bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: egene_temp_file_orthology_annotation_similarity_blast_database_866
164,496 sequences; 82,071,388 total letters
Query= Eten_1375_orf1
Length=317
Score E
Sequences producing significant alignments: (Bits) Value
tgo:TGME49_007820 mitogen-activated protein kinase, putative (... 506 3e-143
cpv:cgd2_4340 mitogen-activated protein kinase 2 ; K08293 mito... 400 3e-111
pfa:PF11_0147 map-2; mitogen-activated protein kinase 2; K0829... 354 2e-97
bbo:BBOV_IV005520 23.m06268; mitogen-activated protein kinase;... 343 5e-94
tpv:TP01_0359 mitogen-activated protein kinase 2; K08293 mitog... 342 1e-93
ath:AT2G18170 ATMPK7; ATMPK7 (ARABIDOPSIS THALIANA MAP KINASE ... 204 3e-52
mmu:26417 Mapk3, Erk-1, Erk1, Ert2, Esrk1, Mnk1, Mtap2k, Prkm3... 193 8e-49
ath:AT1G10210 ATMPK1; ATMPK1 (MITOGEN-ACTIVATED PROTEIN KINASE... 191 4e-48
ath:AT2G43790 ATMPK6; ATMPK6 (ARABIDOPSIS THALIANA MAP KINASE ... 190 5e-48
hsa:5595 MAPK3, ERK1, HS44KDAP, HUMKER1A, MGC20180, P44ERK1, P... 189 2e-47
ath:AT4G36450 ATMPK14 (Mitogen-activated protein kinase 14); M... 188 2e-47
ath:AT1G59580 ATMPK2; ATMPK2 (ARABIDOPSIS THALIANA MITOGEN-ACT... 187 3e-47
ath:AT3G45640 ATMPK3; ATMPK3 (ARABIDOPSIS THALIANA MITOGEN-ACT... 187 5e-47
xla:398985 mapk1-a, MGC68934, erk, erk2, mapk, mapk1, mapk1a, ... 183 9e-46
dre:541323 mapk7, bmk1, erk5, wu:fb73b02, zgc:113111; mitogen-... 182 1e-45
dre:399480 mapk3, ERK1, fi06b09, wu:fi06b09, zERK1; mitogen-ac... 182 1e-45
dre:100330818 mitogen-activated protein kinase 3-like; K04371 ... 182 1e-45
dre:360144 mapk1, zERK2; mitogen-activated protein kinase 1 (E... 182 1e-45
ath:AT3G59790 ATMPK10; MAP kinase/ kinase; K04371 extracellula... 182 2e-45
hsa:5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2,... 181 2e-45
mmu:26413 Mapk1, 9030612K14Rik, AA407128, AU018647, C78273, ER... 181 3e-45
tgo:TGME49_033010 mitogen-activated protein kinase 2 (EC:2.7.1... 178 2e-44
mmu:29857 Mapk12, AW123708, Erk6, P38gamma, Prkm12, Sapk3; mit... 178 3e-44
xla:397785 mapk1-b, Xp42, erk, erk2, mapk, mapk1b, mpk1; mitog... 178 3e-44
ath:AT1G07880 ATMPK13; MAP kinase/ kinase; K04371 extracellula... 178 3e-44
cel:F43C1.2 mpk-1; MAP Kinase family member (mpk-1); K04371 ex... 177 4e-44
xla:398592 mapk12, Xp38gamma, sapk3; mitogen-activated protein... 176 9e-44
hsa:5600 MAPK11, P38B, P38BETA2, PRKM11, SAPK2, SAPK2B, p38-2,... 176 1e-43
ath:AT1G01560 ATMPK11; MAP kinase/ kinase; K04371 extracellula... 176 2e-43
sce:YLR113W HOG1, SSK3; Hog1p (EC:2.7.11.24); K04441 p38 MAP k... 175 2e-43
ath:AT4G01370 ATMPK4; ATMPK4 (ARABIDOPSIS THALIANA MAP KINASE ... 175 2e-43
xla:494669 mapk11, p38-2, p38Beta, p38b, p38beta2, prkm11, sap... 174 3e-43
dre:100002318 mapk13, im:7136778; mitogen-activated protein ki... 174 3e-43
mmu:19094 Mapk11, DKFZp586C1322, P38b, Prkm11, Sapk2, Sapk2b, ... 174 3e-43
cpv:cgd3_3030 MAPK ; K04371 extracellular signal-regulated kin... 174 4e-43
sce:YBL016W FUS3, DAC2; Fus3p (EC:2.7.11.24); K04371 extracell... 174 4e-43
sce:YHR030C SLT2, BYC2, MPK1, SLK2; Serine/threonine MAP kinas... 174 5e-43
xla:446599 mapk7, MGC81757, bmk1, erk4, prkm7; mitogen-activat... 174 5e-43
hsa:6300 MAPK12, ERK3, ERK6, P38GAMMA, PRKM12, SAPK-3, SAPK3; ... 173 7e-43
hsa:100509694 mitogen-activated protein kinase 12-like 172 1e-42
xla:100329215 p38-beta; mitogen-activated protein kinase p38 b... 172 2e-42
ath:AT4G11330 ATMPK5; ATMPK5 (MAP KINASE 5); MAP kinase/ kinas... 171 2e-42
dre:415185 zgc:86905; K04441 p38 MAP kinase [EC:2.7.11.24] 171 3e-42
cel:B0218.3 pmk-1; P38 Map Kinase family member (pmk-1); K0444... 169 1e-41
pfa:PF14_0294 PfMAP1; mitogen-activated protein kinase 1; K043... 169 1e-41
xla:379992 mapk14, MGC69036, csbp, mapk14a, mxi2, p38, p38-alp... 167 6e-41
hsa:5598 MAPK7, BMK1, ERK4, ERK5, PRKM7; mitogen-activated pro... 166 9e-41
mmu:23939 Mapk7, BMK1, ERK5, Erk5-T, PRKM7; mitogen-activated ... 166 9e-41
xla:734485 mapk15, MGC99048; mitogen-activated protein kinase ... 165 2e-40
dre:65237 mapk14a, MAPK14, fk28c03, hm:zeh1243, p38, p38a, wu:... 165 2e-40
> tgo:TGME49_007820 mitogen-activated protein kinase, putative
(EC:2.7.11.24); K08293 mitogen-activated protein kinase [EC:2.7.11.24]
Length=548
Score = 506 bits (1304), Expect = 3e-143, Method: Compositional matrix adjust.
Identities = 236/315 (74%), Positives = 272/315 (86%), Gaps = 2/315 (0%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
DFKKLFR PVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG
Sbjct 232 DFKKLFRTPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 291
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVT--HTKNLKRQLTGQVVTRWYRAPELILLAENY 118
LART+D+PE NS P++ ++DD+ VT HTKNLKRQLTG VVTRWYRAPELILL ENY
Sbjct 292 LARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENY 351
Query 119 TEAIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNK 178
TEAIDVWSIGCIF+ELL+MI+ENV H DRGPLFPGSSCFPLSPDQK G+D + TRGN+
Sbjct 352 TEAIDVWSIGCIFAELLNMIKENVAYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNR 411
Query 179 DQLNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRML 238
DQLNVIFN+LGTP+EE+I A E +AK+YIR FP ++ DLA+RF ASS +A++LLKRML
Sbjct 412 DQLNVIFNILGTPSEEDIEALEKEDAKRYIRIFPKREGTDLAERFPASSADAIHLLKRML 471
Query 239 VFNPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQR 298
VFNP +RI+++ECLAHPFF+ VR +E ATEKVRLPFNDW NMDEPQLR F++E+QR
Sbjct 472 VFNPNKRITINECLAHPFFKEVRIAEVETNATEKVRLPFNDWMNMDEPQLRYAFVKEIQR 531
Query 299 FHPELQLPKSLLERA 313
+HPE+QLP+ RA
Sbjct 532 YHPEIQLPRRSPNRA 546
> cpv:cgd2_4340 mitogen-activated protein kinase 2 ; K08293 mitogen-activated
protein kinase [EC:2.7.11.24]
Length=563
Score = 400 bits (1028), Expect = 3e-111, Method: Compositional matrix adjust.
Identities = 193/333 (57%), Positives = 244/333 (73%), Gaps = 24/333 (7%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
DFKKLFR PVYL+ELH+KTLLYNLLVG+KY+HSAGI HRDLKPANCLVNQDC VK+CDFG
Sbjct 226 DFKKLFRTPVYLSELHVKTLLYNLLVGLKYIHSAGIYHRDLKPANCLVNQDCGVKICDFG 285
Query 61 LARTMDFPEGQNSHCPVAQQD--------DDIVNVTHTKN---------------LKRQL 97
LART+ P ++ VA + I+ T K+ LKRQL
Sbjct 286 LARTVKRPTDTINYNSVASNNINNSVVNRKSIMTGTSIKSDNSQENGGFQQGGRFLKRQL 345
Query 98 TGQVVTRWYRAPELILLAENYTEAIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSC 157
TG VVTRWYRAPELILL ENYTEAID+WS+GCIF+ELL+M++ENV + DR PLFPGSSC
Sbjct 346 TGHVVTRWYRAPELILLQENYTEAIDMWSVGCIFAELLNMLKENVAYYSDRSPLFPGSSC 405
Query 158 FPLSPDQKN-GDDSRLQTRGNKDQLNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKA 216
FPLSPD K +D R + RGN+DQLN+IFNVLG+P +E+I E +AK+YIR F +
Sbjct 406 FPLSPDNKQQTEDYRFKIRGNRDQLNMIFNVLGSPLDEDIEVLEKEDAKRYIRIFSKRTG 465
Query 217 HDLAQRFSASSPEALNLLKRMLVFNPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLP 276
DL RF +S ++++LLK+MLVFNP +RI+VDE L+H F+ +RN +E+ + EKV LP
Sbjct 466 IDLQTRFPGASSQSIDLLKKMLVFNPNKRITVDEALSHSLFKNIRNEMLEIISHEKVTLP 525
Query 277 FNDWANMDEPQLRLGFLREMQRFHPELQLPKSL 309
F+DW++M E +LR FL+E+QRF P+L +P S+
Sbjct 526 FDDWSSMTERELRYFFLKEIQRFSPDLVIPDSI 558
> pfa:PF11_0147 map-2; mitogen-activated protein kinase 2; K08293
mitogen-activated protein kinase [EC:2.7.11.24]
Length=508
Score = 354 bits (909), Expect = 2e-97, Method: Compositional matrix adjust.
