bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: egene_temp_file_orthology_annotation_similarity_blast_database_866
164,496 sequences; 82,071,388 total letters
Query= Eten_3223_orf3
Length=420
Score E
Sequences producing significant alignments: (Bits) Value
tgo:TGME49_046550 eukaryotic aspartyl protease, putative (EC:3... 537 2e-152
bbo:BBOV_IV007890 23.m06476; aspartyl protease 291 5e-78
pfa:PF14_0281 plasmepsin IX; K01386 [EC:3.4.23.-] 265 3e-70
pfa:PF08_0108 plasmepsin X (EC:3.4.23.1); K06002 pepsin A [EC:... 259 9e-69
tpv:TP01_0692 pepsinogen; K06002 pepsin A [EC:3.4.23.1] 216 1e-55
hsa:643834 PGA3, DKFZp666J2410, PGA4, PGA5; pepsinogen 3, grou... 180 8e-45
hsa:643847 PGA4, FLJ58952, FLJ77962, PGA3, PGA5; pepsinogen 4,... 180 8e-45
hsa:5222 PGA5, PGA3, PGA4; pepsinogen 5, group I (pepsinogen A... 180 1e-44
tpv:TP03_0306 pepsin A (EC:3.4.23.1); K06002 pepsin A [EC:3.4.... 179 2e-44
mmu:13034 Ctse, A430072O03Rik, C920004C08Rik, CE, CatE; cathep... 176 1e-43
mmu:58803 Pga5, 1110035E17Rik, Pepf; pepsinogen 5, group I (EC... 176 2e-43
xla:373564 pga4, pga-A; pepsinogen 4, group I (pepsinogen A); ... 175 3e-43
cpv:cgd6_660 secreted pepsinogen like aspartyl protease having... 173 1e-42
hsa:1510 CTSE, CATE; cathepsin E (EC:3.4.23.34); K01382 cathep... 167 5e-41
mmu:109820 Pgc, 2210410L06Rik, MGC117575, Upg-1, Upg1; progast... 162 2e-39
mmu:229697 Cym, Gm131; chymosin (EC:3.4.23.4); K01378 chymosin... 161 4e-39
xla:398994 napsa, MGC68767, kap, kdap, nap1, napa, snapa; naps... 160 1e-38
xla:373563 pgc-A; pepsinogen C (EC:3.4.23.3); K01377 gastricsi... 157 7e-38
xla:443829 MGC82347 protein; K01379 cathepsin D [EC:3.4.23.5] 157 7e-38
bbo:BBOV_IV010360 23.m06120; aspartyl protease 156 1e-37
xla:373573 ctse-b, CE2, cate, ce1, ce2-A; cathepsin E (EC:3.4.... 154 7e-37
xla:398557 cathepsin D (EC:3.4.23.5); K01379 cathepsin D [EC:3... 153 1e-36
mmu:16541 Napsa, KAP, Kdap, NAP1, SNAPA, pronapsin; napsin A a... 152 2e-36
xla:443721 ctsd; cathepsin D (EC:3.4.23.5); K01379 cathepsin D... 148 4e-35
xla:373572 ctse-a, CE1, cate, ce1-A, ce2, ctse; cathepsin E (E... 147 5e-35
hsa:9476 NAPSA, KAP, Kdap, NAP1, NAPA, SNAPA; napsin A asparti... 145 4e-34
hsa:1509 CTSD, CLN10, CPSD, MGC2311; cathepsin D (EC:3.4.23.5)... 143 1e-33
hsa:5972 REN, FLJ10761, HNFJ2; renin (EC:3.4.23.15); K01380 re... 142 3e-33
tgo:TGME49_062940 eukaryotic aspartyl protease, putative (EC:3... 141 5e-33
dre:336746 fa94d12, wu:fa94d12; zgc:63831; K01379 cathepsin D ... 140 1e-32
mmu:13033 Ctsd, CD, CatD; cathepsin D (EC:3.4.23.5); K01379 ca... 140 1e-32
bbo:BBOV_III003510 17.m07331; eukaryotic aspartyl protease fam... 140 1e-32
mmu:100044656 renin-1-like 138 3e-32
mmu:19701 Ren1, D19352, Ren, Ren-1, Ren-A, Ren1c, Ren1d, Rn-1,... 137 5e-32
dre:65225 ctsd, catD, fb93e11, fj17b09, wu:fb93e11, wu:fj17b09... 137 9e-32
mmu:19702 Ren2, Ren, Ren-2, Ren-B, Rn-2, Rnr; renin 2 tandem d... 135 3e-31
cel:R12H7.2 asp-4; ASpartyl Protease family member (asp-4); K0... 131 5e-30
ath:AT1G62290 aspartyl protease family protein; K08245 phyteps... 127 6e-29
ath:AT4G04460 aspartyl protease family protein; K08245 phyteps... 127 7e-29
pfa:PFC0495w plasmepsin VI (EC:3.4.23.-); K01386 [EC:3.4.23.-] 126 2e-28
dre:114367 nots, LAP, MGC192423, ctsel, zgc:103608; nothepsin 125 4e-28
cpv:cgd6_3820 membrane bound aspartyl proteinase with a signal... 124 6e-28
sce:YPL154C PEP4, PHO9, PRA1, yscA; Pep4p (EC:3.4.23.25); K013... 122 2e-27
ath:AT1G11910 aspartyl protease family protein; K08245 phyteps... 122 4e-27
cel:Y39B6A.23 hypothetical protein 121 4e-27
cel:Y39B6A.20 asp-1; ASpartyl Protease family member (asp-1) 117 8e-26
dre:405786 ren; renin (EC:3.4.23.15); K01380 renin [EC:3.4.23.15] 117 1e-25
tpv:TP03_0056 cathepsin E (EC:3.4.23.34); K01386 [EC:3.4.23.-] 117 1e-25
pfa:PF14_0625 plasmepsin VIII (EC:3.4.17.4) 105 5e-22
cel:ZK384.3 hypothetical protein 101 5e-21
> tgo:TGME49_046550 eukaryotic aspartyl protease, putative (EC:3.4.23.1);
K06002 pepsin A [EC:3.4.23.1]
Length=643
Score = 537 bits (1384), Expect = 2e-152, Method: Compositional matrix adjust.
Identities = 274/467 (58%), Positives = 324/467 (69%), Gaps = 50/467 (10%)
Query 4 AAAVLTAVSSSSETLQIAGNGEVLSSVTKQQHVRPY-------------SGAVPLCRNC- 49
+A + ++SS +++G +S T ++ +RPY S +PLC C
Sbjct 74 SALKIEEIASSGSAPEVSGAAGASASKTSEKPIRPYHTGPSSRSSAYSASSGIPLCHTCS 133
Query 50 -FGKDQQTCKVCLHGEHESSFLMPMTRARA--SAEDETFAALETNHNAVKNLNRTFYMKR 106
F C++C+HGE S FLMPM R + +ET + LE NH N + FY+ R
Sbjct 134 SFDAANGGCRLCVHGEVASDFLMPMMPIRNIDTHREETLSRLEANHRTHLNEKKNFYVLR 193
Query 107 GEGPFGSLGNKPTDTKAGGAGA----------TSFLQ--NKEAAD--------------- 139
G+GPFGSLGN P A A SF Q NK+++D
Sbjct 194 GKGPFGSLGNLPGTPGLDAAIAFGLSSPDLPSASFAQIKNKDSSDSGDVAAVGEETDSAV 253
Query 140 -----TLDLELGLAQTSVPIMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCE 194
TLDL+L LA+TSVPI+QMKDSQY G++GIGTPPQ+V PIFDTGSTNLWVVGSKC
Sbjct 254 ADGSKTLDLDLKLAETSVPILQMKDSQYVGVIGIGTPPQFVQPIFDTGSTNLWVVGSKCT 313
Query 195 DDTCTKVTRFDPSKSSSFQYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLV 254
DDTCTKVTRFDPS S +F+ +PPVHLDITFGTGRIEGSTG+D+F VGPF VKGQ+FGLV
Sbjct 314 DDTCTKVTRFDPSASKTFRAANPPVHLDITFGTGRIEGSTGIDDFTVGPFLVKGQSFGLV 373
Query 255 EKEGGHNEHGNIFKSINFEGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDS 314
E EGGHN HGNIFK+INFEGIVG+ FP+MSSTG PIYDNI+ Q LK +EFAFY+AK S
Sbjct 374 ESEGGHNMHGNIFKTINFEGIVGLAFPEMSSTGTVPIYDNIISQGTLKENEFAFYMAKGS 433
Query 315 PVSALFFGGVDPRFYESPIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGT 374
VSALFFGGVDPRFYE+PIHMFPV REHYWE +LDAI++GDKKFCCEEGTKNYVILDSGT
Sbjct 434 QVSALFFGGVDPRFYEAPIHMFPVTREHYWETSLDAIYIGDKKFCCEEGTKNYVILDSGT 493
Query 375 SFNTMPGNEMRSFLEMIPSQECG-DDDSFLSSYPDITYVIGGVSFVL 420
SFNTMP E+ L+MIPS+EC DD F S +P ITYVIGGV F L
Sbjct 494 SFNTMPSGELGKLLDMIPSKECNLDDPEFTSDFPTITYVIGGVKFPL 540
> bbo:BBOV_IV007890 23.m06476; aspartyl protease
Length=463
Score = 291 bits (744), Expect = 5e-78, Method: Compositional matrix adjust.
Identities = 150/357 (42%), Positives = 201/357 (56%), Gaps = 9/357 (2%)
Query 59 VCLHGEHESSFLMPMTRARASAEDETFAALETNHNAVKNLNRTFYMKRGEGPFGSLGNKP 118
+CLH + S + + R + E NHNA + + + +R EG FGS+G
Sbjct 52 ICLHHGNASEHSITLKRYNRADGLSALQMAEDNHNAFRR-GKISFARRSEGSFGSIGYSG 110
Query 119 TDTKAGGAGATSFLQNKEAADTLDLELGLAQTSVPIMQMKDSQYCGMLGIGTPPQWVHPI 178
+ A ++ L +PI + KDS Y G + IGTPPQ VHPI
Sbjct 111 SHV---SQNALKLMRRSNPKSLSMLSRSEYGKYIPIKETKDSLYIGEIMIGTPPQIVHPI 167
Query 179 FDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSSSFQYTSPPVHLDITFGTGRIEGSTGVDN 238
FDTGSTNLWVVG C+D +C KV R++ S SS+F+ PV + + FGTG IEG +D
Sbjct 168 FDTGSTNLWVVGYDCKDPSCLKVARYNTSVSSTFERLKNPVRIHVKFGTGEIEGYPALDT 227
Query 239 FQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSINFEGIVGMGFPDMSSTGATPIYDNIMKQ 298
+G V Q +V+ E + NIF INFEGIVG+ FP+MSS PI+D++
Sbjct 228 VTIGETVVPKQALAVVDSENSGTQISNIFNKINFEGIVGLAFPEMSSIPGMPIFDHMALL 287
Query 299 ADLKRSEFAFYVAKDSPVSALFFGGVDPRFYESPIHMFPVEREHYWEVALDAIHVGDKKF 358
++K EFAFY++ + S L GGVDP++Y I MFPV REHYWEV LDA++VGD+K
Sbjct 288 RNMKHKEFAFYISNNDKDSKLMLGGVDPQYYTGKIKMFPVVREHYWEVKLDALYVGDEKL 347
Query 359 CCEEGTKNYVILDSGTSFNTMPGNEMRSFLEMIPSQECGDDDSFLSSYPDITYVIGG 415
CC +G +Y+I DSGTS NT+P + F+ + C D YP ITYVIGG
Sbjct 348 CC-DGESSYLIFDSGTSLNTVPSSYFDRFISHFKIKTCDD----YEVYPTITYVIGG 399
> pfa:PF14_0281 plasmepsin IX; K01386 [EC:3.4.23.-]
Length=627
Score = 265 bits (676), Expect = 3e-70, Method: Compositional matrix adjust.
