bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schaffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: egene_temp_file_orthology_annotation_similarity_blast_database_866 164,496 sequences; 82,071,388 total letters Query= Eten_1312_orf1 Length=183 Score E Sequences producing significant alignments: (Bits) Value cpv:cgd3_2320 cGMP phosphodiesterase A4 126 3e-29 tgo:TGME49_020420 3'5'-cyclic nucleotide phosphodiesterase, pu... 119 4e-27 tgo:TGME49_002540 3',5'-cyclic nucleotide phosphodiesterase, p... 108 1e-23 tgo:TGME49_118680 3',5'--cyclic-nucleotide phosphodiesterase, ... 98.2 1e-20 tgo:TGME49_024840 cAMP phosphodiesterase, putative (EC:3.1.4.1... 95.9 7e-20 pfa:MAL13P1.118 3',5'-cyclic nucleotide phosphodiesterase (EC:... 95.1 1e-19 tgo:TGME49_041880 3', 5'-cyclic nucleotide phosphodiesterase, ... 94.7 2e-19 dre:564465 pde1a; phosphodiesterase 1A, calmodulin-dependent; ... 85.1 1e-16 tgo:TGME49_026770 cGMP-inhibited 3',5'-cyclic phosphodiesteras... 84.0 2e-16 hsa:5136 PDE1A, HCAM1, HSPDE1A, MGC26303; phosphodiesterase 1A... 82.8 7e-16 mmu:18573 Pde1a, AI987702, AW125737, MGC116577; phosphodiester... 82.4 8e-16 mmu:18574 Pde1b, 63kDa, Pde1b1; phosphodiesterase 1B, Ca2+-cal... 78.2 2e-14 tpv:TP01_1200 hypothetical protein 77.4 2e-14 mmu:18575 Pde1c; phosphodiesterase 1C (EC:3.1.4.17); K13755 ca... 77.4 2e-14 hsa:5137 PDE1C, Hcam3; phosphodiesterase 1C, calmodulin-depend... 77.4 3e-14 pfa:PFL0475w PDE1; cGMP-specific phosphodiesterase (EC:3.1.4.1... 77.0 3e-14 hsa:5153 PDE1B, PDE1B1, PDES1B; phosphodiesterase 1B, calmodul... 77.0 3e-14 tgo:TGME49_057080 cAMP-specific 3',5'-cyclic phosphodiesterase... 77.0 4e-14 tgo:TGME49_080410 3',5'-cyclic phosphodiesterase, putative (EC... 76.6 5e-14 tgo:TGME49_066920 phosphodiesterase, putative (EC:3.1.4.17) 76.3 6e-14 tgo:TGME49_110520 calcium/calmodulin-dependent 3', 5'-cyclic n... 75.9 8e-14 tgo:TGME49_072650 calcium/calmodulin-dependent 3',5'-cyclic nu... 75.5 1e-13 dre:563432 pde3b; phosphodiesterase 3B, cGMP-inhibited; K13296... 75.1 1e-13 xla:496104 pde3b; phosphodiesterase 3b, cGMP-inhibited; K13296... 74.3 2e-13 xla:444562 pde4b, MGC83972; phosphodiesterase 4B, cAMP-specifi... 73.9 3e-13 hsa:5142 PDE4B, DKFZp686F2182, DPDE4, MGC126529, PDE4B5, PDEIV... 73.2 5e-13 mmu:18578 Pde4b, Dpde4, R74983, dunce; phosphodiesterase 4B, c... 72.8 6e-13 dre:566998 novel protein similar to vertebrate phosphodiestera... 71.6 1e-12 dre:565706 cAMP-specific 3,5-cyclic phosphodiesterase 4B-like;... 71.2 2e-12 dre:572061 pde4a; phosphodiesterase 4A, cAMP-specific; K01120 ... 71.2 2e-12 mmu:238871 Pde4d, 9630011N22Rik, Dpde3; phosphodiesterase 4D, ... 70.5 3e-12 hsa:5140 PDE3B, HcGIP1, cGIPDE1; phosphodiesterase 3B, cGMP-in... 70.5 3e-12 hsa:5144 PDE4D, DKFZp686M11213, DPDE3, FLJ97311, HSPDE4D, PDE4... 70.5 3e-12 dre:571344 fc68c05, si:ch211-255d18.8, wu:fc68c05; si:ch211-25... 70.1 4e-12 xla:495146 hypothetical LOC495146; K01120 3',5'-cyclic-nucleot... 70.1 4e-12 dre:565259 pde4c, im:7160317, si:dkey-149i17.5; phosphodiester... 69.7 5e-12 cel:R153.1 pde-4; PhosphoDiEsterase family member (pde-4); K01... 69.3 6e-12 mmu:18576 Pde3b, 9830102A01Rik, AI847709; phosphodiesterase 3B... 69.3 6e-12 dre:567051 si:dkey-48h7.2; K13296 cGMP-inhibited 3',5'-cyclic ... 69.3 7e-12 hsa:5141 PDE4A, DPDE2, PDE4, PDE46; phosphodiesterase 4A, cAMP... 69.3 7e-12 hsa:27115 PDE7B, MGC88256, bA472E5.1; phosphodiesterase 7B (EC... 68.9 9e-12 mmu:29863 Pde7b; phosphodiesterase 7B (EC:3.1.4.17); K01120 3'... 68.9 1e-11 mmu:18577 Pde4a, D9Ertd60e, Dpde2; phosphodiesterase 4A, cAMP ... 68.9 1e-11 pfa:MAL13P1.119 calcium/calmodulin-dependent 3',5'-cyclic nucl... 68.6 1e-11 hsa:5143 PDE4C, DPDE1, MGC126222; phosphodiesterase 4C, cAMP-s... 68.6 1e-11 hsa:5139 PDE3A, CGI-PDE; phosphodiesterase 3A, cGMP-inhibited ... 65.9 7e-11 dre:100151215 phosphodiesterase 7A-like (EC:3.1.4.17); K01120 ... 65.1 1e-10 mmu:54611 Pde3a, A930022O17Rik, C87899; phosphodiesterase 3A, ... 64.7 2e-10 cel:T04D3.3 pde-1; PhosphoDiEsterase family member (pde-1); K1... 63.9 3e-10 hsa:5150 PDE7A, HCP1, PDE7; phosphodiesterase 7A (EC:3.1.4.17)... 