Identities = 164/320 (51%), Positives = 229/320 (71%), Gaps = 25/320 (7%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D KKLF+ P++LTE H+KT+LYNLL+G K++H +GI+HRDLKPANCL+NQDCSVK+CDFG
Sbjct 193 DLKKLFKTPIFLTEQHVKTILYNLLLGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFG 252
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVT-----------HTKNLKRQLTGQVVTRWYRAP 109
LART++ + +D IVN H KNLK+QLT VVTRWYRAP
Sbjct 253 LARTIN-----------SDKDIHIVNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAP 301
Query 110 ELILLAENYTEAIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDD 169
ELILL ENYT +ID+WS GCIF+ELL+M++ ++ + +R PLFPGSSCFPLSPD +
Sbjct 302 ELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNRFPLFPGSSCFPLSPDH---NS 358
Query 170 SRLQTRGNKDQLNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPE 229
++ + N+DQLN+IFNV+GTP EE++ E +YI+ FP + DL++++S+ S E
Sbjct 359 KKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKLFPTRDGIDLSKKYSSISKE 418
Query 230 ALNLLKRMLVFNPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLR 289
++LL+ ML FN ++RI++D+ L+HP+ + VR ++E +TEK+ LPF+DW + E QLR
Sbjct 419 GIDLLESMLRFNAQKRITIDKALSHPYLKDVRKENLENFSTEKIILPFDDWMVLSETQLR 478
Query 290 LGFLREMQRFHPELQLPKSL 309
FL+E+Q FH +L +P L
Sbjct 479 YIFLKEIQSFHADLIIPAKL 498
> bbo:BBOV_IV005520 23.m06268; mitogen-activated protein kinase;
K08293 mitogen-activated protein kinase [EC:2.7.11.24]
Length=584
Score = 343 bits (880), Expect = 5e-94, Method: Compositional matrix adjust.
Identities = 173/341 (50%), Positives = 220/341 (64%), Gaps = 33/341 (9%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D K L R+P +L + HIK ++YNLL GV Y+H+ GI HRDLKPANCLVN+DCSVK+CDFG
Sbjct 247 DIKLLIRSPAFLNDSHIKLIMYNLLCGVYYLHARGIYHRDLKPANCLVNRDCSVKICDFG 306
Query 61 LARTMDFPEGQ---NSHCP-VAQQDDDIVNVTHTKNL----------------------- 93
LART+ P Q HC A++ +D + +NL
Sbjct 307 LARTIAQPVTQAPLGKHCSFTAREVEDEMCQVGVRNLPNSARLVDYNDELAHFQRKRMNV 366
Query 94 --KRQLTGQVVTRWYRAPELILLAENYTEAIDVWSIGCIFSELLSMIEENVESHCDRGPL 151
RQLTG VVTRWYRAPELILL +NYT AIDVWS+GCIF+ELL+M++ N+ R PL
Sbjct 367 SHSRQLTGHVVTRWYRAPELILLQDNYTAAIDVWSVGCIFAELLNMVKGNMSDVSQRSPL 426
Query 152 FPGSSCFPLSPDQKNGDDSRLQTRGNKDQLNVIFNVLGTPTEEEINAPESNEAKQYIRTF 211
FPG+SCFPLSPD KN D + DQLN+IFNV+GTP EE+I A E ++YIR F
Sbjct 427 FPGTSCFPLSPDNKNPSDKAKE----HDQLNIIFNVIGTPCEEDIAAIIKPEVRRYIRMF 482
Query 212 PPKKAHDLAQRFSASSPEALNLLKRMLVFNPKRRISVDECLAHPFFEGVRNPSIEVTATE 271
P+K DL +RF + P A+NLL++ML FNP +RI+V E L H +F P TE
Sbjct 483 HPRKGIDLYKRFKGTPPAAVNLLQQMLTFNPYKRITVAEALKHEYFREFYKPQHVEIPTE 542
Query 272 KVRLPFNDWANMDEPQLRLGFLREMQRFHPELQLPKSLLER 312
++ PFNDW NM E QLR FLRE+QR+HPE ++P ++ +
Sbjct 543 QLVTPFNDWINMSESQLRYAFLREIQRYHPEFKIPLKIIYK 583
> tpv:TP01_0359 mitogen-activated protein kinase 2; K08293 mitogen-activated
protein kinase [EC:2.7.11.24]
Length=642
Score = 342 bits (876), Expect = 1e-93, Method: Compositional matrix adjust.
Identities = 170/365 (46%), Positives = 225/365 (61%), Gaps = 55/365 (15%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D K+L R+P +L E HI+ L++NLL GV Y+HS GI HRDLKPANCL+N+DCSVK+CDFG
Sbjct 281 DIKQLVRSPAFLNENHIRLLVFNLLSGVHYLHSVGIYHRDLKPANCLINRDCSVKICDFG 340
Query 61 LARTMDFPE---------GQNSH-------------------------CPVAQQDDDI-- 84
LART FPE G+ + C + + I
Sbjct 341 LARTTTFPEEFMDSTSYSGRQAEVSYSSRPVESISTSYSTSRSLPDYACGLGSSEKLISD 400
Query 85 -----------VNVTHTKNLKRQL-----TGQVVTRWYRAPELILLAENYTEAIDVWSIG 128
N K RQ+ TG VVTRWYRAPELILL ENY+ A+D+WS+G
Sbjct 401 TASGNATLNPYTNTVTVKGPMRQIYRRQLTGHVVTRWYRAPELILLQENYSFAVDIWSVG 460
Query 129 CIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQLNVIFNVL 188
CIF+ELL+M++ NV CDR PLFPGSSCFPLSPD KN + +T DQLN+IFNVL
Sbjct 461 CIFAELLNMMKVNVSDPCDRSPLFPGSSCFPLSPDNKNANP---RTTRENDQLNLIFNVL 517
Query 189 GTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVFNPKRRISV 248
GTP+EE+IN + + ++Y++ F + DL +F +S E+++LLK+ML FNP +RISV
Sbjct 518 GTPSEEDINCIQKADVRRYVKFFAKRSFQDLRTKFKGASLESIDLLKKMLTFNPDKRISV 577
Query 249 DECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQRFHPELQLPKS 308
+ L HP+F+ + P + KV LPFNDW NM E QLR FLRE+QR+H + ++P
Sbjct 578 FDALNHPYFKSISKPRNNFDSIPKVTLPFNDWVNMSESQLRYSFLREIQRYHKDFKIPVK 637
Query 309 LLERA 313
++ R+
Sbjct 638 IIYRS 642
> ath:AT2G18170 ATMPK7; ATMPK7 (ARABIDOPSIS THALIANA MAP KINASE
7); MAP kinase/ kinase; K08293 mitogen-activated protein kinase
[EC:2.7.11.24]
Length=368
Score = 204 bits (519), Expect = 3e-52, Method: Compositional matrix adjust.
Identities = 110/308 (35%), Positives = 171/308 (55%), Gaps = 58/308 (18%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D ++ ++ L++ H K L+ LL G+KY+HSA ILHRDLKP N LVN +C +K+CDFG
Sbjct 119 DLHQIIKSSQSLSDDHCKYFLFQLLRGLKYLHSANILHRDLKPGNLLVNANCDLKICDFG 178
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LART ++ ++ +T VVTRWYRAPEL+L +NY
Sbjct 179 LART-------------------------SQGNEQFMTEYVVTRWYRAPELLLCCDNYGT 213
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
+IDVWS+GCIF+E+L R P+FPG+ C +Q
Sbjct 214 SIDVWSVGCIFAEILG-----------RKPIFPGTECL--------------------NQ 242
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
L +I NV+G+ E +I ++ +A+++I++ P + L+ + ++P A++LL+RMLVF
Sbjct 243 LKLIINVVGSQQESDIRFIDNPKARRFIKSLPYSRGTHLSNLYPQANPLAIDLLQRMLVF 302
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQRFH 300
+P +RISV + L HP+ G+ +P A + L ++ NM+EP +R EM +H
Sbjct 303 DPTKRISVTDALLHPYMAGLFDPGSNPPAHVPISLDIDE--NMEEPVIREMMWNEMLYYH 360
Query 301 PELQLPKS 308
PE ++ +
Sbjct 361 PEAEISNA 368
> mmu:26417 Mapk3, Erk-1, Erk1, Ert2, Esrk1, Mnk1, Mtap2k, Prkm3,
p44, p44erk1, p44mapk; mitogen-activated protein kinase
3 (EC:2.7.11.24); K04371 extracellular signal-regulated kinase
1/2 [EC:2.7.11.24]
Length=380
Score = 193 bits (490), Expect = 8e-49, Method: Compositional matrix adjust.
Identities = 115/304 (37%), Positives = 164/304 (53%), Gaps = 61/304 (20%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D KL ++ L+ HI LY +L G+KY+HSA +LHRDLKP+N L+N C +K+CDFG
Sbjct 129 DLYKLLKSQ-QLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFG 187
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LAR D PE ++ LT V TRWYRAPE++L ++ YT+
Sbjct 188 LARIAD-PEHDHTGF---------------------LTEYVATRWYRAPEIMLNSKGYTK 225
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
+ID+WS+GCI +E+LS P+FPG DQ
Sbjct 226 SIDIWSVGCILAEMLS-----------NRPIFPGKHYL--------------------DQ 254
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
LN I +LG+P++E++N + +A+ Y+++ P K A+ F S +AL+LL RML F
Sbjct 255 LNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTF 314
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDE-PQLRLG--FLREMQ 297
NP +RI+V+E LAHP+ E +P+ E A E PF +D+ P+ RL +E
Sbjct 315 NPNKRITVEEALAHPYLEQYYDPTDEPVAEE----PFTFDMELDDLPKERLKELIFQETA 370
Query 298 RFHP 301
RF P
Sbjct 371 RFQP 374
> ath:AT1G10210 ATMPK1; ATMPK1 (MITOGEN-ACTIVATED PROTEIN KINASE
1); MAP kinase/ kinase; K04371 extracellular signal-regulated
kinase 1/2 [EC:2.7.11.24]
Length=370
Score = 191 bits (484), Expect = 4e-48, Method: Compositional matrix adjust.
Identities = 108/303 (35%), Positives = 161/303 (53%), Gaps = 60/303 (19%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D ++ ++ L+ H + L+ LL G+KY+HSA ILHRDLKP N LVN +C +K+CDFG
Sbjct 119 DLHQIIKSSQVLSNDHCQYFLFQLLRGLKYIHSANILHRDLKPGNLLVNANCDLKICDFG 178
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQ-LTGQVVTRWYRAPELILLAENYT 119
LAR N K Q +T VVTRWYRAPEL+L +NY
Sbjct 179 LAR--------------------------ASNTKGQFMTEYVVTRWYRAPELLLCCDNYG 212
Query 120 EAIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKD 179
+IDVWS+GCIF+ELL R P+F G+ C +
Sbjct 213 TSIDVWSVGCIFAELLG-----------RKPIFQGTECL--------------------N 241
Query 180 QLNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLV 239
QL +I N+LG+ EE++ ++ +AK+YIR+ P L++ + + A++LL++MLV
Sbjct 242 QLKLIVNILGSQREEDLEFIDNPKAKRYIRSLPYSPGMSLSRLYPGAHVLAIDLLQKMLV 301
Query 240 FNPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQRF 299
F+P +RISV E L HP+ + +P+ A + L ++ ++ E +R EM +
Sbjct 302 FDPSKRISVSEALQHPYMAPLYDPNANPPAQVPIDLDVDE--DLREEMIREMMWNEMLHY 359
Query 300 HPE 302
HP+
Sbjct 360 HPQ 362
> ath:AT2G43790 ATMPK6; ATMPK6 (ARABIDOPSIS THALIANA MAP KINASE
6); MAP kinase/ kinase; K14512 mitogen-activated protein kinase
6 [EC:2.7.11.24]
Length=395
Score = 190 bits (483), Expect = 5e-48, Method: Compositional matrix adjust.