Identities = 110/212 (51%), Positives = 157/212 (74%), Gaps = 0/212 (0%)
Query 149 QTSVPIMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSK 208
+ ++P+ Q++DSQY G + IGTPPQ + PIFDTGSTN+W+V +KC+D+TC KV R++
Sbjct 215 KVTLPLQQLEDSQYVGYIQIGTPPQTIRPIFDTGSTNIWIVSTKCKDETCLKVHRYNHKL 274
Query 209 SSSFQYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFK 268
SSSF+Y P +LDI FGTG I+G GV+ F++GPF +K Q+FGLV++E + N+F+
Sbjct 275 SSSFKYYEPHTNLDIMFGTGIIQGVIGVETFKIGPFEIKNQSFGLVKREKASDNKSNVFE 334
Query 269 SINFEGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDSPVSALFFGGVDPRF 328
INFEGIVG+ FP+M STG + +Y+N+M L+ +EF+ Y+ KDS SAL FGGVD F
Sbjct 335 RINFEGIVGLAFPEMLSTGKSTLYENLMSSYKLQHNEFSIYIGKDSKYSALIFGGVDKNF 394
Query 329 YESPIHMFPVEREHYWEVALDAIHVGDKKFCC 360
+E I+MFPV +E+YWE+ D +++ +KFCC
Sbjct 395 FEGDIYMFPVVKEYYWEIHFDGLYIDHQKFCC 426
Score = 62.4 bits (150), Expect = 3e-09, Method: Compositional matrix adjust.
Identities = 27/56 (48%), Positives = 40/56 (71%), Gaps = 2/56 (3%)
Query 367 YVILDSGTSFNTMPGNEMRSFLEMIPSQECGDD--DSFLSSYPDITYVIGGVSFVL 420
Y+I DSGTSFN++P +E+ F ++PS++C D D +SSYP++TYVI + F L
Sbjct 491 YLIFDSGTSFNSVPKDEIEYFFRVVPSKKCDDSNIDQVVSSYPNLTYVINKMPFTL 546
> pfa:PF08_0108 plasmepsin X (EC:3.4.23.1); K06002 pepsin A [EC:3.4.23.1]
Length=573
Score = 259 bits (663), Expect = 9e-69, Method: Compositional matrix adjust.
Identities = 130/267 (48%), Positives = 182/267 (68%), Gaps = 6/267 (2%)
Query 152 VPIMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSSS 211
VP+ ++DSQ+ G L +GTPPQ V+PIFDTGSTN+WVV + CE+++C KV R+DP+KS +
Sbjct 238 VPLKHLRDSQFVGELLVGTPPQTVYPIFDTGSTNVWVVTTACEEESCKKVRRYDPNKSKT 297
Query 212 FQYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHG--NIFKS 269
F+ + +L I FG+G I GS G D F +G V+ QTFGLVE E +N++G NIF
Sbjct 298 FRRSFIEKNLHIVFGSGSISGSVGTDTFMLGKHLVRNQTFGLVESESNNNKNGGDNIFDY 357
Query 270 INFEGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDSPVSALFFGGVDPRFY 329
I+FEGIVG+GFP M S G P +DN++KQ +F+FY++ S L GG+ FY
Sbjct 358 ISFEGIVGLGFPGMLSAGNIPFFDNLLKQNPNVDPQFSFYISPYDGKSTLIIGGISKSFY 417
Query 330 ESPIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSFLE 389
E I+M PV +E YWEV LD +++G ++ CC+E ++YVI D+GTS+NTMP ++M++FL
Sbjct 418 EGDIYMLPVLKESYWEVKLDELYIGKERICCDE--ESYVIFDTGTSYNTMPSSQMKTFLN 475
Query 390 MIPSQECGDDD--SFLSSYPDITYVIG 414
+I S C + + L SYP I YV G
Sbjct 476 LIHSTACTEQNYKDILKSYPIIKYVFG 502
Score = 41.6 bits (96), Expect = 0.006, Method: Compositional matrix adjust.
Identities = 27/82 (32%), Positives = 42/82 (51%), Gaps = 5/82 (6%)
Query 40 SGAVPLCRNCFGKDQQTCKVCLHGEHESSFLMPMTRARASAEDETFAALETNHNAVKNLN 99
+ A+P C C D C CL E ESS ++P+ + + D L+ +H ++K +
Sbjct 34 TKALP-CSEC--HDVFDCTGCLFEEKESSHVIPLKLNKKNPNDH--KKLQKHHESLKLGD 88
Query 100 RTFYMKRGEGPFGSLGNKPTDT 121
+Y+ RGEG GSLG +T
Sbjct 89 VKYYVNRGEGISGSLGTSSGNT 110
> tpv:TP01_0692 pepsinogen; K06002 pepsin A [EC:3.4.23.1]
Length=377
Score = 216 bits (551), Expect = 1e-55, Method: Compositional matrix adjust.
Identities = 124/361 (34%), Positives = 195/361 (54%), Gaps = 29/361 (8%)
Query 48 NCFGKDQQTCKVCLHGEHESSFLMPMTRARASAEDETFAALETNHNAVKNLNRTFYMKRG 107
NC + T K C++ + + P+ ++ + + E N N V ++ R
Sbjct 19 NC--SEINTIKPCIYNGPKQKRIFPLKSLSPNSVERSAEITEENWNNVTR-GHIHFLYRS 75
Query 108 EGPFGSLGNKPTDTKAGGAGATSFLQNKE----AADTLD------LELGLAQTSVPIMQM 157
+GP+GSLG ++ + T N + + +++D + + +PI +
Sbjct 76 QGPYGSLGTSQHNSHNCNSYHTHNSVNTDDSVNSVNSVDGTRLTPIREHPMKKCIPIPHL 135
Query 158 KDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSSSFQYTSP 217
+ QY +G+GTP Q ++PI DTGSTN WV+ +C TC+ V F+ KSS+F
Sbjct 136 RHVQYVMSIGVGTPKQEIYPIIDTGSTNTWVISEQCNSITCSGVPTFNSRKSSTFS---- 191
Query 218 PVH--LDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSINFEGI 275
PV+ L I FGTG I+G G+DN +G T++ Q FGLV +E N+FK I F+GI
Sbjct 192 PVNEGLRIRFGTGTIKGVLGIDNVTIGQDTIEKQIFGLVNEES-----SNVFKVIKFQGI 246
Query 276 VGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDSPVSALFFGGVDPRFYESPIHM 335
+G+GFP ++ T +YDN KQ + ++ F + + S + GGVD RFY ++M
Sbjct 247 IGLGFPKLAFDHHTSLYDNYSKQIN---ADLIFSLYFSNQYSYVMIGGVDERFYVGDLYM 303
Query 336 FPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSFLEMIPSQE 395
PV RE+YWE+ L + VG+ K CC++ ++YVI DSGTSFNTMP ++ F ++ +
Sbjct 304 LPVVREYYWEIKLYELWVGNVKLCCDD--ESYVIFDSGTSFNTMPHDQFLYFKHIVSPKI 361
Query 396 C 396
C
Sbjct 362 C 362
> hsa:643834 PGA3, DKFZp666J2410, PGA4, PGA5; pepsinogen 3, group
I (pepsinogen A) (EC:3.4.23.1); K06002 pepsin A [EC:3.4.23.1]
Length=388
Score = 180 bits (457), Expect = 8e-45, Method: Compositional matrix adjust.
Identities = 104/272 (38%), Positives = 149/272 (54%), Gaps = 15/272 (5%)
Query 153 PIMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSSSF 212
P+ D +Y G +GIGTP Q +FDTGS+NLWV C CT RF+P SS++
Sbjct 67 PLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTY 126
Query 213 QYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSINF 272
Q TS V IT+GTG + G G D QVG + Q FGL E E G+ F
Sbjct 127 QSTSETVS--ITYGTGSMTGILGYDTVQVGGISDTNQIFGLSE-----TEPGSFLYYAPF 179
Query 273 EGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYV-AKDSPVSALFFGGVDPRFYES 331
+GI+G+ +P +SS+GATP++DNI Q + + F+ Y+ A D S + FGG+D +Y
Sbjct 180 DGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTG 239
Query 332 PIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSFLEMI 391
++ PV E YW++ +D+I + + C EG + I+D+GTS T P + + + I
Sbjct 240 SLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQ--AIVDTGTSLLTGPTSPIANIQSDI 297
Query 392 PSQECGDDD-----SFLSSYPDITYVIGGVSF 418
+ E D D S +SS PDI + I GV +
Sbjct 298 GASENSDGDMVVSCSAISSLPDIVFTINGVQY 329
> hsa:643847 PGA4, FLJ58952, FLJ77962, PGA3, PGA5; pepsinogen
4, group I (pepsinogen A) (EC:3.4.23.1); K06002 pepsin A [EC:3.4.23.1]
Length=388
Score = 180 bits (457), Expect = 8e-45, Method: Compositional matrix adjust.
Identities = 104/272 (38%), Positives = 149/272 (54%), Gaps = 15/272 (5%)
Query 153 PIMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSSSF 212
P+ D +Y G +GIGTP Q +FDTGS+NLWV C CT RF+P SS++
Sbjct 67 PLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTY 126
Query 213 QYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSINF 272
Q TS V IT+GTG + G G D QVG + Q FGL E E G+ F
Sbjct 127 QSTSETVS--ITYGTGSMTGILGYDTVQVGGISDTNQIFGLSE-----TEPGSFLYYAPF 179
Query 273 EGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYV-AKDSPVSALFFGGVDPRFYES 331
+GI+G+ +P +SS+GATP++DNI Q + + F+ Y+ A D S + FGG+D +Y
Sbjct 180 DGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTG 239
Query 332 PIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSFLEMI 391
++ PV E YW++ +D+I + + C EG + I+D+GTS T P + + + I
Sbjct 240 SLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQ--AIVDTGTSLLTGPTSPIANIQSDI 297
Query 392 PSQECGDDD-----SFLSSYPDITYVIGGVSF 418
+ E D D S +SS PDI + I GV +
Sbjct 298 GASENSDGDMVVSCSAISSLPDIVFTINGVQY 329
> hsa:5222 PGA5, PGA3, PGA4; pepsinogen 5, group I (pepsinogen
A) (EC:3.4.23.1); K06002 pepsin A [EC:3.4.23.1]
Length=388
Score = 180 bits (456), Expect = 1e-44, Method: Compositional matrix adjust.
Identities = 104/272 (38%), Positives = 149/272 (54%), Gaps = 15/272 (5%)
Query 153 PIMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSSSF 212
P+ D +Y G +GIGTP Q +FDTGS+NLWV C CT RF+P SS++
Sbjct 67 PLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTY 126
Query 213 QYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSINF 272
Q TS V IT+GTG + G G D QVG + Q FGL E E G+ F
Sbjct 127 QSTSETVS--ITYGTGSMTGILGYDTVQVGGISDTNQIFGLSE-----TEPGSFLYYAPF 179
Query 273 EGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYV-AKDSPVSALFFGGVDPRFYES 331
+GI+G+ +P +SS+GATP++DNI Q + + F+ Y+ A D S + FGG+D +Y
Sbjct 180 DGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDKSGSVVIFGGIDSSYYTG 239
Query 332 PIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSFLEMI 391
++ PV E YW++ +D+I + + C EG + I+D+GTS T P + + + I
Sbjct 240 SLNWVPVTVEGYWQITVDSITMNGETIACAEGCQ--AIVDTGTSLLTGPTSPIANIQSDI 297
Query 392 PSQECGDDD-----SFLSSYPDITYVIGGVSF 418
+ E D D S +SS PDI + I GV +
Sbjct 298 GASENSDGDMVVSCSAISSLPDIVFTINGVQY 329
> tpv:TP03_0306 pepsin A (EC:3.4.23.1); K06002 pepsin A [EC:3.4.23.1]
Length=328
Score = 179 bits (453), Expect = 2e-44, Method: Compositional matrix adjust.
Identities = 100/240 (41%), Positives = 132/240 (55%), Gaps = 39/240 (16%)
Query 185 NLWVVGSKCEDDTCTKVTRFDPSKSSSFQYTSPPVHLDITFGTGRIEGSTGVDNFQVGPF 244
N+WVVG+ CE +TC KV RF+P S++F+ + P + I FGTG IEG D VG
Sbjct 4 NVWVVGTTCESETCKKVKRFNPKLSNTFKRLTNPKKIHIKFGTGEIEGRPASDVITVGDM 63
Query 245 TVKGQTFGLVEKEGGHN----EHG-----------------------------NIFKSIN 271
+ + Q F LV+ E N +G N+ K IN
Sbjct 64 SFE-QNFALVDLESDSNVFQVRYGACTNLCSYYLFTHSLPPIKLRIPIIYTICNLLK-IN 121
Query 272 FEGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDSPVSALFFGGVDPRFYES 331
FEGIVG+ F +MSS + +NI L +EFAFY+ + + L FGG DPRFYE
Sbjct 122 FEGIVGLAFAEMSSISGPSVLENIFSLNRLSENEFAFYIGGEDAL--LMFGGADPRFYEG 179
Query 332 PIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSFLEMI 391
+ MFPV REHYWEVALDAI++G+ K CC + +YVI DSGTS N++P E +F +I
Sbjct 180 ELKMFPVVREHYWEVALDAIYLGNTKICCNQ--PSYVIFDSGTSLNSVPSAEFHTFTTLI 237
> mmu:13034 Ctse, A430072O03Rik, C920004C08Rik, CE, CatE; cathepsin
E (EC:3.4.23.34); K01382 cathepsin E [EC:3.4.23.34]
Length=397
Score = 176 bits (447), Expect = 1e-43, Method: Compositional matrix adjust.
