ++ +A Q+GF+ + Sbjct 363 ADICNPCRPWELSKQWSEKVTEEFFHQGDIEKKLKLEISPLCDSEANT-IASVQIGFMTY 421 Query 123 VVRPLFAELQAIDDQK 138 VV PLFAE D + Sbjct 422 VVEPLFAEWARFSDTR 437 > cel:T04D3.3 pde-1; PhosphoDiEsterase family member (pde-1); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=664 Score = 83.2 bits (204), Expect = 3e-16, Method: Composition-based stats. Identities = 45/120 (37%), Positives = 66/120 (55%), Gaps = 7/120 (5%) Query 7 EVREVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIG 66 E +E+R+ +I+++LATDM THF + +++ + D+ A+ L + A DI Sbjct 429 EYKELRNMVIEIVLATDMSTHFMQIKTMKSMLSLPE------GIDKNKALCLIVHACDIS 482 Query 67 HGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRP 126 H W H WT EF+ QGD EA +G SPLCDR T +A SQ+GF+ +V P Sbjct 483 HPAKPWNLHERWTEGVLEEFFRQGDLEASMGLPYSPLCDRHT-VHVADSQIGFIDFIVEP 541 > mmu:18583 Pde7a, AU015378, AW047537; phosphodiesterase 7A (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=482 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 45/131 (34%), Positives = 76/131 (58%), Gaps = 4/131 (3%) Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDD-DRWLAVELCIRASDIGH 67 +E+ ++I LILATD+ E+L+ FR+ D+ +D R L +++ ++ +DI + Sbjct 308 QEMEAQIGALILATDISRQNEYLSLFRS--HLDKGDLHLDDGRHRHLVLQMALKCADICN 365 Query 68 GVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPL 127 W+ +W+ + T EF+ QGD E + +SPLCDR+T S +A Q+GF+ ++V PL Sbjct 366 PCRNWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRQTES-IANIQIGFMTYLVEPL 424 Query 128 FAELQAIDDQK 138 F E D + Sbjct 425 FTEWARFSDTR 435 > hsa:5141 PDE4A, DPDE2, PDE4, PDE46; phosphodiesterase 4A, cAMP-specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=886 Score = 79.0 bits (193), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 42/125 (33%), Positives = 68/125 (54%), Gaps = 6/125 (4%) Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFS-----FRRNDDDRWLAVELCIRAS 63 + +R +ID++LATDM H L +T+ E+ + + N DR + + + Sbjct 531 QSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA 590 Query 64 DIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123 D+ + + + +WT R EF+ QGD E G ISP+CD+ T S + KSQVGF+ ++ Sbjct 591 DLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTAS-VEKSQVGFIDYI 649 Query 124 VRPLF 128 V PL+ Sbjct 650 VHPLW 654 > mmu:18577 Pde4a, D9Ertd60e, Dpde2; phosphodiesterase 4A, cAMP specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=610 Score = 79.0 bits (193), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 42/125 (33%), Positives = 68/125 (54%), Gaps = 6/125 (4%) Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFS-----FRRNDDDRWLAVELCIRAS 63 + +R +ID++LATDM H L +T+ E+ + + N DR + + + Sbjct 283 QSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA 342 Query 64 DIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123 D+ + + + +WT R EF+ QGD E G ISP+CD+ T S + KSQVGF+ ++ Sbjct 343 DLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTAS-VEKSQVGFIDYI 401 Query 124 VRPLF 128 V PL+ Sbjct 402 VHPLW 406 > cel:E01F3.1 pde-3; PhosphoDiEsterase family member (pde-3); K13296 cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17] Length=578 Score = 79.0 bits (193), Expect = 6e-15, Method: Composition-based stats. Identities = 48/123 (39%), Positives = 69/123 (56%), Gaps = 6/123 (4%) Query 6 AEVREVRSKIIDLILATDMRTHFEFLNRF-RTIRESDQFSFRRNDDDRWLAVELCIRASD 64 AE++ R +++ ILATD++ HFE + F + E D + + DR L +L I+ +D Sbjct 376 AEMKRFRYLVLEYILATDLKQHFEIIMTFTERLTEIDV----QVETDRLLIGKLLIKMAD 431 Query 65 IGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVV 124 I + H +WT R EFY QGD+E R G I+P DR +Q+AK Q F+ HVV Sbjct 432 INSPTKPYGLHRQWTDRICEEFYEQGDDERRRGLPITPYMDR-GDAQVAKLQDSFIAHVV 490 Query 125 RPL 127 PL Sbjct 491 SPL 493 > mmu:238871 Pde4d, 