Identities = 117/307 (38%), Positives = 167/307 (54%), Gaps = 65/307 (21%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D ++ R+ L+E H + LY +L G+KY+HSA +LHRDLKP+N L+N +C +K+CDFG
Sbjct 150 DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFG 209
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LAR VT + +T VVTRWYRAPEL+L + +YT
Sbjct 210 LAR-----------------------VTSESDF---MTEYVVTRWYRAPELLLNSSDYTA 243
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
AIDVWS+GCIF EL+ DR PLFPG R + Q
Sbjct 244 AIDVWSVGCIFMELM-----------DRKPLFPG--------------------RDHVHQ 272
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
L ++ ++GTP+EEE+ + AK+YIR PP + +F P A++L+++ML F
Sbjct 273 LRLLMELIGTPSEEELEF-LNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTF 331
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFN-DWAN--MDEPQLRLGFLREMQ 297
+P+RRI+V + LAHP+ + + S E T +PFN D+ N + E Q++ RE
Sbjct 332 DPRRRITVLDALAHPYLNSLHDISDEPECT----IPFNFDFENHALSEEQMKELIYREAL 387
Query 298 RFHPELQ 304
F+PE Q
Sbjct 388 AFNPEYQ 394
> hsa:5595 MAPK3, ERK1, HS44KDAP, HUMKER1A, MGC20180, P44ERK1,
P44MAPK, PRKM3; mitogen-activated protein kinase 3 (EC:2.7.11.24);
K04371 extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
Length=357
Score = 189 bits (479), Expect = 2e-47, Method: Compositional matrix adjust.
Identities = 104/267 (38%), Positives = 149/267 (55%), Gaps = 54/267 (20%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D KL ++ L+ HI LY +L G+KY+HSA +LHRDLKP+N L+N C +K+CDFG
Sbjct 128 DLYKLLKSQ-QLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFG 186
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LAR D PE ++ LT V TRWYRAPE++L ++ YT+
Sbjct 187 LARIAD-PEHDHTGF---------------------LTEYVATRWYRAPEIMLNSKGYTK 224
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
+ID+WS+GCI +E+LS P+FPG DQ
Sbjct 225 SIDIWSVGCILAEMLS-----------NRPIFPGKHYL--------------------DQ 253
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
LN I +LG+P++E++N + +A+ Y+++ P K A+ F S +AL+LL RML F
Sbjct 254 LNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTF 313
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEV 267
NP +RI+V+E LAHP+ E +P+ EV
Sbjct 314 NPNKRITVEEALAHPYLEQYYDPTDEV 340
> ath:AT4G36450 ATMPK14 (Mitogen-activated protein kinase 14);
MAP kinase/ kinase; K04371 extracellular signal-regulated kinase
1/2 [EC:2.7.11.24]
Length=361
Score = 188 bits (478), Expect = 2e-47, Method: Compositional matrix adjust.
Identities = 107/304 (35%), Positives = 163/304 (53%), Gaps = 66/304 (21%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D ++ ++ L++ H K L+ LL G+KY+HSA ILHRDLKP N LVN +C +K+CDFG
Sbjct 119 DLNQIIKSSQSLSDDHCKYFLFQLLRGLKYLHSANILHRDLKPGNLLVNANCDLKICDFG 178
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LART + + +T VVTRWYRAPEL+L +NY
Sbjct 179 LARTYE----------------------------QFMTEYVVTRWYRAPELLLCCDNYGT 210
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
+IDVWS+GCIF+E+L R P+FPG+ C +Q
Sbjct 211 SIDVWSVGCIFAEILG-----------RKPIFPGTECL--------------------NQ 239
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
L +I NV+G+ + ++ ++ +A+++I++ P K + + ++P A++LL+RMLVF
Sbjct 240 LKLIINVVGSQQDWDLQFIDNQKARRFIKSLPFSKGTHFSHIYPHANPLAIDLLQRMLVF 299
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATEKV---RLPFNDWANMDEPQLRLGFLREMQ 297
+P +RISV + L HP+ EG+ P E +E V L ++ NM+ +R EM
Sbjct 300 DPTKRISVSDALLHPYMEGLLEP--ECNPSENVPVSSLEIDE--NMEGDMIREMMWEEML 355
Query 298 RFHP 301
+ P
Sbjct 356 HYLP 359
> ath:AT1G59580 ATMPK2; ATMPK2 (ARABIDOPSIS THALIANA MITOGEN-ACTIVATED
PROTEIN KINASE HOMOLOG 2); MAP kinase/ kinase/ protein
kinase; K04371 extracellular signal-regulated kinase 1/2
[EC:2.7.11.24]
Length=376
Score = 187 bits (476), Expect = 3e-47, Method: Compositional matrix adjust.
Identities = 107/303 (35%), Positives = 161/303 (53%), Gaps = 58/303 (19%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D ++ ++ L+ H + L+ LL G+KY+HSA ILHRDLKP N LVN +C +K+CDFG
Sbjct 119 DLHQIIKSSQVLSNDHCQYFLFQLLRGLKYIHSANILHRDLKPGNLLVNANCDLKICDFG 178
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQ-LTGQVVTRWYRAPELILLAENYT 119
LAR T N K Q +T VVTRWYRAPEL+L +NY
Sbjct 179 LAR--------------------------TSNTKGQFMTEYVVTRWYRAPELLLCCDNYG 212
Query 120 EAIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKD 179
+IDVWS+GCIF+ELL R P+FPG+ C +
Sbjct 213 TSIDVWSVGCIFAELLG-----------RKPVFPGTECL--------------------N 241
Query 180 QLNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLV 239
Q+ +I N+LG+ EE++ ++ +AK+YI + P ++ + ++ A++LL++MLV
Sbjct 242 QIKLIINILGSQREEDLEFIDNPKAKRYIESLPYSPGISFSRLYPGANVLAIDLLQKMLV 301
Query 240 FNPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQRF 299
+P +RISV E L HP+ + +PS A + L ++ ++ +R +EM +
Sbjct 302 LDPSKRISVTEALQHPYMAPLYDPSANPPAQVPIDLDVDEDEDLGAEMIRELMWKEMIHY 361
Query 300 HPE 302
HPE
Sbjct 362 HPE 364
> ath:AT3G45640 ATMPK3; ATMPK3 (ARABIDOPSIS THALIANA MITOGEN-ACTIVATED
PROTEIN KINASE 3); MAP kinase/ kinase/ protein binding
/ protein kinase; K04371 extracellular signal-regulated
kinase 1/2 [EC:2.7.11.24]
Length=370
Score = 187 bits (475), Expect = 5e-47, Method: Compositional matrix adjust.
Identities = 108/301 (35%), Positives = 161/301 (53%), Gaps = 58/301 (19%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D ++ R+ L+E H + LY LL G+KY+HSA I+HRDLKP+N L+N +C +K+CDFG
Sbjct 125 DLHQIIRSNQSLSEEHCQYFLYQLLRGLKYIHSANIIHRDLKPSNLLLNANCDLKICDFG 184
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LAR P ++ D +T VVTRWYRAPEL+L + +YT
Sbjct 185 LAR------------PTSEND--------------FMTEYVVTRWYRAPELLLNSSDYTA 218
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
AIDVWS+GCIF EL+ +R PLFPG + + Q
Sbjct 219 AIDVWSVGCIFMELM-----------NRKPLFPG--------------------KDHVHQ 247
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
+ ++ +LGTPTE ++ + +AK+YIR P LA+ FS +P A++L+ RML F
Sbjct 248 MRLLTELLGTPTESDLGFTHNEDAKRYIRQLPNFPRQPLAKLFSHVNPMAIDLVDRMLTF 307
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQRFH 300
+P RRI+V++ L H + + +P+ E + F + +DE Q++ +E +
Sbjct 308 DPNRRITVEQALNHQYLAKLHDPNDEPICQKPFSFEF-EQQPLDEEQIKEMIYQEAIALN 366
Query 301 P 301
P
Sbjct 367 P 367
> xla:398985 mapk1-a, MGC68934, erk, erk2, mapk, mapk1, mapk1a,
mpk1, xp42; mitogen-activated protein kinase 1 (EC:2.7.11.24);
K04371 extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
Length=361
Score = 183 bits (464), Expect = 9e-46, Method: Compositional matrix adjust.
Identities = 110/301 (36%), Positives = 158/301 (52%), Gaps = 55/301 (18%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D KL + +L+ HI LY +L G+KY+HSA +LHRDLKP+N L+N C +K+CDFG
Sbjct 114 DLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFG 172
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LAR VA D D HT L T V TRWYRAPE++L ++ YT+
Sbjct 173 LAR-------------VADPDHD-----HTGFL----TEYVATRWYRAPEIMLNSKGYTK 210
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
+ID+WS+GCI +E+LS P+FPG DQ
Sbjct 211 SIDIWSVGCILAEMLS-----------NRPIFPGKHYL--------------------DQ 239
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
LN I +LG+P++E++N + +A+ Y+ + P K + F + P+AL+LL +ML F
Sbjct 240 LNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADPKALDLLDKMLTF 299
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQRFH 300
NP +RI V+ LAHP+ E +PS E A + + ++ + L+ E RF
Sbjct 300 NPHKRIEVEAALAHPYLEQYYDPSDEPVAEAPFKFEM-ELDDLPKETLKELIFEETARFQ 358
Query 301 P 301
P
Sbjct 359 P 359
> dre:541323 mapk7, bmk1, erk5, wu:fb73b02, zgc:113111; mitogen-activated
protein kinase 7 (EC:2.7.1.-); K04464 mitogen-activated
protein kinase 7 [EC:2.7.11.24]
Length=862
Score = 182 bits (463), Expect = 1e-45, Method: Compositional matrix adjust.
Identities = 103/304 (33%), Positives = 152/304 (50%), Gaps = 52/304 (17%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D ++ + LT H + LY LL G+KY+HSA ++HRDLKP+N LVN++C +K+ DFG
Sbjct 168 DLHQIIHSRQPLTPEHTRYFLYQLLRGLKYIHSANVIHRDLKPSNLLVNENCELKIGDFG 227
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
+AR + + +++ + +T V TRWYRAPEL+L +Y+
Sbjct 228 MARGL--------------------SAVYSEESRSFMTEYVATRWYRAPELMLSLHHYSL 267
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
AID+WS+GCIF E+L R +FPG + Q
Sbjct 268 AIDLWSVGCIFGEMLG-----------RRQMFPGKNYV--------------------HQ 296
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
L +I +VLGTP E + + S+ + Y+R+ P K LA + + P ALNLL ML F
Sbjct 297 LQLILSVLGTPPESIVGSIGSDRVRSYVRSLPSKAPEPLAALYPQAEPSALNLLAAMLRF 356
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQRFH 300
+P+ RIS + L HP+ +P E F D M + Q++ L E+Q FH
Sbjct 357 DPRERISACQALEHPYLSKYHDPDDEPVCVPAFNFEF-DRQPMGKEQIKEAILTEIQDFH 415
Query 301 PELQ 304
+ Q
Sbjct 416 KKKQ 419
> dre:399480 mapk3, ERK1, fi06b09, wu:fi06b09, zERK1; mitogen-activated
protein kinase 3 (EC:2.7.11.1); K04371 extracellular
signal-regulated kinase 1/2 [EC:2.7.11.24]
Length=392
Score = 182 bits (463), Expect = 1e-45, Method: Compositional matrix adjust.