Identities = 102/275 (37%), Positives = 148/275 (53%), Gaps = 16/275 (5%)
Query 153 PIMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSSSF 212
P++ D +Y G + IGTPPQ IFDTGS+NLWV C C F PS+S +
Sbjct 70 PLINYLDMEYFGTISIGTPPQNFTVIFDTGSSNLWVPSVYCTSPACKAHPVFHPSQSDT- 128
Query 213 QYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSINF 272
YT H I +GTG + G G D V TV GQ FG KE G F + F
Sbjct 129 -YTEVGNHFSIQYGTGSLTGIIGADQVSVEGLTVDGQQFGESVKEPGQT-----FVNAEF 182
Query 273 EGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKD---SPVSALFFGGVDPRFY 329
+GI+G+G+P +++ G TP++DN+M Q + F+ Y++ D S L FGG DP +
Sbjct 183 DGILGLGYPSLAAGGVTPVFDNMMAQNLVALPMFSVYLSSDPQGGSGSELTFGGYDPSHF 242
Query 330 ESPIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSFLE 389
++ PV ++ YW++ALD I VGD C EG + I+D+GTS T P ++++ E
Sbjct 243 SGSLNWIPVTKQAYWQIALDGIQVGDTVMFCSEGCQ--AIVDTGTSLITGPPDKIKQLQE 300
Query 390 MIPSQ----ECGDDDSFLSSYPDITYVIGGVSFVL 420
I + E D + L + P++T++I VS+ L
Sbjct 301 AIGATPIDGEYAVDCATLDTMPNVTFLINEVSYTL 335
> mmu:58803 Pga5, 1110035E17Rik, Pepf; pepsinogen 5, group I (EC:3.4.23.1);
K06002 pepsin A [EC:3.4.23.1]
Length=387
Score = 176 bits (445), Expect = 2e-43, Method: Compositional matrix adjust.
Identities = 97/278 (34%), Positives = 153/278 (55%), Gaps = 17/278 (6%)
Query 148 AQTSVPIMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPS 207
A T P+ D Y G++ IGTPPQ + DTGS+ LWV C C F+P
Sbjct 60 AVTYEPMRNYLDLVYIGIISIGTPPQEFRVVLDTGSSVLWVPSIYCSSPACAHHKAFNPL 119
Query 208 KSSSFQYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIF 267
+SS+F + PV ++ +G+G + G D ++G TV Q FGL +E G IF
Sbjct 120 RSSTFLVSGRPV--NVAYGSGEMSGFLAYDTVRIGDLTVVAQAFGLSLEEPG------IF 171
Query 268 KSIN-FEGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYV-AKDSPVSALFFGGVD 325
F+GI+G+G+P++ G TP++DN+ Q + ++ FAFY+ +KD S L GGVD
Sbjct 172 MEYAVFDGILGLGYPNLGLQGITPVFDNLWLQGLIPQNLFAFYLSSKDEKGSMLMLGGVD 231
Query 326 PRFYESPIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMR 385
P +Y +H PV + YW++A+D+I + + C+ G + I+D+GTS T P + +
Sbjct 232 PSYYHGELHWVPVSKPSYWQLAVDSISMNGEVIACDGGCQG--IMDTGTSLLTGPRSSIV 289
Query 386 SFLEMIPSQECGDDDSFL-----SSYPDITYVIGGVSF 418
+ +I ++ GD + FL ++ PDI + IG V++
Sbjct 290 NIQNLIGAKASGDGEYFLKCDTINTLPDIVFTIGSVTY 327
> xla:373564 pga4, pga-A; pepsinogen 4, group I (pepsinogen A);
K06002 pepsin A [EC:3.4.23.1]
Length=384
Score = 175 bits (444), Expect = 3e-43, Method: Compositional matrix adjust.
Identities = 98/281 (34%), Positives = 150/281 (53%), Gaps = 16/281 (5%)
Query 147 LAQTSVPIMQ-MKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFD 205
LAQ+S +Q D +Y G + IGTPPQ IFDTGS NLWV C C+ RF+
Sbjct 56 LAQSSAETLQNYMDIEYYGTISIGTPPQEFTVIFDTGSANLWVPSVYCSSQACSNHNRFN 115
Query 206 PSKSSSFQYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGN 265
P +SS+FQ T+ PV I +GTG + G G D QVG + Q FGL E E G+
Sbjct 116 PQQSSTFQATNTPV--SIQYGTGSMSGFLGYDTLQVGNIQISNQMFGLSES-----EPGS 168
Query 266 IFKSINFEGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDSPV-SALFFGGV 324
F+GI+G+ FP ++S+ ATP++DN+ Q + ++ F+ Y++ D S + FGGV
Sbjct 169 FLYYSPFDGILGLAFPSIASSQATPVFDNMWSQGLIPQNLFSVYLSSDGQTGSYVLFGGV 228
Query 325 DPRFYESPIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEM 384
D +Y ++ P+ E YW++ LD++ + + C + + I+D+GTS T P +
Sbjct 229 DNSYYSGSLNWVPLTAETYWQITLDSVSINGQVIACSQSCQ--AIVDTGTSLMTGPSTPI 286
Query 385 RSFLEMIPSQECGDDDSF-----LSSYPDITYVIGGVSFVL 420
+ I + + + +S+ P I + I GV + L
Sbjct 287 ANIQNYIGASQDSNGQYVINCNNISNMPTIVFTINGVQYPL 327
> cpv:cgd6_660 secreted pepsinogen like aspartyl protease having
a signal peptide ; K01386 [EC:3.4.23.-]
Length=633
Score = 173 bits (439), Expect = 1e-42, Method: Compositional matrix adjust.
Identities = 101/358 (28%), Positives = 166/358 (46%), Gaps = 77/358 (21%)
Query 131 FLQNKEAADTLDL----------ELGLAQTSVPIMQMKDSQYCGMLGIGTPPQWVHPIFD 180
F NK+ T+++ ++ + ++P+ ++K+S + + IG P Q PI D
Sbjct 150 FSNNKQIYKTINVLNVNGEIIPYDVFITNITIPLFEVKNSLFVCRIRIGEPEQEFWPIID 209
Query 181 TGSTNLWVVGSKCEDDTCTKVTRFDPSKSSSFQYTSPPVHLDITFGTGRIEGSTGVDNFQ 240
TGS+NLWV+G +C +C KV R+ S SF+ S ++ + FGTG+I G ++ +
Sbjct 210 TGSSNLWVIGEECNQSSCQKVKRYSKYISKSFKRISKYDNISVIFGTGKIYGKLILETLK 269
Query 241 VGPFTVKGQTFGLVEK-EGGHNEHGNIFKSINFEGIVGMGFPDMSSTGA--TPIYDNIMK 297
F + G++E+ E N +IF +I EG++G+GF MSS+ P+ + +
Sbjct 270 FDNFQLNKHVIGIIEQVENTENSKIDIFDAIELEGVLGLGFTQMSSSKKLQLPLIERLQS 329
Query 298 QADLKRSEFAFYVAK------------DSPVSALFFGGVDPRFYESPIHMFPVEREHYWE 345
Q ++ + F+ Y+ P + L GG+D +E +H+ PV REHYW+
Sbjct 330 QGLIQNNIFSIYINDYRIKPINNNDKLSKPCAILLLGGIDQNLFEEELHILPVIREHYWQ 389
Query 346 VALDAIHVGDKKFCCEEG------------------------------------------ 363
V L+++++GD K+CC+ G
Sbjct 390 VELESLYIGDTKYCCDYGSLAYEWENLENEHLYKKFGHYEDPPMDVYIYKTFNKSIDKTN 449
Query 364 -TKNYVILDSGTSFNTMPGNEMRSFL-EMIPSQECGD--------DDSFLSSYPDITY 411
T YVI DSGTSF T+P E F+ E P +C D + +P+ITY
Sbjct 450 RTPGYVIFDSGTSFYTLPNFEYNHFIKEYQPFGDCSQIHLDSKKIDPKIIQHFPNITY 507
> hsa:1510 CTSE, CATE; cathepsin E (EC:3.4.23.34); K01382 cathepsin
E [EC:3.4.23.34]
Length=396
Score = 167 bits (424), Expect = 5e-41, Method: Compositional matrix adjust.
Identities = 98/279 (35%), Positives = 144/279 (51%), Gaps = 24/279 (8%)
Query 153 PIMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSSSF 212
P++ D +Y G + IG+PPQ IFDTGS+NLWV C C +RF PS+SS+
Sbjct 69 PLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSST- 127
Query 213 QYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSINF 272
Y+ P I +GTG + G G D V TV GQ FG E G F F
Sbjct 128 -YSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFG-----ESVTEPGQTFVDAEF 181
Query 273 EGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDSPVSA---LFFGGVDPRFY 329
+GI+G+G+P ++ G TP++DN+M Q + F+ Y++ + A L FGG D +
Sbjct 182 DGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHF 241
Query 330 ESPIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSFLE 389
++ PV ++ YW++ALD I VG C EG + I+D+GTS T P ++++
Sbjct 242 SGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQ--AIVDTGTSLITGPSDKIKQLQN 299
Query 390 MIPSQ--------ECGDDDSFLSSYPDITYVIGGVSFVL 420
I + EC + L+ PD+T+ I GV + L
Sbjct 300 AIGAAPVDGEYAVECAN----LNVMPDVTFTINGVPYTL 334
> mmu:109820 Pgc, 2210410L06Rik, MGC117575, Upg-1, Upg1; progastricsin
(pepsinogen C) (EC:3.4.23.3); K01377 gastricsin [EC:3.4.23.3]
Length=392
Score = 162 bits (411), Expect = 2e-39, Method: Compositional matrix adjust.
Identities = 98/275 (35%), Positives = 143/275 (52%), Gaps = 18/275 (6%)
Query 155 MQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSSSFQY 214
M D+ Y G + IGTPPQ +FDTGS+NLWV C+ + CT TR++PSKSS++ Y
Sbjct 69 MAYMDASYYGEISIGTPPQNFLVLFDTGSSNLWVSSVYCQSEACTTHTRYNPSKSSTY-Y 127
Query 215 TSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSINFEG 274
T + +GTG + G G D +V V Q FGL E E G N F F+G
Sbjct 128 TQGQT-FSLQYGTGSLTGFFGYDTLRVQSIQVPNQEFGLSENEPGTN-----FVYAQFDG 181
Query 275 IVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVA--KDSPVSALFFGGVDPRFYESP 332
I+G+ +P +SS GAT ++ + L + F Y+ + S + FGGVD Y
Sbjct 182 IMGLAYPGLSSGGATTALQGMLGEGALSQPLFGVYLGSQQGSNGGQIVFGGVDENLYTGE 241
Query 333 IHMFPVEREHYWEVALDAIHVGDKK--FCCEEGTKNYVILDSGTSFNTMPGNEMRSFLEM 390
+ PV +E YW++ +D +G++ +C G + I+D+GTS MP + L+
Sbjct 242 LTWIPVTQELYWQITIDDFLIGNQASGWCSSSGCQG--IVDTGTSLLVMPAQYLNELLQT 299
Query 391 IPSQECGDDDSF-----LSSYPDITYVIGGVSFVL 420
I +QE F +SS P +T+V+ GV F L
Sbjct 300 IGAQEGEYGQYFVSCDSVSSLPTLTFVLNGVQFPL 334
> mmu:229697 Cym, Gm131; chymosin (EC:3.4.23.4); K01378 chymosin
[EC:3.4.23.4]
Length=379
Score = 161 bits (408), Expect = 4e-39, Method: Compositional matrix adjust.