9630011N22Rik, Dpde3; phosphodiesterase 4D, cAMP specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=747 Score = 78.2 bits (191), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 41/125 (32%), Positives = 68/125 (54%), Gaps = 6/125 (4%) Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFS-----FRRNDDDRWLAVELCIRAS 63 + +R +ID++LATDM H L +T+ E+ + + N DR ++ + + Sbjct 499 QSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCA 558 Query 64 DIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123 D+ + + + +WT R EF+ QGD E G ISP+CD+ S + KSQVGF+ ++ Sbjct 559 DLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNAS-VEKSQVGFIDYI 617 Query 124 VRPLF 128 V PL+ Sbjct 618 VHPLW 622 > xla:444562 pde4b, MGC83972; phosphodiesterase 4B, cAMP-specific; K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=721 Score = 77.8 bits (190), Expect = 1e-14, Method: Composition-based stats. Identities = 43/125 (34%), Positives = 68/125 (54%), Gaps = 6/125 (4%) Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFS-----FRRNDDDRWLAVELCIRAS 63 + +R +IDL+LATDM H L +T+ E+ + + N DR + + + Sbjct 490 QSLRKMVIDLVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCA 549 Query 64 DIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123 D+ + + + +WT R EF+ QGD E G ISP+CD+ T S + KSQVGF+ ++ Sbjct 550 DLSNPTKSLELYRQWTDRIMEEFFQQGDRERERGMEISPMCDKHTAS-VEKSQVGFIDYI 608 Query 124 VRPLF 128 V PL+ Sbjct 609 VHPLW 613 > mmu:18578 Pde4b, Dpde4, R74983, dunce; phosphodiesterase 4B, cAMP specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=564 Score = 77.4 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 42/125 (33%), Positives = 69/125 (55%), Gaps = 6/125 (4%) Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFS-----FRRNDDDRWLAVELCIRAS 63 + +R +ID++LATDM H L +T+ E+ + + N DR + + + Sbjct 332 QTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCA 391 Query 64 DIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123 D+ + + + +WT R EF+ QGD+E G ISP+CD+ T S + KSQVGF+ ++ Sbjct 392 DLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTAS-VEKSQVGFIDYI 450 Query 124 VRPLF 128 V PL+ Sbjct 451 VHPLW 455 > hsa:5142 PDE4B, DKFZp686F2182, DPDE4, MGC126529, PDE4B5, PDEIVB; phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=564 Score = 77.4 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 42/125 (33%), Positives = 69/125 (55%), Gaps = 6/125 (4%) Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFS-----FRRNDDDRWLAVELCIRAS 63 + +R +ID++LATDM H L +T+ E+ + + N DR + + + Sbjct 332 QTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCA 391 Query 64 DIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123 D+ + + + +WT R EF+ QGD+E G ISP+CD+ T S + KSQVGF+ ++ Sbjct 392 DLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTAS-VEKSQVGFIDYI 450 Query 124 VRPLF 128 V PL+ Sbjct 451 VHPLW 455 > hsa:5144 PDE4D, DKFZp686M11213, DPDE3, FLJ97311, HSPDE4D, PDE4DN2, STRK1; phosphodiesterase 4D, cAMP-specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=809 Score = 77.4 bits (189), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 41/125 (32%), Positives = 68/125 (54%), Gaps = 6/125 (4%) Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFS-----FRRNDDDRWLAVELCIRAS 63 + +R +ID++LATDM H L +T+ E+ + + N DR ++ + + Sbjct 560 QSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCA 619 Query 64 DIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123 D+ + + + +WT R EF+ QGD E G ISP+CD+ S + KSQVGF+ ++ Sbjct 620 DLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNAS-VEKSQVGFIDYI 678 Query 124 VRPLF 128 V PL+ Sbjct 679 VHPLW 683 > dre:565706 cAMP-specific 3,5-cyclic phosphodiesterase 4B-like; K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=713 