Identities = 111/307 (36%), Positives = 160/307 (52%), Gaps = 61/307 (19%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D KL + L+ HI LY +L G+KY+HSA +LHRDLKP+N L+N C +K+CDFG
Sbjct 142 DLYKLLKTQQ-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFG 200
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LAR D PE ++ LT V TRWYRAPE++L ++ YT+
Sbjct 201 LARIAD-PEHDHTGF---------------------LTEYVATRWYRAPEIMLNSKGYTK 238
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
+ID+WS+GCI +E+LS P+FPG DQ
Sbjct 239 SIDIWSVGCILAEMLS-----------NRPIFPGKHYL--------------------DQ 267
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
LN I VLG+P+++++N + +A+ Y+++ P K + F + +AL+LL RML F
Sbjct 268 LNHILGVLGSPSQDDLNCIINMKARNYLQSLPQKPKIPWNKLFPKADNKALDLLDRMLTF 327
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDE---PQLRLGFLREMQ 297
NP +RI+V++ LAHP+ E +PS E A E PF +D+ +L+ E
Sbjct 328 NPLKRINVEQALAHPYLEQYYDPSDEPVAEE----PFTFNMELDDLPKEKLKELIFEETA 383
Query 298 RFHPELQ 304
RF Q
Sbjct 384 RFQANYQ 390
> dre:100330818 mitogen-activated protein kinase 3-like; K04371
extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
Length=392
Score = 182 bits (463), Expect = 1e-45, Method: Compositional matrix adjust.
Identities = 111/307 (36%), Positives = 160/307 (52%), Gaps = 61/307 (19%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D KL + L+ HI LY +L G+KY+HSA +LHRDLKP+N L+N C +K+CDFG
Sbjct 142 DLYKLLKTQQ-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFG 200
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LAR D PE ++ LT V TRWYRAPE++L ++ YT+
Sbjct 201 LARIAD-PEHDHTGF---------------------LTEYVATRWYRAPEIMLNSKGYTK 238
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
+ID+WS+GCI +E+LS P+FPG DQ
Sbjct 239 SIDIWSVGCILAEMLS-----------NRPIFPGKHYL--------------------DQ 267
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
LN I VLG+P+++++N + +A+ Y+++ P K + F + +AL+LL RML F
Sbjct 268 LNHILGVLGSPSQDDLNCIINMKARNYLQSLPQKPKIPWNKLFPKADNKALDLLDRMLTF 327
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDE---PQLRLGFLREMQ 297
NP +RI+V++ LAHP+ E +PS E A E PF +D+ +L+ E
Sbjct 328 NPLKRINVEQALAHPYLEQYYDPSDEPVAEE----PFTFNMELDDLPKEKLKELIFEETA 383
Query 298 RFHPELQ 304
RF Q
Sbjct 384 RFQANYQ 390
> dre:360144 mapk1, zERK2; mitogen-activated protein kinase 1
(EC:2.7.11.24); K04371 extracellular signal-regulated kinase
1/2 [EC:2.7.11.24]
Length=369
Score = 182 bits (463), Expect = 1e-45, Method: Compositional matrix adjust.
Identities = 109/301 (36%), Positives = 159/301 (52%), Gaps = 55/301 (18%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D KL + +L+ HI LY +L G+KY+HSA +LHRDLKP+N L+N C +K+CDFG
Sbjct 120 DLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFG 178
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LAR VA D D HT LT V TRWYRAPE++L ++ YT+
Sbjct 179 LAR-------------VADPDHD-----HTGF----LTEYVATRWYRAPEIMLNSKGYTK 216
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
+ID+WS+GCI +E+LS P+FPG DQ
Sbjct 217 SIDIWSVGCILAEMLS-----------NRPIFPGKHYL--------------------DQ 245
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
LN I +LG+P++E++N + +A+ Y+ + P + + F + P+AL+LL +ML F
Sbjct 246 LNHILGILGSPSQEDLNCIINIKARNYLLSLPLRSKVPWNRLFPNADPKALDLLDKMLTF 305
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQRFH 300
NP +RI V+E LAHP+ E +P+ E A + + ++ + L+ E RF
Sbjct 306 NPHKRIEVEEALAHPYLEQYYDPTDEPVAEAPFKFDM-ELDDLPKETLKELIFEETARFQ 364
Query 301 P 301
P
Sbjct 365 P 365
> ath:AT3G59790 ATMPK10; MAP kinase/ kinase; K04371 extracellular
signal-regulated kinase 1/2 [EC:2.7.11.24]
Length=393
Score = 182 bits (461), Expect = 2e-45, Method: Compositional matrix adjust.
Identities = 114/305 (37%), Positives = 158/305 (51%), Gaps = 65/305 (21%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D + ++ LT+ H +Y +L G+KY+HSA +LHRDLKP+N L++ C +K+CDFG
Sbjct 147 DLYRTLKSDQELTKDHGMYFMYQILRGLKYIHSANVLHRDLKPSNLLLSTQCDLKICDFG 206
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LAR T NL +T VVTRWYRAPEL+L + +YT
Sbjct 207 LAR-----------------------ATPESNL---MTEYVVTRWYRAPELLLGSSDYTA 240
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
AIDVWS+GCIF E++ +R PLFPG DQ N Q
Sbjct 241 AIDVWSVGCIFMEIM-----------NREPLFPGK-------DQVN-------------Q 269
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
L ++ ++GTP+EEE+ + S AK+YIR P ++F P A++L+++ML F
Sbjct 270 LRLLLELIGTPSEEELGS-LSEYAKRYIRQLPTLPRQSFTEKFPNVPPLAIDLVEKMLTF 328
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFN---DWANMDEPQLRLGFLREMQ 297
+PK+RISV E LAHP+ + + E +E PFN D E Q R E
Sbjct 329 DPKQRISVKEALAHPYLSSFHDITDEPECSE----PFNFDLDEHPFSEEQFRELIYCEAL 384
Query 298 RFHPE 302
F+PE
Sbjct 385 AFNPE 389
> hsa:5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2,
p38, p40, p41, p41mapk; mitogen-activated protein kinase
1 (EC:2.7.11.24); K04371 extracellular signal-regulated kinase
1/2 [EC:2.7.11.24]
Length=360
Score = 181 bits (460), Expect = 2e-45, Method: Compositional matrix adjust.
Identities = 109/301 (36%), Positives = 159/301 (52%), Gaps = 55/301 (18%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D KL + +L+ HI LY +L G+KY+HSA +LHRDLKP+N L+N C +K+CDFG
Sbjct 111 DLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFG 169
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LAR VA D D HT LT V TRWYRAPE++L ++ YT+
Sbjct 170 LAR-------------VADPDHD-----HTGF----LTEYVATRWYRAPEIMLNSKGYTK 207
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
+ID+WS+GCI +E+LS P+FPG DQ
Sbjct 208 SIDIWSVGCILAEMLS-----------NRPIFPGKHYL--------------------DQ 236
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
LN I +LG+P++E++N + +A+ Y+ + P K + F + +AL+LL +ML F
Sbjct 237 LNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTF 296
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQRFH 300
NP +RI V++ LAHP+ E +PS E A + + ++ + +L+ E RF
Sbjct 297 NPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDM-ELDDLPKEKLKELIFEETARFQ 355
Query 301 P 301
P
Sbjct 356 P 356
> mmu:26413 Mapk1, 9030612K14Rik, AA407128, AU018647, C78273,
ERK, Erk2, MAPK2, PRKM2, Prkm1, p41mapk, p42mapk; mitogen-activated
protein kinase 1 (EC:2.7.11.24); K04371 extracellular
signal-regulated kinase 1/2 [EC:2.7.11.24]
Length=358
Score = 181 bits (460), Expect = 3e-45, Method: Compositional matrix adjust.
Identities = 109/301 (36%), Positives = 159/301 (52%), Gaps = 55/301 (18%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D KL + +L+ HI LY +L G+KY+HSA +LHRDLKP+N L+N C +K+CDFG
Sbjct 109 DLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFG 167
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LAR VA D D HT LT V TRWYRAPE++L ++ YT+
Sbjct 168 LAR-------------VADPDHD-----HTGF----LTEYVATRWYRAPEIMLNSKGYTK 205
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
+ID+WS+GCI +E+LS P+FPG DQ
Sbjct 206 SIDIWSVGCILAEMLS-----------NRPIFPGKHYL--------------------DQ 234
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
LN I +LG+P++E++N + +A+ Y+ + P K + F + +AL+LL +ML F
Sbjct 235 LNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTF 294
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQRFH 300
NP +RI V++ LAHP+ E +PS E A + + ++ + +L+ E RF
Sbjct 295 NPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDM-ELDDLPKEKLKELIFEETARFQ 353
Query 301 P 301
P
Sbjct 354 P 354
> tgo:TGME49_033010 mitogen-activated protein kinase 2 (EC:2.7.11.24);
K08293 mitogen-activated protein kinase [EC:2.7.11.24]
Length=669
Score = 178 bits (452), Expect = 2e-44, Method: Compositional matrix adjust.
Identities = 100/282 (35%), Positives = 148/282 (52%), Gaps = 54/282 (19%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D + RA + L E+H + ++Y LL +KY+HS +LHRD+KP+N L+N +C VKV DFG
Sbjct 98 DLHAVIRADI-LEEIHKQYIVYQLLRAIKYMHSGELLHRDMKPSNVLLNSECQVKVADFG 156
Query 61 LARTMDFPEGQNSHC---PVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAEN 117
LAR++ E NS PV LT V TRWYRAPE++L + +
Sbjct 157 LARSVAHSESNNSEAGGNPV-------------------LTDYVATRWYRAPEILLGSTS 197
Query 118 YTEAIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGN 177
YT+ +D+WS+GCI ELLS P+FPG+S
Sbjct 198 YTKGVDMWSLGCILGELLSGR-----------PIFPGTSTM------------------- 227
Query 178 KDQLNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRM 237
+QL I + G P+ E+++A +S A + + P K + F +SPEAL+LLK++
Sbjct 228 -NQLERIMTLTGRPSPEDVDAVKSPFAATMMESLPLGKVKNFKDAFPNASPEALDLLKQL 286
Query 238 LVFNPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFND 279
L FNP +RIS ++ L HP+ +P E + + +P +D
Sbjct 287 LQFNPNKRISAEKGLEHPYVRQFHSPEDEPVCGKIIAIPIDD 328
> mmu:29857 Mapk12, AW123708, Erk6, P38gamma, Prkm12, Sapk3; mitogen-activated
protein kinase 12 (EC:2.7.11.24); K04441 p38
MAP kinase [EC:2.7.11.24]
Length=367
Score = 178 bits (451), Expect = 3e-44, Method: Compositional matrix adjust.