Identities = 94/276 (34%), Positives = 145/276 (52%), Gaps = 16/276 (5%)
Query 151 SVPIMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSS 210
S P++ DS+Y G + IGTPPQ +FDTGS+ LWV C C RFDPSKS
Sbjct 63 SEPLINYLDSEYFGTIYIGTPPQEFTVVFDTGSSELWVPSVYCNSKVCRNHHRFDPSKSI 122
Query 211 SFQYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSI 270
+FQ S P L + +GTGR+EG D V V QT GL +E G+IF
Sbjct 123 TFQNLSKP--LFVQYGTGRMEGFLAYDTVTVSDIVVSHQTVGLSTQEP-----GDIFTYS 175
Query 271 NFEGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDSPVSALFFGGVDPRFYE 330
F+GI+G+ +P +S + PI+DN+M + + + F+ Y++++ S L G +D ++
Sbjct 176 PFDGILGLAYPTFASKYSVPIFDNMMNRHLVAQDLFSVYMSRNEQGSMLTLGAIDQSYFI 235
Query 331 SPIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSFLEM 390
+H PV + YW+ +D I + + C+ G +LD+GT+ T PG ++ + ++
Sbjct 236 GSLHWVPVTVQGYWQFTVDRITINGEVVACQGGCP--AVLDTGTALLTGPGRDILNIQQV 293
Query 391 IPSQECGDDDSF------LSSYPDITYVIGGVSFVL 420
I + + G +D F L P + + I G F L
Sbjct 294 IGAVQ-GHNDQFDIDCWRLDIMPTVVFEIHGREFPL 328
> xla:398994 napsa, MGC68767, kap, kdap, nap1, napa, snapa; napsin
A aspartic peptidase; K01379 cathepsin D [EC:3.4.23.5]
Length=392
Score = 160 bits (405), Expect = 1e-38, Method: Compositional matrix adjust.
Identities = 92/272 (33%), Positives = 146/272 (53%), Gaps = 19/272 (6%)
Query 159 DSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCE--DDTCTKVTRFDPSKSSSFQYTS 216
D+QY G + IGTPPQ IFDTGS+NLWV KC D C ++ SS+++ +
Sbjct 64 DAQYYGEIFIGTPPQKFAVIFDTGSSNLWVPSVKCSFFDFACWVHKKYRSQNSSTYRQNN 123
Query 217 PPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSINFEGIV 276
I +GTG + G D +G V QTF K+ G +F +F+GI+
Sbjct 124 --TAFAIQYGTGSLSGFLSQDTVSIGSIEVANQTFAEAIKQ-----PGIVFVFAHFDGIL 176
Query 277 GMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDSPVSA---LFFGGVDPRFYESPI 333
GMG+PD+S G P++DN+M+Q L+ + F+FY+++D + L GG DP +Y
Sbjct 177 GMGYPDISVDGVVPVFDNMMQQNLLEENVFSFYLSRDPMATVGGELILGGTDPNYYTGDF 236
Query 334 HMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSFLEMIPS 393
H V R YW++ D + V ++ C+ G + I+D+GTS T P E+R+ + I +
Sbjct 237 HYLNVTRMAYWQIKADEVRVNNQLVLCKGGCQ--AIVDTGTSLITGPKEEIRALHKAIGA 294
Query 394 QECGDDDSFLS-----SYPDITYVIGGVSFVL 420
+ F++ S P +++++GGV++ L
Sbjct 295 FPLFAGEYFINCKRIQSLPTVSFILGGVAYNL 326
> xla:373563 pgc-A; pepsinogen C (EC:3.4.23.3); K01377 gastricsin
[EC:3.4.23.3]
Length=383
Score = 157 bits (397), Expect = 7e-38, Method: Compositional matrix adjust.
Identities = 93/276 (33%), Positives = 142/276 (51%), Gaps = 17/276 (6%)
Query 153 PIMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSSSF 212
P+ D Y G + IGTPPQ +FDTGS+NLWV + C+ CT F+PS+SS+
Sbjct 58 PLSNYMDMSYYGEISIGTPPQNFLVLFDTGSSNLWVASTYCQSQACTNHPLFNPSQSST- 116
Query 213 QYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSINF 272
Y+S + +GTG + G G D + + Q FGL E E G N F F
Sbjct 117 -YSSNQQQFSLQYGTGSLTGILGYDTVTIQNVAISQQEFGLSETEPGTN-----FVYAQF 170
Query 273 EGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDSPVSA--LFFGGVDPRFYE 330
+GI+G+ +P ++ GAT + +M+Q L + F FY++ S + + FGGVD +Y
Sbjct 171 DGILGLAYPSIAVGGATTVMQGMMQQNLLNQPIFGFYLSGQSSQNGGEVAFGGVDQNYYT 230
Query 331 SPIHMFPVEREHYWEVALDAIHV-GDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSFLE 389
I+ PV E YW++ + + G C +G + I+D+GTS T P + S ++
Sbjct 231 GQIYWTPVTSETYWQIGIQGFSINGQATGWCSQGCQ--AIVDTGTSLLTAPQSVFSSLIQ 288
Query 390 MIPSQECGDDDSFLS-----SYPDITYVIGGVSFVL 420
I +Q+ + +S + P I++ I GVSF L
Sbjct 289 SIGAQQDQNGQYVVSCSNIQNLPTISFTISGVSFPL 324
> xla:443829 MGC82347 protein; K01379 cathepsin D [EC:3.4.23.5]
Length=401
Score = 157 bits (397), Expect = 7e-38, Method: Compositional matrix adjust.
Identities = 95/278 (34%), Positives = 144/278 (51%), Gaps = 21/278 (7%)
Query 154 IMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCE--DDTCTKVTRFDPSKSSS 211
+M D+QY G +GIGTPPQ +FDTGS+NLWV C D C ++D SKSS+
Sbjct 73 LMNYLDAQYYGEIGIGTPPQTFTVVFDTGSSNLWVPSVHCSMFDIACWMHHKYDSSKSST 132
Query 212 FQYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSIN 271
Y I +GTG + G D +G +K Q FG K+ G F +
Sbjct 133 --YVKNGTEFAIQYGTGSLSGYLSKDTVTIGNLGIKEQLFGEAIKQPGVT-----FIAAK 185
Query 272 FEGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKD---SPVSALFFGGVDPRF 328
F+GI+GM +P +S G +P++DNIM Q ++ + F+FY+ ++ P L GG DP++
Sbjct 186 FDGILGMAYPIISVDGVSPVFDNIMAQKLVESNVFSFYLNRNPDTQPGGELLLGGTDPKY 245
Query 329 YESPIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSF- 387
Y H V R+ YW++ +D + VGD+ C+ G + I+D+GTS T P E+ +
Sbjct 246 YTGDFHYLNVTRKAYWQIHMDQLGVGDQLTLCKGGCE--AIVDTGTSLITGPLEEVTALQ 303
Query 388 -----LEMIPSQECGDDDSFLSSYPDITYVIGGVSFVL 420
+ +I Q D + + P I+ +GG + L
Sbjct 304 KAIGAVPLIQGQYMVQCDK-IPTLPVISLTLGGQVYTL 340
> bbo:BBOV_IV010360 23.m06120; aspartyl protease
Length=532
Score = 156 bits (395), Expect = 1e-37, Method: Compositional matrix adjust.
Identities = 83/258 (32%), Positives = 140/258 (54%), Gaps = 17/258 (6%)
Query 168 IGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSSSFQ-YTSPPVHLDITFG 226
IG P Q PI DTGSTN+W + +C C + ++DP++S +F+ + + F
Sbjct 191 IGKPGQKFLPILDTGSTNVWAIHPECTSAGCMEAIKYDPARSKTFKPLEAADSIVRARFV 250
Query 227 TGRIEGSTGVDNFQVGPFTVKGQTFGLVEK----------EGGHNEHGNIF-KSINFEGI 275
+G + G+ G D+F +G FTVKGQ F ++ + ++ +IF + F G+
Sbjct 251 SGVVLGTLGYDDFTIGGFTVKGQLFAMMRDIPDKSTNDILTVSNGQNVDIFTQETPFNGM 310
Query 276 VGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDSPVSALFFGGVDPRFYESPIHM 335
+G+GF D+ + P+Y MK + F+FY +++ SA GG D R ++ P+ M
Sbjct 311 IGLGFKDLMVMNSEPLYQRYMKVVGAE-PIFSFYYSRNGVGSAFLVGGADERLHKGPMQM 369
Query 336 FPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSFLEMIPSQE 395
PV +YW+V L+ + VG +K CC++ ++Y + D+GT+FN+MP + + LE P E
Sbjct 370 MPVVPGYYWQVELEEVFVGKRKVCCDK--QSYAVFDTGTAFNSMPHAAINTLLEEYPFYE 427
Query 396 CGDD--DSFLSSYPDITY 411
C + + ++ P I Y
Sbjct 428 CNAENMNRVYAALPTIKY 445
> xla:373573 ctse-b, CE2, cate, ce1, ce2-A; cathepsin E (EC:3.4.23.34);
K01382 cathepsin E [EC:3.4.23.34]
Length=397
Score = 154 bits (388), Expect = 7e-37, Method: Compositional matrix adjust.
Identities = 94/275 (34%), Positives = 147/275 (53%), Gaps = 16/275 (5%)
Query 151 SVPIMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSS 210
S P++ D QY G + IGTPPQ IFDTGS+NLWV C C + RF P SS
Sbjct 63 SEPLINYMDVQYFGEISIGTPPQNFTVIFDTGSSNLWVPSVYCISPACAQHNRFQPQLSS 122
Query 211 SFQYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSI 270
+ Y S + + +GTG + G G+D+ V V+ Q FG +E G+ F
Sbjct 123 T--YESNGNNFSLQYGTGSLSGVIGIDSVTVEGILVQNQQFG-----ESVSEPGSTFVDA 175
Query 271 NFEGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKD--SPVSA-LFFGGVDPR 327
+F+GI+G+G+P ++ G TP++DN++ Q ++ F+ Y+++D SPV L FGG D
Sbjct 176 SFDGILGLGYPSIAVGGCTPVFDNMIAQNLVELPMFSVYMSRDPNSPVGGELVFGGFDAS 235
Query 328 FYESPIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSF 387
+ ++ PV + YW++ LD I + + C G + I+D+GTS T P +++
Sbjct 236 RFSGQLNWVPVTNQGYWQIQLDNIQINGEVVFCSGGCQ--AIVDTGTSMITGPSSDIVQL 293
Query 388 LEMI-PSQECGD---DDSFLSSYPDITYVIGGVSF 418
+I S GD D + L+ P +T+ I G+ +
Sbjct 294 QSIIGASAANGDYEVDCTVLNKMPTMTFTINGIGY 328
> xla:398557 cathepsin D (EC:3.4.23.5); K01379 cathepsin D [EC:3.4.23.5]
Length=409
Score = 153 bits (386), Expect = 1e-36, Method: Compositional matrix adjust.
Identities = 87/243 (35%), Positives = 127/243 (52%), Gaps = 14/243 (5%)
Query 154 IMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCE--DDTCTKVTRFDPSKSSS 211
++ D+QY G + IGTPPQ +FDTGS+NLWV C D C ++D SKSS+
Sbjct 71 LLNYLDAQYYGEISIGTPPQPFTVVFDTGSSNLWVASVHCSMFDIACWMHRKYDSSKSST 130
Query 212 FQYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSIN 271
Y I +GTG I G D +G K Q FG K+ G F +
Sbjct 131 --YVKNGTEFAIQYGTGSISGYLSKDTVTIGNLGYKEQIFGEAIKQPGVT-----FIAAK 183
Query 272 FEGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKD---SPVSALFFGGVDPRF 328
F+GI+GM +P +S G +P +DNIM Q ++ + F+FY+ ++ P L GG DP++
Sbjct 184 FDGILGMAYPIISVDGVSPCFDNIMAQKLVESNVFSFYLNRNPDTQPGGELLLGGTDPKY 243
Query 329 YESPIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSFL 388
Y H V R+ YW++ +D + VGD+ C+ G + I+D+GTS T P E+ +
Sbjct 244 YTGDFHYLNVTRKAYWQIHMDQLGVGDQLTLCKGGCE--AIVDTGTSLITGPVEEVAALQ 301
Query 389 EMI 391
I
Sbjct 302 RAI 304
> mmu:16541 Napsa, KAP, Kdap, NAP1, SNAPA, pronapsin; napsin A
aspartic peptidase; K08565 napsin-A [EC:3.4.23.-]
Length=419
Score = 152 bits (384), Expect = 2e-36, Method: Compositional matrix adjust.