62.0 1e-09 > cpv:cgd3_2320 cGMP phosphodiesterase A4 Length=997 Score = 126 bits (317), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 59/164 (35%), Positives = 96/164 (58%), Gaps = 23/164 (14%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 D+ HF+ +++FR+ ++ +D+ +P+ D D LA+ C+ Sbjct 840 DMHRHFECVSRFRV------------RRQAVDW------DPYG----DAQDRLMLARTCL 877 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVPKSQIGFLK 120 + AD+GH A+KW QHYKW ++++ EFF QG +E L L +SP+CD +TDVPKSQ+GFL Sbjct 878 KAADIGHGALKWNQHYKWCRSVVEEFFLQGDEEKALSLPISPICDRESTDVPKSQVGFLN 937 Query 121 LICFPLFESLAQADNSGDLAAICLSFLKDNSETWQRISDSEMDW 164 +C PLF+ L D GD+ C+ + +N W+ I+++ + W Sbjct 938 FVCLPLFQELCYVDVEGDVRR-CIDRILENINNWEDIAEAGIQW 980 > tgo:TGME49_020420 3'5'-cyclic nucleotide phosphodiesterase, putative (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=466 Score = 119 bits (299), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 67/155 (43%), Positives = 94/155 (60%), Gaps = 11/155 (7%) Query 1 DLSTHFDFLAQFRLQLHFLNS-KVNSEKKSEIDF-KSPQTL--NPHKTL-------KTDP 49 D+ HFDF+ +FRL+ K+ E+ + F ++P +L +P +T K + Sbjct 308 DILFHFDFIGRFRLRRPMSPFFKLLGERGANPSFGQNPVSLLSSPSRTATDVEATSKEEA 367 Query 50 ADCWTLAKACIRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAAT 109 D LAKACIR ADVGH+AV+W QHY +S+A+ EFF QG+ E L L++SP CD +T Sbjct 368 QDLTLLAKACIRSADVGHAAVEWRQHYFYSKAVQTEFFNQGKAEKRLRLRISPCCDPVST 427 Query 110 DVPKSQIGFLKLICFPLFESLAQADNSGDLAAICL 144 DVPK Q GF+ I PLFE LA + +G + +CL Sbjct 428 DVPKCQDGFISYISRPLFEELALINTNGAIMQVCL 462 > tgo:TGME49_002540 3',5'-cyclic nucleotide phosphodiesterase, putative (EC:3.1.4.17 1.6.99.5) Length=1670 Score = 108 bits (269), Expect = 1e-23, Method: Composition-based stats. Identities = 52/161 (32%), Positives = 89/161 (55%), Gaps = 24/161 (14%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 D+ HF+ +++FR++ + L+ ++SE+ D W K + Sbjct 1450 DMKNHFETVSRFRVRRNALDFDLSSEE-----------------------DFWFAVKIIM 1486 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCD-EAATDVPKSQIGFL 119 +CAD+ H +V W QH++W Q L EF+ QG +E+ L +SP+CD E ++V KSQ+GF+ Sbjct 1487 KCADLSHCSVPWSQHFQWCQRLSVEFYDQGDEEVARHLPMSPLCDREKHSEVAKSQLGFM 1546 Query 120 KLICFPLFESLAQADNSGDLAAICLSFLKDNSETWQRISDS 160 + PLFE L D +G++ C+S +K N+ W+ +S + Sbjct 1547 SFVAVPLFEELMAIDGTGNIEKYCISVMKTNASHWEALSSA 1587 > tgo:TGME49_118680 3',5'--cyclic-nucleotide phosphodiesterase, putative (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=812 Score = 98.2 bits (243), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 54/166 (32%), Positives = 84/166 (50%), Gaps = 27/166 (16%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 D+ THFDFL++FR + + N HK + D W A+ CI Sbjct 486 DMKTHFDFLSRFR------------------NRRQAPGFNFHKVAE----DQWLAAEICI 523 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVP---KSQIG 117 R +D+GH+ +W+QH++W+ ++ EF+ QG +E LGL VSP+CD D P K Q G Sbjct 524 RASDLGHAMTEWDQHFEWASRVVTEFYLQGEEERRLGLHVSPLCDR--DDHPSFSKCQHG 581 Query 118 FLKLICFPLFESLAQADNSGDLAAICLSFLKDNSETWQRISDSEMD 163 FL + PL L + D + + LK+N E W+ ++ ++ Sbjct 582 FLGYVVKPLIAELGECDTLQRIIPQLMQNLKENMERWEAFTNEGVN 627 > tgo:TGME49_024840 cAMP phosphodiesterase, putative (EC:3.1.4.17 1.1.99.3) Length=1324 Score = 95.9 bits (237), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 49/161 (30%), Positives = 85/161 (52%), Gaps = 23/161 (14%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 D+ HF+ L++FR++ + +P + D W +A+ C+ Sbjct 856 DMKQHFESLSRFRIRRN----------------------SPEFNYVKNVEDRWFVARMCV 893 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCD-EAATDVPKSQIGFL 119 + AD+GHS V W QH++WS ++ EF+ QG +E + VSP+CD + D+ KSQ GFL Sbjct 894 KVADIGHSCVPWNQHFEWSSRVVEEFYLQGDEERSRNMPVSPLCDRDKHADMAKSQGGFL 953 Query 120 KLICFPLFESLAQADNSGDLAAICLSFLKDNSETWQRISDS 160 + + PL + + + D G + + LS ++ N + WQ + +S Sbjct 954 EFVVKPLIKEIDEIDPFGRVRSDILSHIEYNEKKWQELQES 994 > pfa:MAL13P1.118 3',5'-cyclic nucleotide phosphodiesterase (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=1139 Score = 95.1 bits (235), Expect = 1e-19, Method: Composition-based stats. Identities = 52/162 (32%), Positives = 81/162 (50%), Gaps = 23/162 (14%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 D+ HF+ +++FR++ N + K S+ D L K I Sbjct 959 DMKHHFEIISKFRIRRE--NEDFDYIKNSD--------------------DLLILTKMII 996 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAA-TDVPKSQIGFL 119 + AD+ H +V W +HY W Q +++EF+ QG +EL+ + +SP+CD +V KSQI FL Sbjct 997 KSADISHGSVSWSEHYCWCQRVLSEFYTQGDEELKNKMPLSPLCDRTKHNEVCKSQITFL 1056 Query 120 KLICFPLFESLAQADNSGDLAAICLSFLKDNSETWQRISDSE 161 K + PLFE L+ DN+ + + CL L N W + E Sbjct 1057 KFVVMPLFEELSHIDNNKFIKSFCLKRLNSNCIMWDTLMKEE 1098 > tgo:TGME49_041880 3', 5'-cyclic nucleotide phosphodiesterase, putative (EC:2.1.1.43 3.1.4.17) Length=1281 Score = 94.7 bits (234), Expect = 2e-19, Method: Composition-based stats. Identities = 50/168 (29%), Positives = 80/168 (47%), Gaps = 24/168 (14%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 D+ HF+ +++FRL +++ DF +T+ D W L + CI Sbjct 976 DMKMHFEMVSKFRL------------RRNSPDF-----------CRTNDDDVWMLLRMCI 1012 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAA-TDVPKSQIGFL 119 + D+ H + W+ H WS +EF+ QG EL G ++P+ D D PK Q GFL Sbjct 1013 KGGDLSHGLLSWDSHVSWSYRAASEFYEQGDLELAQGRTITPMFDRRKHADFPKGQEGFL 1072 Query 120 KLICFPLFESLAQADNSGDLAAICLSFLKDNSETWQRISDSEMDWREI 167 + I PL+E +A D + + CL NSE W+++ S ++ I Sbjct 1073 RFIIIPLYEEIAAVDTTDVVQTCCLQNAVANSERWRQLQSSPEEFEAI 