Identities = 107/305 (35%), Positives = 157/305 (51%), Gaps = 62/305 (20%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D KL + L+E I+ L+Y +L G+KY+H+AG++HRDLKP N VN+DC +K+ DFG
Sbjct 115 DLGKLMKHET-LSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFG 173
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LAR D ++TG VVTRWYRAPE+IL YT+
Sbjct 174 LARQAD----------------------------SEMTGYVVTRWYRAPEVILNWMRYTQ 205
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
+D+WS+GCI +E+++ G F G+D + DQ
Sbjct 206 TVDIWSVGCIMAEMIT-----------------GKILF-------KGND-------HLDQ 234
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
L I + GTP E + +S EAK Y+ P + D A + +SP+A+NLL+RMLV
Sbjct 235 LKEIMKITGTPPPEFVQKLQSAEAKNYMEGLPELEKKDFASVLTNASPQAVNLLERMLVL 294
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQRFH 300
+ ++R++ E L HP+FE +R+ E A +K F+D E R+ + +E+ F
Sbjct 295 DAEQRVTAAEALTHPYFESLRDTEDEPKA-QKYDDSFDDVDRTLEEWKRVTY-KEVLSFK 352
Query 301 PELQL 305
P QL
Sbjct 353 PPRQL 357
> xla:397785 mapk1-b, Xp42, erk, erk2, mapk, mapk1b, mpk1; mitogen-activated
protein kinase 1 (EC:2.7.11.24); K04371 extracellular
signal-regulated kinase 1/2 [EC:2.7.11.24]
Length=361
Score = 178 bits (451), Expect = 3e-44, Method: Compositional matrix adjust.
Identities = 109/301 (36%), Positives = 157/301 (52%), Gaps = 55/301 (18%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D KL + +L+ HI LY +L G+KY+HSA +LHRDLKP+N L+N C +K+CDFG
Sbjct 114 DLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFG 172
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LAR VA D D HT L T V TR YRAPE++L ++ YT+
Sbjct 173 LAR-------------VADPDHD-----HTGFL----TEYVATRCYRAPEIMLNSKGYTK 210
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
+ID+WS+GCI +E+LS P+FPG DQ
Sbjct 211 SIDIWSVGCILAEMLS-----------NRPIFPGKHYL--------------------DQ 239
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
LN I +LG+P++E++N + +A+ Y+ + P K + F + P+AL+LL +ML F
Sbjct 240 LNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADPKALDLLDKMLTF 299
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQRFH 300
NP +RI V+ LAHP+ E +PS E A + + ++ + L+ E RF
Sbjct 300 NPHKRIEVEAALAHPYLEQYYDPSDEPVAEAPFKFEM-ELDDLPKETLKELIFEETARFQ 358
Query 301 P 301
P
Sbjct 359 P 359
> ath:AT1G07880 ATMPK13; MAP kinase/ kinase; K04371 extracellular
signal-regulated kinase 1/2 [EC:2.7.11.24]
Length=363
Score = 178 bits (451), Expect = 3e-44, Method: Compositional matrix adjust.
Identities = 102/299 (34%), Positives = 152/299 (50%), Gaps = 58/299 (19%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D ++ R+ LT+ H + LY +L G+KY+HSA +LHRDLKP+N ++N +C +K+CDFG
Sbjct 120 DLHQIIRSTQTLTDDHCQYFLYQILRGLKYIHSANVLHRDLKPSNLVLNTNCDLKICDFG 179
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LART N +T VVTRWYRAPEL+L + YT
Sbjct 180 LART--------------------------SNETEIMTEYVVTRWYRAPELLLNSSEYTG 213
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
AID+WS+GCIF E+L R LFPG + Q
Sbjct 214 AIDIWSVGCIFMEILR-----------RETLFPG--------------------KDYVQQ 242
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
L +I +LG+P + +++ S+ A++Y++ P + ++F SP AL+L ++MLVF
Sbjct 243 LKLITELLGSPDDSDLDFLRSDNARKYVKQLPHVQKQSFREKFPNISPMALDLAEKMLVF 302
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQRF 299
+P +RI+VDE L P+ + + E T F + A +DE ++ RE F
Sbjct 303 DPSKRITVDEALKQPYLASLHEINEEPTCPTPFSFDFEETA-LDEQDIKELVWRESLHF 360
> cel:F43C1.2 mpk-1; MAP Kinase family member (mpk-1); K04371
extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
Length=444
Score = 177 bits (449), Expect = 4e-44, Method: Compositional matrix adjust.
Identities = 101/281 (35%), Positives = 146/281 (51%), Gaps = 56/281 (19%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D KL + L+ H+ LY +L G+KY+HSA +LHRDLKP+N L+N C +K+CDFG
Sbjct 182 DLYKLLKTQK-LSNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFG 240
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LAR D Q H LT V TRWYRAPE++L ++ YT+
Sbjct 241 LARVTD---PQTDHTGF-------------------LTEYVATRWYRAPEIMLNSKGYTK 278
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
+IDVWS+GCI +E+LS PLFPG DQ
Sbjct 279 SIDVWSVGCILAEMLS-----------NRPLFPGKHYL--------------------DQ 307
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
LN+I V+G+P+ ++ +++A+ Y+ + P K A+ + + P AL+LL +ML F
Sbjct 308 LNLILAVVGSPSNADLQCIINDKARSYLISLPHKPKQPWARLYPGADPRALDLLDKMLTF 367
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATE--KVRLPFND 279
NP RI +++ LAHP+ E +P E E + + F+D
Sbjct 368 NPHNRIDIEQALAHPYLEQYYDPGDEPVCEEPFTLEMEFDD 408
> xla:398592 mapk12, Xp38gamma, sapk3; mitogen-activated protein
kinase 12 (EC:2.7.11.24); K04441 p38 MAP kinase [EC:2.7.11.24]
Length=363
Score = 176 bits (447), Expect = 9e-44, Method: Compositional matrix adjust.
Identities = 96/283 (33%), Positives = 144/283 (50%), Gaps = 65/283 (22%)
Query 12 LTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTMDFPEGQ 71
L+E I+ L+Y +L G+KY+HSAGI+HRDLKP N VN+DC +K+ DFGLAR D
Sbjct 125 LSEDRIQFLVYQILRGLKYIHSAGIIHRDLKPGNLAVNEDCELKILDFGLARHTD----- 179
Query 72 NSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTEAIDVWSIGCIF 131
++TG VVTRWYRAPE+IL +YT+ +D+WS+GCI
Sbjct 180 -----------------------SEMTGYVVTRWYRAPEVILNWMHYTQTVDIWSVGCIM 216
Query 132 SELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQLNVIFNVLGTP 191
+E+ + PLF G+ +QL I + GTP
Sbjct 217 AEMYT-----------GRPLFKGNDHL--------------------NQLTEIMKITGTP 245
Query 192 TEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVFNPKRRISVDEC 251
T++ + +S +AK YI++ P + D ++P A+N+L++MLV + ++RI+ E
Sbjct 246 TQDFVQKLQSTDAKNYIKSLPKVQKKDFGSLLRYANPLAVNILEKMLVLDAEKRITATEA 305
Query 252 LAHPFFEGVRNPSIEVTAT------EKVRLPFNDWANMDEPQL 288
LAH +FE + E A + V LP +W + +L
Sbjct 306 LAHAYFEQFHDIDDETEAEPYDDSFDNVNLPLEEWKRLTHEEL 348
> hsa:5600 MAPK11, P38B, P38BETA2, PRKM11, SAPK2, SAPK2B, p38-2,
p38Beta; mitogen-activated protein kinase 11 (EC:2.7.11.24);
K04441 p38 MAP kinase [EC:2.7.11.24]
Length=364
Score = 176 bits (445), Expect = 1e-43, Method: Compositional matrix adjust.
Identities = 94/255 (36%), Positives = 133/255 (52%), Gaps = 59/255 (23%)
Query 12 LTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTMDFPEGQ 71
L++ H++ L+Y LL G+KY+HSAGI+HRDLKP+N VN+DC +++ DFGLAR D
Sbjct 122 LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD----- 176
Query 72 NSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTEAIDVWSIGCIF 131
++TG V TRWYRAPE++L +Y + +D+WS+GCI
Sbjct 177 -----------------------EEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIM 213
Query 132 SELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQLNVIFNVLGTP 191
+ELL LFPGS DQL I V+GTP
Sbjct 214 AELLQ-----------GKALFPGSDYI--------------------DQLKRIMEVVGTP 242
Query 192 TEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVFNPKRRISVDEC 251
+ E + S A+ YI++ PP DL+ F ++P A++LL RMLV + +R+S E
Sbjct 243 SPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEA 302
Query 252 LAHPFFEGVRNPSIE 266
LAH +F +P E
Sbjct 303 LAHAYFSQYHDPEDE 317
> ath:AT1G01560 ATMPK11; MAP kinase/ kinase; K04371 extracellular
signal-regulated kinase 1/2 [EC:2.7.11.24]
Length=369
Score = 176 bits (445), Expect = 2e-43, Method: Compositional matrix adjust.
Identities = 105/301 (34%), Positives = 151/301 (50%), Gaps = 58/301 (19%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D + R+ LT+ H + LY LL G+KYVHSA +LHRDLKP+N L+N +C +K+ DFG
Sbjct 127 DLHHIIRSNQPLTDDHSRFFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKIGDFG 186
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LART K+ +T VVTRWYRAPEL+L YT
Sbjct 187 LART--------------------------KSETDFMTEYVVTRWYRAPELLLNCSEYTA 220
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
AID+WS+GCI E+++ R PLFPG R Q
Sbjct 221 AIDIWSVGCILGEIMT-----------REPLFPG--------------------RDYVQQ 249
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
L +I ++G+P + + S+ A++Y+R P + A RF S A++LL++MLVF
Sbjct 250 LRLITELIGSPDDSSLGFLRSDNARRYVRQLPQYPRQNFAARFPNMSVNAVDLLQKMLVF 309
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQRFH 300
+P RRI+VDE L HP+ + + E F + ++ E ++ RE +F+
Sbjct 310 DPNRRITVDEALCHPYLAPLHEYNEEPVCVRPFHFDF-EQPSLTEENIKELIYRESVKFN 368
Query 301 P 301
P
Sbjct 369 P 369
> sce:YLR113W HOG1, SSK3; Hog1p (EC:2.7.11.24); K04441 p38 MAP
kinase [EC:2.7.11.24]
Length=435
Score = 175 bits (444), Expect = 2e-43, Method: Compositional matrix adjust.