Identities = 96/279 (34%), Positives = 143/279 (51%), Gaps = 19/279 (6%)
Query 152 VPIMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCE--DDTCTKVTRFDPSKS 209
VP+ + ++QY G +G+GTPPQ +FDTGS+NLWV ++C C RF+P S
Sbjct 63 VPLSKFMNTQYFGTIGLGTPPQNFTVVFDTGSSNLWVPSTRCHFFSLACWFHHRFNPKAS 122
Query 210 SSFQYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKS 269
SSF+ I +GTGR+ G DN +G TFG E IF
Sbjct 123 SSFRPNG--TKFAIQYGTGRLSGILSQDNLTIGGIHDAFVTFGEALW-----EPSLIFAL 175
Query 270 INFEGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDSPVS---ALFFGGVDP 326
+F+GI+G+GFP ++ G P D +++Q L++ F+FY+ +DS S L GG DP
Sbjct 176 AHFDGILGLGFPTLAVGGVQPPLDAMVEQGLLEKPVFSFYLNRDSEGSDGGELVLGGSDP 235
Query 327 RFYESPIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRS 386
Y P+ PV YW+V ++++ VG C +G ILD+GTS T P E+R+
Sbjct 236 AHYVPPLTFIPVTIPAYWQVHMESVKVGTGLSLCAQGCS--AILDTGTSLITGPSEEIRA 293
Query 387 FLEMIPSQECGDDDSFLS-----SYPDITYVIGGVSFVL 420
+ I + F+ + P +++ +GGV F L
Sbjct 294 LNKAIGGYPFLNGQYFIQCSKTPTLPPVSFHLGGVWFNL 332
> xla:443721 ctsd; cathepsin D (EC:3.4.23.5); K01379 cathepsin
D [EC:3.4.23.5]
Length=399
Score = 148 bits (373), Expect = 4e-35, Method: Compositional matrix adjust.
Identities = 85/243 (34%), Positives = 128/243 (52%), Gaps = 14/243 (5%)
Query 154 IMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCE--DDTCTKVTRFDPSKSSS 211
++ D+QY G + IGTPPQ +FDTGS+NLWV C D C ++D SKSS+
Sbjct 71 LLNYLDAQYYGEISIGTPPQPFTVVFDTGSSNLWVPSVHCSFWDIACWLHHKYDSSKSST 130
Query 212 FQYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSIN 271
Y + I +G+G + G D +G VKGQ F K+ G F +
Sbjct 131 --YVNNGTAFAIQYGSGSLTGYLSKDTVTIGDLAVKGQLFAEAVKQPGIT-----FVAAK 183
Query 272 FEGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKD---SPVSALFFGGVDPRF 328
F+GI+GMG+P +S G P++D+IM+Q + + F+FY+ ++ P L GG DP +
Sbjct 184 FDGILGMGYPRISVDGVPPVFDDIMEQKLVDSNLFSFYLNRNPDTQPGGELLLGGTDPTY 243
Query 329 YESPIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSFL 388
Y V R+ YW++ +D + VGD+ C+ G + I+D+GTS T P E+ +
Sbjct 244 YTGDFSYMNVTRKAYWQIRMDQLSVGDQLTLCKGGCE--AIVDTGTSLITGPVEEVAALQ 301
Query 389 EMI 391
I
Sbjct 302 RAI 304
> xla:373572 ctse-a, CE1, cate, ce1-A, ce2, ctse; cathepsin E
(EC:3.4.23.34); K01382 cathepsin E [EC:3.4.23.34]
Length=397
Score = 147 bits (372), Expect = 5e-35, Method: Compositional matrix adjust.
Identities = 90/276 (32%), Positives = 144/276 (52%), Gaps = 18/276 (6%)
Query 151 SVPIMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSS 210
S P++ D +Y G + +GTPPQ IFDTGS+NLWV C C + RF P SS
Sbjct 63 SEPLINYMDVEYFGEISVGTPPQNFTVIFDTGSSNLWVPSVYCISQACAQHDRFQPQLSS 122
Query 211 SFQYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSI 270
+ Y S + + +GTG + G G+D V V+ Q FG +E G+ F
Sbjct 123 T--YESNGNNFSLQYGTGSLSGVIGIDAVTVEGILVQNQQFG-----ESVSEPGSTFVDA 175
Query 271 NFEGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDSPVSA----LFFGGVDP 326
F+GI+G+G+P ++ TP++DN++ Q ++ F+ Y++++ P SA L FGG D
Sbjct 176 EFDGILGLGYPSIAVGDCTPVFDNMIAQNLVELPMFSVYMSRN-PNSAVGGELVFGGFDA 234
Query 327 RFYESPIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRS 386
+ ++ PV + YW++ LD + + + C G + I+D+GTS T P +++
Sbjct 235 SRFSGQLNWVPVTNQGYWQIQLDNVQINGEVLFCSGGCQ--AIVDTGTSLITGPSSDIVQ 292
Query 387 FLEMI-PSQECGD---DDSFLSSYPDITYVIGGVSF 418
+I S GD D S L+ P +T+ I G+ +
Sbjct 293 LQNIIGASAANGDYEVDCSVLNEMPTVTFTINGIGY 328
> hsa:9476 NAPSA, KAP, Kdap, NAP1, NAPA, SNAPA; napsin A aspartic
peptidase; K08565 napsin-A [EC:3.4.23.-]
Length=420
Score = 145 bits (365), Expect = 4e-34, Method: Compositional matrix adjust.
Identities = 95/279 (34%), Positives = 137/279 (49%), Gaps = 19/279 (6%)
Query 152 VPIMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCE--DDTCTKVTRFDPSKS 209
VP+ +D QY G +G+GTPPQ FDTGS+NLWV +C C RFDP S
Sbjct 68 VPLSNYRDVQYFGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKAS 127
Query 210 SSFQYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKS 269
SSFQ I +GTGR++G D +G +KG + E E +F
Sbjct 128 SSFQANG--TKFAIQYGTGRVDGILSEDKLTIG--GIKGASVIFGEALW---EPSLVFAF 180
Query 270 INFEGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDSPV---SALFFGGVDP 326
+F+GI+G+GFP +S G P D +++Q L + F+FY+ +D L GG DP
Sbjct 181 AHFDGILGLGFPILSVEGVRPPMDVLVEQGLLDKPVFSFYLNRDPEEPDGGELVLGGSDP 240
Query 327 RFYESPIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRS 386
Y P+ PV YW++ ++ + VG C +G ILD+GTS T P E+R+
Sbjct 241 AHYIPPLTFVPVTVPAYWQIHMERVKVGPGLTLCAKGCA--AILDTGTSLITGPTEEIRA 298
Query 387 FLEMIPSQECGDDD-----SFLSSYPDITYVIGGVSFVL 420
I + S + P +++++GGV F L
Sbjct 299 LHAAIGGIPLLAGEYIILCSEIPKLPAVSFLLGGVWFNL 337
> hsa:1509 CTSD, CLN10, CPSD, MGC2311; cathepsin D (EC:3.4.23.5);
K01379 cathepsin D [EC:3.4.23.5]
Length=412
Score = 143 bits (361), Expect = 1e-33, Method: Compositional matrix adjust.
Identities = 93/290 (32%), Positives = 143/290 (49%), Gaps = 44/290 (15%)
Query 159 DSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCE--DDTCTKVTRFDPSKSSSFQYTS 216
D+QY G +GIGTPPQ +FDTGS+NLWV C+ D C +++ KSS+ Y
Sbjct 76 DAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST--YVK 133
Query 217 PPVHLDITFGTGRIEGSTGVDNFQV-----------GPFTVKGQTFGLVEKEGGHNEHGN 265
DI +G+G + G D V G V+ Q FG K+ G
Sbjct 134 NGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGIT---- 189
Query 266 IFKSINFEGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKD---SPVSALFFG 322
F + F+GI+GM +P +S P++DN+M+Q + ++ F+FY+++D P L G
Sbjct 190 -FIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLG 248
Query 323 GVDPRFYESPIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGN 382
G D ++Y+ + V R+ YW+V LD + V C+EG + I+D+GTS P +
Sbjct 249 GTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCE--AIVDTGTSLMVGPVD 306
Query 383 EMRSFLE------------MIPSQECGDDDSFLSSYPDITYVIGGVSFVL 420
E+R + MIP ++ +S+ P IT +GG + L
Sbjct 307 EVRELQKAIGAVPLIQGEYMIPCEK-------VSTLPAITLKLGGKGYKL 349
> hsa:5972 REN, FLJ10761, HNFJ2; renin (EC:3.4.23.15); K01380
renin [EC:3.4.23.15]
Length=406
Score = 142 bits (358), Expect = 3e-33, Method: Compositional matrix adjust.
Identities = 94/293 (32%), Positives = 143/293 (48%), Gaps = 29/293 (9%)
Query 143 LELGLAQTSVPIMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCED--DTCTK 200
L LG +SV + D+QY G +GIGTPPQ +FDTGS+N+WV SKC C
Sbjct 67 LTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVY 126
Query 201 VTRFDPSKSSSFQYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGH 260
FD S SSS+++ L + + TG + G D VG TV Q FG V +
Sbjct 127 HKLFDASDSSSYKHNG--TELTLRYSTGTVSGFLSQDIITVGGITVT-QMFGEVTEMPAL 183
Query 261 NEHGNIFKSINFEGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDSPVS--- 317
F F+G+VGMGF + + TPI+DNI+ Q LK F+FY +DS S
Sbjct 184 P-----FMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSL 238
Query 318 --ALFFGGVDPRFYESPIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTS 375
+ GG DP+ YE H + + W++ + + VG CE+G ++D+G S
Sbjct 239 GGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGC--LALVDTGAS 296
Query 376 FNTMPGNEMRSFLEMIPSQ--------ECGDDDSFLSSYPDITYVIGGVSFVL 420
+ + + + +E + ++ +C + + PDI++ +GG + L
Sbjct 297 YISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTL----PDISFHLGGKEYTL 345
> tgo:TGME49_062940 eukaryotic aspartyl protease, putative (EC:3.4.23.34)
Length=469
Score = 141 bits (355), Expect = 5e-33, Method: Compositional matrix adjust.
Identities = 89/272 (32%), Positives = 137/272 (50%), Gaps = 20/272 (7%)
Query 154 IMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSSSFQ 213
++ +SQY G + +GTPP +FDTGS+NLW+ S+C+ C TRFDP SS++
Sbjct 96 LLNFHNSQYFGEIQVGTPPVSFIVVFDTGSSNLWIPASECKQGGCVPHTRFDPKTSSTYL 155
Query 214 YTSP----PVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKS 269
+ P I +GTG D +G V+ QT GL +E H F
Sbjct 156 PINAGAGEPAIAFIQYGTGACVLRMAKDTVSIGGIRVQNQTLGLALQESVHP-----FAD 210
Query 270 INFEGIVGMGFPDMSST-----GATPIYDNIMKQADLKRSEFAFYVAKD-SPVSALFFGG 323
+ F+G+VG+GFPD++ A P+ D++MKQ LKR+ FA Y+++D + + FG
Sbjct 211 LPFDGLVGLGFPDVAGEEGLPPDALPLVDSMMKQKLLKRNAFAVYMSEDLNQPGEITFGS 270
Query 324 VDPR--FYESPIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPG 381
V+PR F FPV YWEV + + + K E T+ +D+G+S T P
Sbjct 271 VNPRHTFEGHKPQWFPVISLDYWEVGVHGLRLNRKSLGFCERTRCKAAVDTGSSLITGPS 330
Query 382 NEMRSFLEMIPSQECGDDDSFLSSYPDITYVI 413
+ L+ S +D S + P +T+++
Sbjct 331 KVINPLLK---SLNVAEDCSNKGNLPTVTFIL 359
> dre:336746 fa94d12, wu:fa94d12; zgc:63831; K01379 cathepsin
D [EC:3.4.23.5]
Length=412
Score = 140 bits (352), Expect = 1e-32, Method: Compositional matrix adjust.
Identities = 86/272 (31%), Positives = 133/272 (48%), Gaps = 19/272 (6%)
Query 159 DSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCE--DDTCTKVTRFDPSKSSSFQYTS 216
D+QY GM+ IGTPPQ +FDTGS+NLWV C D C R++ KSS+ Y
Sbjct 89 DAQYYGMISIGTPPQDFSVLFDTGSSNLWVPSIHCAFLDIACWLHRRYNSKKSST--YVQ 146
Query 217 PPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSINFEGIV 276
I +G G + G D + V GQ F K + G +F F+G++
Sbjct 147 NGTEFSIQYGRGSLSGFISQDTVNLAGLNVTGQQFAEAVK-----QPGIVFAVARFDGVL 201
Query 277 GMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDSPVSA---LFFGGVDPRFYESPI 333
GM +P +S TP++D M L ++ F+FY+ +D L GG D +++ +
Sbjct 202 GMAYPAISVDRVTPVFDTAMAAKILPQNIFSFYINRDPAGDVGGELMLGGFDQQYFNGDL 261
Query 334 HMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSFLEMIPS 393
H V R+ YW++ +D + VG C+ G + I+D+GTS T P E+R+ + I +
Sbjct 262 HYVNVTRKAYWQIKMDEVQVGSTLTLCKSGCQ--AIVDTGTSMITGPVQEVRALQKAIGA 319
Query 394 -----QECGDDDSFLSSYPDITYVIGGVSFVL 420
E D + + P +++ +GG F L
Sbjct 320 IPLLMGEYWIDCKKIPTLPVVSFSLGGKMFNL 351
> mmu:13033 Ctsd, CD, CatD; cathepsin D (EC:3.4.23.5); K01379
cathepsin D [EC:3.4.23.5]
Length=410
Score = 140 bits (352), Expect = 1e-32, Method: Compositional matrix adjust.
