bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schaffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: egene_temp_file_orthology_annotation_similarity_blast_database_866 164,496 sequences; 82,071,388 total letters Query= Eten_0992_orf1 Length=246 Score E Sequences producing significant alignments: (Bits) Value tgo:TGME49_118680 3',5'--cyclic-nucleotide phosphodiesterase, ... 204 3e-52 tgo:TGME49_024840 cAMP phosphodiesterase, putative (EC:3.1.4.1... 184 2e-46 tgo:TGME49_041880 3', 5'-cyclic nucleotide phosphodiesterase, ... 160 3e-39 tgo:TGME49_110520 calcium/calmodulin-dependent 3', 5'-cyclic n... 154 2e-37 pfa:MAL13P1.118 3',5'-cyclic nucleotide phosphodiesterase (EC:... 150 4e-36 tgo:TGME49_002540 3',5'-cyclic nucleotide phosphodiesterase, p... 150 6e-36 tgo:TGME49_066920 phosphodiesterase, putative (EC:3.1.4.17) 139 1e-32 tgo:TGME49_072650 calcium/calmodulin-dependent 3',5'-cyclic nu... 135 1e-31 cpv:cgd3_2320 cGMP phosphodiesterase A4 124 4e-28 pfa:PFL0475w PDE1; cGMP-specific phosphodiesterase (EC:3.1.4.1... 123 7e-28 tgo:TGME49_026770 cGMP-inhibited 3',5'-cyclic phosphodiesteras... 122 9e-28 tgo:TGME49_080410 3',5'-cyclic phosphodiesterase, putative (EC... 122 2e-27 tgo:TGME49_057080 cAMP-specific 3',5'-cyclic phosphodiesterase... 115 2e-25 tpv:TP01_1200 hypothetical protein 113 6e-25 pfa:MAL13P1.119 calcium/calmodulin-dependent 3',5'-cyclic nucl... 106 8e-23 mmu:18573 Pde1a, AI987702, AW125737, MGC116577; phosphodiester... 105 1e-22 hsa:5136 PDE1A, HCAM1, HSPDE1A, MGC26303; phosphodiesterase 1A... 105 2e-22 hsa:5153 PDE1B, PDE1B1, PDES1B; phosphodiesterase 1B, calmodul... 103 7e-22 mmu:18574 Pde1b, 63kDa, Pde1b1; phosphodiesterase 1B, Ca2+-cal... 103 7e-22 dre:564465 pde1a; phosphodiesterase 1A, calmodulin-dependent; ... 98.6 2e-20 bbo:BBOV_IV010070 23.m06154; 3'5'-cyclic nucleotide phosphodie... 97.4 4e-20 mmu:18575 Pde1c; phosphodiesterase 1C (EC:3.1.4.17); K13755 ca... 96.7 7e-20 hsa:5137 PDE1C, Hcam3; phosphodiesterase 1C, calmodulin-depend... 96.3 8e-20 tpv:TP01_0664 3',5' cyclic nucleotide phosphodiesterase; K0112... 95.1 2e-19 bbo:BBOV_IV006510 23.m05980; 3'5'-cyclic nucleotide phosphodie... 91.7 2e-18 mmu:18583 Pde7a, AU015378, AW047537; phosphodiesterase 7A (EC:... 87.8 3e-17 cel:T04D3.3 pde-1; PhosphoDiEsterase family member (pde-1); K1... 86.7 7e-17 mmu:18585 Pde9a, PDE9A1; phosphodiesterase 9A (EC:3.1.4.35); K... 84.3 3e-16 hsa:5152 PDE9A, FLJ90181, HSPDE9A2; phosphodiesterase 9A (EC:3... 84.0 5e-16 mmu:18578 Pde4b, Dpde4, R74983, dunce; phosphodiesterase 4B, c... 83.2 8e-16 hsa:5142 PDE4B, DKFZp686F2182, DPDE4, MGC126529, PDE4B5, PDEIV... 82.8 9e-16 hsa:5150 PDE7A, HCP1, PDE7; phosphodiesterase 7A (EC:3.1.4.17)... 82.8 1e-15 dre:565259 pde4c, im:7160317, si:dkey-149i17.5; phosphodiester... 82.8 1e-15 xla:444562 pde4b, MGC83972; phosphodiesterase 4B, cAMP-specifi... 82.8 1e-15 mmu:238871 Pde4d, 9630011N22Rik, Dpde3; phosphodiesterase 4D, ... 82.4 2e-15 dre:565706 cAMP-specific 3,5-cyclic phosphodiesterase 4B-like;... 82.0 2e-15 cel:R153.1 pde-4; PhosphoDiEsterase family member (pde-4); K01... 82.0 2e-15 mmu:18577 Pde4a, D9Ertd60e, Dpde2; phosphodiesterase 4A, cAMP ... 81.6 2e-15 hsa:5141 PDE4A, DPDE2, PDE4, PDE46; phosphodiesterase 4A, cAMP... 81.6 2e-15 dre:566998 novel protein similar to vertebrate phosphodiestera... 81.6 2e-15 tgo:TGME49_057950 3'5'-cyclic nucleotide phosphodiesterase dom... 80.9 4e-15 hsa:5144 PDE4D, DKFZp686M11213, DPDE3, FLJ97311, HSPDE4D, PDE4... 80.9 4e-15 dre:562357 phosphodiesterase 9A-like 80.5 5e-15 dre:572061 pde4a; phosphodiesterase 4A, cAMP-specific; K01120 ... 80.5 5e-15 dre:571344 fc68c05, si:ch211-255d18.8, wu:fc68c05; si:ch211-25... 79.7 8e-15 hsa:5143 PDE4C, DPDE1, MGC126222; phosphodiesterase 4C, cAMP-s... 79.7 8e-15 xla:495146 hypothetical LOC495146; K01120 3',5'-cyclic-nucleot... 79.7 1e-14 dre:567051 si:dkey-48h7.2; K13296 cGMP-inhibited 3',5'-cyclic ... 79.3 1e-14 mmu:54611 Pde3a, A930022O17Rik, C87899; phosphodiesterase 3A, ... 77.8 3e-14 hsa:5139 PDE3A, CGI-PDE; phosphodiesterase 3A, cGMP-inhibited ... 77.8 3e-14 > tgo:TGME49_118680 3',5'--cyclic-nucleotide phosphodiesterase, putative (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=812 Score = 204 bits (518), Expect = 3e-52, Method: Compositional matrix adjust. Identities = 93/197 (47%), Positives = 130/197 (65%), Gaps = 0/197 (0%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H LTF+VL CN+FA L+ +E VR+NMI LILATDMK+HF ++R R RQ P F Sbjct 447 HSALTFRVLGRHDCNVFAYLSDEEFKHVRANMIDLILATDMKTHFDFLSRFRNRRQAPGF 506 Query 63 DHRKQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPL 122 + K +D WL E+C+RA+D+GH++ WDQHFEW+SRV EFYLQG+EE R G +SPL Sbjct 507 NFHKVAEDQWLAAEICIRASDLGHAMTEWDQHFEWASRVVTEFYLQGEEERRLGLHVSPL 566 Query 123 CDRDLHSSMARNQVGFLEHLVKPLFVELHSVDSMKGAFQEAVNTIDANISRWQQLQDIGV 182 CDRD H S ++ Q GFL ++VKPL EL D+++ + + + N+ RW+ + GV Sbjct 567 CDRDDHPSFSKCQHGFLGYVVKPLIAELGECDTLQRIIPQLMQNLKENMERWEAFTNEGV 626 Query 183 DVTFSPVVMACEDRLKG 199 +V S +A + + +G Sbjct 627 NVVLSSAALAYDIKGQG 643 > tgo:TGME49_024840 cAMP phosphodiesterase, putative (EC:3.1.4.17 1.1.99.3) Length=1324 Score = 184 bits (467), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 85/184 (46%), Positives = 117/184 (63%), Gaps = 0/184 (0%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H LTF+ L + NIFA L + +R +I ILATDMK HF +++R R R +P F Sbjct 817 HSCLTFRTLENKDRNIFACLDESSFRYIRQYVIECILATDMKQHFESLSRFRIRRNSPEF 876 Query 63 DHRKQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPL 122 ++ K +D W + MC++ ADIGHS + W+QHFEWSSRV EFYLQGDEE +SPL Sbjct 877 NYVKNVEDRWFVARMCVKVADIGHSCVPWNQHFEWSSRVVEEFYLQGDEERSRNMPVSPL 