Identities = 98/284 (34%), Positives = 150/284 (52%), Gaps = 60/284 (21%)
Query 17 IKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTMDFPEGQNSHCP 76
++ LY +L G+KYVHSAG++HRDLKP+N L+N++C +K+CDFGLAR D
Sbjct 121 VQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQD---------- 170
Query 77 VAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTEAIDVWSIGCIFSELLS 136
Q+TG V TR+YRAPE++L + Y +D+WS GCIF+E
Sbjct 171 ------------------PQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAE--- 209
Query 137 MIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQLNVIFNVLGTPTEEEI 196
MIE PLFPG + + Q ++I ++LG+P ++ I
Sbjct 210 MIEGK--------PLFPG--------------------KDHVHQFSIITDLLGSPPKDVI 241
Query 197 NAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVFNPKRRISVDECLAHPF 256
N S +++ + P + ++RF P+A++LL++MLVF+PK+RI+ + LAHP+
Sbjct 242 NTICSENTLKFVTSLPHRDPIPFSERFKTVEPDAVDLLEKMLVFDPKKRITAADALAHPY 301
Query 257 FEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQRFH 300
+P+ E A K FND A++ R+ E+ FH
Sbjct 302 SAPYHDPTDEPVADAKFDWHFND-ADLPVDTWRVMMYSEILDFH 344
> ath:AT4G01370 ATMPK4; ATMPK4 (ARABIDOPSIS THALIANA MAP KINASE
4); MAP kinase/ kinase; K04371 extracellular signal-regulated
kinase 1/2 [EC:2.7.11.24]
Length=376
Score = 175 bits (444), Expect = 2e-43, Method: Compositional matrix adjust.
Identities = 104/302 (34%), Positives = 151/302 (50%), Gaps = 58/302 (19%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D ++ R+ LT+ H + LY LL G+KYVHSA +LHRDLKP+N L+N +C +K+ DFG
Sbjct 130 DLHQIIRSNQPLTDDHCRFFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKLGDFG 189
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LART K+ +T VVTRWYRAPEL+L YT
Sbjct 190 LART--------------------------KSETDFMTEYVVTRWYRAPELLLNCSEYTA 223
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
AID+WS+GCI E ++ R PLFPG Q
Sbjct 224 AIDIWSVGCILGETMT-----------REPLFPGKDYV--------------------HQ 252
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
L +I ++G+P + + S+ A++Y+R P + A RF S A++LL++MLVF
Sbjct 253 LRLITELIGSPDDSSLGFLRSDNARRYVRQLPQYPRQNFAARFPNMSAGAVDLLEKMLVF 312
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQRFH 300
+P RRI+VDE L HP+ + + + E F + + E ++ RE +F+
Sbjct 313 DPSRRITVDEALCHPYLAPLHDINEEPVCVRPFNFDF-EQPTLTEENIKELIYRETVKFN 371
Query 301 PE 302
P+
Sbjct 372 PQ 373
> xla:494669 mapk11, p38-2, p38Beta, p38b, p38beta2, prkm11, sapk2,
sapk2b; mitogen-activated protein kinase 11; K04441 p38
MAP kinase [EC:2.7.11.24]
Length=361
Score = 174 bits (442), Expect = 3e-43, Method: Compositional matrix adjust.
Identities = 100/278 (35%), Positives = 140/278 (50%), Gaps = 65/278 (23%)
Query 12 LTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTMDFPEGQ 71
LT+ HI+ L+Y LL G+KY+HSAGI+HRDLKP N VN+DC +++ DFGLAR
Sbjct 121 LTDDHIQFLIYQLLRGLKYIHSAGIIHRDLKPGNLAVNEDCELRILDFGLAR-------- 172
Query 72 NSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTEAIDVWSIGCIF 131
Q DD ++TG V TRWYRAPE++L +Y + +D+WS+GCI
Sbjct 173 -------QADD-------------EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIM 212
Query 132 SELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQLNVIFNVLGTP 191
+ELL LFPG+ DQL I V GTP
Sbjct 213 AELLK-----------GKALFPGNDYI--------------------DQLKRIMEVAGTP 241
Query 192 TEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVFNPKRRISVDEC 251
E + S A++YI + P DL + F ++P A++LL++ML+ + +RIS E
Sbjct 242 NSEFLMKISSEHARRYIESLPYMPHQDLKEVFRGANPLAIDLLEKMLILDSDKRISATEA 301
Query 252 LAHPFFEGVRNPSIEVTA------TEKVRLPFNDWANM 283
LAHP+F +P E A TE ++W +
Sbjct 302 LAHPYFVQYHDPDDEPEAEPYDESTENKERTIDEWKEI 339
> dre:100002318 mapk13, im:7136778; mitogen-activated protein
kinase 13; K04441 p38 MAP kinase [EC:2.7.11.24]
Length=362
Score = 174 bits (442), Expect = 3e-43, Method: Compositional matrix adjust.
Identities = 103/284 (36%), Positives = 142/284 (50%), Gaps = 65/284 (22%)
Query 12 LTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTMDFPEGQ 71
LTE I+ L+Y +L G+KY+H AGI+HRDLKP N VNQDC +K+ DFGLAR D
Sbjct 119 LTEDRIQFLVYQMLCGLKYIHGAGIIHRDLKPGNLAVNQDCELKILDFGLARHTD----- 173
Query 72 NSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTEAIDVWSIGCIF 131
++TG VVTRWYRAPE+IL +YT+ +D+WS+GCI
Sbjct 174 -----------------------AEMTGYVVTRWYRAPEVILNWMHYTQTVDIWSVGCIM 210
Query 132 SELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQLNVIFNVLGTP 191
G +F G + F G D DQL I V GTP
Sbjct 211 -----------------GEMFNGKTLF-------KGKDYM-------DQLTQIMKVAGTP 239
Query 192 TEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVFNPKRRISVDEC 251
E + ES EAK Y+R+ P D + F +S +A+ LL++MLV + R++
Sbjct 240 GPEFVEKLESPEAKSYVRSLPHYPHRDFSTLFPRASKKAVELLEKMLVLDADARLTASGA 299
Query 252 LAHPFFEGVRNPSI--EVTA----TEKVRLPFNDWANMDEPQLR 289
LAH +F+G+R+P E TA + LP +W + ++R
Sbjct 300 LAHSYFDGLRDPDDWPEPTAYDDSYDNATLPLEEWKRLSFKEVR 343
> mmu:19094 Mapk11, DKFZp586C1322, P38b, Prkm11, Sapk2, Sapk2b,
p38-2, p38beta, p38beta2; mitogen-activated protein kinase
11 (EC:2.7.11.24); K04441 p38 MAP kinase [EC:2.7.11.24]
Length=364
Score = 174 bits (442), Expect = 3e-43, Method: Compositional matrix adjust.
Identities = 95/258 (36%), Positives = 136/258 (52%), Gaps = 59/258 (22%)
Query 12 LTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTMDFPEGQ 71
L++ H++ L+Y LL G+KY+HSAGI+HRDLKP+N VN+DC +++ DFGLAR D
Sbjct 122 LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD----- 176
Query 72 NSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTEAIDVWSIGCIF 131
++TG V TRWYRAPE++L +Y + +D+WS+GCI
Sbjct 177 -----------------------EEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIM 213
Query 132 SELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQLNVIFNVLGTP 191
+ELL G + FP G+D DQL I V+GTP
Sbjct 214 AELLQ-----------------GKALFP-------GND-------YIDQLKRIMEVVGTP 242
Query 192 TEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVFNPKRRISVDEC 251
+ E + S A+ YI++ PP DL+ F ++P A++LL RMLV + +R+S E
Sbjct 243 SPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAIDLLGRMLVLDSDQRVSAAEA 302
Query 252 LAHPFFEGVRNPSIEVTA 269
LAH +F +P E A
Sbjct 303 LAHAYFSQYHDPDDEPEA 320
> cpv:cgd3_3030 MAPK ; K04371 extracellular signal-regulated kinase
1/2 [EC:2.7.11.24]
Length=566
Score = 174 bits (441), Expect = 4e-43, Method: Compositional matrix adjust.
Identities = 109/339 (32%), Positives = 160/339 (47%), Gaps = 92/339 (27%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D ++ + LT HI+ +Y +L G+ Y+H I+HRDLKP+N LVN C +K+CDFG
Sbjct 109 DLHRVIYSKQTLTNEHIQYFMYQILRGLSYLHKVNIIHRDLKPSNILVNLSCDLKICDFG 168
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LAR NV K +LT VVTRWYRAPE+IL Y +
Sbjct 169 LARG---------------------NVCDIDKSKDELTDYVVTRWYRAPEIILCVNRYDK 207
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
A+D+WS GCIF+EL+ R LF G DQ
Sbjct 208 AVDIWSAGCIFAELIK-----------RSALFAGHDHL--------------------DQ 236
Query 181 LNVIFNVLGTPTEEEINA-----PESNEAKQYIRTFPPKKAHDLAQRFSA-SSPEALNLL 234
L I + LGTP+ +++++ + A++Y+ T P K ++ F + PEA++L+
Sbjct 237 LKAIISCLGTPSRDDLDSWLPYKGSTENARKYLDTLPNYKGRHISTLFPGFNCPEAIDLI 296
Query 235 KRMLVFNPKRRISVDECLAHPFFEGVR--------------------NPSIE-------V 267
++ML FNPK+RI+ +E L+HP+F G+ N SIE
Sbjct 297 EKMLSFNPKKRITAEEALSHPYFNGININSGYDSPKSSSAHNIQFKSNNSIEPELISLDS 356
Query 268 TATEKVRLPFNDWANMDEPQLRL---GFLREMQRFHPEL 303
T+ + F+++ EP RL E+ FHPE+
Sbjct 357 NTTDSIDWSFDNF----EPTKRLLQNKVYEEIADFHPEI 391
> sce:YBL016W FUS3, DAC2; Fus3p (EC:2.7.11.24); K04371 extracellular
signal-regulated kinase 1/2 [EC:2.7.11.24]
Length=353
Score = 174 bits (441), Expect = 4e-43, Method: Compositional matrix adjust.
Identities = 94/256 (36%), Positives = 140/256 (54%), Gaps = 47/256 (18%)
Query 12 LTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTMDFPEGQ 71
L++ HI+ +Y L VK +H + ++HRDLKP+N L+N +C +KVCDFGLAR +D
Sbjct 109 LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAAD 168
Query 72 NSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTEAIDVWSIGCIF 131
NS P QQ +T V TRWYRAPE++L + Y+ A+DVWS GCI
Sbjct 169 NSE-PTGQQSG--------------MTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCIL 213
Query 132 SELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQLNVIFNVLGTP 191
+EL R P+FPG R + QL +IF ++GTP
Sbjct 214 AELFL-----------RRPIFPG--------------------RDYRHQLLLIFGIIGTP 242
Query 192 -TEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVFNPKRRISVDE 250
++ ++ ES A++YI++ P A L + F +P+ ++LL+RMLVF+P +RI+ E
Sbjct 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302
Query 251 CLAHPFFEGVRNPSIE 266
L HP+ + +P+ E
Sbjct 303 ALEHPYLQTYHDPNDE 318
> sce:YHR030C SLT2, BYC2, MPK1, SLK2; Serine/threonine MAP kinase
involved in regulating the maintenance of cell wall integrity
and progression through the cell cycle; regulated by the
PKC1-mediated signaling pathway (EC:2.7.11.24); K04464 mitogen-activated
protein kinase 7 [EC:2.7.11.24]
Length=484
Score = 174 bits (440), Expect = 5e-43, Method: Compositional matrix adjust.