Identities = 89/283 (31%), Positives = 146/283 (51%), Gaps = 32/283 (11%)
Query 159 DSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCE--DDTCTKVTRFDPSKSSSFQYTS 216
D+QY G +GIGTPPQ +FDTGS+NLWV C+ D C +++ KSS+ Y
Sbjct 76 DAQYYGDIGIGTPPQCFTVVFDTGSSNLWVPSIHCKILDIACWVHHKYNSDKSST--YVK 133
Query 217 PPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGL-VEKE---GGHNEHGNIFKSINF 272
DI +G+G + G D V + + + G+ VEK+ + G +F + F
Sbjct 134 NGTSFDIHYGSGSLSGYLSQDTVSVPCKSDQSKARGIKVEKQIFGEATKQPGIVFVAAKF 193
Query 273 EGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKD---SPVSALFFGGVDPRFY 329
+GI+GMG+P +S P++DN+M+Q + ++ F+FY+ +D P L GG D ++Y
Sbjct 194 DGILGMGYPHISVNNVLPVFDNLMQQKLVDKNIFSFYLNRDPEGQPGGELMLGGTDSKYY 253
Query 330 ESPIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSFLE 389
+ V R+ YW+V +D + VG++ C+ G + I+D+GTS P E++ +
Sbjct 254 HGELSYLNVTRKAYWQVHMDQLEVGNELTLCKGGCE--AIVDTGTSLLVGPVEEVKELQK 311
Query 390 ------------MIPSQECGDDDSFLSSYPDITYVIGGVSFVL 420
MIP ++ +SS P + +GG ++ L
Sbjct 312 AIGAVPLIQGEYMIPCEK-------VSSLPTVYLKLGGKNYEL 347
> bbo:BBOV_III003510 17.m07331; eukaryotic aspartyl protease family
protein
Length=521
Score = 140 bits (352), Expect = 1e-32, Method: Compositional matrix adjust.
Identities = 90/270 (33%), Positives = 143/270 (52%), Gaps = 25/270 (9%)
Query 154 IMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSSSFQ 213
++ +++QY G + +GTPP+ +FDTGS+ LW+ +C C+ +FD SS+
Sbjct 141 LLNFENNQYFGEIEVGTPPEKFVVVFDTGSSQLWIPSKECSSTGCSTHRKFDAKGSST-- 198
Query 214 YTSPPV---HLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSI 270
Y P+ + I +GTG + G D ++GP VK Q+ GL E H F +
Sbjct 199 YKKAPLDAANAYIQYGTGECVLALGSDTVKIGPLEVKNQSIGLATYESDHP-----FGDL 253
Query 271 NFEGIVGMGFPD---MSSTGATPIYDNIMKQADLKRSEFAFYVAKD-SPVSALFFGGVDP 326
F+G+VG+GFPD + G P+ DNIM+Q L R+ AFY++KD + ++ FG +DP
Sbjct 254 PFDGLVGLGFPDKMYKDTDGMLPLLDNIMQQKLLNRNLVAFYMSKDKTQPGSMSFGSIDP 313
Query 327 RFYESPIH---MFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNE 383
R Y P H FPV +WE+A++AI + K E K +D+G+S + P
Sbjct 314 R-YVLPGHSPWWFPVVATDFWEIAMEAILIDGKPMKLE--NKYNAAIDTGSSLISGPSEV 370
Query 384 MRSFLEMIP-SQECGDDDSFLSSYPDITYV 412
+ L+ + S +C + L+ P I++V
Sbjct 371 VGPLLDRLALSPDCSN----LNQLPTISFV 396
> mmu:100044656 renin-1-like
Length=425
Score = 138 bits (348), Expect = 3e-32, Method: Compositional matrix adjust.
Identities = 89/270 (32%), Positives = 138/270 (51%), Gaps = 17/270 (6%)
Query 159 DSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSSSFQYTSPP 218
++QY G +GIGTPPQ IFDTGS NLWV +KC S S Y
Sbjct 104 NTQYYGEIGIGTPPQTFKVIFDTGSANLWVPSTKCSRLYLACGIHSLYESSDSSSYMENG 163
Query 219 VHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNI-FKSINFEGIVG 277
I +G+GR++G D VG TV QTFG V E I F F+G++G
Sbjct 164 SDFTIHYGSGRVKGFLSQDVVTVGGITVT-QTFGEV------TELPLIPFMLAKFDGVLG 216
Query 278 MGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDSPV--SALFFGGVDPRFYESPIHM 335
MGFP + G TP++D+I+ Q LK F+ Y + S + + GG DP+ Y+ H
Sbjct 217 MGFPAQAVGGVTPVFDHILSQGVLKEEVFSVYYNRGSHLLGGEVVLGGSDPQHYQGNFHY 276
Query 336 FPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSFLEMIPSQE 395
+ + W++ + + VG CEEG V++D+G+SF + P + ++ ++ + ++E
Sbjct 277 VSISKTDSWQITMKGVSVGSSTLLCEEGCA--VVVDTGSSFISAPTSSLKLIMQALGAKE 334
Query 396 CGDDD-----SFLSSYPDITYVIGGVSFVL 420
D+ S + + PDI++ +GG ++ L
Sbjct 335 KRIDEYVVNCSQVPTLPDISFDLGGRAYTL 364
> mmu:19701 Ren1, D19352, Ren, Ren-1, Ren-A, Ren1c, Ren1d, Rn-1,
Rnr; renin 1 structural (EC:3.4.23.15); K01380 renin [EC:3.4.23.15]
Length=402
Score = 137 bits (346), Expect = 5e-32, Method: Compositional matrix adjust.
Identities = 88/270 (32%), Positives = 139/270 (51%), Gaps = 17/270 (6%)
Query 159 DSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSSSFQYTSPP 218
++QY G +GIGTPPQ IFDTGS NLWV +KC S S Y
Sbjct 81 NTQYYGEIGIGTPPQTFKVIFDTGSANLWVPSTKCSRLYLACGIHSLYESSDSSSYMENG 140
Query 219 VHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNI-FKSINFEGIVG 277
I +G+GR++G D+ VG TV QTFG V E I F F+G++G
Sbjct 141 SDFTIHYGSGRVKGFLSQDSVTVGGITVT-QTFGEV------TELPLIPFMLAKFDGVLG 193
Query 278 MGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDSPV--SALFFGGVDPRFYESPIHM 335
MGFP + G TP++D+I+ Q LK F+ Y + S + + GG DP+ Y+ H
Sbjct 194 MGFPAQAVGGVTPVFDHILSQGVLKEEVFSVYYNRGSHLLGGEVVLGGSDPQHYQGNFHY 253
Query 336 FPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSFLEMIPSQE 395
+ + W++ + + VG CEEG V++D+G+SF + P + ++ ++ + ++E
Sbjct 254 VSISKTDSWQITMKGVSVGSSTLLCEEGCA--VVVDTGSSFISAPTSSLKLIMQALGAKE 311
Query 396 CGDDD-----SFLSSYPDITYVIGGVSFVL 420
++ S + + PDI++ +GG ++ L
Sbjct 312 KRIEEYVVNCSQVPTLPDISFDLGGRAYTL 341
> dre:65225 ctsd, catD, fb93e11, fj17b09, wu:fb93e11, wu:fj17b09;
cathepsin D (EC:3.4.23.5); K01379 cathepsin D [EC:3.4.23.5]
Length=399
Score = 137 bits (344), Expect = 9e-32, Method: Compositional matrix adjust.
Identities = 85/298 (28%), Positives = 147/298 (49%), Gaps = 21/298 (7%)
Query 137 AADTLDLELGLAQTSVP----IMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSK 192
++++L LG ++ P + D+QY G +G+GTP Q +FDTGS+NLWV
Sbjct 46 SSNSLKYNLGFPASNDPTPETLKNYLDAQYYGEIGLGTPVQTFTVVFDTGSSNLWVPSVH 105
Query 193 CE--DDTCTKVTRFDPSKSSSFQYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQT 250
C D C +++ KSS+ Y I +G+G + G D +G V+ Q
Sbjct 106 CSLTDIACLLHHKYNGGKSST--YVKNGTQFAIQYGSGSLSGYLSQDTCTIGDIAVEKQI 163
Query 251 FGLVEKEGGHNEHGNIFKSINFEGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYV 310
FG K+ G F + F+GI+GM +P +S G P++D +M Q ++++ F+FY+
Sbjct 164 FGEAIKQ-----PGVAFIAAKFDGILGMAYPRISVDGVPPVFDMMMSQKKVEKNVFSFYL 218
Query 311 AKD---SPVSALFFGGVDPRFYESPIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNY 367
++ P L GG DP++Y + + R+ YW++ +D + +G C+ G +
Sbjct 219 NRNPDTQPGGELLLGGTDPKYYTGDFNYVDISRQAYWQIHMDGMSIGSGLSLCKGGCEAI 278
Query 368 VILDSGTSFNTMPGNEMRSFLEMIPS-----QECGDDDSFLSSYPDITYVIGGVSFVL 420
V + TS T P E+++ + I + E D + + P I++ +GG + L
Sbjct 279 VDTGTSTSLITGPAAEVKALQKAIGAIPLMQGEYMVDCKKVPTLPTISFSLGGKVYSL 336
> mmu:19702 Ren2, Ren, Ren-2, Ren-B, Rn-2, Rnr; renin 2 tandem
duplication of Ren1 (EC:3.4.23.15); K01380 renin [EC:3.4.23.15]
Length=424
Score = 135 bits (340), Expect = 3e-31, Method: Compositional matrix adjust.
Identities = 88/270 (32%), Positives = 137/270 (50%), Gaps = 17/270 (6%)
Query 159 DSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSSSFQYTSPP 218
+SQY G +GIGTPPQ IFDTGS NLWV +KC S S Y
Sbjct 103 NSQYYGEIGIGTPPQTFKVIFDTGSANLWVPSTKCSRLYLACGIHSLYESSDSSSYMENG 162
Query 219 VHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNI-FKSINFEGIVG 277
I +G+GR++G D+ VG TV QTFG V E I F F+G++G
Sbjct 163 DDFTIHYGSGRVKGFLSQDSVTVGGITVT-QTFGEV------TELPLIPFMLAQFDGVLG 215
Query 278 MGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDSPV--SALFFGGVDPRFYESPIHM 335
MGFP + G TP++D+I+ Q LK F+ Y + + + GG DP Y+ H
Sbjct 216 MGFPAQAVGGVTPVFDHILSQGVLKEKVFSVYYNRGPHLLGGEVVLGGSDPEHYQGDFHY 275
Query 336 FPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSFLEMIPSQE 395
+ + W++ + + VG CEEG + V++D+G+SF + P + ++ ++ + ++E
Sbjct 276 VSLSKTDSWQITMKGVSVGSSTLLCEEGCE--VVVDTGSSFISAPTSSLKLIMQALGAKE 333
Query 396 CGDDDSFLS-----SYPDITYVIGGVSFVL 420
+ +S + PDI++ +GG ++ L
Sbjct 334 KRLHEYVVSCSQVPTLPDISFNLGGRAYTL 363
> cel:R12H7.2 asp-4; ASpartyl Protease family member (asp-4);
K01379 cathepsin D [EC:3.4.23.5]
Length=444
Score = 131 bits (329), Expect = 5e-30, Method: Compositional matrix adjust.
Identities = 88/272 (32%), Positives = 138/272 (50%), Gaps = 20/272 (7%)
Query 159 DSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCE--DDTCTKVTRFDPSKSSSFQYTS 216
D+QY G + IGTP Q IFDTGS+NLW+ KC D C R+D SKSSS Y
Sbjct 91 DAQYFGTISIGTPAQNFTVIFDTGSSNLWIPSKKCPFYDIACMLHHRYD-SKSSS-TYKE 148
Query 217 PPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSINFEGIV 276
+ I +GTG ++G D+ V + Q F +E G F + F+GI+
Sbjct 149 DGRKMAIQYGTGSMKGFISKDSVCVAGVCAEDQPFA-----EATSEPGITFVAAKFDGIL 203
Query 277 GMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAK--DSPVSA-LFFGGVDPRFYESPI 333
GM +P+++ G P+++ + +Q + + F+F++ + DS + + FGG+D R Y PI
Sbjct 204 GMAYPEIAVLGVQPVFNTLFEQKKVPSNLFSFWLNRNPDSEIGGEITFGGIDSRRYVEPI 263
Query 334 HMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSFLEMIPS 393
PV R+ YW+ +D + VG C G + I D+GTS P ++ + I +
Sbjct 264 TYVPVTRKGYWQFKMDKV-VGSGVLGCSNGCQ--AIADTGTSLIAGPKAQIEAIQNFIGA 320
Query 394 QECGDDDSFLS-----SYPDITYVIGGVSFVL 420
+ + +S + P +++VIGG F L
Sbjct 321 EPLIKGEYMISCDKVPTLPPVSFVIGGQEFSL 352
> ath:AT1G62290 aspartyl protease family protein; K08245 phytepsin
[EC:3.4.23.40]
Length=513
Score = 127 bits (320), Expect = 6e-29, Method: Compositional matrix adjust.