1120 > dre:564465 pde1a; phosphodiesterase 1A, calmodulin-dependent; K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=625 Score = 85.1 bits (209), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 37/72 (51%), Positives = 47/72 (65%), Gaps = 0/72 (0%) Query 60 IRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVPKSQIGFL 119 + AD+ H A W+ HY+W+QALM EFF QG +E ELGL SP+CD AT + +SQIGF+ Sbjct 365 LHAADISHPAKGWKLHYRWTQALMEEFFRQGDKEAELGLPFSPLCDRKATMIAQSQIGFI 424 Query 120 KLICFPLFESLA 131 I P F L Sbjct 425 DFIVEPTFSVLV 436 > tgo:TGME49_026770 cGMP-inhibited 3',5'-cyclic phosphodiesterase, putative (EC:3.1.4.17) Length=995 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 44/132 (33%), Positives = 66/132 (50%), Gaps = 24/132 (18%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 D+S HF ++ R++ + +T N T+ D W + K C+ Sbjct 418 DMSQHFSTISTVRVR------------------RESRTFN----FITNEEDRWMMKKLCM 455 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVP--KSQIGF 118 + D+GH+A+ W+QHYKWS + EF QG EL+ GL VSP+CD A ++ KSQ F Sbjct 456 KIGDIGHAALDWDQHYKWSMRVTEEFLLQGDAELKAGLPVSPLCDRNAPEIELHKSQSSF 515 Query 119 LKLICFPLFESL 130 + + PL L Sbjct 516 INYLVVPLINEL 527 > hsa:5136 PDE1A, HCAM1, HSPDE1A, MGC26303; phosphodiesterase 1A, calmodulin-dependent (EC:3.1.4.17); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=535 Score = 82.8 bits (203), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 36/75 (48%), Positives = 47/75 (62%), Gaps = 0/75 (0%) Query 59 CIRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVPKSQIGF 118 + AD+ H A W+ HY+W+ ALM EFF QG +E ELGL SP+CD +T V +SQIGF Sbjct 361 ILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF 420 Query 119 LKLICFPLFESLAQA 133 + I P F L + Sbjct 421 IDFIVEPTFSLLTDS 435 > mmu:18573 Pde1a, AI987702, AW125737, MGC116577; phosphodiesterase 1A, calmodulin-dependent (EC:3.1.4.17); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=545 Score = 82.4 bits (202), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 36/75 (48%), Positives = 47/75 (62%), Gaps = 0/75 (0%) Query 59 CIRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVPKSQIGF 118 + AD+ H A W+ HY+W+ ALM EFF QG +E ELGL SP+CD +T V +SQIGF Sbjct 361 ILHAADISHPAKTWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF 420 Query 119 LKLICFPLFESLAQA 133 + I P F L + Sbjct 421 IDFIVEPTFSLLTDS 435 > mmu:18574 Pde1b, 63kDa, Pde1b1; phosphodiesterase 1B, Ca2+-calmodulin dependent (EC:3.1.4.17); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=535 Score = 78.2 bits (191), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 34/72 (47%), Positives = 45/72 (62%), Gaps = 0/72 (0%) Query 60 IRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVPKSQIGFL 119 + AD+ H +W H +W++ALM EFF QG +E ELGL SP+CD +T V +SQIGF+ Sbjct 365 LHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFI 424 Query 120 KLICFPLFESLA 131 I P F L Sbjct 425 DFIVEPTFSVLT 436 > tpv:TP01_1200 hypothetical protein Length=840 Score = 77.4 bits (189), Expect = 2e-14, Method: Composition-based stats. Identities = 42/132 (31%), Positives = 65/132 (49%), Gaps = 26/132 (19%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 DL HF + QFR++ + + EID T+ K I Sbjct 717 DLEDHFQTITQFRVR----RASREFSVEGEID---------------------TICKMLI 751 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCD-EAATDVPKSQIGFL 119 + +D+G S ++W +WSQ L+ EF+ QG +EL LGL ++P+CD +PK+Q GFL Sbjct 752 KASDIGSSCMEWRLTLEWSQRLVQEFYTQGLEELSLGLPITPLCDPNKHNHLPKAQSGFL 811 Query 120 KLICFPLFESLA 131 + PL+ +A Sbjct 812 AIFVIPLYTEIA 823 > mmu:18575 Pde1c; phosphodiesterase 1C (EC:3.1.4.17); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=631 Score = 77.4 bits (189), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 37/93 (39%), Positives = 53/93 (56%), Gaps = 6/93 (6%) Query 59 CIRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVPKSQIGF 118 + AD+ H A W+ H++W+ +L+ EFF QG +E ELGL SP+CD +T V +SQ+GF Sbjct 371 MLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGF 430 Query 119 LKLICFPLFESLAQADNSGDLAAICLSFLKDNS 151 + I P F L D+ +S L D S Sbjct 431 IDFIVEPTFTVLT------DMTEKIVSPLIDES 457 > hsa:5137 PDE1C, Hcam3; phosphodiesterase 1C, calmodulin-dependent 70kDa (EC:3.1.4.17); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=634 Score = 77.4 bits (189), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 32/72 (44%), Positives = 46/72 (63%), Gaps = 0/72 (0%) Query 59 CIRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVPKSQIGF 118 + AD+ H A W+ H++W+ +L+ EFF QG +E ELGL SP+CD +T V +SQ+GF Sbjct 371 MLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGF 430 Query 119 LKLICFPLFESL 130 + I P F L Sbjct 431 IDFIVEPTFTVL 442 > pfa:PFL0475w PDE1; cGMP-specific phosphodiesterase (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=954 