936 Query 123 CDRDLHSSMARNQVGFLEHLVKPLFVELHSVDSMKGAFQEAVNTIDANISRWQQLQDIGV 182 CDRD H+ MA++Q GFLE +VKPL E+ +D + ++ I+ N +WQ+LQ+ G Sbjct 937 CDRDKHADMAKSQGGFLEFVVKPLIKEIDEIDPFGRVRSDILSHIEYNEKKWQELQESGT 996 Query 183 DVTF 186 +V Sbjct 997 EVVL 1000 > tgo:TGME49_041880 3', 5'-cyclic nucleotide phosphodiesterase, putative (EC:2.1.1.43 3.1.4.17) Length=1281 Score = 160 bits (406), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 79/201 (39%), Positives = 113/201 (56%), Gaps = 6/201 (2%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H LTFK+L+ CNIF L ++ VR+ MI LILATDMK HF +++ R R +P F Sbjct 937 HACLTFKILARPECNIFTHLPPEDFQIVRNRMIDLILATDMKMHFEMVSKFRLRRNSPDF 996 Query 63 DHRKQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPL 122 R DD W+++ MC++ D+ H +LSWD H WS R +EFY QGD E GR I+P+ Sbjct 997 -CRTNDDDVWMLLRMCIKGGDLSHGLLSWDSHVSWSYRAASEFYEQGDLELAQGRTITPM 1055 Query 123 CDRDLHSSMARNQVGFLEHLVKPLFVELHSVDSMKGAFQEAVNTIDANISRWQQLQDI-- 180 DR H+ + Q GFL ++ PL+ E+ +VD+ + AN RW+QLQ Sbjct 1056 FDRRKHADFPKGQEGFLRFIIIPLYEEIAAVDTTDVVQTCCLQNAVANSERWRQLQSSPE 1115 Query 181 ---GVDVTFSPVVMACEDRLK 198 +D ++ +DRL+ Sbjct 1116 EFEAIDAKHQAIICVLKDRLE 1136 > tgo:TGME49_110520 calcium/calmodulin-dependent 3', 5'-cyclic nucleotide phosphodiesterase, putative (EC:3.4.21.69 3.1.4.17) Length=1531 Score = 154 bits (390), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 69/155 (44%), Positives = 101/155 (65%), Gaps = 1/155 (0%) Query 3 HDVLTFKVLSHTS-CNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPH 61 H L F++LS N+F+ L ++ R N+I+LILATD+K HF I+R R R +P Sbjct 1290 HSALLFRILSEIPDSNVFSGLPQETFRIARQNIITLILATDIKQHFETISRFRLRRNSPE 1349 Query 62 FDHRKQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISP 121 F+ K+ +D WL+ +M + ADI H+ ++WD HF WS +V AEFY QGD E R G +SP Sbjct 1350 FNFLKKEEDDWLVRKMIFKIADISHATVAWDAHFFWSCKVNAEFYAQGDAEVRLGLPVSP 1409 Query 122 LCDRDLHSSMARNQVGFLEHLVKPLFVELHSVDSM 156 LCDR+ H M ++QV FL +V+PL EL +++++ Sbjct 1410 LCDREKHFEMGKSQVAFLNFVVEPLLRELEAIEAL 1444 > pfa:MAL13P1.118 3',5'-cyclic nucleotide phosphodiesterase (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=1139 Score = 150 bits (379), Expect = 4e-36, Method: Composition-based stats. Identities = 69/175 (39%), Positives = 108/175 (61%), Gaps = 0/175 (0%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H +TFK+L CNI + ++ + +RS +I LIL+TDMK HF I++ R R+N F Sbjct 920 HASITFKILQLNQCNILKNFSEKDFRMMRSYIIELILSTDMKHHFEIISKFRIRRENEDF 979 Query 63 DHRKQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPL 122 D+ K DD ++ +M +++ADI H +SW +H+ W RV +EFY QGDEE ++ +SPL Sbjct 980 DYIKNSDDLLILTKMIIKSADISHGSVSWSEHYCWCQRVLSEFYTQGDEELKNKMPLSPL 1039 Query 123 CDRDLHSSMARNQVGFLEHLVKPLFVELHSVDSMKGAFQEAVNTIDANISRWQQL 177 CDR H+ + ++Q+ FL+ +V PLF EL +D+ K + +++N W L Sbjct 1040 CDRTKHNEVCKSQITFLKFVVMPLFEELSHIDNNKFIKSFCLKRLNSNCIMWDTL 1094 > tgo:TGME49_002540 3',5'-cyclic nucleotide phosphodiesterase, putative (EC:3.1.4.17 1.6.99.5) Length=1670 Score = 150 bits (378), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 74/184 (40%), Positives = 106/184 (57%), Gaps = 1/184 (0%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H LTFK L C+IF SL + VRS +I LILATDMK+HF ++R R R F Sbjct 1411 HSCLTFKTLELPDCDIFFSLRTKDYHMVRSLIIDLILATDMKNHFETVSRFRVRRNALDF 1470 Query 63 DHRKQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPL 122 D + +D W +++ M+ AD+ H + W QHF+W R++ EFY QGDEE +SPL Sbjct 1471 DLSSE-EDFWFAVKIIMKCADLSHCSVPWSQHFQWCQRLSVEFYDQGDEEVARHLPMSPL 1529 Query 123 CDRDLHSSMARNQVGFLEHLVKPLFVELHSVDSMKGAFQEAVNTIDANISRWQQLQDIGV 182 CDR+ HS +A++Q+GF+ + PLF EL ++D + ++ + N S W+ L V Sbjct 1530 CDREKHSEVAKSQLGFMSFVAVPLFEELMAIDGTGNIEKYCISVMKTNASHWEALSSAAV 1589 Query 183 DVTF 186 V Sbjct 1590 PVPL 1593 > tgo:TGME49_066920 phosphodiesterase, putative (EC:3.1.4.17) Length=1065 Score = 139 bits (349), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 81/224 (36%), Positives = 111/224 (49%), Gaps = 9/224 (4%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H L F+ L N+F + ++ VRS +I ILATDMK HF I+R R F Sbjct 687 HCCLCFRTLQKEENNVFYYVDNEQFRFVRSKLIEAILATDMKQHFETISRFRLRTSADDF 746 Query 63 DHRKQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPL 122 D K DD W +++M ++ ADI H L WD HF S + EFY QGDEE R G +S L Sbjct 747 DVAKHVDDRWAVLKMFVKMADISHVALPWDMHFRLSCDIVEEFYQQGDEELRRGMPLSQL 806 Query 123 CDRDLHSSMARNQVGFLEHLVKPLFVELHSVDSMKGAFQEAVNTIDANISRWQQLQDIGV 182 CDR H+ M ++Q GF+E L KPL L DS E ++ N+ RW+Q+ V Sbjct 807 CDRSKHNEMPKSQEGFIEFLAKPLVGVLIEGDSTGTIKTEVSEQMERNLLRWKQMVADQV 866 Query 183 DVTFSPV---------VMACEDRLKGKDHVIDVSLITETRCRCP 217 V P+ + RL G + V I+++ + P Sbjct 867 VVPLRPLGPRTQVRTFTASAVRRLAGVESVQAAPTISQSVIKWP 910 > tgo:TGME49_072650 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative (EC:3.1.4.17) Length=1320 Score = 135 bits (340), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 71/177 (40%), Positives = 95/177 (53%), Gaps = 0/177 (0%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H LTF LSH NIF + +VR I LIL+TDM HF + R+ A R+NP F Sbjct 1136 HACLTFYTLSHRKSNIFRGKTVTQYRDVRKKAIELILSTDMSLHFEFLTRVAARRENPDF 1195 Query 63 DHRKQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPL 122 + + +D L++ + ++ AD+GH L W+ H WS+R+ EF QGDEE R G +SPL Sbjct 1196 NFVDREEDRALVLSLAIKVADLGHCALDWEAHTLWSARLKEEFLAQGDEELRLGLPVSPL 1255 Query 123 CDRDLHSSMARNQVGFLEHLVKPLFVELHSVDSMKGAFQEAVNTIDANISRWQQLQD 179 CDR +AR+Q F+E L PL L +V V NIS W+ QD Sbjct 1256 CDRTQQGQLARSQANFIEFLFLPLAQHLAAVAPDDRFEATVVTRARQNISMWEGAQD 1312 > cpv:cgd3_2320 cGMP phosphodiesterase A4 Length=997 Score = 124 bits (310), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 67/183 (36%), Positives = 103/183 (56%), Gaps = 5/183 (2%) Query 3 HDVLTFKVLSHT---SCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQN 59 H LTF+++ + + + S + E R +I LIL TDM HF ++R R RQ Sbjct 798 HASLTFRIIYYYGGGAADFLQSWDAELHKEFRRIVIELILETDMHRHFECVSRFRVRRQA 857 Query 60 PHFDHRKQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGI 119 +D D ++ C++AADIGH L W+QH++W V EF+LQGDEE I Sbjct 858 VDWDPYGDAQDRLMLARTCLKAADIGHGALKWNQHYKWCRSVVEEFFLQGDEEKALSLPI 917 Query 120 SPLCDRDLHSSMARNQVGFLEHLVKPLFVELHSVDSMKGAFQEAVNTIDANISRWQQLQD 179 SP+CDR+ + + ++QVGFL + PLF EL VD ++G + ++ I NI+ W+ + + Sbjct 918 SPICDRE-STDVPKSQVGFLNFVCLPLFQELCYVD-VEGDVRRCIDRILENINNWEDIAE 975 Query 180 IGV 182 G+ Sbjct 976 AGI 978 > pfa:PFL0475w PDE1; cGMP-specific phosphodiesterase (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=954 Score = 123 bits (308), Expect = 7e-28, Method: Composition-based stats. Identities = 62/173 (35%), Positives = 96/173 (55%), Gaps = 1/173 (0%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H L FK L + + NIF + + N+I IL+TDMK+HF I+ R +++ + Sbjct 753 HCSLLFKTLKNPNYNIFEHYPYHIFISCKKNIIKAILSTDMKNHFEYISDFRTSKEFIDY 812 Query 63 DHRKQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPL 122 D+ D W I + ++A+DIGHS L W++H EW+ ++ EFYLQG E S L Sbjct 813 DNLSN-DQIWQIFCLILKASDIGHSTLEWNKHLEWTLKINEEFYLQGLLEKSLNIQNSFL 871 Query 123 CDRDLHSSMARNQVGFLEHLVKPLFVELHSVDSMKGAFQEAVNTIDANISRWQ 175 CD + + +A +Q+ FL+HL PLF EL+ + + + I+ NI RW+ Sbjct 872 CDINTMNKLALSQIDFLKHLCIPLFNELNYICKNNDVYTHCIQPIENNIERWE 924 > tgo:TGME49_026770 cGMP-inhibited 3',5'-cyclic phosphodiesterase, putative (EC:3.1.4.17) Length=995 Score = 122 bits (307), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 62/160 (38%), Positives = 93/160 (58%), Gaps = 12/160 (7%) Query 3 HDVLTFKVLS-HTSC----------NIFASLAKDEILEVRSNMISLILATDMKSHFGAIN 51 H +TF+ L+ +TS ++ + E R ++I LILATDM HF I+ Sbjct 368 HAYITFRTLTCYTSTTDTNGQGCEGSVLKGITPAEYRYFRKHLIELILATDMSQHFSTIS 427 Query 52 RLRAARQNPHFDHRKQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDE 111 +R R++ F+ +D W++ ++CM+ DIGH+ L WDQH++WS RVT EF LQGD Sbjct 428 TVRVRRESRTFNFITNEEDRWMMKKLCMKIGDIGHAALDWDQHYKWSMRVTEEFLLQGDA 487 Query 112 EARHGRGISPLCDRDLHS-SMARNQVGFLEHLVKPLFVEL 150 E + G +SPLCDR+ + ++Q F+ +LV PL EL Sbjct 488 ELKAGLPVSPLCDRNAPEIELHKSQSSFINYLVVPLINEL 527 > tgo:TGME49_080410 3',5'-cyclic phosphodiesterase, putative (EC:3.1.4.17 1.6.5.3); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=1085 Score = 122 bits (305), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 69/181 (38%), Positives = 97/181 (53%), Gaps = 7/181 (3%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H LTFK+L + L ++ R +I LI++TDMK+HF I R RQ F Sbjct 886 HASLTFKLLLDRRLGLLNHLHREAYRSFRMTVIELIMSTDMKTHFEQIANFRVRRQKEEF 945 Query 63 DHRKQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPL 122 D DD +M M +++ADIGH L W H W + V EFY QGDEE R G +S L Sbjct 946 DPINNYDDRQKVMSMIIKSADIGHGTLPWADHERWCNLVVQEFYEQGDEEKRLGLPVSFL 1005 Query 123 CDRDLHS-SMARNQVGFLEHLVKPLFVELHSVDSMKGAFQE------AVNTIDANISRWQ 175 CDRD H ++QVGFL+ +VKPL+ EL ++++ + + + NIS W+ Sbjct 1006 CDRDQHDREFFKSQVGFLDFVVKPLYEELKALETQLNLNPQLPIENICLKNLQENISEWK 1065 Query 176 Q 176 + Sbjct 1066 K 1066 > tgo:TGME49_057080 cAMP-specific 3',5'-cyclic phosphodiesterase, putative (EC:3.1.4.17) Length=1691 Score = 115 bits (287), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 57/164 (34%), Positives = 95/164 (57%), Gaps = 5/164 (3%) Query 17 NIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHFDHRKQRDDTWLIME 76 NIF+ LAK+ +R N+I LIL+TDM H ++RLR ++ +FD + D WL+ + Sbjct 1435 NIFSGLAKEVYQYMRQNIIGLILSTDMSKHISYVSRLRVRAESGNFDVNNE-GDRWLLFQ 1493 Query 77 MCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPLCDRDLHSSMARNQV 136 C++AAD+ H+ WD H W+ + EF+ QGDEE R G + + DR ++Q Sbjct 1494 GCIKAADLAHTATFWDNHKRWAECLCEEFFKQGDEERRQGMNVMDIFDRRQKDRFPQSQY 1553 Query 137 GFLEHLVKPLFVELHSVDSM----KGAFQEAVNTIDANISRWQQ 176 F+E +V+PLF + S++ + G + T+ +N++RW++ Sbjct 1554 RFIELVVEPLFNSVCSIEDLLKGRGGVRGKICKTLSSNLARWKE 1597 > tpv:TP01_1200 hypothetical protein Length=840 Score = 113 bits (283), Expect = 6e-25, Method: Composition-based stats. Identities = 60/151 (39%), Positives = 87/151 (57%), Gaps = 5/151 (3%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H LTF VL + N+F+ L K+E+ VR +I LIL+TD++ HF I + R R + F Sbjct 680 HCCLTFNVLRQS--NLFSFLDKEEMKIVRRKIIQLILSTDLEDHFQTITQFRVRRASREF 737 Query 63 DHRKQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPL 122 + D I +M ++A+DIG S + W EWS R+ EFY QG EE G I+PL Sbjct 738 SVEGEIDT---ICKMLIKASDIGSSCMEWRLTLEWSQRLVQEFYTQGLEELSLGLPITPL 794 Query 123 CDRDLHSSMARNQVGFLEHLVKPLFVELHSV 153 CD + H+ + + Q GFL V PL+ E+ ++ Sbjct 795 CDPNKHNHLPKAQSGFLAIFVIPLYTEIANI 825 > pfa:MAL13P1.119 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1b (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=769 Score = 106 bits (265), Expect = 8e-23, Method: Composition-based stats. Identities = 55/178 (30%), Positives = 98/178 (55%), Gaps = 8/178 (4%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAIN--RLRAARQNP 60 H F +L NIF + +L +R +I LILATDM H + R+++ + Sbjct 561 HCSYLFNILLKDENNIFKNEDPKCLLALRQQIIELILATDMSKHIKILAQFRIKSIKIKS 620 Query 61 HFDHRKQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGIS 120 + + + L ++M ++AAD+ H+ + W +H++W R+ EFY +GDE + G I+ Sbjct 621 YIE-----KNIILCLKMIIKAADLSHNCVDWSEHYQWVKRLVNEFYYEGDELFQMGYKIN 675 Query 121 PLCDRDLHSSMARNQVGFLEHLVKPLFVELHSVDSMKGAFQEAVNTIDANISRWQQLQ 178 PL DR+ H++ + Q FL+ LV PL + L ++D+ Q+ +N + N S+W +++ Sbjct 676 PLFDRNCHNNFIQIQRTFLKELVYPLIISLKTLDNTS-ITQDMINNVKRNYSKWTKIE 732 > mmu:18573 Pde1a, AI987702, AW125737, MGC116577; phosphodiesterase 