Identities = 98/295 (33%), Positives = 144/295 (48%), Gaps = 27/295 (9%)
Query 101 TFYMKRGEGPFGSLGNKPTDTKAGGAGATSFLQNKEAA---------DTLDLELGLAQTS 151
T Y KR +G F +G K AT F +E A + L + G A
Sbjct 21 TAYSKRNDGTF-RVGLKKLKLDPNNRLATRFGSKQEEALRSSLRSYNNNLGGDSGDADI- 78
Query 152 VPIMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKC-EDDTCTKVTRFDPSKSS 210
VP+ D+QY G + IGTPPQ IFDTGS+NLWV KC +C ++ S+SS
Sbjct 79 VPLKNYLDAQYYGEIAIGTPPQKFTVIFDTGSSNLWVPSGKCFFSLSCYFHAKYKSSRSS 138
Query 211 SFQYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSI 270
+++ + I +G+G I G D VG VK Q F +E +E G F
Sbjct 139 TYKKSGK--RAAIHYGSGSISGFFSYDAVTVGDLVVKDQEF--IETT---SEPGLTFLVA 191
Query 271 NFEGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDSPVS----ALFFGGVDP 326
F+G++G+GF +++ ATP++ N++KQ +KR F+F++ +D P S + FGGVDP
Sbjct 192 KFDGLLGLGFQEIAVGNATPVWYNMLKQGLIKRPVFSFWLNRD-PKSEEGGEIVFGGVDP 250
Query 327 RFYESPIHMFPVEREHYWEVALDAIHV-GDKKFCCEEGTKNYVILDSGTSFNTMP 380
+ + PV + YW+ + + + G+ C G I DSGTS P
Sbjct 251 KHFRGEHTFVPVTQRGYWQFDMGEVLIAGESTGYCGSGCS--AIADSGTSLLAGP 303
> ath:AT4G04460 aspartyl protease family protein; K08245 phytepsin
[EC:3.4.23.40]
Length=508
Score = 127 bits (320), Expect = 7e-29, Method: Compositional matrix adjust.
Identities = 84/248 (33%), Positives = 129/248 (52%), Gaps = 14/248 (5%)
Query 152 VPIMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCE-DDTCTKVTRFDPSKSS 210
VP+ D+QY G + IGTPPQ IFDTGS+NLW+ +KC C +++ S+SS
Sbjct 77 VPLKNYLDAQYYGDITIGTPPQKFTVIFDTGSSNLWIPSTKCYLSVACYFHSKYKASQSS 136
Query 211 SFQYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSI 270
S++ P I +GTG I G D+ +VG VK Q F +E +E G F
Sbjct 137 SYRKNGKPA--SIRYGTGAISGYFSNDDVKVGDIVVKEQEF--IE---ATSEPGITFLLA 189
Query 271 NFEGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYV---AKDSPVSALFFGGVDPR 327
F+GI+G+GF ++S +TP++ N++++ +K F+F++ KD + FGGVDP+
Sbjct 190 KFDGILGLGFKEISVGNSTPVWYNMVEKGLVKEPIFSFWLNRNPKDPEGGEIVFGGVDPK 249
Query 328 FYESPIHMFPVEREHYWEVALDAIHVGDKKF-CCEEGTKNYVILDSGTSFNTMPGNEMRS 386
++ PV + YW+ + + + K C +G I DSGTS T P +
Sbjct 250 HFKGEHTFVPVTHKGYWQFDMGDLQIAGKPTGYCAKGCS--AIADSGTSLLTGPSTVITM 307
Query 387 FLEMIPSQ 394
I +Q
Sbjct 308 INHAIGAQ 315
> pfa:PFC0495w plasmepsin VI (EC:3.4.23.-); K01386 [EC:3.4.23.-]
Length=432
Score = 126 bits (316), Expect = 2e-28, Method: Compositional matrix adjust.
Identities = 88/275 (32%), Positives = 136/275 (49%), Gaps = 21/275 (7%)
Query 154 IMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSSSF- 212
++ +SQ+ +G+G PPQ +FDTGS+NL + +KC C +F+P+KS +F
Sbjct 92 LLNFHNSQFIADIGVGNPPQVFKVVFDTGSSNLAIPSTKCIKGGCASHKKFNPNKSRTFT 151
Query 213 ---QYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKS 269
+ V+ I +GTG D+ + +K Q GL +E H F
Sbjct 152 KNLKNNQESVYTYIQYGTGTSILEQSYDDVYLKGLKIKHQCIGLAIEESLHP-----FSD 206
Query 270 INFEGIVGMGF--PDMSSTG--ATPIYDNIMKQADLKRSEFAFYVAKDSPVS-ALFFGGV 324
+ F+GIVG+GF PD S A+P+ + I KQ LKR+ F+FYV K S A+ FG
Sbjct 207 LPFDGIVGLGFSDPDFRSQNKYASPLIETIKKQNLLKRNIFSFYVPKKLEKSGAITFGKA 266
Query 325 DPRFYE--SPIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGN 382
+ ++ I FPV +YWE+ L I + K E K +D+G+S T P
Sbjct 267 NKKYTVEGKSIEWFPVISLYYWEINLLDIQLSHKNLFLCESKKCRAAIDTGSSLITGPST 326
Query 383 EMRSFLEMIP-SQECGDDDSFLSSYPDITYVIGGV 416
++ LE I ++C + +S P I++V+ V
Sbjct 327 FIQPLLEKINLERDCSNKESL----PIISFVLKNV 357
> dre:114367 nots, LAP, MGC192423, ctsel, zgc:103608; nothepsin
Length=416
Score = 125 bits (314), Expect = 4e-28, Method: Compositional matrix adjust.
Identities = 82/275 (29%), Positives = 134/275 (48%), Gaps = 15/275 (5%)
Query 154 IMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSSSFQ 213
+ D+Q+ G + +G P Q +FDTGS++LWV S C C +F +SS+
Sbjct 78 LYNFMDAQFFGQISLGRPEQNFTVVFDTGSSDLWVPSSYCVTQACALHNKFKAFESST-- 135
Query 214 YTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSINFE 273
YT I +G+G + G D +VG V+ Q FG E G + F F+
Sbjct 136 YTHDGRVFGIHYGSGHLLGVMARDELKVGSVRVQNQVFGEAVYEPGFS-----FVLAQFD 190
Query 274 GIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDSP--VSALFFGGVDPRFYES 331
G++G+GFP ++ +P++D +M+Q L + F+FY+ + L FG D +
Sbjct 191 GVLGLGFPQLAEEKGSPVFDTMMEQNMLDQPVFSFYLTNNGSGFGGELVFGANDESRFLP 250
Query 332 PIHMFPVEREHYWEVALDAIHV-GDKKFCCEEGTKNYVILDSGTSFNTMPGNE---MRSF 387
PI+ PV ++ YW++ LDA+ V G F I+D+GTS P + ++ F
Sbjct 251 PINWIPVTQKGYWQIKLDAVKVQGALSFSDRSVQGCQAIVDTGTSLIGGPARDILILQQF 310
Query 388 LEMIPSQ--ECGDDDSFLSSYPDITYVIGGVSFVL 420
+ P+ E D +SS P ++++I V + L
Sbjct 311 IGATPTANGEFVVDCVRVSSLPVVSFLINSVEYSL 345
> cpv:cgd6_3820 membrane bound aspartyl proteinase with a signal
peptide plus transmembrane domain
Length=467
Score = 124 bits (311), Expect = 6e-28, Method: Compositional matrix adjust.
Identities = 83/271 (30%), Positives = 142/271 (52%), Gaps = 25/271 (9%)
Query 154 IMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSSSFQ 213
+ ++SQY G + +GTPP+ IFDTGS+++W+ +C+ C ++DP S+S+Q
Sbjct 88 LRNYQNSQYFGKIEVGTPPREFVVIFDTGSSSVWIPSIECKHKGCEPHNKYDPKLSTSYQ 147
Query 214 YTSP-PVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSINF 272
+ I +GTG G + +G ++ Q+FG+ +E + F + F
Sbjct 148 KLGDGSLETYIQYGTGSCVLKFGKEVINIGKLKIEDQSFGMAIEES-----TSPFAELPF 202
Query 273 EGIVGMGFPDMSS--TGATPIYDNIMKQADLKRSEFAFYVAKDSPV-SALFFGGVDPRFY 329
+G+VG+GFPD +S I +NI ++ L R+ F Y+++DS ++ FG DP++
Sbjct 203 DGLVGLGFPDKNSKKNNIPTIVENIKERNILPRNLFGVYISRDSSTPGSISFGAADPKYT 262
Query 330 ES--PIHMFPVEREHYWEVALDAIHVG--DKKFC---CEEGTKNYVILDSGTSFNTMPGN 382
S I + HYWE+ + I + +C C+ +D+G+S +T P +
Sbjct 263 ISGQKITWHRLTGSHYWEIKIKDIKINGVSTNYCFGDCKAA------IDTGSSVSTAPSS 316
Query 383 EMRSFLEMIPSQECGDDDSFLSSYPDITYVI 413
MR ++IP + G+ + +LSS P ITYVI
Sbjct 317 FMRKITKVIPME--GECNRYLSS-PRITYVI 344
> sce:YPL154C PEP4, PHO9, PRA1, yscA; Pep4p (EC:3.4.23.25); K01381
saccharopepsin [EC:3.4.23.25]
Length=405
Score = 122 bits (307), Expect = 2e-27, Method: Compositional matrix adjust.
Identities = 86/283 (30%), Positives = 129/283 (45%), Gaps = 29/283 (10%)
Query 152 VPIMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSSS 211
VP+ ++QY + +GTPPQ I DTGS+NLWV ++C C +++D SSS
Sbjct 81 VPLTNYLNAQYYTDITLGTPPQNFKVILDTGSSNLWVPSNECGSLACFLHSKYDHEASSS 140
Query 212 FQYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSIN 271
Y + I +GTG +EG D +G T+ Q F E G F
Sbjct 141 --YKANGTEFAIQYGTGSLEGYISQDTLSIGDLTIPKQDFAEATSEPGLT-----FAFGK 193
Query 272 FEGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDSPVS----ALFFGGVDPR 327
F+GI+G+G+ +S P + N ++Q L FAFY+ S + FGG+D
Sbjct 194 FDGILGLGYDTISVDKVVPPFYNAIQQDLLDEKRFAFYLGDTSKDTENGGEATFGGIDES 253
Query 328 FYESPIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSF 387
++ I PV R+ YWEV + I +GD+ E + +D+GTS T+P
Sbjct 254 KFKGDITWLPVRRKAYWEVKFEGIGLGDEYAELE---SHGAAIDTGTSLITLP----SGL 306
Query 388 LEMIPSQECGDDDSFLSSY----------PDITYVIGGVSFVL 420
EMI + E G + Y PD+ + G +F +
Sbjct 307 AEMI-NAEIGAKKGWTGQYTLDCNTRDNLPDLIFNFNGYNFTI 348
> ath:AT1G11910 aspartyl protease family protein; K08245 phytepsin
[EC:3.4.23.40]
Length=506
Score = 122 bits (305), Expect = 4e-27, Method: Compositional matrix adjust.
Identities = 82/227 (36%), Positives = 114/227 (50%), Gaps = 14/227 (6%)
Query 159 DSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCE-DDTCTKVTRFDPSKSSSFQYTSP 217
D+QY G + IGTPPQ +FDTGS+NLWV SKC C ++ S+SS+++
Sbjct 79 DAQYYGEIAIGTPPQKFTVVFDTGSSNLWVPSSKCYFSLACLLHPKYKSSRSSTYEKNGK 138
Query 218 PVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSINFEGIVG 277
I +GTG I G D VG VK Q F KE G F F+GI+G
Sbjct 139 AAA--IHYGTGAIAGFFSNDAVTVGDLVVKDQEFIEATKEPGIT-----FVVAKFDGILG 191
Query 278 MGFPDMSSTGATPIYDNIMKQADLKRSEFAFYV---AKDSPVSALFFGGVDPRFYESPIH 334
+GF ++S A P++ N++KQ +K F+F++ A + L FGGVDP ++
Sbjct 192 LGFQEISVGKAAPVWYNMLKQGLIKEPVFSFWLNRNADEEEGGELVFGGVDPNHFKGKHT 251
Query 335 MFPVEREHYWEVAL-DAIHVGDKKFCCEEGTKNYVILDSGTSFNTMP 380
PV ++ YW+ + D + G CE G I DSGTS P
Sbjct 252 YVPVTQKGYWQFDMGDVLIGGAPTGFCESGCS--AIADSGTSLLAGP 296
> cel:Y39B6A.23 hypothetical protein
Length=395
Score = 121 bits (304), Expect = 4e-27, Method: Compositional matrix adjust.