Score = 77.0 bits (188), Expect = 3e-14, Method: Composition-based stats. Identities = 42/156 (26%), Positives = 73/156 (46%), Gaps = 24/156 (15%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 D+ HF++++ FR F++ + L D W + + Sbjct 792 DMKNHFEYISDFRTSKEFID---------------------YDNLSND--QIWQIFCLIL 828 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCD-EAATDVPKSQIGFL 119 + +D+GHS ++W +H +W+ + EF+ QG E L +Q S +CD + SQI FL Sbjct 829 KASDIGHSTLEWNKHLEWTLKINEEFYLQGLLEKSLNIQNSFLCDINTMNKLALSQIDFL 888 Query 120 KLICFPLFESLAQADNSGDLAAICLSFLKDNSETWQ 155 K +C PLF L + D+ C+ +++N E W+ Sbjct 889 KHLCIPLFNELNYICKNNDVYTHCIQPIENNIERWE 924 > hsa:5153 PDE1B, PDE1B1, PDES1B; phosphodiesterase 1B, calmodulin-dependent (EC:3.1.4.17); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=536 Score = 77.0 bits (188), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 34/72 (47%), Positives = 45/72 (62%), Gaps = 0/72 (0%) Query 60 IRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVPKSQIGFL 119 + AD+ H +W H +W++ALM EFF QG +E ELGL SP+CD +T V +SQIGF+ Sbjct 366 LHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFI 425 Query 120 KLICFPLFESLA 131 I P F L Sbjct 426 DFIVEPTFSVLT 437 > tgo:TGME49_057080 cAMP-specific 3',5'-cyclic phosphodiesterase, putative (EC:3.1.4.17) Length=1691 Score = 77.0 bits (188), Expect = 4e-14, Method: Composition-based stats. Identities = 46/166 (27%), Positives = 77/166 (46%), Gaps = 30/166 (18%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 D+S H ++++ R++ N VN+E D W L + CI Sbjct 1460 DMSKHISYVSRLRVRAESGNFDVNNE-----------------------GDRWLLFQGCI 1496 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATD-VPKSQIGFL 119 + AD+ H+A W+ H +W++ L EFF QG +E G+ V + D D P+SQ F+ Sbjct 1497 KAADLAHTATFWDNHKRWAECLCEEFFKQGDEERRQGMNVMDIFDRRQKDRFPQSQYRFI 1556 Query 120 KLICFPLFESLAQADN-----SGDLAAICLSFLKDNSETWQRISDS 160 +L+ PLF S+ ++ G IC + L N W+ +++ Sbjct 1557 ELVVEPLFNSVCSIEDLLKGRGGVRGKICKT-LSSNLARWKEAAEA 1601 > tgo:TGME49_080410 3',5'-cyclic phosphodiesterase, putative (EC:3.1.4.17 1.6.5.3); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=1085 Score = 76.6 bits (187), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 50/164 (30%), Positives = 77/164 (46%), Gaps = 30/164 (18%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 D+ THF+ +A FR++ +K E D +N + D + I Sbjct 925 DMKTHFEQIANFRVR----------RQKEEFD-----PINNYD-------DRQKVMSMII 962 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVP--KSQIGF 118 + AD+GH + W H +W ++ EF+ QG +E LGL VS +CD D KSQ+GF Sbjct 963 KSADIGHGTLPWADHERWCNLVVQEFYEQGDEEKRLGLPVSFLCDRDQHDREFFKSQVGF 1022 Query 119 LKLICFPLFESLAQADNSGDLAA------ICLSFLKDNSETWQR 156 L + PL+E L + +L ICL L++N W++ Sbjct 1023 LDFVVKPLYEELKALETQLNLNPQLPIENICLKNLQENISEWKK 1066 > tgo:TGME49_066920 phosphodiesterase, putative (EC:3.1.4.17) Length=1065 Score = 76.3 bits (186), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 42/158 (26%), Positives = 81/158 (51%), Gaps = 23/158 (14%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 D+ HF+ +++FRL + S DF + ++ D W + K + Sbjct 726 DMKQHFETISRFRL------------RTSADDFDVAKHVD----------DRWAVLKMFV 763 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAA-TDVPKSQIGFL 119 + AD+ H A+ W+ H++ S ++ EF+ QG +EL G+ +S +CD + ++PKSQ GF+ Sbjct 764 KMADISHVALPWDMHFRLSCDIVEEFYQQGDEELRRGMPLSQLCDRSKHNEMPKSQEGFI 823 Query 120 KLICFPLFESLAQADNSGDLAAICLSFLKDNSETWQRI 157 + + PL L + D++G + ++ N W+++ Sbjct 824 EFLAKPLVGVLIEGDSTGTIKTEVSEQMERNLLRWKQM 861 > tgo:TGME49_110520 calcium/calmodulin-dependent 3', 5'-cyclic nucleotide phosphodiesterase, putative (EC:3.4.21.69 3.1.4.17) Length=1531 Score = 75.9 bits (185), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 44/131 (33%), Positives = 67/131 (51%), Gaps = 23/131 (17%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 D+ HF+ +++FRL+ + + + N KK E D W + K Sbjct 1330 DIKQHFETISRFRLRRN--SPEFNFLKKEEDD--------------------WLVRKMIF 1367 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCD-EAATDVPKSQIGFL 119 + AD+ H+ V W+ H+ WS + EF+AQG E+ LGL VSP+CD E ++ KSQ+ FL Sbjct 1368 KIADISHATVAWDAHFFWSCKVNAEFYAQGDAEVRLGLPVSPLCDREKHFEMGKSQVAFL 1427 Query 120 KLICFPLFESL 130 + PL L Sbjct 1428 NFVVEPLLREL 1438 > tgo:TGME49_072650 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative (EC:3.1.4.17) Length=1320 Score = 75.5 bits (184), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 54/164 (32%), Positives = 75/164 (45%), Gaps = 24/164 (14%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 D+S HF+FL R+ N N + E D A +LA I Sbjct 1175 DMSLHFEFLT--RVAARRENPDFNFVDREE-----------------DRALVLSLA---I 1212 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEA-ATDVPKSQIGFL 119 + AD+GH A+ WE H WS L EF AQG +EL LGL VSP+CD + +SQ F+ Sbjct 1213 