1A, calmodulin-dependent (EC:3.1.4.17); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=545 Score = 105 bits (262), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 50/140 (35%), Positives = 83/140 (59%), Gaps = 7/140 (5%) Query 8 FKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHFDHRKQ 67 ++++ NI +L+KD+ ++R+ +I ++LATDM HF I +R + Q P R + Sbjct 297 YRLMQEEEMNILVNLSKDDWRDLRNLVIEMVLATDMSGHFQQIKNIRNSLQQPEGIDRAK 356 Query 68 RDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPLCDRDL 127 M + + AADI H +W H+ W+ + EF+LQGD+EA G SPLCDR Sbjct 357 ------TMSLILHAADISHPAKTWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRK- 409 Query 128 HSSMARNQVGFLEHLVKPLF 147 + +A++Q+GF++ +V+P F Sbjct 410 STMVAQSQIGFIDFIVEPTF 429 > hsa:5136 PDE1A, HCAM1, HSPDE1A, MGC26303; phosphodiesterase 1A, calmodulin-dependent (EC:3.1.4.17); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=535 Score = 105 bits (261), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 50/140 (35%), Positives = 83/140 (59%), Gaps = 7/140 (5%) Query 8 FKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHFDHRKQ 67 ++++ NI +L+KD+ ++R+ +I ++L+TDM HF I +R + Q P R + Sbjct 297 YRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAK 356 Query 68 RDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPLCDRDL 127 M + + AADI H SW H+ W+ + EF+LQGD+EA G SPLCDR Sbjct 357 ------TMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRK- 409 Query 128 HSSMARNQVGFLEHLVKPLF 147 + +A++Q+GF++ +V+P F Sbjct 410 STMVAQSQIGFIDFIVEPTF 429 > hsa:5153 PDE1B, PDE1B1, PDES1B; phosphodiesterase 1B, calmodulin-dependent (EC:3.1.4.17); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=536 Score = 103 bits (256), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 53/146 (36%), Positives = 84/146 (57%), Gaps = 7/146 (4%) Query 8 FKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHFDHRKQ 67 F+++ NIF +L KDE +E+R+ +I ++LATDM HF + ++ A Q + + Sbjct 301 FRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQ------QLE 354 Query 68 RDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPLCDRDL 127 R D + + + AADI H W H W+ + EF+ QGD+EA G SPLCDR Sbjct 355 RIDKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRT- 413 Query 128 HSSMARNQVGFLEHLVKPLFVELHSV 153 + +A++Q+GF++ +V+P F L V Sbjct 414 STLVAQSQIGFIDFIVEPTFSVLTDV 439 > mmu:18574 Pde1b, 63kDa, Pde1b1; phosphodiesterase 1B, Ca2+-calmodulin dependent (EC:3.1.4.17); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=535 Score = 103 bits (256), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 53/146 (36%), Positives = 83/146 (56%), Gaps = 7/146 (4%) Query 8 FKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHFDHRKQ 67 F+++ NIF +L KDE E+R+ +I ++LATDM HF + ++ A Q + + Sbjct 300 FRMMQDDEMNIFINLTKDEFAELRALVIEMVLATDMSCHFQQVKTMKTALQ------QLE 353 Query 68 RDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPLCDRDL 127 R D + + + AADI H W H W+ + EF+ QGD+EA G SPLCDR Sbjct 354 RIDKSKALSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRT- 412 Query 128 HSSMARNQVGFLEHLVKPLFVELHSV 153 + +A++Q+GF++ +V+P F L V Sbjct 413 STLVAQSQIGFIDFIVEPTFSVLTDV 438 > dre:564465 pde1a; phosphodiesterase 1A, calmodulin-dependent; K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=625 Score = 98.6 bits (244), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 48/145 (33%), Positives = 82/145 (56%), Gaps = 7/145 (4%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H ++++ NI +L+KD+ E+R+ +I ++++TDM HF I +R + Q P Sbjct 295 HVSAAYRLMQEDEMNILVNLSKDDWRELRTLVIEMVMSTDMSCHFQQIKTMRNSLQQP-- 352 Query 63 DHRKQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPL 122 + D + + + AADI H W H+ W+ + EF+ QGD+EA G SPL Sbjct 353 ----EGIDKAKALSLMLHAADISHPAKGWKLHYRWTQALMEEFFRQGDKEAELGLPFSPL 408 Query 123 CDRDLHSSMARNQVGFLEHLVKPLF 147 CDR + +A++Q+GF++ +V+P F Sbjct 409 CDRKA-TMIAQSQIGFIDFIVEPTF 432 > bbo:BBOV_IV010070 23.m06154; 3'5'-cyclic nucleotide phosphodiesterase (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=485 Score = 97.4 bits (241), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 51/172 (29%), Positives = 89/172 (51%), Gaps = 6/172 (3%) Query 30 VRSNMISLILATDMKSHFGAINRLRAARQNPHFDHRKQRDDTWLIMEMCMRAADIGHSIL 89 +R +I L+LATDM +HF +N ++ R + FD+ +D W + + ++ ADIGH+ L Sbjct 310 IRKRIIQLVLATDMMTHFTHVNNVKERRLSGTFDYVNNPEDLWFCLVLLVKTADIGHNFL 369 Query 90 SWDQHFEWSSRVTAEFYLQGDEEARHGRGISPLCDRDLHSSMARNQVGFLEHLVKPLFVE 149 W +H W++ + EF++QGDEE + DR + + +Q+GF + PL E Sbjct 370 PWCEHLPWTNALFDEFHMQGDEERLLSLPLLLFFDRTRSADIPDSQLGFFQGFTSPLIDE 429 Query 150 LHSVDSMKGAFQEAVN-TIDANISRWQ-----QLQDIGVDVTFSPVVMACED 195 L +++ + +N N+ W+ QL +I +D+ S V +D Sbjct 430 LTFINTNSTYLNDFLNANAHDNLEHWKKNSKRQLVEIVIDLEKSEEVFEIKD 481 > mmu:18575 Pde1c; phosphodiesterase 1C (EC:3.1.4.17); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=631 Score = 96.7 bits (239), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 49/135 (36%), Positives = 76/135 (56%), Gaps = 7/135 (5%) Query 16 CNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHFDHRKQRDDTWLIM 75 NI +L+KD+ E R+ +I +++ATDM HF I ++ A Q P + + + Sbjct 315 MNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPK------AL 368 Query 76 EMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPLCDRDLHSSMARNQ 135 + + ADI H +WD H W+ + EF+ QGD EA G SPLCDR + +A++Q Sbjct 369 SLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRK-STMVAQSQ 427 Query 136 VGFLEHLVKPLFVEL 150 VGF++ +V+P F L Sbjct 428 VGFIDFIVEPTFTVL 442 > hsa:5137 PDE1C, Hcam3; phosphodiesterase 1C, calmodulin-dependent 70kDa (EC:3.1.4.17); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=634 Score = 96.3 bits (238), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 49/135 (36%), Positives = 76/135 (56%), Gaps = 7/135 (5%) Query 16 CNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHFDHRKQRDDTWLIM 75 NI +L+KD+ E R+ +I +++ATDM HF I ++ A Q P + + + Sbjct 315 MNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPK------AL 368 Query 76 EMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPLCDRDLHSSMARNQ 135 + + ADI H +WD H W+ + EF+ QGD EA G SPLCDR + +A++Q Sbjct 369 SLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRK-STMVAQSQ 427 Query 136 VGFLEHLVKPLFVEL 150 VGF++ +V+P F L Sbjct 428 VGFIDFIVEPTFTVL 442 > tpv:TP01_0664 3',5' cyclic nucleotide phosphodiesterase; K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=450 Score = 95.1 bits (235), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 57/157 (36%), Positives = 86/157 (54%), Gaps = 12/157 (7%) Query 6 LTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHFDHR 65 L F ++ + + N ++ + KD +R +I LIL+TDM +HF I+ ++ R FD Sbjct 246 LLFYIIKNNT-NFYSIIPKDIWPSLRKRIIQLILSTDMINHFLHIDNVKEKRLQGKFD-I 303 Query 66 KQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPLC-- 123 K DD WL++ +C++AADIGH+ L W H W+ + EFY QGDEE + ISPL Sbjct 304 KNDDDFWLLLVLCIKAADIGHNFLPWADHLPWTQVLFEEFYKQGDEEKM--QSISPLMFF 361 Query 124 DRDLHSSMARNQVGFLEH------LVKPLFVELHSVD 154 DR+ ++ Q+ F L +PL EL+ D Sbjct 362 DRNESRNIPILQLQFFNTMTQLLILSQPLLSELNYFD 398 > bbo:BBOV_IV006510 23.m05980; 3'5'-cyclic nucleotide phosphodiesterase (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=777 Score = 91.7 bits (226), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 59/184 (32%), Positives = 87/184 (47%), Gaps = 10/184 (5%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINR--LRAARQNP 60 H +VL CN+F D VRS +I ILATD F I++ L R + Sbjct 571 HAASALRVLCTPGCNLFPDCDYDY---VRSQIIEHILATDTVDQFHMISQFVLSCKRDDF 627 Query 61 HFDHRKQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGIS 120 F+ R L +M M+AAD+ + W EW SR+ EFY QG EE + IS Sbjct 628 TFEEYNSRI---LTSKMLMKAADVAAPTMQWANSLEWVSRLLGEFYAQGAEEVDYCIPIS 684 Query 121 PLCDRDLHSSMARNQVGFLEHLVKPLFVELHSVDSMKGAFQEAVNTIDANISRWQQLQDI 180 LCDR H A++Q FL +V PL+ + S+ S + ++ ++ N +W ++ Sbjct 685 ALCDRQHHEQSAKSQAAFLRIVVAPLYEAIASLGSPE--IDAIMDQLEENAEKWNEMDKA 742 Query 181 GVDV 184 G + Sbjct 743 GTII 746 > mmu:18583 Pde7a, AU015378, AW047537; phosphodiesterase 7A (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=482 Score = 87.8 bits (216), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 52/164 (31%), Positives = 93/164 (56%), Gaps = 7/164 (4%) Query 17 NIFASLAKDEILEVRSNMISLILATDM--KSHFGAINRLRAARQNPHFDHRKQRDDTWLI 74 +F+ L + E+ + + +LILATD+ ++ + ++ R + + H D + R L+ Sbjct 297 GLFSHLPLESRQEMEAQIGALILATDISRQNEYLSLFRSHLDKGDLHLDDGRHRH---LV 353 Query 75 MEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPLCDRDLHSSMARN 134 ++M ++ ADI + +W+ +WS +VT EF+ QGD E ++ G+SPLCDR S+A Sbjct 354 LQMALKCADICNPCRNWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRQT-ESIANI 412 Query 135 QVGFLEHLVKPLFVELHSVDSMKGAFQEAVNTIDANISRWQQLQ 178 Q+GF+ +LV+PLF E + + Q + + N + W+ LQ Sbjct 413 QIGFMTYLVEPLFTEWARFSDTRLS-QTMLGHVGLNKASWKGLQ 455 > cel:T04D3.3 pde-1; PhosphoDiEsterase family member (pde-1); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=664 Score = 86.7 bits (213), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 50/143 (34%), Positives = 77/143 (53%), Gaps = 11/143 (7%) Query 8 FKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPH-FDHRK 66 F+++ NI L +DE E+R+ +I ++LATDM +HF I +++ P D K Sbjct 411 FRLMKEDDKNILTHLTRDEYKELRNMVIEIVLATDMSTHFMQIKTMKSMLSLPEGIDKNK 470 Query 67 QRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPLCDR- 125 + + + A DI H W+ H W+ V EF+ QGD EA G SPLCDR Sbjct 471 A-------LCLIVHACDISHPAKPWNLHERWTEGVLEEFFRQGDLEASMGLPYSPLCDRH 523 Query 126 DLHSSMARNQVGFLEHLVKPLFV 148 +H +A +Q+GF++ +V+P V Sbjct 524 TVH--VADSQIGFIDFIVEPTMV 544 > mmu:18585 Pde9a, PDE9A1; phosphodiesterase 9A (EC:3.1.4.35); K13761 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9 [EC:3.1.4.35] Length=534 Score = 84.3 bits (207), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 44/145 (30%), Positives = 78/145 (53%), Gaps = 4/145 (2%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H + F++L+ CNIFAS+ + ++R MI+LILATDM H ++ + +N F Sbjct 324 HCAIAFQILARPECNIFASVPPEGFRQIRQGMITLILATDMARHAEIMDSFKEKMEN--F 381 Query 63 DHRKQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPL 122 D+ + T L M + ++ DI + + + W + E+++Q D E G ++P Sbjct 382 DYSNEEHLTLLKM-ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPF 440 Query 123 CDRDLHSSMARNQVGFLEHLVKPLF 147 DRD + A Q+GF++ ++ P+F Sbjct 441 MDRD-KVTKATAQIGFIKFVLIPMF 464 > hsa:5152 PDE9A, FLJ90181, HSPDE9A2; phosphodiesterase 9A (EC:3.1.4.35); K13761 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9 [EC:3.1.4.35] Length=533 Score = 84.0 bits (206), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 43/145 (29%), Positives = 78/145 (53%), Gaps = 4/145 (2%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H + F++L+ CNIF+++ D ++R MI+LILATDM H ++ + +N F Sbjct 325 HCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--F 382 Query 63 DHRKQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPL 122 D+ + T L M + ++ DI + + + W + E+++Q D E G ++P Sbjct 383 DYSNEEHMTLLKM-ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPF 441 Query 123 CDRDLHSSMARNQVGFLEHLVKPLF 147 DRD + A Q+GF++ ++ P+F Sbjct 442 MDRD-KVTKATAQIGFIKFVLIPMF 465 > mmu:18578 Pde4b, Dpde4, R74983, dunce; phosphodiesterase 4B, cAMP specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=564 Score = 83.2 bits (204), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 