Identities = 105/301 (34%), Positives = 151/301 (50%), Gaps = 58/301 (19%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D ++ ++ LT+ H ++ Y +L G+KY+HSA +LHRDLKP N LVN DC +K+CDFG
Sbjct 114 DMHQIIKSGQPLTDAHYQSFTYQILCGLKYIHSADVLHRDLKPGNLLVNADCQLKICDFG 173
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LAR +NS LT V TRWYRAPE++L + YT+
Sbjct 174 LARGYSENPVENSQF---------------------LTEYVATRWYRAPEIMLSYQGYTK 212
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
AIDVWS GCI +E L P+F G +Q
Sbjct 213 AIDVWSAGCILAEFLG-----------GKPIFKGKDYV--------------------NQ 241
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRT--FPPKKAHDLAQRFSASSPEALNLLKRML 238
LN I VLGTP +E + S + YI F PK + ++ +AL+LL++ML
Sbjct 242 LNQILQVLGTPPDETLRRIGSKNVQDYIHQLGFIPKVP--FVNLYPNANSQALDLLEQML 299
Query 239 VFNPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQR 298
F+P++RI+VDE L HP+ +P+ E +EK F +M++ L+ ++E+Q
Sbjct 300 AFDPQKRITVDEALEHPYLSIWHDPADEPVCSEKFEFSFESVNDMED--LKQMVIQEVQD 357
Query 299 F 299
F
Sbjct 358 F 358
> xla:446599 mapk7, MGC81757, bmk1, erk4, prkm7; mitogen-activated
protein kinase 7; K04464 mitogen-activated protein kinase
7 [EC:2.7.11.24]
Length=925
Score = 174 bits (440), Expect = 5e-43, Method: Compositional matrix adjust.
Identities = 102/300 (34%), Positives = 149/300 (49%), Gaps = 53/300 (17%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D ++ + LT H + LY LL G+KY+HSA +LHRDLKP+N L+N++C +K+ DFG
Sbjct 138 DLHQIIHSSQPLTLEHARYFLYQLLRGLKYIHSANVLHRDLKPSNLLINENCELKIGDFG 197
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
+AR + T K +T V TRWYRAPEL+L YT+
Sbjct 198 MARGL---------------------CTKPDEYKYFMTEYVATRWYRAPELMLSLHEYTQ 236
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
AID+WS+GCIF+E+L R PLFPG++ Q
Sbjct 237 AIDMWSVGCIFAEMLG-----------RKPLFPGNNYL--------------------HQ 265
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
L++I VLGTP+ + I A + + YI++ P ++ A + + +AL+LL +ML F
Sbjct 266 LHLIMTVLGTPSSQVIRAIGAERVRAYIQSLPSRQPVPWATLYPQAGKKALDLLSKMLRF 325
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQRFH 300
+ + RISV E L HPF +P E F D + + Q++ E+ FH
Sbjct 326 DTRDRISVAEALRHPFLSKYHDPDDEPECIPAFDFGF-DKNILTKDQIKEAITTEIDSFH 384
> hsa:6300 MAPK12, ERK3, ERK6, P38GAMMA, PRKM12, SAPK-3, SAPK3;
mitogen-activated protein kinase 12 (EC:2.7.11.24); K04441
p38 MAP kinase [EC:2.7.11.24]
Length=367
Score = 173 bits (439), Expect = 7e-43, Method: Compositional matrix adjust.
Identities = 102/294 (34%), Positives = 150/294 (51%), Gaps = 61/294 (20%)
Query 12 LTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTMDFPEGQ 71
L E I+ L+Y +L G++Y+H+AGI+HRDLKP N VN+DC +K+ DFGLAR D
Sbjct 125 LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQAD----- 179
Query 72 NSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTEAIDVWSIGCIF 131
++TG VVTRWYRAPE+IL YT+ +D+WS+GCI
Sbjct 180 -----------------------SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIM 216
Query 132 SELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQLNVIFNVLGTP 191
+E+++ LF GS DQL I V GTP
Sbjct 217 AEMIT-----------GKTLFKGSDHL--------------------DQLKEIMKVTGTP 245
Query 192 TEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVFNPKRRISVDEC 251
E + +S+EAK Y++ P + D A + +SP A+NLL++MLV + ++R++ E
Sbjct 246 PAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEA 305
Query 252 LAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQRFHPELQL 305
LAHP+FE + + E +K F+D + R+ + +E+ F P QL
Sbjct 306 LAHPYFESLHDTEDE-PQVQKYDDSFDDVDRTLDEWKRVTY-KEVLSFKPPRQL 357
> hsa:100509694 mitogen-activated protein kinase 12-like
Length=357
Score = 172 bits (437), Expect = 1e-42, Method: Compositional matrix adjust.
Identities = 102/294 (34%), Positives = 152/294 (51%), Gaps = 61/294 (20%)
Query 12 LTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTMDFPEGQ 71
L E I+ L+Y +L G++Y+H+AGI+HRDLKP N VN+DC +K+ DFGLAR D
Sbjct 115 LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQAD----- 169
Query 72 NSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTEAIDVWSIGCIF 131
++TG VVTRWYRAPE+IL YT+ +D+WS+GCI
Sbjct 170 -----------------------SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIM 206
Query 132 SELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQLNVIFNVLGTP 191
+E+++ G + F G D + DQL I V GTP
Sbjct 207 AEMIT-----------------GKTLF-------KGSD-------HLDQLKEIMKVTGTP 235
Query 192 TEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVFNPKRRISVDEC 251
E + +S+EAK Y++ P + D A + +SP A+NLL++MLV + ++R++ E
Sbjct 236 PAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEA 295
Query 252 LAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQRFHPELQL 305
LAHP+FE + + E +K F+D + R+ + +E+ F P QL
Sbjct 296 LAHPYFESLHDTEDE-PQVQKYDDSFDDVDRTLDEWKRVTY-KEVLSFKPPRQL 347
> xla:100329215 p38-beta; mitogen-activated protein kinase p38
beta; K04441 p38 MAP kinase [EC:2.7.11.24]
Length=361
Score = 172 bits (436), Expect = 2e-42, Method: Compositional matrix adjust.
Identities = 98/278 (35%), Positives = 141/278 (50%), Gaps = 65/278 (23%)
Query 12 LTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTMDFPEGQ 71
LT+ HI+ L+Y LL G+KY+HSAGI+HRDLKP+N VN+DC +++ DFGLAR
Sbjct 121 LTDDHIQFLIYQLLRGLKYIHSAGIIHRDLKPSNLAVNEDCELRILDFGLAR-------- 172
Query 72 NSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTEAIDVWSIGCIF 131
Q DD ++TG V TRWYRAPE++L +Y + +D+WS+GCI
Sbjct 173 -------QADD-------------EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIM 212
Query 132 SELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQLNVIFNVLGTP 191
+ELL LFPG+ DQL I V+GTP
Sbjct 213 AELLK-----------GKALFPGNDYI--------------------DQLKRIMEVVGTP 241
Query 192 TEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVFNPKRRISVDEC 251
E + S A++YI + P DL + F ++P A++LL++ML+ + +RI+ E
Sbjct 242 NSEFLMKISSEHARRYIESLPYMPQQDLKEVFHGANPLAIDLLEKMLILDSDKRIAATEA 301
Query 252 LAHPFFEGVRNPSIEVTA------TEKVRLPFNDWANM 283
LAH +F +P E A TE ++W +
Sbjct 302 LAHAYFVQYHDPDDEPEAEPYDESTENKERTIDEWKEI 339
> ath:AT4G11330 ATMPK5; ATMPK5 (MAP KINASE 5); MAP kinase/ kinase;
K04371 extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
Length=376
Score = 171 bits (434), Expect = 2e-42, Method: Compositional matrix adjust.
Identities = 99/301 (32%), Positives = 155/301 (51%), Gaps = 58/301 (19%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D ++ R+ L + H + LY +L G+KY+HSA +LHRDLKP+N L+N +C +K+ DFG
Sbjct 130 DLHQIIRSNQSLNDDHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNSNCDLKITDFG 189
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LART E +T VVTRWYRAPEL+L + YT
Sbjct 190 LARTTSETE--------------------------YMTEYVVTRWYRAPELLLNSSEYTS 223
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
AIDVWS+GCIF+E+++ R PLFPG + Q
Sbjct 224 AIDVWSVGCIFAEIMT-----------REPLFPG--------------------KDYVHQ 252
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
L +I ++G+P + S A++Y++ P + + RF + + A++LL++MLVF
Sbjct 253 LKLITELIGSPDGASLEFLRSANARKYVKELPKFPRQNFSARFPSMNSTAIDLLEKMLVF 312
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQRFH 300
+P +RI+V+E L +P+ + + + E + F D ++ +E L +L E +F+
Sbjct 313 DPVKRITVEEALCYPYLSALHDLNDEPVCSNHFSFHFEDPSSTEEEIKELVWL-ESVKFN 371
Query 301 P 301
P
Sbjct 372 P 372
> dre:415185 zgc:86905; K04441 p38 MAP kinase [EC:2.7.11.24]
Length=361
Score = 171 bits (433), Expect = 3e-42, Method: Compositional matrix adjust.
Identities = 99/275 (36%), Positives = 143/275 (52%), Gaps = 61/275 (22%)
Query 12 LTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTMDFPEGQ 71
L++ H++ L+Y LL G+KY+HSAG++HRDLKP+N VN+DC +++ DFGLAR
Sbjct 121 LSDEHVQFLIYQLLRGLKYIHSAGLIHRDLKPSNVAVNEDCELRILDFGLAR-------- 172
Query 72 NSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTEAIDVWSIGCIF 131
Q DD ++TG V TRWYRAPE++L +Y + +D+WS+GCI
Sbjct 173 -------QTDD-------------EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIM 212
Query 132 SELLSMIEENVESHCDRGP-LFPGSSCFPLSPDQKNGDDSRLQTRGNKDQLNVIFNVLGT 190
ELL +G LFPG+ DQL I V+GT
Sbjct 213 GELL------------KGKVLFPGNDYI--------------------DQLKRIMEVVGT 240
Query 191 PTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVFNPKRRISVDE 250
PT + + S A++YI++ P DL + F ++P A++LLK+MLV + RIS E
Sbjct 241 PTPDVLKKISSEHAQKYIQSLPHMPQQDLGKIFRGANPLAVDLLKKMLVLDCDGRISASE 300
Query 251 CLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDE 285
L HP+F +P E A + P + M+E
Sbjct 301 ALCHPYFSQYHDPEDEPEAPPYDQTPESKDRTMEE 335
> cel:B0218.3 pmk-1; P38 Map Kinase family member (pmk-1); K04441
p38 MAP kinase [EC:2.7.11.24]
Length=377
Score = 169 bits (429), Expect = 1e-41, Method: Compositional matrix adjust.