Identities = 80/307 (26%), Positives = 140/307 (45%), Gaps = 35/307 (11%)
Query 131 FLQNKEAADTLDLELGLAQTSVPIMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVG 190
FL ++ AA L G S P++ D Y + +GTPPQ + DT S NLWV+
Sbjct 41 FLASQHAARLQQLNTG----SQPLIDYYDDMYLANITVGTPPQPASVVLDTASANLWVID 96
Query 191 SKCEDDTCT-------KVTRFDPSKSSSFQYTSPPVHLDITFGTGRIEGSTGVDNFQVGP 243
+ C C +F+P+KSS+F I +G+G G G D Q+G
Sbjct 97 AACNSQACNGNPGSGYTKQKFNPNKSSTF--VKGTRRFSIQYGSGTSSGYLGTDVLQLGG 154
Query 244 FTVKGQTFGLVEKEGGHNEHGNIFKSINFEGIVGMGFPDMSSTGATPIYDNIMKQADLKR 303
TVK Q FG+ G++ S +GI G+G+P +S TP N++ Q L
Sbjct 155 LTVKAQEFGVA------TNLGSVLGSEPMDGIFGLGWPAISVDQVTPPMQNLISQKQLDA 208
Query 304 SEFAFYVAKDSPVSA------LFFGGVDPRFYESPIHMFPVEREHYWEVALDAIHVGDKK 357
F+ +V + VS + +G VD + ++ ++ + + YW+ +D + +G+
Sbjct 209 PLFSIWVDRKLQVSQGGTGGLITYGAVDTKNCDAQVNYVALSSKTYWQFPMDGVAIGNYA 268
Query 358 FCCEEGTKNYVILDSGTSFNTMPGNEMRSFLEMIPSQECGD------DDSFLSSYPDITY 411
+E I D+G+++ +P + + ++ + + D S + + PD+ +
Sbjct 269 MMKQE----QAISDTGSAWLGLPNPVLNAIVQQTKATYDWNYEIYTLDCSTMQTQPDLVF 324
Query 412 VIGGVSF 418
IGG+ +
Sbjct 325 TIGGMQY 331
> cel:Y39B6A.20 asp-1; ASpartyl Protease family member (asp-1)
Length=396
Score = 117 bits (293), Expect = 8e-26, Method: Compositional matrix adjust.
Identities = 83/309 (26%), Positives = 136/309 (44%), Gaps = 35/309 (11%)
Query 129 TSFLQNKEAADTLDLELGLAQTSVPIMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWV 188
T+FL ++ AA L G P + D Y G + +GTPPQ + DTGS+NLWV
Sbjct 39 TAFLASQHAARAQQLNTGFQ----PFVDYFDDFYLGNITLGTPPQPATVVLDTGSSNLWV 94
Query 189 VGSKCEDDTCTKV-------TRFDPSKSSSFQYTSPPVHLDITFGTGRIEGSTGVDNFQV 241
+ + C+ C +FD +KS++F I +G+G G G D
Sbjct 95 IDAACKTQACNGYPDSGYTKQKFDTTKSTTF--VKETRKFSIQYGSGSCNGYLGKDVLNF 152
Query 242 GPFTVKGQTFGLVEKEGGHNEHGNIFKSINFEGIVGMGFPDMSSTGATPIYDNIMKQADL 301
G TV+ Q FG+ ++F +GI+G+G+P ++ P N++ Q L
Sbjct 153 GGLTVQSQEFGV------STHLADVFGYQPVDGILGLGWPALAVDQVVPPMQNLIAQKQL 206
Query 302 KRSEFAFY------VAKDSPVSALFFGGVDPRFYESPIHMFPVEREHYWEVALDAIHVGD 355
F + +A+ +P + +G +D + P+ + YW+ LDA VG
Sbjct 207 DAPLFTVWLDRNLQIAQGTPGGLITYGAIDTVNCAKQVTYVPLSAKTYWQFPLDAFAVGT 266
Query 356 KKFCCEEGTKNYVILDSGTSFNTMPGNEMRSFLEMIP------SQECGDDDSFLSSYPDI 409
E K+ VI D+GTS+ P + + ++ ++ D S + + PD+
Sbjct 267 Y----SETKKDQVISDTGTSWLGAPNTIVSAIVKQTKAVFDWSTELYTVDCSTMKTQPDL 322
Query 410 TYVIGGVSF 418
+ IGG F
Sbjct 323 IFTIGGAQF 331
> dre:405786 ren; renin (EC:3.4.23.15); K01380 renin [EC:3.4.23.15]
Length=395
Score = 117 bits (292), Expect = 1e-25, Method: Compositional matrix adjust.
Identities = 77/278 (27%), Positives = 127/278 (45%), Gaps = 20/278 (7%)
Query 153 PIMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCED--DTCTKVTRFDPSKSS 210
P++ D+QY G + IG+P Q + +FDTGS NLWV C C R+D SKS
Sbjct 67 PLINYLDTQYFGEISIGSPAQMFNVVFDTGSANLWVPSHSCSPLYTACFTHNRYDASKSL 126
Query 211 SFQYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSI 270
+ + I + +G + G D V E F
Sbjct 127 THIFNG--TGFSIQYASGNVRGFLSEDVVVV---GGIPVVQVFAEATA---LPAIPFILA 178
Query 271 NFEGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDS---PVSALFFGGVDPR 327
F+G++GMG+P+++ G TP++D IM Q LK + F+ Y ++D P L GG DP
Sbjct 179 KFDGVLGMGYPNVAIDGITPVFDRIMSQHVLKENVFSVYYSRDPTHIPGGELVLGGTDPN 238
Query 328 FYESPIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNTMPGNEMRSF 387
++ P H + + WEV + + VG C++G ++D+G+S+ T P + +
Sbjct 239 YHTGPFHYINTKEQGKWEVIMKGVSVGADILFCKDGCT--AVIDTGSSYITGPASSISIL 296
Query 388 LEMIPSQECGDDDSFLSS-----YPDITYVIGGVSFVL 420
++ I + E + +S P + + +GG + L
Sbjct 297 MKTIGAVELAEGGYTVSCNVVRLLPTVAFHLGGQEYSL 334
> tpv:TP03_0056 cathepsin E (EC:3.4.23.34); K01386 [EC:3.4.23.-]
Length=513
Score = 117 bits (292), Expect = 1e-25, Method: Compositional matrix adjust.
Identities = 89/282 (31%), Positives = 139/282 (49%), Gaps = 34/282 (12%)
Query 154 IMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDT---CTKVTRFDPSKSS 210
++ ++SQY G + +GTPP+ +FDTGS+ LW+ C + + C + FD S S+
Sbjct 153 LLNFENSQYFGEIQVGTPPKSFVVVFDTGSSQLWIPSKACLNHSSNGCARHRMFDSSAST 212
Query 211 SFQYTSPPVHLD------ITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHG 264
+++ P + D I +GTG + G DN ++G VK Q+ GL E H
Sbjct 213 TYE---PMMKGDEMMSEYIRYGTGECVLALGFDNVKIGSLNVKHQSIGLSVLESEHP--- 266
Query 265 NIFKSINFEGIVGMGFPDM---SSTGATPIYDNIMKQADLKRSE----FAFYVAKDSPVS 317
F + F+G+VG+GFPD S TPI+D+I Q L S F Y SP
Sbjct 267 --FGDLPFDGLVGLGFPDTELKESKKLTPIFDSIRNQVPLTYSTVNRIFNCYNLTKSP-G 323
Query 318 ALFFGGVDPRFYESPIH---MFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGT 374
+L FG +DP+ Y P H FPV + YWE+ + ++ V + + K +D+G+
Sbjct 324 SLSFGSIDPK-YVLPGHKPWWFPVVKTDYWEIEVSSLLVDGEP--VQFDRKYNAAIDTGS 380
Query 375 SFNTMPGNEMRSFLEMIPSQECGDDDSFLSSYPDITYVIGGV 416
S + P + + LE I +E D S + P +++V V
Sbjct 381 SLISGPSDVIIPLLEKITVEE---DCSNIDKLPRLSFVFSDV 419
> pfa:PF14_0625 plasmepsin VIII (EC:3.4.17.4)
Length=385
Score = 105 bits (261), Expect = 5e-22, Method: Compositional matrix adjust.
Identities = 68/223 (30%), Positives = 105/223 (47%), Gaps = 13/223 (5%)
Query 159 DSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVTRFDPSKSSSFQYTSPP 218
+ Q+ G + IG PPQ +FDTGSTNLW+ C C ++D S +++
Sbjct 59 NRQFIGEINIGNPPQTFKVLFDTGSTNLWIPSKNCFTRACYNKRKYDHKISKNYKLVKKK 118
Query 219 VHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHGNIFKSINFEGIVGM 278
++I FGTG I + D+ +G VK Q FGL + F + F+G+ G+
Sbjct 119 DPVEILFGTGEIHIAYVTDDIHLGDIKVKNQEFGLASYIS-----DDPFSDMQFDGLFGL 173
Query 279 GFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKD-SPVSALFFGGVDPRFYE--SPIHM 335
G D IYD+I K L+++ FA Y K+ A+ FGG D +F S I
Sbjct 174 GISD-DKKKKQLIYDSIPKNI-LEKNMFAIYYPKNVDDDGAITFGGYDKKFIRENSSIEW 231
Query 336 FPVEREHYWEVALDAIHVGDKKF-CCEEGTKNY--VILDSGTS 375
F V YW + + + + D C + + + ++D+GTS
Sbjct 232 FDVTSSKYWAIQMKGLKINDVFLDVCSKNHEGFCQAVIDTGTS 274
> cel:ZK384.3 hypothetical protein
Length=392
Score = 101 bits (252), Expect = 5e-21, Method: Compositional matrix adjust.
Identities = 77/290 (26%), Positives = 124/290 (42%), Gaps = 37/290 (12%)
Query 151 SVPIMQMKDSQYCGMLGIGTPPQWVHPIFDTGSTNLWVVGSKCEDDTCTKVT------RF 204
S P++ D G + IG+PPQ DT S NLWV+GS C C +F
Sbjct 51 SQPLLGFSDDPCIGNITIGSPPQSAFVFMDTTSANLWVMGSACTSVNCNDPLLGIIKHKF 110
Query 205 DPSKSSSFQYTSPPVHLDITFGTGRIEGSTGVDNFQVGPFTVKGQTFGLVEKEGGHNEHG 264
+ +KS+SF ++ +I +G+G G G D ++G ++ Q FG+ N
Sbjct 111 NTTKSTSFVKSNR--KFNIQYGSGECSGYLGTDTVEIGGLKIQKQEFGVA------NIVD 162
Query 265 NIFKSINFEGIVGMGFPDMSSTGATPIYDNIMKQADLKRSEFAFYVAKDSP------VSA 318
F + +GI G+ +P +S TP N++ Q L F + K P
Sbjct 163 YDFGTRPIDGIFGLAWPALSVDQVTPPMQNLVSQNQLDAPIFTIFFDKRDPDYYYPSNGL 222
Query 319 LFFGGVDPRFYESPIHMFPVEREHYWEVALDAIHVGDKKFCCEEGTKNYVILDSGTSFNT 378
+ +GG+D + + I PV + YW+ +D VG ++ I+D+G+S+
Sbjct 223 ITYGGLDTKNCNANISYVPVSSKTYWQFKVDGFQVGTYN---RTVNRDQAIMDTGSSWFG 279
Query 379 MPGNEMRSFLEMIPSQECGDDDSFLSSY----------PDITYVIGGVSF 418
+P S + I +Q D + S Y PD+ + IG F
Sbjct 280 LP----YSVIAGIATQTNATWDLYASVYTVPCSTMNSLPDLVFTIGAEKF 325
Lambda K H
0.317 0.134 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 19262076140
Database: egene_temp_file_orthology_annotation_similarity_blast_database_866
Posted date: Sep 17, 2011 2:57 PM
Number of letters in database: 82,071,388
Number of sequences in database: 164,496
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40