49/180 (27%), Positives = 94/180 (52%), Gaps = 8/180 (4%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H + FK+L C+IF +L K + +R +I ++LATDM H + L+ + Sbjct 307 HLAVGFKLLQEEHCDIFQNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKV 366 Query 63 DHR-----KQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGR 117 D ++ + AD+ + S + + +W+ R+ EF+ QGD+E G Sbjct 367 TSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGM 426 Query 118 GISPLCDRDLHSSMARNQVGFLEHLVKPLFVELHSVDSMKGAFQEAVNTIDANISRWQQL 177 ISP+CD+ +S+ ++QVGF++++V PL+ D ++ Q+ ++T++ N + +Q + Sbjct 427 EISPMCDKHT-ASVEKSQVGFIDYIVHPLWETW--ADLVQPDAQDILDTLEDNRNWYQSM 483 > hsa:5142 PDE4B, DKFZp686F2182, DPDE4, MGC126529, PDE4B5, PDEIVB; phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=564 Score = 82.8 bits (203), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 49/180 (27%), Positives = 94/180 (52%), Gaps = 8/180 (4%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H + FK+L C+IF +L K + +R +I ++LATDM H + L+ + Sbjct 307 HLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKV 366 Query 63 DHR-----KQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGR 117 D ++ + AD+ + S + + +W+ R+ EF+ QGD+E G Sbjct 367 TSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGM 426 Query 118 GISPLCDRDLHSSMARNQVGFLEHLVKPLFVELHSVDSMKGAFQEAVNTIDANISRWQQL 177 ISP+CD+ +S+ ++QVGF++++V PL+ D ++ Q+ ++T++ N + +Q + Sbjct 427 EISPMCDKHT-ASVEKSQVGFIDYIVHPLWETW--ADLVQPDAQDILDTLEDNRNWYQSM 483 > hsa:5150 PDE7A, HCP1, PDE7; phosphodiesterase 7A (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=456 Score = 82.8 bits (203), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 50/163 (30%), Positives = 93/163 (57%), Gaps = 7/163 (4%) Query 18 IFASLAKDEILEVRSNMISLILATDM--KSHFGAINRLRAARQNPHFDHRKQRDDTWLIM 75 +F+ L + ++ + + +LILATD+ ++ + ++ R R + + + R L++ Sbjct 272 LFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRH---LVL 328 Query 76 EMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPLCDRDLHSSMARNQ 135 +M ++ ADI + +W+ +WS +VT EF+ QGD E ++ G+SPLCDR S+A Q Sbjct 329 QMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHT-ESIANIQ 387 Query 136 VGFLEHLVKPLFVELHSVDSMKGAFQEAVNTIDANISRWQQLQ 178 +GF+ +LV+PLF E + + + Q + + N + W+ LQ Sbjct 388 IGFMTYLVEPLFTEWARFSNTRLS-QTMLGHVGLNKASWKGLQ 429 > dre:565259 pde4c, im:7160317, si:dkey-149i17.5; phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila) Length=672 Score = 82.8 bits (203), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 49/180 (27%), Positives = 93/180 (51%), Gaps = 8/180 (4%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H + FK+L +C+IF +L K + +R +I ++LATDM H + L+ + Sbjct 447 HLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDMVLATDMSKHMNLLADLKTMVETKKV 506 Query 63 DHR-----KQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGR 117 D +++ + AD+ + + + +W+ R+ EF+ QGD E G Sbjct 507 TSLGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLELYRQWTDRIMVEFFTQGDRERDKGM 566 Query 118 GISPLCDRDLHSSMARNQVGFLEHLVKPLFVELHSVDSMKGAFQEAVNTIDANISRWQQL 177 ISP+CD+ ++S+ ++QVGF++++V PL+ D + QE ++T++ N +Q + Sbjct 567 EISPMCDKH-NASIEKSQVGFIDYIVHPLWETW--ADLVHPDAQEILDTLEDNREWYQSM 623 > xla:444562 pde4b, MGC83972; phosphodiesterase 4B, cAMP-specific; K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=721 Score = 82.8 bits (203), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 50/180 (27%), Positives = 93/180 (51%), Gaps = 8/180 (4%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H + FK+L C+IF +L K + +R +I L+LATDM H + L+ + Sbjct 465 HLAVGFKLLQEEHCDIFQNLTKKQRQSLRKMVIDLVLATDMSKHMSLLADLKTMVETKKV 524 Query 63 DHR-----KQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGR 117 D ++ + AD+ + S + + +W+ R+ EF+ QGD E G Sbjct 525 TSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDRERERGM 584 Query 118 GISPLCDRDLHSSMARNQVGFLEHLVKPLFVELHSVDSMKGAFQEAVNTIDANISRWQQL 177 ISP+CD+ +S+ ++QVGF++++V PL+ D ++ Q+ ++T++ N + +Q + Sbjct 585 EISPMCDKHT-ASVEKSQVGFIDYIVHPLWETWG--DLVQPDAQDILDTLEDNRNWYQSM 641 > mmu:238871 Pde4d, 9630011N22Rik, Dpde3; phosphodiesterase 4D, cAMP specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=747 Score = 82.4 bits (202), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 103/217 (47%), Gaps = 12/217 (5%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H + FK+L +C+IF +L K + +R +I ++LATDM H + L+ + Sbjct 474 HLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKV 533 Query 63 DHR-----KQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGR 117 D +++ + AD+ + + +W+ R+ EF+ QGD E G Sbjct 534 TSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGM 593 Query 118 GISPLCDRDLHSSMARNQVGFLEHLVKPLFVELHSVDSMKGAFQEAVNTIDANISRWQQL 177 ISP+CD+ ++S+ ++QVGF++++V PL+ D + Q+ ++T++ N +Q Sbjct 594 EISPMCDKH-NASVEKSQVGFIDYIVHPLWETW--ADLVHPDAQDILDTLEDNREWYQS- 649 Query 178 QDIGVDVTFSPVVMACEDRLKGKDHVIDVSLITETRC 214 + + SP E+ +G+ L E C Sbjct 650 ---TIPQSPSPAPDDQEEGRQGQTEKFQFELTLEEDC 683 > dre:565706 cAMP-specific 3,5-cyclic phosphodiesterase 4B-like; K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=713 Score = 82.0 bits (201), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 49/180 (27%), Positives = 93/180 (51%), Gaps = 8/180 (4%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H + FK+L +C+IF +L K + +R +I ++LATDM H + L+ + Sbjct 457 HLAVGFKLLQEDNCDIFQNLTKKQRTSLRRMVIDMVLATDMSKHMSLLADLKTMVETKKV 516 Query 63 DHR-----KQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGR 117 D ++ + AD+ + S + + +W+ R+ EF+ QGD E G Sbjct 517 TSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFHQGDRERERGM 576 Query 118 GISPLCDRDLHSSMARNQVGFLEHLVKPLFVELHSVDSMKGAFQEAVNTIDANISRWQQL 