KVADLGHCALDWEAHTLWSARLKEEFLAQGDEELRLGLPVSPLCDRTQQGQLARSQANFI 1272 Query 120 KLICFPLFESLAQADNSGDLAAICLSFLKDNSETWQRISDSEMD 163 + + PL + LA A ++ + N W+ D E+D Sbjct 1273 EFLFLPLAQHLAAVAPDDRFEATVVTRARQNISMWEGAQD-EVD 1315 > dre:563432 pde3b; phosphodiesterase 3B, cGMP-inhibited; K13296 cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17] Length=1107 Score = 75.1 bits (183), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 47/133 (35%), Positives = 64/133 (48%), Gaps = 20/133 (15%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 DL HFDFLA+F NSKVN ID+ T+ D + + CI Sbjct 883 DLKKHFDFLAEF-------NSKVNDVNSPGIDW-------------TNENDRLLVCQVCI 922 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVPKSQIGFLK 120 + AD+ A H KW++ ++NEF+ QG +E LGL +SP D +A + K Q F+ Sbjct 923 KLADINGPAKDRSLHLKWTEGIVNEFYEQGDEEGTLGLPISPFMDRSAPQLAKLQESFIT 982 Query 121 LICFPLFESLAQA 133 I PL S A Sbjct 983 HIVGPLCNSYDAA 995 > xla:496104 pde3b; phosphodiesterase 3b, cGMP-inhibited; K13296 cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17] Length=985 Score = 74.3 bits (181), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 44/126 (34%), Positives = 63/126 (50%), Gaps = 20/126 (15%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 DL HFDFLA+F N+KVN ID+ ++ D + + CI Sbjct 763 DLKKHFDFLAEF-------NAKVNDVNGLGIDW-------------SNENDRLLVCQVCI 802 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVPKSQIGFLK 120 + AD+ A E H KW++ ++NEF+ QG +E LGL +SP D +A + K Q F+ Sbjct 803 KLADINGPAKTRELHLKWTEGIVNEFYEQGDEESSLGLPISPFMDRSAPQLAKLQESFIT 862 Query 121 LICFPL 126 I PL Sbjct 863 HIVGPL 868 > xla:444562 pde4b, MGC83972; phosphodiesterase 4B, cAMP-specific; K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=721 Score = 73.9 bits (180), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 38/111 (34%), Positives = 60/111 (54%), Gaps = 8/111 (7%) Query 50 ADCWTLAKACIRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAAT 109 D + + + CAD+ + E + +W+ +M EFF QG +E E G+++SP+CD+ Sbjct 536 TDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDRERERGMEISPMCDKHTA 595 Query 110 DVPKSQIGFLKLICFPLFES---LAQADNSGDLAAICLSFLKDNSETWQRI 157 V KSQ+GF+ I PL+E+ L Q D A L L+DN +Q + Sbjct 596 SVEKSQVGFIDYIVHPLWETWGDLVQPD-----AQDILDTLEDNRNWYQSM 641 > hsa:5142 PDE4B, DKFZp686F2182, DPDE4, MGC126529, PDE4B5, PDEIVB; phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=564 Score = 73.2 bits (178), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 38/111 (34%), Positives = 60/111 (54%), Gaps = 8/111 (7%) Query 50 ADCWTLAKACIRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAAT 109 D + + + CAD+ + E + +W+ +M EFF QG +E E G+++SP+CD+ Sbjct 378 TDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTA 437 Query 110 DVPKSQIGFLKLICFPLFES---LAQADNSGDLAAICLSFLKDNSETWQRI 157 V KSQ+GF+ I PL+E+ L Q D A L L+DN +Q + Sbjct 438 SVEKSQVGFIDYIVHPLWETWADLVQPD-----AQDILDTLEDNRNWYQSM 483 > mmu:18578 Pde4b, Dpde4, R74983, dunce; phosphodiesterase 4B, cAMP specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=564 Score = 72.8 bits (177), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 38/111 (34%), Positives = 60/111 (54%), Gaps = 8/111 (7%) Query 50 ADCWTLAKACIRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAAT 109 D + + + CAD+ + E + +W+ +M EFF QG +E E G+++SP+CD+ Sbjct 378 TDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTA 437 Query 110 DVPKSQIGFLKLICFPLFES---LAQADNSGDLAAICLSFLKDNSETWQRI 157 V KSQ+GF+ I PL+E+ L Q D A L L+DN +Q + Sbjct 438 SVEKSQVGFIDYIVHPLWETWADLVQPD-----AQDILDTLEDNRNWYQSM 483 > dre:566998 novel protein similar to vertebrate phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) (PDE4D); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=745 Score = 71.6 bits (174), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 37/106 (34%), Positives = 61/106 (57%), Gaps = 2/106 (1%) Query 50 ADCWTLAKACIRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAAT 109 +D + + + CAD+ + + + +W+ +M EFF+QG +E E G+++SP+CD+ Sbjct 518 SDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFSQGDRERERGMEISPMCDKHNA 577 Query 110 DVPKSQIGFLKLICFPLFESLAQADNSGDLAAICLSFLKDNSETWQ 155 V KSQ+GF+ I PL+E+ AD A L L+DN E +Q Sbjct 578 SVEKSQVGFIDYIVHPLWETW--ADLVHPDAQDILDTLEDNREWYQ 621 > dre:565706 cAMP-specific 3,5-cyclic phosphodiesterase 4B-like; K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=713 Score = 71.2 bits (173), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 36/108 (33%), Positives = 59/108 (54%), Gaps = 2/108 (1%) Query 50 ADCWTLAKACIRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAAT 109 D + + + CAD+ + E + +W+ +M EFF QG +E E G+++SP+CD+ Sbjct 528 TDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFHQGDRERERGMEISPMCDKHTA 587 Query 110 DVPKSQIGFLKLICFPLFESLAQADNSGDLAAICLSFLKDNSETWQRI 