Score = 77.0 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 42/123 (34%), Positives = 67/123 (54%), Gaps = 6/123 (4%) Query 11 VRSKIIDLILATDMRTHFEFLNRFRTIRESDQFS-----FRRNDDDRWLAVELCIRASDI 65 +R +ID++LATDM H L +T+ E+ + + N DR + + +D+ Sbjct 484 LRRMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADL 543 Query 66 GHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVR 125 + + + +WT R EF+ QGD E G ISP+CD+ T S + KSQVGF+ ++V Sbjct 544 SNPTKSLELYRQWTDRIMEEFFHQGDRERERGMEISPMCDKHTAS-VEKSQVGFIDYIVH 602 Query 126 PLF 128 PL+ Sbjct 603 PLW 605 > hsa:5143 PDE4C, DPDE1, MGC126222; phosphodiesterase 4C, cAMP-specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=712 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 41/123 (33%), Positives = 66/123 (53%), Gaps = 6/123 (4%) Query 11 VRSKIIDLILATDMRTHFEFLNRFRTIRESDQFS-----FRRNDDDRWLAVELCIRASDI 65 +R +ID++LATDM H L +T+ E+ + + N DR ++ + +D+ Sbjct 488 LRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADL 547 Query 66 GHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVR 125 + + +WT R EF+ QGD E G ISP+CD+ T S + KSQVGF+ ++ Sbjct 548 SNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTAS-VEKSQVGFIDYIAH 606 Query 126 PLF 128 PL+ Sbjct 607 PLW 609 > hsa:5150 PDE7A, HCP1, PDE7; phosphodiesterase 7A (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=456 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 41/122 (33%), Positives = 71/122 (58%), Gaps = 2/122 (1%) Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFSFRRNDDDRWLAVELCIRASDIGHG 68 +++ ++I LILATD+ E+L+ FR+ + + R L +++ ++ +DI + Sbjct 282 QQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLE-DTRHRHLVLQMALKCADICNP 340 Query 69 VLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHVVRPLF 128 W+ +W+ + T EF+ QGD E + +SPLCDR T S +A Q+GF+ ++V PLF Sbjct 341 CRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTES-IANIQIGFMTYLVEPLF 399 Query 129 AE 130 E Sbjct 400 TE 401 > dre:565259 pde4c, im:7160317, si:dkey-149i17.5; phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila) Length=672 Score = 76.6 bits (187), Expect = 3e-14, Method: Composition-based stats. Identities = 41/125 (32%), Positives = 68/125 (54%), Gaps = 6/125 (4%) Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFS-----FRRNDDDRWLAVELCIRAS 63 + +R +ID++LATDM H L +T+ E+ + + N DR ++ + + Sbjct 472 QSLRKMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNMVHCA 531 Query 64 DIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123 D+ + + + +WT R EF+ QGD E G ISP+CD+ S + KSQVGF+ ++ Sbjct 532 DLSNPTKPLELYRQWTDRIMVEFFTQGDRERDKGMEISPMCDKHNAS-IEKSQVGFIDYI 590 Query 124 VRPLF 128 V PL+ Sbjct 591 VHPLW 595 > dre:572061 pde4a; phosphodiesterase 4A, cAMP-specific; K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=736 Score = 76.6 bits (187), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 41/125 (32%), Positives = 69/125 (55%), Gaps = 6/125 (4%) Query 9 REVRSKIIDLILATDMRTHFEFLNRFRTIRESDQFS-----FRRNDDDRWLAVELCIRAS 63 + +R +ID++LATDM H L +T+ E+ + + + +DR + + + Sbjct 490 QSLRKLVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLMLDHYNDRIQVLRNMVHCA 549 Query 64 DIGHGVLGWKQHFEWTARATTEFYLQGDEEARLGRTISPLCDRETHSQLAKSQVGFLRHV 123 D+ + + +WT R EF+ QGD+E G ISP+CD+ T S + KSQVGF+ ++ Sbjct 550 DLSNPTKPLAVYRQWTERIMEEFFQQGDKERERGMEISPMCDKHTAS-VEKSQVGFIDYI 608 Query 124 VRPLF 128 V PL+ Sbjct 609 VHPLW 613 Lambda K H 0.325 0.137 0.413 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 2938175820 Database: egene_temp_file_orthology_annotation_similarity_blast_database_866 Posted date: Sep 17, 2011 2:57 PM Number of letters in database: 82,071,388 Number of sequences in database: 164,496 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40