177 ISP+CD+ +S+ ++QVGF++++V PL+ D + Q+ ++T++ N + +Q + Sbjct 577 EISPMCDKHT-ASVEKSQVGFIDYIVHPLWETW--ADLVHPDAQDILDTLEDNRNWYQSM 633 > cel:R153.1 pde-4; PhosphoDiEsterase family member (pde-4); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=673 Score = 82.0 bits (201), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 41/150 (27%), Positives = 84/150 (56%), Gaps = 6/150 (4%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H + FK+L ++C+ A+L++ + L+ R +I ++LATDM H + L+ + Sbjct 479 HLAVAFKLLQDSNCDFLANLSRKQRLQFRKIVIDMVLATDMSKHMSLLADLKTMVEAKKV 538 Query 63 DHRK-----QRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGR 117 + +D +++ + AD+ + + + +W+ R+ E++ QGD+E G Sbjct 539 AGNNVIVLDKYNDKIQVLQSMIHLADLSNPTKPIELYQQWNQRIMEEYWRQGDKEKELGL 598 Query 118 GISPLCDRDLHSSMARNQVGFLEHLVKPLF 147 ISP+CDR + ++ ++QVGF++++V PL+ Sbjct 599 EISPMCDRG-NVTIEKSQVGFIDYIVHPLY 627 > mmu:18577 Pde4a, D9Ertd60e, Dpde2; phosphodiesterase 4A, cAMP specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=610 Score = 81.6 bits (200), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 44/150 (29%), Positives = 80/150 (53%), Gaps = 6/150 (4%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H + FK+L +C+IF +L+K + +R +I ++LATDM H + L+ + Sbjct 258 HLAVGFKLLQEENCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKV 317 Query 63 DHR-----KQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGR 117 D ++ + AD+ + + + +W+ R+ AEF+ QGD E G Sbjct 318 TSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGM 377 Query 118 GISPLCDRDLHSSMARNQVGFLEHLVKPLF 147 ISP+CD+ +S+ ++QVGF++++V PL+ Sbjct 378 EISPMCDKHT-ASVEKSQVGFIDYIVHPLW 406 > hsa:5141 PDE4A, DPDE2, PDE4, PDE46; phosphodiesterase 4A, cAMP-specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=886 Score = 81.6 bits (200), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 49/173 (28%), Positives = 90/173 (52%), Gaps = 8/173 (4%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H + FK+L +C+IF +L+K + +R +I ++LATDM H + L+ + Sbjct 506 HLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKV 565 Query 63 DHR-----KQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGR 117 D ++ + AD+ + + + +W+ R+ AEF+ QGD E G Sbjct 566 TSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGM 625 Query 118 GISPLCDRDLHSSMARNQVGFLEHLVKPLFVELHSVDSMKGAFQEAVNTIDAN 170 ISP+CD+ +S+ ++QVGF++++V PL+ D + QE ++T++ N Sbjct 626 EISPMCDKHT-ASVEKSQVGFIDYIVHPLWETW--ADLVHPDAQEILDTLEDN 675 > dre:566998 novel protein similar to vertebrate phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) (PDE4D); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=745 Score = 81.6 bits (200), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 43/150 (28%), Positives = 79/150 (52%), Gaps = 6/150 (4%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H + FK+L +C+IF +L K + +R +I ++LATDM H + L+ + Sbjct 447 HLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKV 506 Query 63 DHR-----KQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGR 117 D +++ + AD+ + + +W+ R+ EF+ QGD E G Sbjct 507 TSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFSQGDRERERGM 566 Query 118 GISPLCDRDLHSSMARNQVGFLEHLVKPLF 147 ISP+CD+ ++S+ ++QVGF++++V PL+ Sbjct 567 EISPMCDKH-NASVEKSQVGFIDYIVHPLW 595 > tgo:TGME49_057950 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein (EC:3.1.4.17) Length=587 Score = 80.9 bits (198), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 43/111 (38%), Positives = 63/111 (56%), Gaps = 1/111 (0%) Query 31 RSNMISLILATDMKSHFGAINRLRAARQNPHFDHRKQRDDTWLIMEMCMRAADIGHSILS 90 R +I LI+ TDM HF + + RQ D +D ++++M ++AADIGH+ + Sbjct 286 RKEVIELIVHTDMTKHFSLLALFKVKRQTGGLDIVNNEEDRSMLLKMLLKAADIGHATKA 345 Query 91 WDQHFEWSSRVTAEFYLQGDEEARHGRGISPLCDRDLH-SSMARNQVGFLE 140 +D HF S + EF+ QGDEE + G ISPLCDR + +Q GFL+ Sbjct 346 FDFHFFLSCCLIEEFHRQGDEEKKRGMVISPLCDRQQELRQIFSSQAGFLQ 396 > hsa:5144 PDE4D, DKFZp686M11213, DPDE3, FLJ97311, HSPDE4D, PDE4DN2, STRK1; phosphodiesterase 4D, cAMP-specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=809 Score = 80.9 bits (198), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 43/150 (28%), Positives = 79/150 (52%), Gaps = 6/150 (4%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H + FK+L +C+IF +L K + +R +I ++LATDM H + L+ + Sbjct 535 HLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKV 594 Query 63 DHR-----KQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGR 117 D +++ + AD+ + + +W+ R+ EF+ QGD E G Sbjct 595 TSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGM 654 Query 118 GISPLCDRDLHSSMARNQVGFLEHLVKPLF 147 ISP+CD+ ++S+ ++QVGF++++V PL+ Sbjct 655 EISPMCDKH-NASVEKSQVGFIDYIVHPLW 683 > dre:562357 phosphodiesterase 9A-like Length=529 Score = 80.5 bits (197), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 49/167 (29%), Positives = 80/167 (47%), Gaps = 13/167 (7%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H + F++L T NIF +L ++ +R +I ILATDM H +N+ +A F Sbjct 324 HCAVAFEILEKTESNIFRNLPTEQYKRIREGIIKCILATDMSRHTDILNKFKAILPVFDF 383 Query 63 DHRKQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPL 122 ++ RD +IM ++ +DI + D W + EF+ Q D E G ++P Sbjct 384 GNKDHRDVLMMIM---IKVSDISNEARPMDVAEPWLDCLLQEFFNQSDMEKLEGLPVTPF 440 Query 123 CDRDLHSSMARNQVGFLEHLVKPLFVEL---------HSVDSMKGAF 160 DRD + +Q GF+ ++ PLF+EL H +D ++ A Sbjct 441 MDRD-KVTKPSSQTGFIRFVLFPLFIELANLFPCLEQHIIDPVRKAL 486 > dre:572061 pde4a; phosphodiesterase 4A, cAMP-specific; K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=736 Score = 80.5 bits (197), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 53/181 (29%), Positives = 91/181 (50%), Gaps = 14/181 (7%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPH- 61 H + FK+L +C+IF +L K + +R +I ++LATDM H + L+ + Sbjct 465 HLAVGFKLLHEENCDIFQNLTKRQRQSLRKLVIDMVLATDMSKHMSLLADLKTMVETKKV 524 Query 62 -------FDHRKQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEAR 114 DH R M C AD+ + + +W+ R+ EF+ QGD+E Sbjct 525 TSSGVLMLDHYNDRIQVLRNMVHC---ADLSNPTKPLAVYRQWTERIMEEFFQQGDKERE 581 Query 115 HGRGISPLCDRDLHSSMARNQVGFLEHLVKPLFVELHSVDSMKGAFQEAVNTIDANISRW 174 G ISP+CD+ +S+ ++QVGF++++V PL+ D + QE ++T++ N + Sbjct 582 RGMEISPMCDKHT-ASVEKSQVGFIDYIVHPLWETWG--DLVHPDAQEILDTLEDNRDWY 638 Query 175 Q 175 Q Sbjct 639 Q 639 > dre:571344 fc68c05, si:ch211-255d18.8, wu:fc68c05; si:ch211-255d18.1 Length=709 Score = 79.7 bits (195), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 47/180 (26%), Positives = 91/180 (50%), Gaps = 8/180 (4%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H + FK+L +C+IF +L+K + +R I ++LATDM H + L+ + Sbjct 433 HLAVGFKLLQEENCDIFCNLSKKQRQSLRQMTIDMVLATDMSKHMNFLADLKTMVETKKV 492 Query 63 DHR-----KQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGR 117 + D +++ + AD+ + + + +W+ R+ EF+ QGD E G Sbjct 493 TSQGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLELYRKWTDRIMVEFFSQGDRERDKGI 552 Query 118 GISPLCDRDLHSSMARNQVGFLEHLVKPLFVELHSVDSMKGAFQEAVNTIDANISRWQQL 177 +SP+CD+ +SM QVGF+++++ PL+ D + Q+ ++T++ N +Q + Sbjct 553 DVSPMCDKHT-ASMENTQVGFIDYIIHPLWETW--ADLVHPDAQDILDTLEDNREWYQSM 609 > hsa:5143 PDE4C, DPDE1, MGC126222; phosphodiesterase 4C, cAMP-specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=712 Score = 79.7 bits (195), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 43/150 (28%), Positives = 79/150 (52%), Gaps = 6/150 (4%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H + FK+L +C+IF +L+ + L +R +I ++LATDM H + L+ + Sbjct 461 HLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKV 520 Query 63 DHR-----KQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGR 117 D +++ + AD+ + + +W+ R+ AEF+ QGD E G Sbjct 521 TSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGL 580 Query 118 GISPLCDRDLHSSMARNQVGFLEHLVKPLF 147 ISP+CD+ +S+ ++QVGF++++ PL+ Sbjct 581 DISPMCDKHT-ASVEKSQVGFIDYIAHPLW 609 > xla:495146 hypothetical LOC495146; K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=682 Score = 79.7 bits (195), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 43/150 (28%), Positives = 79/150 (52%), Gaps = 6/150 (4%) Query 3 HDVLTFKVLSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHF 62 H + FK+L +C+IF +L K + +R +I ++LATDM H + L+ + Sbjct 417 HLAVGFKLLQEENCDIFQNLPKRQRQMMRKMVIDMVLATDMSKHMSLLADLKTMVETKKV 476 Query 63 DHR-----KQRDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGR 117 D ++ + AD+ + + + +W+ R+ EF+ QGD+E G Sbjct 477 TSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKPLELYRQWTDRILEEFFRQGDKERERGM 536 Query 118 GISPLCDRDLHSSMARNQVGFLEHLVKPLF 147 ISP+CD+ +S+ ++QVGF++++V PL+ Sbjct 537 EISPMCDKHT-ASVEKSQVGFIDYIVHPLW 565 > dre:567051 si:dkey-48h7.2; K13296 cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17] Length=1117 Score = 79.3 bits (194), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 52/151 (34%), Positives = 72/151 (47%), Gaps = 5/151 (3%) Query 11 LSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQN---PHFDHRKQ 67 +S N ASL E R +I ILATD+K HF + A + D + Sbjct 804 MSRPEYNFLASLDHMEFKRFRFLVIEAILATDLKKHFDFLAEFNAKVGDDGCSGIDWTNE 863 Query 68 RDDTWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPLCDRDL 127 +D L+ +MC++ ADI + D H +W+ + EFY QGDEE+ G ISP DR Sbjct 864 -NDRLLVCQMCIKLADINGPLKCKDLHLQWTEGIVNEFYEQGDEESSLGLPISPFMDRSA 922 Query 128 HSSMARNQVGFLEHLVKPLFVELHSVDSMKG 158 +A+ Q F+ H+V PL S M G Sbjct 923 -PQLAKLQESFITHIVGPLCSSYDSAALMPG 952 > mmu:54611 Pde3a, A930022O17Rik, C87899; phosphodiesterase 3A, cGMP inhibited (EC:3.1.4.17); K13296 cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17] Length=1141 Score = 77.8 bits (190), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 50/145 (34%), Positives = 69/145 (47%), Gaps = 4/145 (2%) Query 11 LSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHFDHRKQRDD 70 +S N +L E R +I ILATD+K HF + + A + +D Sbjct 878 MSRPEYNFLVNLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNAKVNDDVGIDWTNEND 937 Query 71 TWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPLCDRDLHSS 130 L+ +MC++ ADI + H W+ + +EFY QGDEEA G ISP DR Sbjct 938 RLLVCQMCIKLADINGPAKCKELHLRWTEGIASEFYEQGDEEASLGLPISPFMDRSA-PQ 996 Query 131 MARNQVGFLEHLVKPLFVELHSVDS 155 +A Q F+ H+V PL HS DS Sbjct 997 LANLQESFISHIVGPL---CHSYDS 1018 > hsa:5139 PDE3A, CGI-PDE; phosphodiesterase 3A, cGMP-inhibited (EC:3.1.4.17); K13296 cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17] Length=1141 Score = 77.8 bits (190), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 49/152 (32%), Positives = 69/152 (45%), Gaps = 1/152 (0%) Query 11 LSHTSCNIFASLAKDEILEVRSNMISLILATDMKSHFGAINRLRAARQNPHFDHRKQRDD 70 +S N +L E R +I ILATD+K HF + + + +D Sbjct 878 MSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNEND 937 Query 71 TWLIMEMCMRAADIGHSILSWDQHFEWSSRVTAEFYLQGDEEARHGRGISPLCDRDLHSS 130 L+ +MC++ ADI + H +W+ + EFY QGDEEA G ISP DR Sbjct 938 RLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSA-PQ 996 Query 131 MARNQVGFLEHLVKPLFVELHSVDSMKGAFQE 162 +A Q F+ H+V PL S M G + E Sbjct 997 LANLQESFISHIVGPLCNSYDSAGLMPGKWVE 1028 Lambda K H 0.323 0.134 0.414 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 8700848608 Database: egene_temp_file_orthology_annotation_similarity_blast_database_866 Posted date: Sep 17, 2011 2:57 PM Number of letters in database: 82,071,388 Number of sequences in database: 164,496 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40