157 V KSQ+GF+ I PL+E+ A + A L L+DN +Q + Sbjct 588 SVEKSQVGFIDYIVHPLWETWADLVHPD--AQDILDTLEDNRNWYQSM 633 > dre:572061 pde4a; phosphodiesterase 4A, cAMP-specific; K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=736 Score = 71.2 bits (173), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 37/109 (33%), Positives = 60/109 (55%), Gaps = 10/109 (9%) Query 51 DCWTLAKACIRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATD 110 D + + + CAD+ + + +W++ +M EFF QG +E E G+++SP+CD+ Sbjct 537 DRIQVLRNMVHCADLSNPTKPLAVYRQWTERIMEEFFQQGDKERERGMEISPMCDKHTAS 596 Query 111 VPKSQIGFLKLICFPLFESLAQADNSGDL----AAICLSFLKDNSETWQ 155 V KSQ+GF+ I PL+E+ GDL A L L+DN + +Q Sbjct 597 VEKSQVGFIDYIVHPLWETW------GDLVHPDAQEILDTLEDNRDWYQ 639 > mmu:238871 Pde4d, 9630011N22Rik, Dpde3; phosphodiesterase 4D, cAMP specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=747 Score = 70.5 bits (171), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 36/106 (33%), Positives = 60/106 (56%), Gaps = 2/106 (1%) Query 50 ADCWTLAKACIRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAAT 109 +D + + + CAD+ + + + +W+ +M EFF QG +E E G+++SP+CD+ Sbjct 545 SDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNA 604 Query 110 DVPKSQIGFLKLICFPLFESLAQADNSGDLAAICLSFLKDNSETWQ 155 V KSQ+GF+ I PL+E+ A + A L L+DN E +Q Sbjct 605 SVEKSQVGFIDYIVHPLWETWADLVHPD--AQDILDTLEDNREWYQ 648 > hsa:5140 PDE3B, HcGIP1, cGIPDE1; phosphodiesterase 3B, cGMP-inhibited (EC:3.1.4.17); K13296 cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17] Length=1112 Score = 70.5 bits (171), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 52/175 (29%), Positives = 81/175 (46%), Gaps = 24/175 (13%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 DL HFDFLA+F N+K N + I++ ++ D + + CI Sbjct 894 DLKKHFDFLAEF-------NAKANDVNSNGIEW-------------SNENDRLLVCQVCI 933 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVPKSQIGFLK 120 + AD+ A + H KW++ ++NEF+ QG +E LGL +SP D ++ + K Q F+ Sbjct 934 KLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRSSPQLAKLQESFIT 993 Query 121 LICFPLFESLAQADNSGDLAAICLSFLKDN-SETWQRISDSEMDWREISQINKCN 174 I PL S D +G L L +DN +E+ E+D + N N Sbjct 994 HIVGPLCNSY---DAAGLLPGQWLEAEEDNDTESGDDEDGEELDTEDEEMENNLN 1045 > hsa:5144 PDE4D, DKFZp686M11213, DPDE3, FLJ97311, HSPDE4D, PDE4DN2, STRK1; phosphodiesterase 4D, cAMP-specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=809 Score = 70.5 bits (171), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 37/106 (34%), Positives = 60/106 (56%), Gaps = 2/106 (1%) Query 50 ADCWTLAKACIRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAAT 109 +D + + + CAD+ + + + +W+ +M EFF QG +E E G+++SP+CD+ Sbjct 606 SDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNA 665 Query 110 DVPKSQIGFLKLICFPLFESLAQADNSGDLAAICLSFLKDNSETWQ 155 V KSQ+GF+ I PL+E+ AD A L L+DN E +Q Sbjct 666 SVEKSQVGFIDYIVHPLWETW--ADLVHPDAQDILDTLEDNREWYQ 709 > dre:571344 fc68c05, si:ch211-255d18.8, wu:fc68c05; si:ch211-255d18.1 Length=709 Score = 70.1 bits (170), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 46/157 (29%), Positives = 76/157 (48%), Gaps = 19/157 (12%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 D+S H +FLA + + KV S+ +D S D + + + Sbjct 472 DMSKHMNFLADLKTMVE--TKKVTSQGVLLLDNYS---------------DRIQVLQNMV 514 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVPKSQIGFLK 120 CAD+ + E + KW+ +M EFF+QG +E + G+ VSP+CD+ + +Q+GF+ Sbjct 515 HCADLSNPTKPLELYRKWTDRIMVEFFSQGDRERDKGIDVSPMCDKHTASMENTQVGFID 574 Query 121 LICFPLFESLAQADNSGDLAAICLSFLKDNSETWQRI 157 I PL+E+ A + A L L+DN E +Q + Sbjct 575 YIIHPLWETWADLVHPD--AQDILDTLEDNREWYQSM 609 > xla:495146 hypothetical LOC495146; K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=682 Score = 70.1 bits (170), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 36/109 (33%), Positives = 59/109 (54%), Gaps = 8/109 (7%) Query 50 ADCWTLAKACIRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAAT 109 D + + + CAD+ + E + +W+ ++ EFF QG +E E G+++SP+CD+ Sbjct 488 TDRIQVLRNMVHCADLSNPTKPLELYRQWTDRILEEFFRQGDKERERGMEISPMCDKHTA 547 Query 110 DVPKSQIGFLKLICFPLFES---LAQADNSGDLAAICLSFLKDNSETWQ 155 V KSQ+GF+ I PL+E+ L D A L L+DN + +Q Sbjct 548 SVEKSQVGFIDYIVHPLWETWSDLVHPD-----AQDILDTLEDNRDWYQ 591 > dre:565259 pde4c, im:7160317, si:dkey-149i17.5; phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila) Length=672 Score = 69.7 bits (169), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 36/111 (32%), Positives = 61/111 (54%), Gaps = 8/111 (7%) Query 50 ADCWTLAKACIRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAAT 109 +D + + + CAD+ + E + +W+ +M EFF QG +E + G+++SP+CD+ Sbjct 518 SDRIQVLQNMVHCADLSNPTKPLELYRQWTDRIMVEFFTQGDRERDKGMEISPMCDKHNA 577 Query 110 DVPKSQIGFLKLICFPLFES---LAQADNSGDLAAICLSFLKDNSETWQRI 157 + KSQ+GF+ I PL+E+ L D