Identities = 93/260 (35%), Positives = 134/260 (51%), Gaps = 59/260 (22%)
Query 12 LTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTMDFPEGQ 71
L + HI+ L+Y +L G+KY+HSA I+HRDLKP+N VN+DC +K+ DFGLAR D
Sbjct 133 LNDDHIQFLVYQILRGLKYIHSADIIHRDLKPSNIAVNEDCELKILDFGLARQTD----- 187
Query 72 NSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTEAIDVWSIGCIF 131
++TG V TRWYRAPE++L +YT+ +DVWS+GCI
Sbjct 188 -----------------------SEMTGYVATRWYRAPEIMLNWMHYTQTVDVWSVGCIL 224
Query 132 SELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQLNVIFNVLGTP 191
+EL++ LFPGS + DQL I +V GTP
Sbjct 225 AELIT-----------GKTLFPGSD--------------------HIDQLTRIMSVTGTP 253
Query 192 TEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVFNPKRRISVDEC 251
EE + S EA+ YIR P D + F+ ++P+A++LL++ML +P RR + E
Sbjct 254 DEEFLKKISSEEARNYIRNLPKMTRRDFKRLFAQATPQAIDLLEKMLHLDPDRRPTAKEA 313
Query 252 LAHPFFEGVRNPSIEVTATE 271
+ H + + + E A E
Sbjct 314 MEHEYLAAYHDETDEPIAEE 333
> pfa:PF14_0294 PfMAP1; mitogen-activated protein kinase 1; K04371
extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
Length=914
Score = 169 bits (428), Expect = 1e-41, Method: Compositional matrix adjust.
Identities = 102/299 (34%), Positives = 153/299 (51%), Gaps = 57/299 (19%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D ++ +A + L E+H K ++Y LL +KY+HS G+LHRD+KP+N LVN +C +KV DFG
Sbjct 108 DLHEVIKADL-LEEIHKKYIIYQLLRALKYIHSGGLLHRDIKPSNILVNSECHIKVADFG 166
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LAR++ +N P+ LT V TRWYRAPE++L + +YTE
Sbjct 167 LARSISTHVNENK-VPI-------------------LTDYVATRWYRAPEILLGSTHYTE 206
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
+D+WS+GCI ELL C + PLF G+S +Q
Sbjct 207 DVDMWSLGCIMGELL----------CGK-PLFTGNSTM--------------------NQ 235
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
L I V+G P +++I S A++ I +F K +L +S E+L+LL+++L F
Sbjct 236 LEKIIQVIGKPNKKDIEDIRSPFAEKIISSFVDLKKKNLKDICYKASNESLDLLEKLLQF 295
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQRF 299
NP +RIS + L H + E + E T + +P N D + R+ F R + F
Sbjct 296 NPSKRISAENALKHKYVEEFHSIIDEPTCRHIITIPIN-----DNTKYRVNFYRNVVYF 349
> xla:379992 mapk14, MGC69036, csbp, mapk14a, mxi2, p38, p38-alpha,
sapk2, sapk2a; mitogen-activated protein kinase 14 (EC:2.7.11.24);
K04441 p38 MAP kinase [EC:2.7.11.24]
Length=361
Score = 167 bits (422), Expect = 6e-41, Method: Compositional matrix adjust.
Identities = 91/258 (35%), Positives = 136/258 (52%), Gaps = 59/258 (22%)
Query 12 LTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTMDFPEGQ 71
LT+ H++ L+Y +L G+KY+HSAGI+HRDLKP+N VN+DC +K+ DFGLAR D
Sbjct 123 LTDDHVQFLIYQILRGLKYIHSAGIIHRDLKPSNLAVNEDCELKILDFGLARHTD----- 177
Query 72 NSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTEAIDVWSIGCIF 131
++TG V TRWYRAPE++L +Y + +D+WS+GCI
Sbjct 178 -----------------------EEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIM 214
Query 132 SELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQLNVIFNVLGTP 191
+ELL+ G + FP G D + DQL +I ++GTP
Sbjct 215 AELLT-----------------GRTLFP-------GTD-------HIDQLKLILRLVGTP 243
Query 192 TEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVFNPKRRISVDEC 251
E + S A+ YI++ P + F ++P+A++LL++MLV + +RI+ E
Sbjct 244 EPELLQKISSEAARNYIQSLPYMPKMNFEDVFLGANPQAVDLLEKMLVLDTDKRITAAEA 303
Query 252 LAHPFFEGVRNPSIEVTA 269
LAH +F +P E A
Sbjct 304 LAHSYFAQYHDPDDEPIA 321
> hsa:5598 MAPK7, BMK1, ERK4, ERK5, PRKM7; mitogen-activated protein
kinase 7 (EC:2.7.11.24); K04464 mitogen-activated protein
kinase 7 [EC:2.7.11.24]
Length=816
Score = 166 bits (421), Expect = 9e-41, Method: Compositional matrix adjust.
Identities = 100/300 (33%), Positives = 145/300 (48%), Gaps = 53/300 (17%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D ++ + LT H++ LY LL G+KY+HSA ++HRDLKP+N LVN++C +K+ DFG
Sbjct 143 DLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFG 202
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
+AR + T + +T V TRWYRAPEL+L YT+
Sbjct 203 MARGL---------------------CTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQ 241
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
AID+WS+GCIF E+L+ R LFPG + Q
Sbjct 242 AIDLWSVGCIFGEMLA-----------RRQLFPGKNYV--------------------HQ 270
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
L +I VLGTP+ I A + + YI++ PP++ + + +AL+LL RML F
Sbjct 271 LQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRF 330
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQRFH 300
P RIS L HPF +P E F+ A E +++ + E++ FH
Sbjct 331 EPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRE-RIKEAIVAEIEDFH 389
> mmu:23939 Mapk7, BMK1, ERK5, Erk5-T, PRKM7; mitogen-activated
protein kinase 7 (EC:2.7.11.24); K04464 mitogen-activated
protein kinase 7 [EC:2.7.11.24]
Length=806
Score = 166 bits (421), Expect = 9e-41, Method: Compositional matrix adjust.
Identities = 100/300 (33%), Positives = 145/300 (48%), Gaps = 53/300 (17%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D ++ + LT H++ LY LL G+KY+HSA ++HRDLKP+N LVN++C +K+ DFG
Sbjct 143 DLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFG 202
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
+AR + T + +T V TRWYRAPEL+L YT+
Sbjct 203 MARGL---------------------CTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQ 241
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
AID+WS+GCIF E+L+ R LFPG + Q
Sbjct 242 AIDLWSVGCIFGEMLA-----------RRQLFPGKNYV--------------------HQ 270
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVF 240
L +I VLGTP+ I A + + YI++ PP++ + + +AL+LL RML F
Sbjct 271 LQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRF 330
Query 241 NPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFNDWANMDEPQLRLGFLREMQRFH 300
P RIS L HPF +P E F+ A E +++ + E++ FH
Sbjct 331 EPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRE-RIKEAIVAEIEDFH 389
> xla:734485 mapk15, MGC99048; mitogen-activated protein kinase
15 (EC:2.7.11.24); K08293 mitogen-activated protein kinase
[EC:2.7.11.24]
Length=586
Score = 165 bits (418), Expect = 2e-40, Method: Compositional matrix adjust.
Identities = 94/280 (33%), Positives = 143/280 (51%), Gaps = 52/280 (18%)
Query 1 DFKKLFRAPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFG 60
D + + L ++H++ +LY LL K++HS ++HRD KP+N L++ DC VK+CDFG
Sbjct 99 DLHAVIKKGNLLKDIHMRYILYQLLKATKFIHSGNVIHRDQKPSNILLDGDCLVKLCDFG 158
Query 61 LARTMDFPEGQNSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTE 120
LAR++ Q +D+ N LT V TRWYRAPE++L + YT+
Sbjct 159 LARSL------------YQIQEDVGNPA--------LTEYVATRWYRAPEILLASNRYTK 198
Query 121 AIDVWSIGCIFSELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQ 180
+D+WS+GCI E+L PLFPG+S +Q
Sbjct 199 GVDMWSVGCILGEMLLG-----------KPLFPGTSTI--------------------NQ 227
Query 181 LNVIFNVLGTPTEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSP-EALNLLKRMLV 239
+ I +++ PT E+I + +S I K +A+ F AS P EAL+LL ++LV
Sbjct 228 IERIMSIIEPPTHEDIVSIKSEYGASVISRMSSKHKVPMAELFPASCPREALDLLSKLLV 287
Query 240 FNPKRRISVDECLAHPFFEGVRNPSIEVTATEKVRLPFND 279
FNP +R++ +E L HP+ +P+ E V LP +D
Sbjct 288 FNPGKRLTAEEALEHPYVSRFHSPAREPALDYDVILPVDD 327
> dre:65237 mapk14a, MAPK14, fk28c03, hm:zeh1243, p38, p38a, wu:fk28c03,
zp38a; mitogen-activated protein kinase 14a (EC:2.7.11.24);
K04441 p38 MAP kinase [EC:2.7.11.24]
Length=361
Score = 165 bits (417), Expect = 2e-40, Method: Compositional matrix adjust.
Identities = 93/258 (36%), Positives = 137/258 (53%), Gaps = 59/258 (22%)
Query 12 LTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTMDFPEGQ 71
LT+ H++ L+Y +L G+KY+HSA I+HRDLKP+N VN+DC +K+ DFGLAR
Sbjct 123 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-------- 174
Query 72 NSHCPVAQQDDDIVNVTHTKNLKRQLTGQVVTRWYRAPELILLAENYTEAIDVWSIGCIF 131
HT + ++TG V TRWYRAPE++L +Y +D+WS+GCI
Sbjct 175 -----------------HTDD---EMTGYVATRWYRAPEIMLNWMHYNVTVDIWSVGCIM 214
Query 132 SELLSMIEENVESHCDRGPLFPGSSCFPLSPDQKNGDDSRLQTRGNKDQLNVIFNVLGTP 191
+ELL+ G + FP G D + +QL I + GTP
Sbjct 215 AELLT-----------------GRTLFP-------GTD-------HINQLQQIMRLTGTP 243
Query 192 TEEEINAPESNEAKQYIRTFPPKKAHDLAQRFSASSPEALNLLKRMLVFNPKRRISVDEC 251
I+ S+EA+ YI + P + A F ++P+A++LL++MLV + +RI+ E
Sbjct 244 PSSLISRMPSHEARTYISSLPQMPKRNFADVFIGANPQAVDLLEKMLVLDTDKRITAAEA 303
Query 252 LAHPFFEGVRNPSIEVTA 269
LAHP+F +P E A
Sbjct 304 LAHPYFAQYHDPDDEPEA 321
Lambda K H
0.320 0.136 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 13047806380
Database: egene_temp_file_orthology_annotation_similarity_blast_database_866
Posted date: Sep 17, 2011 2:57 PM
Number of letters in database: 82,071,388
Number of sequences in database: 164,496
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40