A L L+DN E +Q + Sbjct 578 SIEKSQVGFIDYIVHPLWETWADLVHPD-----AQEILDTLEDNREWYQSM 623 > cel:R153.1 pde-4; PhosphoDiEsterase family member (pde-4); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=673 Score = 69.3 bits (168), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 30/81 (37%), Positives = 50/81 (61%), Gaps = 0/81 (0%) Query 51 DCWTLAKACIRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATD 110 D + ++ I AD+ + E + +W+Q +M E++ QG +E ELGL++SP+CD Sbjct 551 DKIQVLQSMIHLADLSNPTKPIELYQQWNQRIMEEYWRQGDKEKELGLEISPMCDRGNVT 610 Query 111 VPKSQIGFLKLICFPLFESLA 131 + KSQ+GF+ I PL+E+ A Sbjct 611 IEKSQVGFIDYIVHPLYETWA 631 > mmu:18576 Pde3b, 9830102A01Rik, AI847709; phosphodiesterase 3B, cGMP-inhibited (EC:3.1.4.17); K13296 cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17] Length=1099 Score = 69.3 bits (168), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 42/133 (31%), Positives = 64/133 (48%), Gaps = 20/133 (15%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 DL HFDFLA+F N+K N + I++ S D + + CI Sbjct 870 DLKKHFDFLAEF-------NAKANDVNSNGIEWSSEN-------------DRLLVCQVCI 909 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVPKSQIGFLK 120 + AD+ A + H +W++ ++NEF+ QG +E LGL +SP D ++ + K Q F+ Sbjct 910 KLADINGPAKDRDLHLRWTEGIVNEFYEQGDEEATLGLPISPFMDRSSPQLAKLQESFIT 969 Query 121 LICFPLFESLAQA 133 I PL S A Sbjct 970 HIVGPLCNSYDAA 982 > dre:567051 si:dkey-48h7.2; K13296 cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17] Length=1117 Score = 69.3 bits (168), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 44/133 (33%), Positives = 65/133 (48%), Gaps = 20/133 (15%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 DL HFDFLA+F N+KV + S ID+ T+ D + + CI Sbjct 835 DLKKHFDFLAEF-------NAKVGDDGCSGIDW-------------TNENDRLLVCQMCI 874 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVPKSQIGFLK 120 + AD+ + H +W++ ++NEF+ QG +E LGL +SP D +A + K Q F+ Sbjct 875 KLADINGPLKCKDLHLQWTEGIVNEFYEQGDEESSLGLPISPFMDRSAPQLAKLQESFIT 934 Query 121 LICFPLFESLAQA 133 I PL S A Sbjct 935 HIVGPLCSSYDSA 947 > hsa:5141 PDE4A, DPDE2, PDE4, PDE46; phosphodiesterase 4A, cAMP-specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=886 Score = 69.3 bits (168), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 30/82 (36%), Positives = 50/82 (60%), Gaps = 0/82 (0%) Query 50 ADCWTLAKACIRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAAT 109 +D + + + CAD+ + E + +W+ +M EFF QG +E E G+++SP+CD+ Sbjct 577 SDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTA 636 Query 110 DVPKSQIGFLKLICFPLFESLA 131 V KSQ+GF+ I PL+E+ A Sbjct 637 SVEKSQVGFIDYIVHPLWETWA 658 > hsa:27115 PDE7B, MGC88256, bA472E5.1; phosphodiesterase 7B (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=450 Score = 68.9 bits (167), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 33/110 (30%), Positives = 55/110 (50%), Gaps = 0/110 (0%) Query 48 DPADCWTLAKACIRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEA 107 D D + + ++CAD+ + WE +WS+ + EF+ QG E + L++SP+C++ Sbjct 307 DAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQ 366 Query 108 ATDVPKSQIGFLKLICFPLFESLAQADNSGDLAAICLSFLKDNSETWQRI 157 +P QIGF+ I PLF A + L+ L L N W+ + Sbjct 367 KDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSL 416 > mmu:29863 Pde7b; phosphodiesterase 7B (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=446 Score = 68.9 bits (167), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 34/115 (29%), Positives = 59/115 (51%), Gaps = 0/115 (0%) Query 55 LAKACIRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVPKS 114 + + ++CAD+ + WE +WS+ + EF+ QG E + L++SP+C++ +P Sbjct 314 MLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGDLEQKFELEISPLCNQQKDSIPSI 373 Query 115 QIGFLKLICFPLFESLAQADNSGDLAAICLSFLKDNSETWQRISDSEMDWREISQ 169 QIGF+ I PLF A+ + L+ LS L N W+ + ++ R Q Sbjct 374 QIGFMTYIVEPLFREWARFTGNSTLSENMLSHLAHNKAQWKSLLSNQHRRRGSGQ 428 > mmu:18577 Pde4a, D9Ertd60e, Dpde2; phosphodiesterase 4A, cAMP specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=610 Score = 68.9 bits (167), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 30/82 (36%), Positives = 50/82 (60%), Gaps = 0/82 (0%) Query 50 ADCWTLAKACIRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAAT 109 +D + + + CAD+ + E + +W+ +M EFF QG +E E G+++SP+CD+ Sbjct 329 SDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTA 388 Query 110 DVPKSQIGFLKLICFPLFESLA 131 V KSQ+GF+ I PL+E+ A Sbjct 389 SVEKSQVGFIDYIVHPLWETWA 410 > pfa:MAL13P1.119 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1b (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=769 Score = 68.6 bits (166), Expect = 1e-11, Method: Composition-based stats. Identities = 45/175 (25%), Positives = 81/175 (46%), Gaps = 27/175 (15%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 D+S H LAQFR++ + K+ S + I K I Sbjct 600 DMSKHIKILAQFRIK----SIKIKSYIEKNIIL---------------------CLKMII 634 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAA-TDVPKSQIGFL 119 + AD+ H+ V W +HY+W + L+NEF+ +G + ++G +++P+ D + + Q FL Sbjct 635 KAADLSHNCVDWSEHYQWVKRLVNEFYYEGDELFQMGYKINPLFDRNCHNNFIQIQRTFL 694 Query 120 KLICFPLFESLAQADNSGDLAAICLSFLKDNSETWQRISDSEMDWREISQINKCN 174 K + +PL SL DN+ + ++ +K N W +I ++ ++ CN Sbjct 695 KELVYPLIISLKTLDNT-SITQDMINNVKRNYSKWTKIEKCQIKKKKYLNELLCN 748 > hsa:5143 PDE4C, DPDE1, MGC126222; phosphodiesterase 4C, cAMP-specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=712 Score = 68.6 bits (166), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 47/155 (30%), Positives = 75/155 (48%), Gaps = 19/155 (12%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 D+S H + LA L + V ++K + + L + +D + + + Sbjct 500 DMSKHMNLLAD-------LKTMVETKKVTSLGV----------LLLDNYSDRIQVLQNLV 542 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVPKSQIGFLK 120 CAD+ + + +W+ +M EFF QG +E E GL +SP+CD+ V KSQ+GF+ Sbjct 543 HCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFID 602 Query 121 LICFPLFESLAQADNSGDLAAICLSFLKDNSETWQ 155 I PL+E+ AD A L L+DN E +Q Sbjct 603 YIAHPLWETW--ADLVHPDAQDLLDTLEDNREWYQ 635 > hsa:5139 PDE3A, CGI-PDE; phosphodiesterase 3A, cGMP-inhibited (EC:3.1.4.17); K13296 cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17] Length=1141 Score = 65.9 bits (159), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 44/133 (33%), Positives = 63/133 (47%), Gaps = 22/133 (16%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 DL HFDF+A+F N KVN + ID+ T+ D + + CI Sbjct 909 DLKKHFDFVAKF-------NGKVNDDVG--IDW-------------TNENDRLLVCQMCI 946 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVPKSQIGFLK 120 + AD+ A E H +W+ ++NEF+ QG +E LGL +SP D +A + Q F+ Sbjct 947 KLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFIS 1006 Query 121 LICFPLFESLAQA 133 I PL S A Sbjct 1007 HIVGPLCNSYDSA 1019 > dre:100151215 phosphodiesterase 7A-like (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=490 Score = 65.1 bits (157), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 33/98 (33%), Positives = 53/98 (54%), Gaps = 1/98 (1%) Query 57 KACIRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVPKSQI 116 + ++CAD+ + WE +WS+ + EFF QG E +L L++SP+CD A + QI Sbjct 357 QMALKCADICNPCRPWELSKQWSEKVTEEFFHQGDIEKKLKLEISPLCDSEANTIASVQI 416 Query 117 GFLKLICFPLFESLAQADNSGDLAAICLSFLKDNSETW 154 GF+ + PLF A+ ++ L+ L L N +W Sbjct 417 GFMTYVVEPLFAEWARFSDT-RLSQTMLGHLGLNKASW 453 > mmu:54611 Pde3a, A930022O17Rik, C87899; phosphodiesterase 3A, cGMP inhibited (EC:3.1.4.17); K13296 cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17] Length=1141 Score = 64.7 bits (156), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 43/133 (32%), Positives = 64/133 (48%), Gaps = 22/133 (16%) Query 1 DLSTHFDFLAQFRLQLHFLNSKVNSEKKSEIDFKSPQTLNPHKTLKTDPADCWTLAKACI 60 DL HFDF+A+F N+KVN + ID+ T+ D + + CI Sbjct 909 DLKKHFDFVAKF-------NAKVNDDVG--IDW-------------TNENDRLLVCQMCI 946 Query 61 RCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVPKSQIGFLK 120 + AD+ A E H +W++ + +EF+ QG +E LGL +SP D +A + Q F+ Sbjct 947 KLADINGPAKCKELHLRWTEGIASEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFIS 1006 Query 121 LICFPLFESLAQA 133 I PL S A Sbjct 1007 HIVGPLCHSYDSA 1019 > cel:T04D3.3 pde-1; PhosphoDiEsterase family member (pde-1); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=664 Score = 63.9 bits (154), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 26/66 (39%), Positives = 36/66 (54%), Gaps = 0/66 (0%) Query 60 IRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVPKSQIGFL 119 + D+ H A W H +W++ ++ EFF QG E +GL SP+CD V SQIGF+ Sbjct 476 VHACDISHPAKPWNLHERWTEGVLEEFFRQGDLEASMGLPYSPLCDRHTVHVADSQIGFI 535 Query 120 KLICFP 125 I P Sbjct 536 DFIVEP 541 > hsa:5150 PDE7A, HCP1, PDE7; phosphodiesterase 7A (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=456 Score = 62.0 bits (149), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 32/99 (32%), Positives = 51/99 (51%), Gaps = 1/99 (1%) Query 57 KACIRCADVGHSAVKWEQHYKWSQALMNEFFAQGRQELELGLQVSPVCDEAATDVPKSQI 116 + ++CAD+ + WE +WS+ + EFF QG E + L VSP+CD + QI Sbjct 329 QMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQI 388 Query 117 GFLKLICFPLFESLAQADNSGDLAAICLSFLKDNSETWQ 155 GF+ + PLF A+ N+ L+ L + N +W+ Sbjct 389 GFMTYLVEPLFTEWARFSNT-RLSQTMLGHVGLNKASWK 426 Lambda K H 0.320 0.132 0.418 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 4976880524 Database: egene_temp_file_orthology_annotation_similarity_blast_database_866 Posted date: Sep 17, 2011 2:57 PM Number of letters in database: 82,071,388 Number of sequences in database: 164,496 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40